{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:16:21Z","timestamp":1793085381315,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","msard-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.msard.2025.106436","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T09:26:16Z","timestamp":1744104376000},"page":"106436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Investigation of type IV collagen biomarkers in multiple sclerosis"],"prefix":"10.1016","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-1014","authenticated-orcid":false,"given":"Signe","family":"Holm Nielsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Bramlev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Asser","family":"Karsdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Julie","family":"Leeming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Henriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannie Marie B\u00fclow","family":"Sand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2025.106436_bib0001","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/S0140-6736(18)30481-1","article-title":"Multiple sclerosis","volume":"391","author":"Thompson","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.msard.2025.106436_bib0002","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/jama.2020.26858","article-title":"Diagnosis and treatment of multiple sclerosis: a review","volume":"325","author":"McGinley","year":"2021","journal-title":"JAMA - J. Am. Med. Associat."},{"key":"10.1016\/j.msard.2025.106436_bib0003","article-title":"Current knowledge on multiple sclerosis pathophysiology, disability progression assessment and treatment options, and the role of autologous hematopoietic stem cell transplantation","volume":"23","author":"Gakis","year":"2023","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.msard.2025.106436_bib0004","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/brainsci14010004","article-title":"Impact of disease modifying therapy on MS-related fatigue: a narrative review","volume":"14","author":"Elkhooly","year":"2023","journal-title":"Brain Sci"},{"key":"10.1016\/j.msard.2025.106436_bib0005","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/medicina60010006","article-title":"Impact of disease-modifying therapies on gut\u2013Brain axis in multiple sclerosis","volume":"60","author":"Negro","year":"2024","journal-title":"Medicina (B. Aires)."},{"key":"10.1016\/j.msard.2025.106436_bib0019","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1248\/bpb.b17-00308","article-title":"New insights into the role of basement membrane-derived matricryptins in the heart","volume":"40","author":"Okada","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.msard.2025.106436_bib0006","article-title":"Clinical utility of a molecular signature in inflammatory demyelinating disease","volume":"6","author":"Pachner","year":"2018","journal-title":"Neurol. Neuroimmunol. neuroinflammation"},{"key":"10.1016\/j.msard.2025.106436_bib0007","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/nrc1094","article-title":"Basement membranes: structure, assembly and role in tumour angiogenesis","volume":"3","author":"Kalluri","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.msard.2025.106436_bib0008","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/j.1471-4159.2007.04897.x","article-title":"Extensive extracellular matrix depositions in active multiple sclerosis lesions","volume":"103","author":"Van Horssen","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.msard.2025.106436_bib0009","doi-asserted-by":"crossref","unstructured":"Colognato, H. & Yurchenco, P.D. REVIEWS A PEER REVIEWED FORUM form and function: the Laminin Family of heterotrimers. (2000) doi:10.1002\/(SICI)1097-0177(200006)218:2.","DOI":"10.1002\/(SICI)1097-0177(200006)218:2<213::AID-DVDY1>3.0.CO;2-R"},{"key":"10.1016\/j.msard.2025.106436_bib0010","doi-asserted-by":"crossref","first-page":"28532","DOI":"10.1074\/jbc.M103690200","article-title":"The NC1 domain of collagen IV encodes a novel network composed of the alpha 1, alpha 2, alpha 5, and alpha 6 chains in smooth muscle basement membranes","volume":"276","author":"Borza","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.msard.2025.106436_bib0011","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/j.1750-3639.2010.00399.x","article-title":"Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells","volume":"20","author":"Mohan","year":"2010","journal-title":"Brain. Pathol."},{"key":"10.1016\/j.msard.2025.106436_bib0012","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1172\/JCI24813","article-title":"Human \u03b11 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by \u03b11\u03b21 integrin","volume":"115","author":"Sudhakar","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.msard.2025.106436_bib0013","first-page":"2520","article-title":"Anti-angiogenic cues from vascular basement membrane collagen","volume":"60","author":"Colorado","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.msard.2025.106436_bib0014","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1074\/jbc.275.2.1209","article-title":"Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth","volume":"275","author":"Kamphaus","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.msard.2025.106436_bib0015","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.bbrc.2006.12.231","article-title":"Identification of novel short peptides derived from the alpha 4, alpha 5, and alpha 6 fibrils of type IV collagen with anti-angiogenic