{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T17:54:13Z","timestamp":1768413253398,"version":"3.49.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","msard-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.msard.2025.106278","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T16:23:52Z","timestamp":1737217432000},"page":"106278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Development and validation of a scoring system for predicting disease activity in treatment-na\u00efve patients with relapsing-remitting multiple sclerosis"],"prefix":"10.1016","volume":"94","author":[{"given":"Magd","family":"Zakaria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-8367","authenticated-orcid":false,"given":"Nevin Mohieldin","family":"Shalaby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farouk","family":"Talaat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Elmazny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman","family":"Hamdy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud Saad","family":"Swelam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Taha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maged Abdel","family":"Naseer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2025.106278_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.105009","article-title":"Secondary hypogammaglobulinemia in patients with multiple sclerosis on anti-CD20 therapy: pathogenesis, risk of infection, and disease management","volume":"79","author":"Alvarez","year":"2023","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2025.106278_bib0002","doi-asserted-by":"crossref","unstructured":"Amato, M.P. (2022). Getting evidence into practice: the new EAN-ECTRIMS guideline \u201cUpdate on the pharmacological treatment of people with multiple sclerosis\u201d. SYMP02, EAN 2022, 25\u201328 April, Vienna, Austria.","DOI":"10.55788\/b71ff3dc"},{"issue":"1\u20132","key":"10.1016\/j.msard.2025.106278_bib0003","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-510X(01)00572-X","article-title":"Predicting secondary progression in relapsing-remitting multiple sclerosis: a Bayesian analysis","volume":"189","author":"Bergamaschi","year":"2001","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.msard.2025.106278_bib0004","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1056\/NEJMoa011341","article-title":"A longitudinal study of abnormalities on MRI and disability from multiple sclerosis","volume":"346","author":"Brex","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.msard.2025.106278_bib0005","article-title":"Systematic review of prediction models in relapsing-remitting multiple sclerosis","volume":"15","author":"Brown","year":"2020","journal-title":"PLoS. One"},{"key":"10.1016\/j.msard.2025.106278_bib0006","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1751-0473-3-17","article-title":"Purposeful selection of variables in logistic regression","volume":"3","author":"Bursac","year":"2008","journal-title":"Source Code Biol. Med."},{"key":"10.1016\/j.msard.2025.106278_bib0007","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/S0140-6736(00)04725-5","article-title":"Effect of early interferon treatment on conversion to definite multiple sclerosis","volume":"357","author":"Comi","year":"2001","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.msard.2025.106278_bib0008","first-page":"157","article-title":"Evolving concepts in the treatment of relapsing multiple sclerosis","volume":"15","author":"Comi","year":"2016","journal-title":"Lancet Neurol."},{"issue":"9","key":"10.1016\/j.msard.2025.106278_bib0009","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/sim.8063","article-title":"Sample size considerations and predictive performance of multinomial logistic prediction models","volume":"38","author":"de Jong","year":"2019","journal-title":"Stat. Med."},{"issue":"5","key":"10.1016\/j.msard.2025.106278_bib0011","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S1474-4422(12)70056-X","article-title":"Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study","volume":"11","author":"Devonshire","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.msard.2025.106278_bib0012","first-page":"215","article-title":"Highly Active","volume":"30","author":"Diaz","year":"2019","journal-title":"Mult. Scler."},{"issue":"1","key":"10.1016\/j.msard.2025.106278_bib0013","first-page":"118","article-title":"Multiple sclerosis \u2013 a review","volume":"25","author":"Dobson","year":"2018","journal-title":"Eur. J. Neurol."},{"issue":"Suppl 6","key":"10.1016\/j.msard.2025.106278_bib0014","doi-asserted-by":"crossref","first-page":"s53","DOI":"10.7861\/clinmedicine.16-6-s53","article-title":"Multiple sclerosis, a treatable disease","volume":"16","author":"Doshi","year":"2016","journal-title":"Clin. Med."},{"key":"10.1016\/j.msard.2025.106278_bib0016","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1191\/1352458503ms914oa","article-title":"Long-term follow-up of patients with clinically isolated syndromes, relapsing-remitting and secondary progressive multiple sclerosis","volume":"9","author":"Eriksson","year":"2003","journal-title":"Mult. Scler."},{"issue":"9","key":"10.1016\/j.msard.2025.106278_bib0017","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1007\/s00415-010-5560-1","article-title":"Characteristics of multiple sclerosis at onset and delay of diagnosis and treatment in Spain (the Novo Study)","volume":"257","author":"Fern\u00e1ndez","year":"2010","journal-title":"J. Neurol."},{"issue":"2017","key":"10.1016\/j.msard.2025.106278_bib0018","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.msard.2017.07.003","article-title":"Is there a change of paradigm towards more effective treatment early in the course of apparent high-risk MS?","volume":"17","author":"Fern\u00e1ndez","year":"2017","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"10","key":"10.1016\/j.msard.2025.106278_bib0019","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.1007\/s00415-022-11193-w","article-title":"Early use of high-efficacy disease-modifying therapies makes the difference in people with multiple sclerosis: an expert opinion","volume":"269","author":"Filippi","year":"2022","journal-title":"J. Neurol."},{"issue":"3","key":"10.1016\/j.msard.2025.106278_bib0021","first-page":"761","article-title":"Severe, highly active, or aggressive multiple sclerosis","volume":"22","author":"Freedman","year":"2016","journal-title":"Continuum"},{"issue":"4","key":"10.1016\/j.msard.2025.106278_bib0022","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1017\/cjn.2020.66","article-title":"Treatment optimization in multiple sclerosis: Canadian MS working group recommendations","volume":"47","author":"Freedman","year":"2020","journal-title":"Canadian J. Neurol. Sci."},{"key":"10.1016\/j.msard.2025.106278_bib0023","doi-asserted-by":"crossref","first-page":"261","DOI":"10.7224\/1537-2073.2021-006","article-title":"The multiple sclerosis data alliance catalogue: enabling web-based discovery of metadata from real-world multiple sclerosis data sources","volume":"23","author":"Geys","year":"2021","journal-title":"Int. J. MS. Care"},{"key":"10.1016\/j.msard.2025.106278_bib0024","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s40120-018-0112-1","article-title":"European and American Guidelines for Multiple Sclerosis Treatment","volume":"7","author":"Ghezzi","year":"2018","journal-title":"Neurol. Ther."},{"key":"10.1016\/j.msard.2025.106278_bib0025","series-title":"Advanced Analytics","article-title":"Handbook of inter-rater reliability: the definitive guide to measuring the extent of agreement among raters","author":"Gwet","year":"2014"},{"key":"10.1016\/j.msard.2025.106278_bib0026","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.2147\/NDT.S140869","article-title":"Characteristics and predictors of progression in an Egyptian multiple sclerosis cohort: a multicenter registry study","volume":"13","author":"Hamdy","year":"2017","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.msard.2025.106278_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2020.101928","article-title":"Predictive medicine in multiple sclerosis: a systematic review","volume":"40","author":"Havas","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2025.106278_bib0028","unstructured":"Harrell, F. (2022). RMS: regression Modeling Strategies. CRAN.R-project.org."},{"key":"10.1016\/j.msard.2025.106278_bib0029","unstructured":"Harrell, F. (2023). RMS: describing, Resampling, Validating, and Simplifying the Model. Retrieved from https:\/\/discourse.datamethods.org\/t\/rms-describing-resampling-validating-and-simplifying-the-model\/4790\/118."},{"key":"10.1016\/j.msard.2025.106278_bib0031","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/ana.410410315","article-title":"Correlation of clinical, magnetic resonance imaging, and cerebrospinal fluid findings in optic neuritis","volume":"41","author":"Jacobs","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2025.106278_bib0032","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1093\/brain\/awx185","article-title":"Towards personalized therapy for multiple sclerosis: prediction of individual treatment response","volume":"140","author":"Kalincik","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.msard.2025.106278_bib0033","series-title":"Rank Correlation Methods","author":"Kendall","year":"1948"},{"issue":"5","key":"10.1016\/j.msard.2025.106278_bib0034","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S1474-4422(10)70064-8","article-title":"The changing demographic pattern of multiple sclerosis epidemiology","volume":"9","author":"Koch-Henriksen","year":"2010","journal-title":"Lancet Neurol."},{"issue":"6","key":"10.1016\/j.msard.2025.106278_bib0035","first-page":"725","article-title":"How many raters? Toward the most reliable diagnostic consensus","volume":"11","author":"Kraemer","year":"1992","journal-title":"Stat. Med."},{"issue":"12","key":"10.1016\/j.msard.2025.106278_bib0037","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1001\/archneur.63.12.1686","article-title":"Clinical and demographic predictors of long-term disability in patients with relapsing-remitting multiple sclerosis: a systematic review","volume":"63","author":"Langer-Gould","year":"2006","journal-title":"Arch. Neurol."},{"issue":"10","key":"10.1016\/j.msard.2025.106278_bib0039","first-page":"1421","article-title":"Predicting risk of secondary progression in multiple sclerosis: a nomogram","volume":"23","author":"Manouchehrinia","year":"2017","journal-title":"Mult. Scler. J."},{"issue":"11","key":"10.1016\/j.msard.2025.106278_bib0040","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1136\/jnnp-2013-304951","article-title":"Characterising aggressive multiple sclerosis","volume":"84","author":"Menon","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"5","key":"10.1016\/j.msard.2025.106278_bib0041","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1474-4422(05)70071-5","article-title":"Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis","volume":"4","author":"Miller","year":"2005","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.msard.2025.106278_bib0042","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/archneur.61.2.217","article-title":"Infratentorial lesions predict long-term disability in patients with initial findings suggestive of multiple sclerosis","volume":"61","author":"Minneboo","year":"2004","journal-title":"Arch. Neurol."},{"issue":"2","key":"10.1016\/j.msard.2025.106278_bib0043","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/1352458517751049","article-title":"ECTRIMS\/EAN guideline on the pharmacological treatment of people with multiple sclerosis","volume":"24","author":"Montalban","year":"2018","journal-title":"Mult. Scler. J."},{"issue":"3","key":"10.1016\/j.msard.2025.106278_bib0044","first-page":"167","article-title":"How many raters are needed for a reliable diagnosis?","volume":"15","author":"Noda","year":"2006","journal-title":"Int. J. Methods Psychiatr. Res."