{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:04:02Z","timestamp":1784347442027,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.msard.2025.106727","type":"journal-article","created":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T05:30:04Z","timestamp":1757223004000},"page":"106727","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Revisiting the diagnostic marker: Oligoclonal band positivity is not associated with early disability or cognitive performance in relapsing-remitting multiple sclerosis"],"prefix":"10.1016","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1481-151X","authenticated-orcid":false,"given":"Ulvi","family":"Samadzade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said","family":"Alizada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ela Simay","family":"Zengin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcmeyye","family":"\u00c7evik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurbanu Ayg\u00fcnd\u00fcz","family":"Yap\u0131c\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130rem","family":"Kara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cavid","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Ozakbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.msard.2025.106727_bib0003","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.3390\/medicina59061028","article-title":"Oligoclonal band status and features of radiological and clinical findings in patients with multiple sclerosis in Lithuania","volume":"59","author":"Aleksandravi\u010di\u016bt\u0117","year":"2023","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.msard.2025.106727_bib0004","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1007\/s10072-015-2303-1","article-title":"Clinical and cognitive implications of cerebrospinal fluid oligoclonal bands in multiple sclerosis patients","volume":"36","author":"Anagnostouli","year":"2015","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.msard.2025.106727_bib0005","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.3390\/medicina58091178","article-title":"Factors related to the progression of clinically isolated syndrome to multiple sclerosis: a retrospective study in Lithuania","volume":"58","author":"Balnyt\u0117","year":"2022","journal-title":"Medicina (B Aires)"},{"key":"10.1016\/j.msard.2025.106727_bib0006","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1017\/S1355617717000959","article-title":"Neuropsychology of multiple aclerosis: looking back and moving forward","volume":"23","author":"Benedict","year":"2017","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.msard.2025.106727_bib0007","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1067\/mcp.2001.113989","article-title":"Biomarkers and surrogate endpoints: preferred definitions and conceptual framework","volume":"69","year":"2001","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.msard.2025.106727_bib0008","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S1474-4422(08)70259-X","article-title":"Cognitive impairment in multiple sclerosis","volume":"7","author":"Chiaravalloti","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.msard.2025.106727_bib0009","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri3871","article-title":"Immunopathology of multiple sclerosis","volume":"15","author":"Dendrou","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.msard.2025.106727_bib0010","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1136\/jnnp-2012-304695","article-title":"Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude","volume":"84","author":"Dobson","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.msard.2025.106727_bib0011","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12974-017-0812-y","article-title":"Increased cortical lesion load and intrathecal inflammation is associated with oligoclonal bands in multiple sclerosis patients: a combined CSF and MRI study","volume":"14","author":"Farina","year":"2017","journal-title":"J. Neuroinflammation."},{"issue":"1","key":"10.1016\/j.msard.2025.106727_bib0012","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4103\/1673-5374.286949","article-title":"Cognitive impairment in multiple sclerosis: lessons from cerebrospinal fluid biomarkers","volume":"16","author":"Gaetani","year":"2021","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.msard.2025.106727_bib0013","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.362","article-title":"An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis","volume":"5","author":"Garg","year":"2015","journal-title":"Brain Behav."},{"key":"10.1016\/j.msard.2025.106727_bib0014","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1515\/revneuro-2017-0011","article-title":"Cognitive impairment in multiple sclerosis - a review of current knowledge and recent research","volume":"28","author":"Grzegorski","year":"2017","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.msard.2025.106727_bib0015","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1212\/01.wnl.0000237343.93389.35","article-title":"Multiple sclerosis with and without CSF bands: clinically indistinguishable but immunogenetically distinct","volume":"67","author":"Imrell","year":"2006","journal-title":"Neurology."},{"key":"10.1016\/j.msard.2025.106727_bib0017","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-94423-x","article-title":"Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study","volume":"11","author":"Karrenbauer","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.msard.2025.106727_bib0016","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4274\/tnd.2022.72558","article-title":"The effect of oligoclonal bands in patients with multiple sclerosis","volume":"28","author":"Kaya Tutar","year":"2023","journal-title":"Turk. J. Neurol."},{"key":"10.1016\/j.msard.2025.106727_bib0018","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S1474-4422(10)70064-8","article-title":"The changing demographic pattern of multiple sclerosis epidemiology","volume":"9","author":"Koch-Henriksen","year":"2010","journal-title":"Lancet Neurol."},{"issue":"6","key":"10.1016\/j.msard.2025.106727_bib0001","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1177\/1352458511431076","article-title":"Recommendations for a brief international cognitive assessment for Multiple sclerosis (BICAMS)","volume":"18","author":"Langdon","year":"2012","journal-title":"Multiple Scler. J."},{"key":"10.1016\/j.msard.2025.106727_bib0019","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neurol.2015.10.006","article-title":"Epidemiology of multiple sclerosis","volume":"172","author":"Leray","year":"2016","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.msard.2025.106727_bib0020","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jocn.2019.05.025","article-title":"Comparison of multiple sclerosis patients with and without oligoclonal IgG bands in South China","volume":"66","author":"Lu","year":"2019","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.msard.2025.106727_bib0021","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4831647","article-title":"Neuropsychological features of multiple sclerosis: impact and rehabilitation","volume":"2018","author":"Messinis","year":"2018","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.msard.2025.106727_bib0022","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S1474-4422(06)70581-6","article-title":"Canadian Collaborative Study Group sex ratio of multiple sclerosis in Canada: a longitudinal study","volume":"5","author":"Orton","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.msard.2025.106727_bib0002","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12883-017-0993-0","article-title":"The Turkish validation of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery","volume":"17","author":"\u00d6zakbas","year":"2017","journal-title":"BMC. Neurol."},{"key":"10.1016\/j.msard.2025.106727_bib0023","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.866092","article-title":"Biological markers in early multiple sclerosis: the paved way for radiologically isolated syndrome","volume":"13","author":"Rival","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.msard.2025.106727_bib0024","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/jnnp.43.2.102","article-title":"Link. Relation between benign course of multiple sclerosis and low grade humoral immune response in cerebrospinal fluid","volume":"43","author":"Stendahl-Brodin","year":"1980","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.msard.2025.106727_bib0025","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol."},{"issue":"5","key":"10.1016\/j.msard.2025.106727_bib0026","first-page":"824","article-title":"Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?","volume":"57","author":"Tintore","year":"2008","journal-title":"Neurology."},{"issue":"2","key":"10.1016\/j.msard.2025.106727_bib0027","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ana.10441","article-title":"Intrathecal IgM synthesis is a prognostic factor in multiple sclerosis","volume":"53","author":"Villar","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2025.106727_bib0028","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/jnnp.60.1.27","article-title":"A study of oligoclonal band negative multiple sclerosis","volume":"60","author":"Zeman","year":"1996","journal-title":"J. Neurol. Neurosurg. Psychiatry"}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825004699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825004699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:37:08Z","timestamp":1784345828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034825004699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":28,"alternative-id":["S2211034825004699"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2025.106727","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Revisiting the diagnostic marker: Oligoclonal band positivity is not associated with early disability or cognitive performance in relapsing-remitting multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2025.106727","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106727"}}