properties","volume":"354","author":"Karagiannis","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.msard.2025.106436_bib0016","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S1535-6108(03)00133-8","article-title":"Physiological levels of tumstatin, a fragment of collagen IV \u03b13 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via \u03b1V\u03b23 integrin","volume":"3","author":"Hamano","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.msard.2025.106436_bib0017","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/jemt.20564","article-title":"Mammalian collagen IV","volume":"71","author":"Khoshnoodi","year":"2008","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.msard.2025.106436_bib0018","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1177\/0271678X17722436","article-title":"The vascular basement membrane in the healthy and pathological brain","volume":"37","author":"Thomsen","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.msard.2025.106436_bib0020","first-page":"12714","article-title":"Role of canstatin in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts","volume":"9","author":"Urushiyama","year":"2016","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.msard.2025.106436_bib0021","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0968-0004(99)01540-6","article-title":"NPS@: network protein sequence analysis","volume":"25","author":"Combet","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.msard.2025.106436_bib0022","doi-asserted-by":"crossref","first-page":"D158","DOI":"10.1093\/nar\/gkw1099","article-title":"UniProt: the universal protein knowledgebase","volume":"45","author":"Bateman","year":"2017","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.msard.2025.106436_bib0023","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF01551818","article-title":"A simple method for polyethylene glycol-promoted hybridization of mouse myeloma cells","volume":"3","author":"Gefter","year":"1977","journal-title":"Somatic Cell Genet."},{"key":"10.1016\/j.msard.2025.106436_bib0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084934","article-title":"MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodeling in experimental and clinical fibrosis\u2013validation of two novel biomarker assays","volume":"8","author":"Sand","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.msard.2025.106436_bib0025","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.tranon.2018.02.005","article-title":"Tumstatin, a matrikine derived from collagen type IV\u03b13, is elevated in serum from patients with non\u2013Small cell lung cancer","volume":"11","author":"Nielsen","year":"2018","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.msard.2025.106436_bib0026","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1872-034X.2011.00946.x","article-title":"Enzyme-linked immunosorbent serum assay specific for the 7S domain of Collagen Type IV (P4NP 7S): a marker related to the extracellular matrix remodeling during liver fibrogenesis","volume":"42","author":"Leeming","year":"2012","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.msard.2025.106436_bib0027","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1212\/NXI.0000000000000202","article-title":"Cytokine profiles show heterogeneity of interferon-\u03b2 response in multiple sclerosis patients","volume":"3","author":"Hegen","year":"2016","journal-title":"Neurol. Neuroimmunol. Neuroinflammation"},{"key":"10.1016\/j.msard.2025.106436_bib0028","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1177\/08830738050200100801","article-title":"Tau, phospho-Tau, and S-100B in the cerebrospinal fluid of children with multiple sclerosis","volume":"20","author":"Rostasy","year":"2005","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.msard.2025.106436_bib0029","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1177\/1352458509359725","article-title":"Neurofilament light as a prognostic marker in multiple sclerosis","volume":"16","author":"Salzer","year":"2010","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2025.106436_bib0030","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neulet.2008.02.064","article-title":"Biological markers for axonal degeneration in CSF and blood of patients with the first event indicative for multiple sclerosis","volume":"436","author":"Hein (n\u00e9e Maier)","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.msard.2025.106436_bib0031","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1093\/brain\/awab059","article-title":"The extracellular matrix as modifier of neuroinflammation and remyelination in multiple sclerosis","volume":"144","author":"Ghorbani","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.msard.2025.106436_bib0032","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/JTO.0b013e3181ec173d","article-title":"Receiver operating characteristic curve in diagnostic test assessment","volume":"5","author":"Mandrekar","year":"2010","journal-title":"J. Thorac. Oncol."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825001786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825001786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T21:35:10Z","timestamp":1747258510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034825001786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":32,"alternative-id":["S2211034825001786"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2025.106436","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of type IV collagen biomarkers in multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2025.106436","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106436"}}