{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:25:05Z","timestamp":1782102305397,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008361","name":"Danish Multiple Sclerosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.msard.2025.106466","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T06:32:41Z","timestamp":1745649161000},"page":"106466","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Socioeconomic impact of initial high vs. moderate efficacy disease-modifying therapy in multiple sclerosis: Effects on labor market affiliation"],"prefix":"10.1016","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-0228","authenticated-orcid":false,"given":"Rolf Pringler","family":"Holm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Framke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Pontieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malthe Faurschou","family":"Wandall-Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias Due","family":"Buron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhal","family":"Filikci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Sellebjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Magyari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.msard.2025.106466_bib0001","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult. Scler. J."},{"issue":"8","key":"10.1016\/j.msard.2025.106466_bib0002","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1136\/jnnp-2017-315907","article-title":"Excess mortality among patients with multiple sclerosis in Denmark has dropped significantly over the past six decades: a population based study","volume":"88","author":"Koch-Henriksen","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1","key":"10.1016\/j.msard.2025.106466_bib0003","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/ana.24682","article-title":"Predictors of long-term disability accrual in relapse-onset multiple sclerosis","volume":"80","author":"Jokubaitis","year":"2016","journal-title":"Ann. Neurol."},{"issue":"SUPPL.1","key":"10.1016\/j.msard.2025.106466_bib0004","article-title":"Interferon-beta and disability progression in relapsing-remitting multiple sclerosis","volume":"115","author":"Drulovic","year":"2013","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"5","key":"10.1016\/j.msard.2025.106466_bib0005","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1474-4422(15)00018-6","article-title":"Effectiveness and cost-effectiveness of interferon beta and glatiramer acetate in the UK Multiple Sclerosis Risk Sharing Scheme at 6 years: a clinical cohort study with natural history comparator","volume":"14","author":"Palace","year":"2015","journal-title":"Lancet Neurol."},{"issue":"6","key":"10.1016\/j.msard.2025.106466_bib0006","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1177\/1352458512463764","article-title":"Time to secondary progression in patients with multiple sclerosis who were treated with first generation immunomodulating drugs","volume":"19","author":"Tedeholm","year":"2013","journal-title":"Mult. Scler. J."},{"issue":"4","key":"10.1016\/j.msard.2025.106466_bib0007","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ana.21757","article-title":"Real-life impact of early interferon\u03b2 therapy in relapsing multiple sclerosis","volume":"66","author":"Trojano","year":"2009","journal-title":"Ann. Neurol."},{"issue":"10","key":"10.1016\/j.msard.2025.106466_bib0008","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/ene.13692","article-title":"Early versus later treatment start in multiple sclerosis: a register-based cohort study","volume":"25","author":"Chalmer","year":"2018","journal-title":"Eur. J. Neurol."},{"issue":"8","key":"10.1016\/j.msard.2025.106466_bib0009","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1136\/jnnp-2022-329058","article-title":"Time to first treatment and risk of disability pension in relapsing-remitting multiple sclerosis","volume":"93","author":"Wandall-Holm","year":"2022","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"3","key":"10.1016\/j.msard.2025.106466_bib0010","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/ane.12712","article-title":"Safety concerns and risk management of multiple sclerosis therapies","volume":"136","author":"Soelberg Sorensen","year":"2017","journal-title":"Acta Neurol. Scand."},{"issue":"2","key":"10.1016\/j.msard.2025.106466_bib0011","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/1352458517751049","article-title":"ECTRIMS\/EAN guideline on the pharmacological treatment of people with multiple sclerosis","volume":"24","author":"Montalban","year":"2018","journal-title":"Mult. Scler. J."},{"issue":"3","key":"10.1016\/j.msard.2025.106466_bib0012","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/WCO.0000000000001063","article-title":"New drugs for multiple sclerosis: new treatment algorithms","volume":"35","author":"Cree","year":"2022","journal-title":"Curr. Opin. Neurol."},{"issue":"1","key":"10.1016\/j.msard.2025.106466_bib0013","article-title":"Multiple Sclerosis Therapy Consensus Group (MSTCG): position statement on disease-modifying therapies for multiple sclerosis (white paper)","volume":"14","author":"Wiendl","year":"2021","journal-title":"Ther. Adv. Neurol. Disord."},{"issue":"10076","key":"10.1016\/j.msard.2025.106466_bib0014","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0140-6736(16)32388-1","article-title":"Evolving concepts in the treatment of relapsing multiple sclerosis","volume":"389","author":"Comi","year":"2017","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.msard.2025.106466_bib0015","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.autrev.2017.04.010","article-title":"Timing of high-efficacy therapy in relapsing-remitting multiple sclerosis: a systematic review","volume":"16","author":"Merkel","year":"2017","journal-title":"Autoimmun. Rev."},{"issue":"1","key":"10.1016\/j.msard.2025.106466_bib0016","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/eurpub\/ckaa228","article-title":"Disability pension among persons with chronic disease: differential impact of a Danish policy reform","volume":"31","author":"Mathisen","year":"2021","journal-title":"Eur. J. Public Health"},{"issue":"1","key":"10.1016\/j.msard.2025.106466_bib0017","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/1359105317691587","article-title":"Employment and multiple sclerosis: a meta-analytic review of psychological correlates","volume":"24","author":"Dorstyn","year":"2019","journal-title":"J. Health Psychol."