{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T11:43:05Z","timestamp":1762602185951,"version":"build-2065373602"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008866","name":"The First Affiliated Hospital of Naval Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.msard.2025.106440","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T04:55:43Z","timestamp":1744347343000},"page":"106440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Exploring the mediating role of cerebrospinal fluid metabolites in the pathway from circulating inflammatory proteins to multiple sclerosis: A Mendelian randomization study"],"prefix":"10.1016","volume":"98","author":[{"given":"Xiaowei","family":"Mao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hangfei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2296-5781","authenticated-orcid":false,"given":"Binghan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.msard.2025.106440_bib0001","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ajhg.2016.11.007","article-title":"Genome-wide association study identifies 27 loci influencing concentrations of circulating cytokines and growth factors [J]","volume":"100","author":"Ahola-Olli","year":"2017","journal-title":"Am. J. Human Gen."},{"issue":"5","key":"10.1016\/j.msard.2025.106440_bib0002","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/1352458519876020","article-title":"Metabolomics in multiple sclerosis disease course and progression [J]","volume":"26","author":"Bhargava","year":"2020","journal-title":"Multiple Sclerosis J."},{"issue":"11","key":"10.1016\/j.msard.2025.106440_bib0003","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1177\/1352458521996601","article-title":"Depression and multiple sclerosis: a bidirectional mendelian randomisation study [J]","volume":"27","author":"Binzer","year":"2021","journal-title":"Multiple Sclerosis J."},{"issue":"4","key":"10.1016\/j.msard.2025.106440_bib0004","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jrsm.1346","article-title":"Meta-analysis and Mendelian randomization: a review [J]","volume":"10","author":"Bowden","year":"2019","journal-title":"Res. Synth. Methods"},{"issue":"11","key":"10.1016\/j.msard.2025.106440_bib0005","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1212\/WNL.0000000000000768","article-title":"Atlas of multiple sclerosis 2013: a growing global problem with widespread inequity [J]","volume":"83","author":"Browne","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2025.106440_bib0006","doi-asserted-by":"crossref","DOI":"10.12688\/wellcomeopenres.15555.1","article-title":"Guidelines for performing Mendelian randomization investigations [J]","volume":"4","author":"Burgess","year":"2019","journal-title":"Wellcome Open. Res."},{"issue":"2","key":"10.1016\/j.msard.2025.106440_bib0007","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.immuni.2011.06.011","article-title":"Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease [J]","volume":"35","author":"Cao","year":"2011","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.msard.2025.106440_bib0008","doi-asserted-by":"crossref","DOI":"10.1007\/s11306-020-1648-5","article-title":"Targeted metabolomics of CSF in healthy individuals and patients with secondary progressive multiple sclerosis using high-resolution mass spectrometry [J]","volume":"16","author":"Carlsson","year":"2020","journal-title":"Metabolomics"},{"issue":"4","key":"10.1016\/j.msard.2025.106440_bib0009","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.immuni.2011.09.010","article-title":"Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E [J]","volume":"35","author":"Chang Seon","year":"2011","journal-title":"Immunity."},{"issue":"Pt 10","key":"10.1016\/j.msard.2025.106440_bib0010","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1093\/brain\/awf240","article-title":"Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis [J]","volume":"125","author":"Chard","year":"2002","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.msard.2025.106440_bib0011","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1007\/s10238-023-01152-8","article-title":"CXCL6: a potential therapeutic target for inflammation and cancer [J]","volume":"23","author":"Dai","year":"2023","journal-title":"Clin. Exp. Med."},{"issue":"10","key":"10.1016\/j.msard.2025.106440_bib0012","article-title":"Multi-omic evaluation of metabolic alterations in multiple sclerosis identifies shifts in aromatic amino acid metabolism [J]","volume":"2","author":"Fitzgerald","year":"2021","journal-title":"Cell Rep. Med."},{"issue":"1","key":"10.1016\/j.msard.2025.106440_bib0013","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-020-01944-9","article-title":"Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets [J]","volume":"17","author":"Govindarajan","year":"2020","journal-title":"J. Neuroinflammation."