{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:03:46Z","timestamp":1780041826798,"version":"3.53.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006484","name":"AbbVie Deutschland GmbH & Co KG","doi-asserted-by":"publisher","award":["88926"],"award-info":[{"award-number":["88926"]}],"id":[{"id":"10.13039\/100006484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.msard.2025.106626","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T15:23:56Z","timestamp":1752938636000},"page":"106626","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Proximity Extension Assay identifies new targets of grey matter pathology in multiple sclerosis"],"prefix":"10.1016","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-4075","authenticated-orcid":false,"given":"H.","family":"van der Stok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Coenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Weil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Mollon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.E.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rijnsburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.msard.2025.106626_bib0019","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/labinvest.2014.156","article-title":"MALDI imaging mass spectrometry: current frontiers and perspectives in pathology research and practice","volume":"95","author":"Aichler","year":"2015","journal-title":"Lab. Invest."},{"issue":"1","key":"10.1016\/j.msard.2025.106626_bib0015","doi-asserted-by":"crossref","first-page":"6903","DOI":"10.1038\/s41467-023-42682-9","article-title":"Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis","volume":"14","author":"Akesson","year":"2023","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.msard.2025.106626_bib0040","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.4049\/jimmunol.166.9.5464","article-title":"Fine tuning of TCR signaling by CD5","volume":"166","author":"Azzam","year":"2001","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.msard.2025.106626_bib0043","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1191\/1352458503ms917oa","article-title":"Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration","volume":"9","author":"B\u00f8","year":"2003","journal-title":"Mult. Scler."},{"issue":"6","key":"10.1016\/j.msard.2025.106626_bib0031","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nn.3109","article-title":"Hepatocyte growth factor mediates mesenchymal stem cell-induced recovery in multiple sclerosis models","volume":"15","author":"Bai","year":"2012","journal-title":"Nat. Neurosci."},{"issue":"14","key":"10.1016\/j.msard.2025.106626_bib0030","doi-asserted-by":"crossref","first-page":"6424","DOI":"10.1073\/pnas.0912437107","article-title":"Hepatocyte growth factor inhibits CNS autoimmunity by inducing tolerogenic dendritic cells and CD25+Foxp3+ regulatory T cells","volume":"107","author":"Benkhoucha","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.msard.2025.106626_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.683687","article-title":"Expression of IL-20 receptor subunit beta is linked to EAE neuropathology and CNS neuroinflammation","volume":"15","author":"Dayton","year":"2021","journal-title":"Front Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.msard.2025.106626_bib0012","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cell.2024.10.045","article-title":"Atlas of the plasma proteome in health and disease in 53,026 adults","volume":"188","author":"Deng","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.msard.2025.106626_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.683609","article-title":"HGF and MET: from brain development to neurological disorders","volume":"9","author":"Desole","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.msard.2025.106626_bib0008","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/brain\/awad288","article-title":"Prognostic value of single-subject grey matter networks in early multiple sclerosis","volume":"147","author":"Fleischer","year":"2024","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.msard.2025.106626_bib0032","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22042182","article-title":"Increased expression of ephrins on immune cells of patients with relapsing remitting multiple sclerosis affects oligodendrocyte differentiation","volume":"22","author":"Golan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.msard.2025.106626_bib0033","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/glia.23293","article-title":"Ephrin-A1-EphA4 signaling negatively regulates myelination in the central nervous system","volume":"66","author":"Harboe","year":"2018","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.msard.2025.106626_bib0027","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000200322","article-title":"Proteomics reveals age as major modifier of inflammatory CSF signatures in multiple sclerosis","volume":"12","author":"Held","year":"2025","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"23","key":"10.1016\/j.msard.2025.106626_bib0013","doi-asserted-by":"crossref","first-page":"12952","DOI":"10.1073\/pnas.1912839117","article-title":"Inflammation-related plasma and CSF biomarkers for multiple sclerosis","volume":"117","author":"Huang","year":"2020","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.msard.2025.106626_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2021.100157","article-title":"Assessing the preanalytical variability of plasma and cerebrospinal fluid processing and its effects on inflammation-related protein biomarkers","volume":"20","author":"Huang","year":"2021","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.msard.2025.106626_bib0024","unstructured":"Human Protein Atlas proteinatlas.org."},{"issue":"3","key":"10.1016\/j.msard.2025.106626_bib0025","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/acn3.51990","article-title":"Plasma proteomic profiles of UK Biobank participants with multiple sclerosis","volume":"11","author":"Jacobs","year":"2024","journal-title":"Ann Clin Transl Neurol"},{"issue":"3","key":"10.1016\/j.msard.2025.106626_bib0021","doi-asserted-by":"crossref","first-page":"fcad183","DOI":"10.1093\/braincomms\/fcad183","article-title":"Proteomics and relationship with axonal pathology in multiple sclerosis: 5-year diffusion tensor imaging study","volume":"5","author":"Jakimovski","year":"2023","journal-title":"Brain Commun."},{"issue":"10422","key":"10.1016\/j.msard.2025.106626_bib0001","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(23)01473-3","article-title":"Multiple sclerosis","volume":"403","author":"Jakimovski","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.msard.2025.106626_bib0022","doi-asserted-by":"crossref","DOI":"10.1002\/acn3.51996","article-title":"Proteomic signatures of physical, cognitive, and imaging outcomes in multiple sclerosis","author":"Jalaleddini","year":"2024","journal-title":"Ann. Clin. Transl. Neurol"},{"issue":"1","key":"10.1016\/j.msard.2025.106626_bib0017","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cell.2020.08.036","article-title":"A quantitative proteome map of the Human body","volume":"183","author":"Jiang","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.msard.2025.106626_bib0023","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00401-016-1653-y","article-title":"An updated histological classification system for multiple sclerosis lesions","volume":"133","author":"Kuhlmann","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.msard.2025.106626_bib0006","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.3389\/fimmu.2018.03116","article-title":"Pathogenic mechanisms associated with different clinical courses of multiple sclerosis","volume":"9","author":"Lassmann","year":"2018","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.msard.2025.106626_bib0007","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/1352458513494958","article-title":"Clinical and magnetic resonance imaging predictors of disease progression in multiple sclerosis: a nine-year follow-up study","volume":"20","author":"Lavorgna","year":"2014","journal-title":"Mult. Scler."