},{"key":"10.1016\/j.msard.2025.106278_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2021.102988","article-title":"Anti-CD20 antibody therapy and risk of infection in patients with demyelinating diseases","volume":"52","author":"Oksbjerg","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2025.106278_bib0046","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1001\/archopht.121.7.944","article-title":"High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis","volume":"121","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.msard.2025.106278_bib0047","series-title":"R: A language and Environment For Statistical Computing (Version 4.1.2)","year":"2022"},{"issue":"17","key":"10.1016\/j.msard.2025.106278_bib0048","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1212\/WNL.0000000000005347","article-title":"Practice guideline recommendations summary: disease-modifying therapies for adults with multiple sclerosis","volume":"90","author":"Rae-Grant","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2025.106278_bib0049","doi-asserted-by":"crossref","first-page":"m441","DOI":"10.1136\/bmj.m441","article-title":"Calculating the sample size required for developing a clinical prediction model","volume":"368","author":"Riley","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.msard.2025.106278_bib0050","series-title":"Modern Applied Statistics With S","author":"Ripley","year":"2002"},{"key":"10.1016\/j.msard.2025.106278_bib0051","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinfo."},{"issue":"7","key":"10.1016\/j.msard.2025.106278_bib0052","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrneurol.2015.85","article-title":"Aggressive multiple sclerosis: proposed definition and treatment algorithm","volume":"11","author":"Rush","year":"2015","journal-title":"Nature Rev. Neurol."},{"issue":"6","key":"10.1016\/j.msard.2025.106278_bib0053","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1177\/1352458512438454","article-title":"A prospective, randomized, controlled trial of autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: a position paper","volume":"18","author":"Saccardi","year":"2012","journal-title":"Mult. Scler. J."},{"key":"10.1016\/j.msard.2025.106278_bib0054","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1093\/brain\/awq118","article-title":"The natural history of multiple sclerosis, a geographically based study 10: relapses and long-term disability","volume":"133","author":"Scalfari","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.msard.2025.106278_bib0055","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/BF02033357","article-title":"Optic neuritis: findings on MRI, CSF examination, and HLA class II typing in 60 patients and results of a short-term follow-up","volume":"241","author":"Soderstrom","year":"1994","journal-title":"J. Neurol."},{"key":"10.1016\/j.msard.2025.106278_bib0056","article-title":"The topographical model of multiple sclerosis: a dynamic visualization of disease course","author":"Stephen","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2025.106278_bib0057","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/brain\/awv105","article-title":"Defining high, medium, and low impact prognostic factors for developing multiple sclerosis","volume":"138","author":"Tintore","year":"2015","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.msard.2025.106278_bib0058","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1177\/1352458518790397","article-title":"Predicting the profile of increasing disability in multiple sclerosis","volume":"25","author":"Tomassini","year":"2019","journal-title":"Mult. Scler. J."},{"issue":"11\u201312","key":"10.1016\/j.msard.2025.106278_bib0059","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1177\/13524585231197076","article-title":"Diagnostic delay of multiple sclerosis: prevalence, determinants and consequences","volume":"29","author":"Uher","year":"2023","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2025.106278_bib0060","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.991291","article-title":"Using personalized prognosis in the treatment of relapsing multiple sclerosis: a practical guide","volume":"13","author":"Van Wijmeersch","year":"2022","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.msard.2025.106278_bib0063","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1093\/brain\/114.2.1045","article-title":"The natural history of multiple sclerosis: a geographically based study. 3. Multivariate analysis of predictive factors and models of outcome","volume":"114","author":"Weinshenker","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.msard.2025.106278_bib0064","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/17562864211039648","article-title":"Multiple Sclerosis Therapy Consensus Group (MSTCG): position statement on disease-modifying therapies for multiple sclerosis","volume":"14","author":"Wiendl","year":"2021","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"10.1016\/j.msard.2025.106278_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2019.101459","article-title":"Consensus recommendations for the diagnosis and treatment of multiple sclerosis: 2019 revisions to the MENACTRIMS guidelines","volume":"37","author":"Yamout","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2025.106278_bib0067","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2024.105435","article-title":"Consensus recommendations for diagnosis and treatment of Multiple Sclerosis: 2023 revision of the MENACTRIMS guidelines","author":"Yamout","year":"2024","journal-title":"Mult. Scler. Relat. Disord."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825000227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825000227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T14:16:55Z","timestamp":1740665815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034825000227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":58,"alternative-id":["S2211034825000227"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2025.106278","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of a scoring system for predicting disease activity in treatment-na\u00efve patients with relapsing-remitting multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2025.106278","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106278"}}