},{"issue":"5","key":"10.1016\/j.msard.2025.106440_bib0014","doi-asserted-by":"crossref","DOI":"10.1001\/jamaneurol.2018.4905","article-title":"Clinical Outcomes of Escalation vs Early Intensive Disease-Modifying Therapy in Patients With Multiple Sclerosis [J]","volume":"76","author":"Harding","year":"2019","journal-title":"JAMa Neurol."},{"issue":"7","key":"10.1016\/j.msard.2025.106440_bib0015","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s00415-016-8128-x","article-title":"Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study [J]","volume":"263","author":"Havrdov\u00e1","year":"2016","journal-title":"J. Neurol."},{"issue":"2","key":"10.1016\/j.msard.2025.106440_bib0016","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1177\/13524585221134213","article-title":"Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: a systematic review and meta-analysis [J]","volume":"29","author":"Hegen","year":"2022","journal-title":"Multiple Sclerosis J."},{"issue":"12","key":"10.1016\/j.msard.2025.106440_bib0017","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.2337\/db14-0731","article-title":"Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits [J]","volume":"63","author":"Herder","year":"2014","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.msard.2025.106440_bib0018","doi-asserted-by":"crossref","DOI":"10.3390\/cells8020084","article-title":"Biochemical differences in cerebrospinal fluid between secondary progressive and relapsing\u207bremitting multiple sclerosis [J]","volume":"8","author":"Herman","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.msard.2025.106440_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2019.116458","article-title":"Altered hypothalamic metabolism in early multiple sclerosis - MR spectroscopy study [J]","volume":"407","author":"Hnilicov\u00e1","year":"2019","journal-title":"J. Neurol. Sci."},{"issue":"12","key":"10.1016\/j.msard.2025.106440_bib0020","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1016\/j.immuni.2023.10.016","article-title":"Intestinal epithelial dopamine receptor signaling drives sex-specific disease exacerbation in a mouse model of multiple sclerosis [J]","volume":"56","author":"H-r","year":"2023","journal-title":"Immunity."},{"issue":"23","key":"10.1016\/j.msard.2025.106440_bib0021","doi-asserted-by":"crossref","first-page":"12952","DOI":"10.1073\/pnas.1912839117","article-title":"Inflammation-related plasma and CSF biomarkers for multiple sclerosis [J]","volume":"117","author":"Huang","year":"2020","journal-title":"Proce. Natl. Acad. Sci."},{"issue":"10","key":"10.1016\/j.msard.2025.106440_bib0022","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1039\/C9MD00253G","article-title":"Targeted metabolomics approach for identification of relapsing\u2013remitting multiple sclerosis markers and evaluation of diagnostic models [J]","volume":"10","author":"Kasakin","year":"2019","journal-title":"Med. Chem. Comm."},{"issue":"7","key":"10.1016\/j.msard.2025.106440_bib0023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181758","article-title":"Metabolomic profiling of CSF in multiple sclerosis and neuromyelitis optica spectrum disorder by nuclear magnetic resonance [J]","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS. One"},{"issue":"9","key":"10.1016\/j.msard.2025.106440_bib0024","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1016\/j.clnu.2019.12.005","article-title":"Plasma inflammatory biomarkers and modifiable lifestyle factors associated with colorectal cancer risk [J]","volume":"39","author":"Kim","year":"2020","journal-title":"Clin. Nutr."},{"issue":"11","key":"10.1016\/j.msard.2025.106440_bib0025","article-title":"Disease type- and status-specific alteration of CSF metabolome coordinated with clinical parameters in inflammatory demyelinating diseases of CNS [J]","volume":"11","author":"Klein","year":"2016","journal-title":"PLoS. One"},{"issue":"1","key":"10.1016\/j.msard.2025.106440_bib0026","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-024-03036-4","article-title":"Combination protein biomarkers predict multiple sclerosis diagnosis and outcomes [J]","volume":"21","author":"Kodosaki","year":"2024","journal-title":"J. Neuroinflammation."},{"issue":"6608","key":"10.1016\/j.msard.2025.106440_bib0027","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/384467a0","article-title":"Neurturin, a relative of glial-cell-line-derived neurotrophic factor [J]","volume":"384","author":"Kotzbauer","year":"1996","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.msard.2025.106440_bib0028","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/brain\/awh680","article-title":"Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment [J]","volume":"129","author":"Krumbholz","year":"2006","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.msard.2025.106440_bib0029","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1474-4422(22)00289-7","article-title":"Multiple sclerosis progression: time for a new mechanism-driven framework [J]","volume":"22","author":"Kuhlmann","year":"2023","journal-title":"Lancet Neurol."},{"issue":"8","key":"10.1016\/j.msard.2025.106440_bib0030","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1093\/brain\/awad070","article-title":"Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis [J]","volume":"146","author":"Lin","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.msard.2025.106440_bib0031","article-title":"Circulating interleukins and risk of multiple sclerosis: a mendelian randomization study [J]","volume":"12","author":"Lu","year":"2021","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.msard.2025.106440_bib0032","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1080\/1744666X.2017.1400380","article-title":"The role of blood and CSF biomarkers in the evaluation of new treatments against multiple sclerosis [J]","volume":"13","author":"Lycke","year":"2017","journal-title":"Expert. Rev. Clin. Immunol."},{"issue":"1","key":"10.1016\/j.msard.2025.106440_bib0033","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209543","article-title":"Association of cortical lesions with regional glutamate, GABA, N-Acetylaspartate, and myoinositol levels in patients with multiple sclerosis [J]","volume":"103","author":"Madsen","year":"2024","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2025.106440_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2023.117471","article-title":"Biochemical biomarkers for multiple sclerosis [J]","volume":"548","author":"Maroto-Garc\u00eda","year":"2023","journal-title":"Clin. Chim. Acta"},{"issue":"3","key":"10.1016\/j.msard.2025.106440_bib0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031268","article-title":"N-Acetyl-Aspartyl-glutamate in brain health and disease [J]","volume":"23","author":"Morland","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.msard.2025.106440_bib0036","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9030863","article-title":"Multi-platform characterization of cerebrospinal fluid and serum metabolome of patients affected by relapsing\u2013remitting and primary progressive multiple sclerosis [J]","volume":"9","author":"Murgia","year":"2020","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.msard.2025.106440_bib0037","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-020-01583-z","article-title":"Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations [J]","volume":"4","author":"Panyard","year":"2021","journal-title":"Commun. Biol."},{"issue":"6460","key":"10.1016\/j.msard.2025.106440_bib0038","article-title":"Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility [J]","volume":"365","author":"Patsopoulos","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.msard.2025.106440_bib0039","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cytogfr.2019.11.005","article-title":"Leukemia inhibitory factor: recent advances and implications in biotechnology [J]","volume":"52","author":"Pinho","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"issue":"10","key":"10.1016\/j.msard.2025.106440_bib0040","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1177\/1352458513516528","article-title":"Metabolomic profiling in multiple sclerosis: insights into biomarkers and pathogenesis [J]","volume":"20","author":"Reinke","year":"2014","journal-title":"Multiple Sclerosis J."},{"issue":"1","key":"10.1016\/j.msard.2025.106440_bib0041","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-pathol-052920-040318","article-title":"The immune response in multiple sclerosis [J]","volume":"17","author":"Rodr\u00edguez Mur\u00faa","year":"2022","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.msard.2025.106440_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577385","article-title":"12-months prospective Pentraxin-3 and metabolomic evaluation in multiple sclerosis patients treated with glatiramer acetate [J]","volume":"348","author":"Signoriello","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.msard.2025.106440_bib0043","first-page":"87","article-title":"Cytokines and growth factors [J]","volume":"171","author":"Silva","year":"2020","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"issue":"9","key":"10.1016\/j.msard.2025.106440_bib0044","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1136\/jmedgenet-2018-105965","article-title":"Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns [J]","volume":"56","author":"Sliz","year":"2019","journal-title":"J. Med. Genet."