{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:02:45Z","timestamp":1793419365063,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000924","name":"Multiple Sclerosis Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","msard-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.msard.2024.105828","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T06:50:35Z","timestamp":1724395835000},"page":"105828","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Examining the relative contribution of slow-burning inflammation and chronic demyelination to axonal damage in chronic multiple sclerosis lesions"],"prefix":"10.1016","volume":"90","author":[{"given":"Samuel","family":"Klistorner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Parratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Con","family":"Yiannikas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Klistorner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.msard.2024.105828_bib0049","first-page":"358","article-title":"Advanced MRI and staging of multiple sclerosis lesions","volume":"12","author":"Absinta","year":"2016","journal-title":"Nature Publish. Group"},{"key":"10.1016\/j.msard.2024.105828_bib0022","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awae013","article-title":"Imaging chronic active lesions in multiple sclerosis: a consensus statement","author":"Bagnato","year":"2024","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.msard.2024.105828_bib0036","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/1522-2594(200010)44:4<583::AID-MRM12>3.0.CO;2-O","article-title":"Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis","volume":"44","author":"Bammer","year":"2000","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.msard.2024.105828_bib0015","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1001\/archneur.60.8.1073","article-title":"Remyelinated lesions in multiple sclerosis:magnetic resonance image appearance","volume":"60","author":"Barkhof","year":"2003","journal-title":"Arch Neurol."},{"key":"10.1016\/j.msard.2024.105828_bib0027","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/brain\/114.3.1271","article-title":"The longstanding MS lesion. A quantitative MRI and electron microscopic study","volume":"114","author":"Barnes","year":"1991","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.msard.2024.105828_bib0018","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/ana.1053","article-title":"A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions","volume":"49","author":"Bitsch","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2024.105828_bib0052","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1093\/brain\/awq250","article-title":"Demyelination versus remyelination in progressive multiple sclerosis","volume":"133","author":"Bramow","year":"2010","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.msard.2024.105828_bib0028","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1007\/s00234-002-0806-y","article-title":"Diffusion of water in large demyelinating lesions: a follow-up study","volume":"44","author":"Castriota-Scanderbeg","year":"2002","journal-title":"Neuroradiology."},{"issue":"April","key":"10.1016\/j.msard.2024.105828_bib0024","first-page":"663","article-title":"Coefficient Dav is more sensitive than fractional anisotropy in monitoring progression of irreversible tissue damage in focal nonactive multiple sclerosis lesions","volume":"24","author":"Castriota-scanderbeg","year":"2003","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"August","key":"10.1016\/j.msard.2024.105828_bib0048","first-page":"1","article-title":"The role of astrocytes in multiple sclerosis progression","volume":"6","author":"Correale","year":"2015","journal-title":"Front. Neurol."},{"key":"10.1016\/j.msard.2024.105828_bib0047","first-page":"527","article-title":"Progressive multiple sclerosis : from pathogenic mechanisms to treatment multiple sclerosis","volume":"140","author":"Correale","year":"2017","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.msard.2024.105828_bib0050","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00401-016-1636-z","article-title":"Slow expansion of multiple sclerosis iron rim lesions : pathology and 7 T magnetic resonance imaging","volume":"133","author":"Dal-Bianco","year":"2017","journal-title":"Acta Neuropathol."},{"issue":"5","key":"10.1016\/j.msard.2024.105828_bib0035","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0730-725X(99)00011-9","article-title":"Comparison of multiple sclerosis clinical subgroups using navigated spin echo diffusion-weighted imaging","volume":"17","author":"Droogan","year":"1999","journal-title":"Magn. Reson. ImAging"},{"key":"10.1016\/j.msard.2024.105828_bib0046","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/ana.20736","article-title":"Mitochondrial dysfunction cause of axonal degeneration in multiple sclerosis patients","volume":"59","author":"Dutta","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2024.105828_bib0009","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.nicl.2017.06.022","article-title":"Neurological software tool for reliable atrophy measurement (NeuroSTREAM) of the lateral ventricles on clinical-quality T2-FLAIR MRI scans in multiple sclerosis","volume":"15","author":"Dwyer","year":"2017","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.msard.2024.105828_bib0023","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1177\/1352458518814117","article-title":"Slowly expanding \/evolving lesions as a magnetic resonance imaging marker of chronic active multiple sclerosis lesions","volume":"25","author":"Elliott","year":"2019","journal-title":"Mult Scer"},{"issue":"9","key":"10.1016\/j.msard.2024.105828_bib0055","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1093\/brain\/awz212","article-title":"Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis","volume":"142","author":"Elliott","year":"2019","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.msard.2024.105828_bib0037","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1001\/archneur.57.7.1017","article-title":"A quantitative study of water diffusion in multiple sclerosis lesions and normal-appearing white matter using echo-planar imaging","volume":"57","author":"Filippi","year":"2000","journal-title":"Arch. Neurol."},{"issue":"Pt 5","key":"10.1016\/j.msard.2024.105828_bib0054","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/brain\/awp070","article-title":"The relation between inflammation and neurodegeneration in multiple sclerosis brains","volume":"132","author":"Frischer","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.msard.2024.105828_bib0003","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/brain\/awp070","article-title":"The relation between inflammation and neurodegeneration in multiple sclerosis brains","volume":"132","author":"Frischer","year":"2010","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.msard.2024.105828_bib0004","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/ana.24497","article-title":"Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque","volume":"78","author":"Frischer","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2024.105828_bib0013","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1056\/NEJMra052130","article-title":"Multiple Sclerosis \u2014 The plaque and its pathogenesis","volume":"354","author":"Frohman","year":"2006","journal-title":"N Eng. J. MedEngl. J. Med."},{"key":"10.1016\/j.msard.2024.105828_bib0020","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimisation for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"issue":"5","key":"10.1016\/j.msard.2024.105828_bib0010","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1191\/1352458502ms833oa","article-title":"Brain atrophy in multiple sclerosis: impact of lesions and of damage of whole brain tissue","volume":"8","author":"Kalkers","year":"2002","journal-title":"Multiple Sclerosis"},{"key":"10.1016\/j.msard.2024.105828_bib0006","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.nicl.2017.12.010","article-title":"Evidence of progressive tissue loss in the core of chronic MS lesions: a longitudinal DTI study","volume":"17","author":"Klistorner","year":"2018","journal-title":"Neuroimage Clin."},{"issue":"10","key":"10.1016\/j.msard.2024.105828_bib0008","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1177\/1352458520974357","article-title":"Expansion of chronic lesions is linked to disease progression in relapsing\u2013remitting multiple sclerosis patients","volume":"27","author":"Klistorner","year":"2021","journal-title":"Multiple Scler. J."},{"key":"10.1016\/j.msard.2024.105828_bib0011","first-page":"2038","article-title":"Mechanisms of central brain atrophy in multiple sclerosis","volume":"28","author":"Klistorner","year":"2022","journal-title":"MSJ"},{"key":"10.1016\/j.msard.2024.105828_bib0043","doi-asserted-by":"crossref","first-page":"e1155","DOI":"10.1212\/NXI.0000000000001155","article-title":"Long-term effect of permanent demyelination on axonal survival in multiple sclerosis","volume":"9","author":"Klistorner","year":"2022","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"issue":"1","key":"10.1016\/j.msard.2024.105828_bib0005","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0002-9440(10)64537-3","article-title":"Multiple sclerosis and chronic autoimmune encephalomyelitis a comparative quantitative study of axonal injury in active","volume":"157","author":"Kornek","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.msard.2024.105828_bib0045","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0002-9440(10)64537-3","article-title":"Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative study of axonal injury in active, inactive and remyelinated lesons","volume":"157","author":"Kornek","year":"2000","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.msard.2024.105828_bib0014","doi-asserted-by":"crossref","DOI":"10.1007\/s00401-016-1653-y","article-title":"An updated histological classification system for multiple sclerosis lesions","volume":"133","author":"Kuhlmann","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.msard.2024.105828_bib0017","series-title":"The pathology of multiple sclerosis","author":"Lassmann","year":"1841"},{"issue":"Suppl:S42\u20136","key":"10.1016\/j.msard.2024.105828_bib0032","article-title":"Histopathology and the blood-cerebrospinal fluid barrier in multiple sclerosis","volume":"36","author":"Lassmann","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2024.105828_bib0002","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11910-007-0036-0","article-title":"New Concepts on Progressive Multiple Sclerosis","volume":"7","author":"Lassmann","year":"2007","journal-title":"Cur. Neurol. Neurosci. Reports"},{"issue":"2","key":"10.1016\/j.msard.2024.105828_bib0042","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1474-4422(14)70256-X","article-title":"Progressive multiple sclerosis 1 Pathological mechanisms in progressive multiple sclerosis","volume":"14","author":"Mahad","year":"2015","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.msard.2024.105828_bib0038","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuroimage.2011.03.070","article-title":"Diffusion imaging of whole, post-mortem human brains on a clinical MRI scanner","volume":"57","author":"Miller","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.msard.2024.105828_bib0016","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/brain\/114.2.1013","article-title":"Histopathology of multiple sclerosis lesions detected by magnetic resonance imaging in unfixed postmortem central nervous system tissue","volume":"114","author":"Newcombe","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.msard.2024.105828_bib0041","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1148\/radiology.201.3.8939209","article-title":"Diffusion Tensor MR Imaging of the human brain","author":"Pierpaoli","year":"1996","journal-title":"Radiology."