},{"issue":"1","key":"10.1016\/j.msard.2025.106626_bib0039","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12974-020-01814-4","article-title":"Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats","volume":"17","author":"Lee","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"9","key":"10.1016\/j.msard.2025.106626_bib0041","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0222301","article-title":"CD5 on dendritic cells regulates CD4+ and CD8+ T cell activation and induction of immune responses","volume":"14","author":"Li","year":"2019","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.msard.2025.106626_bib0035","doi-asserted-by":"crossref","DOI":"10.1172\/JCI152187","article-title":"The eph receptor A4 plays a role in demyelination and depression-related behavior","volume":"132","author":"Li","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.msard.2025.106626_bib0020","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jchromb.2016.07.001","article-title":"MALDI imaging mass spectrometry analysis-A new approach for protein mapping in multiple sclerosis brain lesions","volume":"1047","author":"Maccarrone","year":"2017","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"Pt 4","key":"10.1016\/j.msard.2025.106626_bib0004","first-page":"1089","article-title":"Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology","volume":"130","author":"Magliozzi","year":"2007","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.msard.2025.106626_bib0002","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/ana.22230","article-title":"A gradient of neuronal loss and meningeal inflammation in multiple sclerosis","volume":"68","author":"Magliozzi","year":"2010","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.msard.2025.106626_bib0005","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/ana.25197","article-title":"Inflammatory intrathecal profiles and cortical damage in multiple sclerosis","volume":"83","author":"Magliozzi","year":"2018","journal-title":"Ann. Neurol."},{"issue":"1\u20132","key":"10.1016\/j.msard.2025.106626_bib0028","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jneuroim.2008.03.001","article-title":"Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF","volume":"196","author":"Malmestrom","year":"2008","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.msard.2025.106626_bib0026","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1038\/s41598-021-82388-w","article-title":"Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis","volume":"11","author":"Mosleth","year":"2021","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.msard.2025.106626_bib0036","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055948","article-title":"EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE)","volume":"8","author":"Munro","year":"2013","journal-title":"PLoS One"},{"issue":"43","key":"10.1016\/j.msard.2025.106626_bib0037","doi-asserted-by":"crossref","first-page":"29461","DOI":"10.1074\/jbc.M804103200","article-title":"Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors","volume":"283","author":"Noberini","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.msard.2025.106626_bib0003","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/nyas.12841","article-title":"Pathological differences between white and grey matter multiple sclerosis lesions","volume":"1351","author":"Prins","year":"2015","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.msard.2025.106626_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.779003","article-title":"Comparative proteomic profiling identifies reciprocal expression of mitochondrial proteins between white and gray matter lesions from multiple sclerosis brains","volume":"12","author":"Rai","year":"2021","journal-title":"Front Neurol"},{"issue":"7772","key":"10.1016\/j.msard.2025.106626_bib0009","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41586-019-1404-z","article-title":"Neuronal vulnerability and multilineage diversity in multiple sclerosis","volume":"573","author":"Schirmer","year":"2019","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.msard.2025.106626_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066117","article-title":"Gray matter is targeted in first-attack multiple sclerosis","volume":"8","author":"Schutzer","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.msard.2025.106626_bib0044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-61012-3","article-title":"Contribution of cortical lesions to cognitive impairment in Japanese patients with multiple sclerosis","volume":"10","author":"Shinoda","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.msard.2025.106626_bib0034","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1750-3639.2005.tb00098.x","article-title":"Ephrin A receptors and ligands in lesions and normal-appearing white matter in multiple sclerosis","volume":"15","author":"Sobel","year":"2005","journal-title":"Brain Pathol."},{"issue":"4","key":"10.1016\/j.msard.2025.106626_bib0016","doi-asserted-by":"crossref","first-page":"fcae209","DOI":"10.1093\/braincomms\/fcae209","article-title":"Potential biomarkers for multiple sclerosis stage from targeted proteomics and microRNA sequencing","volume":"6","author":"Tan","year":"2024","journal-title":"Brain Commun."},{"issue":"6","key":"10.1016\/j.msard.2025.106626_bib0042","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.4049\/jimmunol.150.6.2431","article-title":"Hydrolysis of myelin basic protein in myelin membranes by granzymes of large granular lymphocytes","volume":"150","author":"Vanguri","year":"1993","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.msard.2025.106626_bib0011","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1212\/01.wnl.0000237551.26858.39","article-title":"Neocortical neuronal, synaptic, and glial loss in multiple sclerosis","volume":"67","author":"Wegner","year":"2006","journal-title":"Neurology"}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825003682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825003682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:24:02Z","timestamp":1780039442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034825003682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":44,"alternative-id":["S2211034825003682"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2025.106626","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proximity Extension Assay identifies new targets of grey matter pathology in multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2025.106626","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106626"}}