},{"issue":"19","key":"10.1016\/j.msard.2025.106440_bib0045","article-title":"Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson\u2032s disease [J]","volume":"9","author":"Sullivan","year":"2014","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.msard.2025.106440_bib0046","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3389\/fneur.2019.01173","article-title":"Quantifying the metabolic signature of multiple sclerosis by in vivo proton magnetic resonance spectroscopy: current challenges and future outlook in the translation from proton signal to diagnostic biomarker [J]","volume":"10","author":"Swanberg","year":"2019","journal-title":"Front. Neurol."},{"issue":"12","key":"10.1016\/j.msard.2025.106440_bib0047","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20231397","article-title":"For whom the B(c)ell tolls: CXCL4 AIDs human autoimmunity [J]","volume":"220","author":"Tangye","year":"2023","journal-title":"J. Exper. Med."},{"issue":"15","key":"10.1016\/j.msard.2025.106440_bib0048","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1212\/WNL.0b013e3181a0fe3f","article-title":"Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis [J]","volume":"72","author":"Teunissen","year":"2009","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.msard.2025.106440_bib0049","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2169\/internalmedicine.53.1246","article-title":"Biomarkers for multiple sclerosis [J]","volume":"53","author":"Tomioka","year":"2014","journal-title":"Internal Med."},{"issue":"5","key":"10.1016\/j.msard.2025.106440_bib0050","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases [J]","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.msard.2025.106440_bib0051","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1318","article-title":"Cerebrospinal fluid metabolomics: detection of neuroinflammation in human central nervous system disease [J]","volume":"10","author":"Yan","year":"2021","journal-title":"Clin. Transl. Immunology."},{"issue":"9","key":"10.1016\/j.msard.2025.106440_bib0052","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41590-023-01588-w","article-title":"Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets [J]","volume":"24","author":"Zhao","year":"2023","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.msard.2025.106440_bib0053","doi-asserted-by":"crossref","first-page":"e1346","DOI":"10.1002\/jsp2.1346","article-title":"Effects of circulating inflammatory proteins on spinal degenerative diseases: Evidence from genetic correlations and Mendelian randomization study [J]","volume":"7","author":"Zheng","year":"2024","journal-title":"JOR. Spine"},{"key":"10.1016\/j.msard.2025.106440_bib0054","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1299122","article-title":"Mendelian randomization analysis suggests no associations of human herpes viruses with amyotrophic lateral sclerosis [J]","volume":"17","author":"Zheng","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.msard.2025.106440_bib0055","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1386556","article-title":"Effects of circulating inflammatory proteins on osteoporosis and fractures: evidence from genetic correlation and Mendelian randomization study [J]","volume":"15","author":"Zheng","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.msard.2025.106440_bib0056","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-023-01524-9","article-title":"The role of CXCL family members in different diseases [J]","volume":"9","author":"Zhou","year":"2023","journal-title":"Cell Death. Discov."},{"issue":"22","key":"10.1016\/j.msard.2025.106440_bib0057","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216271","article-title":"Metabolomics of cerebrospinal fluid amino and fatty acids in early stages of multiple sclerosis [J]","volume":"24","author":"\u017did\u00f3","year":"2023","journal-title":"Int. J. Mol. Sci."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825001828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825001828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T11:40:55Z","timestamp":1762602055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034825001828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":57,"alternative-id":["S2211034825001828"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2025.106440","relation":{},"ISSN":["2211-0348"],"issn-type":[{"type":"print","value":"2211-0348"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the mediating role of cerebrospinal fluid metabolites in the pathway from circulating inflammatory proteins to multiple sclerosis: A Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2025.106440","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106440"}}