{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:32:06Z","timestamp":1779229926892,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","msard-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.msard.2025.106277","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T16:23:51Z","timestamp":1737217431000},"page":"106277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Deciphering the bidirectional impact of leukocyte telomere length on multiple sclerosis progression: A Mendelian randomization study"],"prefix":"10.1016","volume":"94","author":[{"given":"Hani","family":"Sabaie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Taghavi Rad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motahareh","family":"Shabestari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Seddiq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toktam","family":"Saadattalab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danial","family":"Habibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Hesam","family":"Saeidian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohadeseh","family":"Abbasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5604-8543","authenticated-orcid":false,"given":"Hanifeh","family":"Mirtavoos-Mahyari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2025.106277_bib0001","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1098\/rstb.2016.0436","article-title":"Reflections on telomere dynamics and ageing-related diseases in humans","volume":"373","author":"Aviv","year":"2018","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"14","key":"10.1016\/j.msard.2025.106277_bib0002","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1182\/blood-2015-08-667485","article-title":"Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia","volume":"127","author":"B\u00e4r","year":"2016","journal-title":"Blood"},{"issue":"6265","key":"10.1016\/j.msard.2025.106277_bib0003","first-page":"1193","article-title":"Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection","volume":"350","author":"Blackburn","year":"2015","journal-title":"Science (1979)"},{"issue":"2","key":"10.1016\/j.msard.2025.106277_bib0004","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.msard.2025.106277_bib0005","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/ije\/dyy258","article-title":"Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption","volume":"48","author":"Bowden","year":"2019","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.msard.2025.106277_bib0006","doi-asserted-by":"crossref","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.1","article-title":"Guidelines for performing Mendelian randomization investigations: update for summer 2023","volume":"4","author":"Burgess","year":"2019","journal-title":"Wellcome Open. Res."},{"issue":"5","key":"10.1016\/j.msard.2025.106277_bib0007","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur. J. Epidemiol."},{"issue":"10","key":"10.1016\/j.msard.2025.106277_bib0008","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/s41588-021-00944-6","article-title":"Polygenic basis and biomedical consequences of telomere length variation","volume":"53","author":"Codd","year":"2021","journal-title":"Nat. Genet."},{"issue":"9313","key":"10.1016\/j.msard.2025.106277_bib0009","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0140-6736(02)08220-X","article-title":"Multiple sclerosis","volume":"359","author":"Compston","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.msard.2025.106277_bib0010","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7156435","article-title":"Aging-Induced Biological Changes and Cardiovascular Diseases","volume":"2018","author":"Fajemiroye","year":"2018","journal-title":"Biomed. Res. Int."},{"issue":"4","key":"10.1016\/j.msard.2025.106277_bib0011","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1212\/NXG.0000000000000087","article-title":"Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies","volume":"2","author":"George","year":"2016","journal-title":"Neurol. Genet."},{"issue":"1","key":"10.1016\/j.msard.2025.106277_bib0012","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1474-4422(22)00184-3","article-title":"Ageing and multiple sclerosis","volume":"22","author":"Graves","year":"2023","journal-title":"Lancet Neurol."},{"issue":"1\u20132","key":"10.1016\/j.msard.2025.106277_bib0013","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11010-014-2274-1","article-title":"Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening","volume":"400","author":"Guan","year":"2015","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.msard.2025.106277_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577187","article-title":"Association between shorter leukocyte telomeres and multiple sclerosis","volume":"341","author":"Habib","year":"2020","journal-title":"J. Neuroimmunol."},{"issue":"7969","key":"10.1016\/j.msard.2025.106277_bib0015","first-page":"1","article-title":"Locus for severity implicates CNS resilience in progression of multiple sclerosis","volume":"619","author":"Harroud","year":"2023","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.msard.2025.106277_bib0016","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/jamaoncol.2016.5945","article-title":"Association between telomere length and risk of cancer and non-neoplastic diseases: a mendelian randomization study","volume":"3","author":"Haycock","year":"2017","journal-title":"JAMa Oncol."},{"issue":"6","key":"10.1016\/j.msard.2025.106277_bib0017","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1007\/s12035-021-02315-y","article-title":"Leukocyte telomere length in patients with multiple sclerosis and its association with clinical phenotypes","volume":"58","author":"Hecker","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"R2","key":"10.1016\/j.msard.2025.106277_bib0018","doi-asserted-by":"crossref","first-page":"R195","DOI":"10.1093\/hmg\/ddy163","article-title":"Evaluating the potential role of pleiotropy in Mendelian randomization studies","volume":"27","author":"Hemani","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"11","key":"10.1016\/j.msard.2025.106277_bib0019","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007081","article-title":"Orienting the causal relationship between imprecisely measured traits using GWAS summary data","volume":"13","author":"Hemani","year":"2017","journal-title":"PLoS. Genet."},{"issue":"6460","key":"10.1016\/j.msard.2025.106277_bib0020","first-page":"eaav7188","article-title":"Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility","volume":"365","year":"2019","journal-title":"Science (1979)"},{"issue":"5","key":"10.1016\/j.msard.2025.106277_bib0021","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/ana.25592","article-title":"Telomere length is associated with disability progression in multiple sclerosis","volume":"86","author":"Krysko","year":"2019","journal-title":"Ann. Neurol."},{"issue":"11","key":"10.1016\/j.msard.2025.106277_bib0022","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology."},{"issue":"6","key":"10.1016\/j.msard.2025.106277_bib0023","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.msard.2025.106277_bib0024","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/00207454.2022.2098737","article-title":"Telomere length and multiple sclerosis: a Mendelian randomization study","volume":"134","author":"Ma","year":"2024","journal-title":"Int. J. Neurosci."},{"issue":"14","key":"10.1016\/j.msard.2025.106277_bib0025","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1177\/1352458517690618","article-title":"Age Related Multiple Sclerosis Severity Score: disability ranked by age","volume":"23","author":"Manouchehrinia","year":"2017","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2025.106277_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2021.103084","article-title":"What telomeres teach us about MS","volume":"54","author":"Miner","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"18","key":"10.1016\/j.msard.2025.106277_bib0027","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1073\/pnas.85.18.6622","article-title":"A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes","volume":"85","author":"Moyzis","year":"1988","journal-title":"Proc. Natl. Acad. Sci. u S. a"},{"key":"10.1016\/j.msard.2025.106277_bib0028","doi-asserted-by":"crossref","DOI":"10.1038\/s43586-021-00092-5","article-title":"Mendelian randomization","volume":"2","author":"Sanderson","year":"2022","journal-title":"Nat. Rev. Methods Primers."},{"issue":"11","key":"10.1016\/j.msard.2025.106277_bib0029","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1681\/ASN.2016010098","article-title":"Mendelian randomization as an approach to assess causality using observational data","volume":"27","author":"Sekula","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.msard.2025.106277_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2022.103731","article-title":"Genetically predicted telomere length and multiple sclerosis","volume":"60","author":"Shu","year":"2022","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"4","key":"10.1016\/j.msard.2025.106277_bib0031","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/gepi.22295","article-title":"A comparison of robust Mendelian randomization methods using summary data","volume":"44","author":"Slob","year":"2020","journal-title":"Genet. Epidemiol."},{"issue":"1","key":"10.1016\/j.msard.2025.106277_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Smith","year":"2003","journal-title":"Int. J. Epidemiol."},{"issue":"10130","key":"10.1016\/j.msard.2025.106277_bib0033","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/S0140-6736(18)30481-1","article-title":"Multiple sclerosis","volume":"391","author":"Thompson","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.msard.2025.106277_bib0034","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2023.5526","article-title":"Role of telomere length in human carcinogenesis (Review)","volume":"63","author":"Tsatsakis","year":"2023","journal-title":"Int. J. Oncol."},{"issue":"5","key":"10.1016\/j.msard.2025.106277_bib0035","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat. Genet."},{"issue":"9","key":"10.1016\/j.msard.2025.106277_bib0036","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/acn3.50862","article-title":"Environmental and genetic risk factors for MS: an integrated review","volume":"6","author":"Waubant","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"2","key":"10.1016\/j.msard.2025.106277_bib0037","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s40484-020-0216-3","article-title":"Mendelian randomization and pleiotropy analysis","volume":"9","author":"Zhu","year":"2021","journal-title":"Quant. Biol."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825000215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825000215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T02:04:13Z","timestamp":1739498653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034825000215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":37,"alternative-id":["S2211034825000215"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2025.106277","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deciphering the bidirectional impact of leukocyte telomere length on multiple sclerosis progression: A Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2025.106277","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106277"}}