{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:03:19Z","timestamp":1791568999827,"version":"4.3.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Minas Gerais State Foundation of Support to the Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.msard.2025.106821","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:26:38Z","timestamp":1761647198000},"page":"106821","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Peak 30-minute cadence as a digital biomarker of real-world mobility in people with multiple sclerosis"],"prefix":"10.1016","volume":"104","author":[{"given":"Rayssa Soares","family":"de Queiroz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Humberto","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jair Sindra","family":"Virtuoso J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Roberto","family":"dos Santos Amorim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson","family":"Sebasti\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlos Aureliano Dias","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor Ant\u00f4nio","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Motl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2083-4104","authenticated-orcid":false,"given":"Jeffer Eidi","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2025.106821_bib0001","first-page":"625","article-title":"Normative Peak 30-Min Cadence (Steps per Minute) values for older adults: NHANES 2005-2006","volume":"27","author":"Aguiar","year":"2019","journal-title":"J. Aging. Phys. Act."},{"key":"10.1016\/j.msard.2025.106821_bib0002","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s40279-016-0663-1","article-title":"Step counting: a review of measurement considerations and health-related applications","volume":"47","author":"Bassett","year":"2017","journal-title":"Sports. Med."},{"key":"10.1016\/j.msard.2025.106821_bib0003","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00415-016-8334-6","article-title":"Continuous daily assessment of multiple sclerosis disability using remote step count monitoring","volume":"264","author":"Block","year":"2017","journal-title":"J. Neurol."},{"key":"10.1016\/j.msard.2025.106821_bib0004","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/eurpub\/cky030","article-title":"Association of physical activity with body mass index, waist circumference and incidence of obesity in older adults","volume":"28","author":"C\u00e1rdenas Fuentes","year":"2018","journal-title":"Eur. J. Public. Health"},{"key":"10.1016\/j.msard.2025.106821_bib0005","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1249\/MSS.0b013e3181ed61a3","article-title":"Validation of accelerometer wear and nonwear time classification algorithm","volume":"43","author":"Choi","year":"2011","journal-title":"Med. Sci. Sports. Exerc."},{"key":"10.1016\/j.msard.2025.106821_bib0006","doi-asserted-by":"crossref","first-page":"27513","DOI":"10.34119\/bjhrv6n6-078","article-title":"An\u00e1lise dos aspectos epidemiol\u00f3gicos da Esclerose M\u00faltipla no Brasil durante o per\u00edodo de 2012 a 2022","volume":"6","author":"Coelho","year":"2023","journal-title":"Braz. J. Health. Rev."},{"key":"10.1016\/j.msard.2025.106821_bib0007","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/jama.1968.03140030033008","article-title":"A means of assessing maximal oxygen intake. Correlation between field and treadmill testing","volume":"203","author":"Cooper","year":"1968","journal-title":"JAMA"},{"key":"10.1016\/j.msard.2025.106821_bib0008","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.msard.2019.02.022","article-title":"Validation of the Brazilian version of the patient-determined disease steps scale in persons with multiple sclerosis","volume":"30","author":"de David","year":"2019","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2025.106821_bib0009","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3390\/sclerosis1030014","article-title":"Digital biomarkers in the assessment of mobility in individuals with multiple sclerosis","volume":"1","author":"de Queiroz","year":"2023","journal-title":"Sclerosis"},{"key":"10.1016\/j.msard.2025.106821_bib0010","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3390\/brainsci11111519","article-title":"Digital biomarkers in multiple sclerosis","volume":"11","author":"Dillenseger","year":"2021","journal-title":"Brain. Sci."