{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:38:17Z","timestamp":1791837497122,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2406903"],"award-info":[{"award-number":["2022YFC2406903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20354"],"award-info":[{"award-number":["U22A20354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102024"],"award-info":[{"award-number":["82102024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.msard.2024.105550","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T13:27:31Z","timestamp":1710163651000},"page":"105550","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Enlarged choroid plexus in relapsing-remitting multiple sclerosis may lead to brain structural changes through the glymphatic impairment"],"prefix":"10.1016","volume":"85","author":[{"given":"Yan","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongquan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaolong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6252-9450","authenticated-orcid":false,"given":"Wenzhen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2024.105550_bib0001","doi-asserted-by":"crossref","first-page":"196","DOI":"10.5483\/BMBRep.2021.54.4.205","article-title":"The blood cerebrospinal fluid barrier orchestrates immunosurveillance, immunoprotection, and immunopathology in the central nervous system","volume":"54","author":"Ayub","year":"2021","journal-title":"BMB Rep."},{"key":"10.1016\/j.msard.2024.105550_bib0002","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/ana.26419","article-title":"Magnetic resonance imaging evaluation of perivascular space abnormalities in neuromyelitis optica","volume":"92","author":"Cacciaguerra","year":"2022","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2024.105550_bib0003","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00401-012-1001-9","article-title":"Clonally expanded mitochondrial DNA deletions within the choroid plexus in multiple sclerosis","volume":"124","author":"Campbell","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.msard.2024.105550_bib0004","doi-asserted-by":"crossref","first-page":"589","DOI":"10.2174\/187152712801661194","article-title":"Clonal expansion of mitochondrial DNA deletions and the progression of multiple sclerosis","volume":"11","author":"Campbell","year":"2012","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.msard.2024.105550_bib0005","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1093\/brain\/awab454","article-title":"Glymphatic system impairment in multiple sclerosis: relation with brain damage and disability","volume":"145","author":"Carotenuto","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.msard.2024.105550_bib0006","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1007\/s00330-022-09277-2","article-title":"Enlarged choroid plexus related to cortical atrophy in multiple sclerosis","volume":"33","author":"Chen","year":"2022","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.msard.2024.105550_bib0007","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1148\/radiol.212400","article-title":"Choroid plexus volume and permeability at brain MRI within the Alzheimer disease clinical spectrum","volume":"304","author":"Choi","year":"2022","journal-title":"Radiology"},{"key":"10.1016\/j.msard.2024.105550_bib0008","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1474-4422(14)70101-2","article-title":"Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging","volume":"13","author":"Ciccarelli","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.msard.2024.105550_bib0009","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1152\/physrev.00004.2013","article-title":"Cerebrospinal fluid secretion by the choroid plexus","volume":"93","author":"Damkier","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.msard.2024.105550_bib0010","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1016\/j.cell.2021.04.003","article-title":"A cellular and spatial map of the choroid plexus across brain ventricles and ages","volume":"184","author":"Dani","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.msard.2024.105550_bib0011","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/brain\/awaa379","article-title":"In vivo gradients of thalamic damage in paediatric multiple sclerosis: a window into pathology","volume":"144","author":"De Meo","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.msard.2024.105550_bib0012","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1093\/brain\/awy088","article-title":"Progression of regional grey matter atrophy in multiple sclerosis","volume":"141","author":"Eshaghi","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.msard.2024.105550_bib0013","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025000118","article-title":"Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans","volume":"118","author":"Fleischer","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.msard.2024.105550_bib0014","doi-asserted-by":"crossref","first-page":"e2648","DOI":"10.1212\/WNL.0000000000201300","article-title":"Association of MRI indices of glymphatic system with amyloid deposition and cognition in mild cognitive impairment and alzheimer disease","volume":"99","author":"Kamagata","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2024.105550_bib0015","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1177\/13524585221080667","article-title":"The expansion and severity of chronic MS lesions follows a periventricular gradient","volume":"28","author":"Klistorner","year":"2022","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2024.105550_bib0016","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/acn3.51644","article-title":"Choroid plexus volume in multiple sclerosis predicts expansion of chronic lesions and brain atrophy","volume":"9","author":"Klistorner","year":"2022","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.msard.2024.105550_bib0017","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1177\/13524585231157206","article-title":"Choroid plexus volume is enlarged in clinically isolated syndrome patients with optic neuritis","volume":"29","author":"Klistorner","year":"2023","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2024.105550_bib0018","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ana.26648","article-title":"Choroid plexus enlargement exacerbates white matter hyperintensity growth through glymphatic impairment","volume":"94","author":"Li","year":"2023","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2024.105550_bib0019","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1002\/mrm.26946","article-title":"MEDI+0: morphology enabled dipole inversion with automatic uniform cerebrospinal fluid zero reference for quantitative susceptibility mapping","volume":"79","author":"Liu","year":"2018","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.msard.2024.105550_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2021.102785","article-title":"Event-related potentials and deep grey matter atrophy in multiple sclerosis: exploring the possible associations with cognition","volume":"49","author":"Lorefice","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2024.105550_bib0021","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2115221118","article-title":"Choroid plexus volumetrics and brain inflammation in multiple sclerosis","volume":"118","author":"Manouchehri","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.msard.2024.105550_bib0022","doi-asserted-by":"crossref","first-page":"6365","DOI":"10.1523\/JNEUROSCI.1974-18.2019","article-title":"Impaired glymphatic transport in spontaneously hypertensive rats","volume":"39","author":"Mortensen","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.msard.2024.105550_bib0023","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1148\/radiol.2021204426","article-title":"Choroid plexus enlargement in inflammatory multiple sclerosis: 3.0-T MRI and translocator protein PET evaluation","volume":"301","author":"Ricigliano","year":"2021","journal-title":"Radiology"},{"key":"10.1016\/j.msard.2024.105550_bib0024","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40478-020-0885-1","article-title":"Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells","volume":"8","author":"Rodr\u00edguez-Lorenzo","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.msard.2024.105550_bib0025","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41531-022-00316-9","article-title":"Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson's disease","volume":"8","author":"Si","year":"2022","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.msard.2024.105550_bib0026","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11604-017-0617-z","article-title":"Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases","volume":"35","author":"Taoka","year":"2017","journal-title":"Jpn. J. Radiol."},{"key":"10.1016\/j.msard.2024.105550_bib0027","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.3348\/kjr.2020.0042","article-title":"Neurofluid dynamics and the glymphatic system: a neuroimaging perspective","volume":"21","author":"Taoka","year":"2020","journal-title":"Korean J. Radiol."},{"key":"10.1016\/j.msard.2024.105550_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.744318","article-title":"Factors associated with dysfunction of glymphatic system in patients with glioma","volume":"11","author":"Toh","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.msard.2024.105550_bib0029","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jneuroim.2008.04.035","article-title":"Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: a neuropathological study","volume":"199","author":"Vercellino","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.msard.2024.105550_bib0030","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1177\/13524585211032800","article-title":"Structural and functional hippocampal alterations in Multiple sclerosis and neuromyelitis optica spectrum disorder","volume":"28","author":"Zheng","year":"2021","journal-title":"Mult. Scler."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034824001299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034824001299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:28:52Z","timestamp":1778840932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034824001299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":30,"alternative-id":["S2211034824001299"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2024.105550","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enlarged choroid plexus in relapsing-remitting multiple sclerosis may lead to brain structural changes through the glymphatic impairment","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2024.105550","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105550"}}