},{"issue":"8","key":"10.1016\/j.msard.2025.106466_bib0018","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1177\/1352458517694432","article-title":"New insights into the burden and costs of multiple sclerosis in Europe","volume":"23","author":"Kobelt","year":"2017","journal-title":"Mult. Scler. J."},{"issue":"8","key":"10.1016\/j.msard.2025.106466_bib0019","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s10198-022-01547-6","article-title":"Excess costs of multiple sclerosis: a register-based study in Sweden","volume":"24","author":"Murley","year":"2023","journal-title":"Eur. J. Heal. Econ."},{"issue":"8","key":"10.1016\/j.msard.2025.106466_bib0020","doi-asserted-by":"crossref","first-page":"e1041","DOI":"10.1212\/WNL.0000000000010135","article-title":"Initial high-efficacy disease-modifying therapy in multiple sclerosis","volume":"95","author":"Buron","year":"2020","journal-title":"Neurology."},{"issue":"3","key":"10.1016\/j.msard.2025.106466_bib0021","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/13524585231225929","article-title":"Recent trends in disease-modifying therapy use and associated sickness absence and disability pension among people with multiple sclerosis in Sweden","volume":"30","author":"Teni","year":"2024","journal-title":"Mult. Scler. J."},{"issue":"1","key":"10.1016\/j.msard.2025.106466_bib0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/brb3.1921","article-title":"The Danish Multiple Sclerosis Registry","volume":"11","author":"Magyari","year":"2021","journal-title":"Brain Behav."},{"key":"10.1016\/j.msard.2025.106466_bib0023","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2147\/CLEP.S99500","article-title":"The Danish multiple sclerosis treatment register","volume":"8","author":"Magyari","year":"2016","journal-title":"Clin Epidemiol"},{"issue":"8","key":"10.1016\/j.msard.2025.106466_bib0024","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10654-014-9930-3","article-title":"The Danish Civil Registration System as a tool in epidemiology","volume":"29","author":"Schmidt","year":"2014","journal-title":"Eur. J. Epidemiol."},{"issue":"7_suppl","key":"10.1016\/j.msard.2025.106466_bib0025","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/1403494811399956","article-title":"Introduction to Danish (nationwide) registers on health and social issues: structure, access, legislation, and archiving","volume":"39","author":"Thygesen","year":"2011","journal-title":"Scand. J. Public Health"},{"issue":"5","key":"10.1016\/j.msard.2025.106466_bib0026","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/14034940701271882","article-title":"Register-based follow-up of social benefits and other transfer payments: accuracy and degree of completeness in a Danish interdepartmental administrative database compared with a population-based survey","volume":"35","author":"Hjollund","year":"2007","journal-title":"Scand. J. Public Health"},{"issue":"3","key":"10.1016\/j.msard.2025.106466_bib0027","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/00273171.2011.568786","article-title":"An introduction to propensity score methods for reducing the effects of confounding in observational studies","volume":"46","author":"Austin","year":"2011","journal-title":"Multivariate Behav. Res."},{"issue":"2","key":"10.1016\/j.msard.2025.106466_bib0028","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/pst.433","article-title":"Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies","volume":"10","author":"Austin","year":"2011","journal-title":"Pharm. Stat."},{"key":"10.1016\/j.msard.2025.106466_bib0029","doi-asserted-by":"crossref","DOI":"10.1177\/17562864211019574","article-title":"Long-term disability trajectories in relapsing multiple sclerosis patients treated with early intensive or escalation treatment strategies","volume":"14","author":"Iaffaldano","year":"2021","journal-title":"Ther. Adv. Neurol. Disord."},{"issue":"5","key":"10.1016\/j.msard.2025.106466_bib0030","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1001\/jamaneurol.2018.4905","article-title":"Clinical outcomes of escalation vs early intensive disease-modifying therapy in patients with multiple sclerosis","volume":"76","author":"Harding","year":"2019","journal-title":"JAMa Neurol."},{"issue":"3","key":"10.1016\/j.msard.2025.106466_bib0031","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00415-018-8764-4","article-title":"The long-term impact of early treatment of multiple sclerosis on the risk of disability pension","volume":"265","author":"Landfeldt","year":"2018","journal-title":"J. Neurol."},{"key":"10.1016\/j.msard.2025.106466_bib0032","series-title":"PLoS One","article-title":"Earnings and financial compensation from Social Security systems correlate strongly with disability for multiple sclerosis patients","volume":"10","author":"Kavaliunas","year":"2015"},{"issue":"1","key":"10.1016\/j.msard.2025.106466_bib0033","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/1352458517740212","article-title":"Cognitive function is a major determinant of income among multiple sclerosis patients in Sweden acting independently from physical disability","volume":"25","author":"Kavaliunas","year":"2019","journal-title":"Mult. Scler. J."},{"issue":"1","key":"10.1016\/j.msard.2025.106466_bib0034","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/jnnp-2019-321523","article-title":"Clinically stable disease is associated with a lower risk of both income loss and disability pension for patients with multiple sclerosis","volume":"91","author":"Chalmer","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1","key":"10.1016\/j.msard.2025.106466_bib0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10926-019-09850-5","article-title":"Predictors of change in employment status and associations with quality of life: a prospective international study of people with multiple sclerosis","volume":"30","author":"Marck","year":"2020","journal-title":"J. Occup. Rehabil."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825002081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825002081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T19:29:39Z","timestamp":1749756579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034825002081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":35,"alternative-id":["S2211034825002081"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2025.106466","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Socioeconomic impact of initial high vs. moderate efficacy disease-modifying therapy in multiple sclerosis: Effects on labor market affiliation","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2025.106466","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106466"}}