},{"key":"10.1016\/j.msard.2025.106821_bib0011","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087085","article-title":"Comparison of the EPIC physical activity questionnaire with combined heart rate and movement sensing in a nationally representative sample of older british adults","volume":"9","author":"Espa\u00f1a-Romero","year":"2014","journal-title":"PLoS. One"},{"key":"10.1016\/j.msard.2025.106821_bib0012","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.apmr.2009.10.025","article-title":"Monitoring of physical activity after stroke: a systematic review of accelerometry-based measures","volume":"91","author":"Gebruers","year":"2010","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.msard.2025.106821_bib0013","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.parkreldis.2015.11.004","article-title":"Feasibility and effects of home-based smartphone-delivered automated feedback training for gait in people with Parkinson\u2019s disease: a pilot randomized controlled trial","volume":"22","author":"Ginis","year":"2016","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.msard.2025.106821_bib0014","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1177\/1352458507082607","article-title":"Evaluation of the six-minute walk in multiple sclerosis subjects and healthy controls","volume":"14","author":"Goldman","year":"2008","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2025.106821_bib0015","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.apmr.2015.07.018","article-title":"Observational gait assessments in people with neurological disorders: a systematic review","volume":"97","author":"Gor-Garc\u00eda-Fogeda","year":"2016","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.msard.2025.106821_bib0016","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.msard.2019.03.024","article-title":"Cognitive and physical fatigue are associated with distinct problems in daily functioning, role fulfilment, and quality of life in multiple sclerosis","volume":"31","author":"Gullo","year":"2019","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2025.106821_bib0017","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jshs.2023.10.010","article-title":"2024 adult compendium of physical activities: a third update of the energy costs of human activities","volume":"13","author":"Herrmann","year":"2024","journal-title":"J. Sport. Health. Sci."},{"key":"10.1016\/j.msard.2025.106821_bib0018","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s11556-019-0214-5","article-title":"Is every-day walking in older adults more analogous to dual-task walking or to usual walking? Elucidating the gaps between gait performance in the lab and during 24\/7 monitoring","volume":"16","author":"Hillel","year":"2019","journal-title":"Eur. Rev. Aging. Phys. Act."},{"key":"10.1016\/j.msard.2025.106821_bib0019","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1590\/0102-311X00189713","article-title":"Validity of the Brazilian version of the godin-shephard leisure-time physical activity questionnaire","volume":"31","author":"Jo\u00e3o","year":"2015","journal-title":"Cad. Saude. Publica."},{"key":"10.1016\/j.msard.2025.106821_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17239044","article-title":"The two-minute walk test in persons with multiple sclerosis: correlations of cadence with free-living walking do not support ecological validity","volume":"17","author":"Karle","year":"2020","journal-title":"Int. J. Env. Res. Public. Health"},{"key":"10.1016\/j.msard.2025.106821_bib0021","article-title":"Using real-world accelerometry-derived diurnal patterns of physical activity to evaluate disability in multiple sclerosis","volume":"9","author":"Keller","year":"2022","journal-title":"J. Rehabil. Assist. Technol. Eng."},{"key":"10.1016\/j.msard.2025.106821_bib0022","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2025.106821_bib0023","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2377-13-37","article-title":"Validation of patient determined disease steps (PDDS) scale scores in persons with multiple sclerosis","volume":"13","author":"Learmonth","year":"2013","journal-title":"BMC. Neurol."},{"key":"10.1016\/j.msard.2025.106821_bib0024","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s41038-019-0170-3","article-title":"Analysis of t-test misuses and SPSS operations in medical research papers","volume":"7","author":"Liang","year":"2019","journal-title":"Burns. Trauma."},{"key":"10.1016\/j.msard.2025.106821_bib0025","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2217\/nmt.14.32","article-title":"Neurological disability and its association with walking impairment in multiple sclerosis: brief review","volume":"4","author":"Motl","year":"2014","journal-title":"Neurodegener. Dis. Manag."},{"key":"10.1016\/j.msard.2025.106821_bib0026","first-page":"245","article-title":"Reliability of scores from physical activity monitors in adults with multiple sclerosis","volume":"24","author":"Motl","year":"2007","journal-title":"Adapt. