{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:40:00Z","timestamp":1785807600901,"version":"3.56.0"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","msard-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.msard.2025.106389","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T23:33:56Z","timestamp":1742081636000},"page":"106389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Radiologically isolated syndrome: A 6-year follow-up study in Chile"],"prefix":"10.1016","volume":"97","author":[{"given":"Felipe","family":"Condeza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Pelayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Del-Canto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Orellana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Guzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"J\u00fcrgensen-Heinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"De-La-Barra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Guenim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Bravo-Grau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Pablo","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardita","family":"Soler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"C\u00e1rcamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-5433","authenticated-orcid":false,"given":"Ethel","family":"Ciampi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.msard.2025.106389_bib0001","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1111\/ene.15922","article-title":"Central vein sign and paramagnetic rim sign: from radiologically isolated syndrome to multiple sclerosis","volume":"30","author":"Abou Mrad","year":"2023","journal-title":"Eur. J. Neurol."},{"issue":"11","key":"10.1016\/j.msard.2025.106389_bib0002","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1111\/ene.14416","article-title":"Inner retinal layer thinning in radiologically isolated syndrome predicts conversion to multiple sclerosis","volume":"27","author":"Aly","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.msard.2025.106389_bib0003","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.msard.2018.09.030","article-title":"Decision-making on radiologically isolated syndrome among Argentinean neurologists: a survey based on clinical experience","volume":"27","author":"Carnero Contentti","year":"2019","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2025.106389_bib0004","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1177\/1352458517717808","article-title":"Radiologically isolated syndrome or subclinical multiple sclerosis: MAGNIMS consensus recommendations","volume":"24","author":"De Stefano","year":"2017","journal-title":"Mul. Scler."},{"issue":"3","key":"10.1016\/j.msard.2025.106389_bib0005","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1177\/1352458512451943","article-title":"Radiologically isolated syndrome \u2013 incidental magnetic resonance imaging findings suggestive of multiple sclerosis, a systematic review","volume":"19","author":"Granberg","year":"2013","journal-title":"Multiple Sclerosis J"},{"key":"10.1016\/j.msard.2025.106389_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2020.102333","article-title":"Social cognition in Multiple Sclerosis is associated to changes in brain connectivity: a resting-state fMRI study","volume":"45","author":"Labbe","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2025.106389_bib0007","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/ana.25799","article-title":"Radiologically isolated syndrome: 10-year risk estimate of a clinical event","volume":"88","author":"Lebrun","year":"2020","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2025.106389_bib0008","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.28271","article-title":"Risk factors and time to clinical symptoms of multiple sclerosis among patients with a radiologically isolated syndrome","volume":"4","author":"Lebrun-Fr\u00e9nay","year":"2021","journal-title":"JAMa Netw. Open."},{"issue":"10","key":"10.1016\/j.msard.2025.106389_bib0009","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1001\/jamaneurol.2023.2815","article-title":"Teriflunomide and time to clinical multiple sclerosis in patients with radiologically isolated syndrome: the TERIS randomized clinical trial","volume":"80","author":"Lebrun-Fr\u00e9nay","year":"2023","journal-title":"JAMa Neurol."},{"issue":"8","key":"10.1016\/j.msard.2025.106389_bib0010","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1093\/brain\/awad073","article-title":"The radiologically isolated syndrome: revised diagnostic criteria","volume":"146","author":"Lebrun-Fr\u00e9nay","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.msard.2025.106389_bib0011","unstructured":"Montalban X. 2024 Revised McDonald Criteria 2023. Presented at ECTRIMS Congress; September 18-20, 2024; Copenhagen, Denmark. Scientific Session 1: new diagnostic criteria. September 18th, 2024, 14:20\u201314:35."},{"issue":"9","key":"10.1016\/j.msard.2025.106389_bib0012","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1212\/01.wnl.0000335764.14513.1a","article-title":"Incidental MRI anomalies suggestive of multiple sclerosis: the radiologically isolated syndrome","volume":"72","author":"Okuda","year":"2009","journal-title":"Neurology."},{"issue":"3","key":"10.1016\/j.msard.2025.106389_bib0013","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/ana.26555","article-title":"Dimethyl fumarate delays multiple sclerosis in radiologically isolated syndrome","volume":"93","author":"Okuda","year":"2023","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.msard.2025.106389_bib0014","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.msard.2025.106389_bib0015","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000200044","article-title":"SFSEP and RISC. Neurofilament light chain levels are predictive of clinical conversion in radiologically isolated syndrome","volume":"10","author":"Rival","year":"2022","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825001312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825001312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T12:26:07Z","timestamp":1746620767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034825001312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":15,"alternative-id":["S2211034825001312"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2025.106389","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiologically isolated syndrome: A 6-year follow-up study in Chile","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2025.106389","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106389"}}