},{"key":"10.1016\/j.msard.2024.105828_bib0001","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/ana.1255","article-title":"Immunopathology of secondary-progressive multiple sclerosis","volume":"50","author":"Prineas","year":"2006","journal-title":"Ann. Neurol."},{"issue":"5","key":"10.1016\/j.msard.2024.105828_bib0019","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1177\/1756285613484079","article-title":"Magnetic resonance monitoring of lesion evolution in multiple sclerosis","volume":"6","author":"Rovira","year":"2013","journal-title":"Ther. Adv. Neurol. Disord."},{"issue":"6","key":"10.1016\/j.msard.2024.105828_bib0030","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2217\/cer-2020-0267","article-title":"Efficacy classification of modern therapies in multiple sclerosis","volume":"10","author":"Samjoo","year":"2021","journal-title":"J. Comp. Eff. Res."},{"key":"10.1016\/j.msard.2024.105828_bib0021","first-page":"1","article-title":"Smouldering-associated worsening in multiple sclerosis : an international consensus statement on definition, biology, clinical implications, and future directions","volume":"00","author":"Scalfari","year":"2024","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.msard.2024.105828_bib0034","first-page":"862","article-title":"Demyelinating plaques in relapsing-remitting and secondary-progressive multiple sclerosis: assessment with diffusion MR imaging","volume":"21","author":"Scanderbeg","year":"2000","journal-title":"Am. J. Neuroradiol."},{"issue":"2","key":"10.1016\/j.msard.2024.105828_bib0029","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.neuroimage.2006.12.010","article-title":"Diffusion tensor imaging of post mortem multiple sclerosis brain","volume":"35","author":"Schmierer","year":"2007","journal-title":"Neuroimage"},{"issue":"4","key":"10.1016\/j.msard.2024.105828_bib0031","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/practneurol-2015-001139","article-title":"Association of British Neurologists: revised (2015) guidelines for prescribing disease-modifying treatments in multiple sclerosis","volume":"15","author":"Scolding","year":"2015","journal-title":"Pract. Neurol."},{"key":"10.1016\/j.msard.2024.105828_bib0040","unstructured":"Shepherd T.M., Flint J., Thelwall P.E., et al. Postmortem interval alters the water relaxation and diffusion. 2010; 9(2):1\u201314."},{"key":"10.1016\/j.msard.2024.105828_bib0012","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/nimg.2002.1040","article-title":"Accurate, robust and automated longitudinal and cross-sectional brain change analysis","volume":"17","author":"Smith","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.msard.2024.105828_bib0007","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"The Lancet"},{"issue":"5","key":"10.1016\/j.msard.2024.105828_bib0053","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1056\/NEJM199801293380502","article-title":"Axonal transection in the lesions of multiple sclerosis","volume":"338","author":"Trapp","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.msard.2024.105828_bib0044","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00019052-199906000-00008","article-title":"Axonal pathology in multiple sclerosis: relationship to neurologic disability","volume":"12","author":"Trapp","year":"1999","journal-title":"Curr. Opin. Neurol."},{"issue":"1","key":"10.1016\/j.msard.2024.105828_bib0051","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1365-2990.2000.00217.x","article-title":"Staging of multiple sclerosis (MS) lesions: pathology of the time frame of MS","volume":"26","author":"van der Valk","year":"2000","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.msard.2024.105828_bib0026","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1212\/WNL.50.5.1282","article-title":"Histopathologic correlate of hypointense lesions on Tl-weighted spin-echo lesions in multiple sclerosis MRI","volume":"50","author":"van Walderveen","year":"1998","journal-title":"Neurology."},{"issue":"5","key":"10.1016\/j.msard.2024.105828_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/NXI.0000000000000593","article-title":"Lesion activity and chronic demyelination are the major determinants of brain atrophy in MS","volume":"6","author":"Wang","year":"2019","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"issue":"6","key":"10.1016\/j.msard.2024.105828_bib0039","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.mri.2008.11.009","article-title":"Alteration of diffusion tensor parameters in postmortem brain","volume":"27","author":"Widjaja","year":"2009","journal-title":"Magn. Reson. ImAging"},{"issue":"3","key":"10.1016\/j.msard.2024.105828_bib0033","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/jmri.22502","article-title":"Using Diffusion Tensor Imaging and Immunofluorescent assay to evaluate the pathology of Multiple Sclerosis","volume":"33","author":"Zollinger","year":"2012","journal-title":"J. Magn. Reson. Imaging"}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221103482400405X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221103482400405X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T07:57:06Z","timestamp":1726387026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221103482400405X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":55,"alternative-id":["S221103482400405X"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2024.105828","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Examining the relative contribution of slow-burning inflammation and chronic demyelination to axonal damage in chronic multiple sclerosis lesions","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2024.105828","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105828"}}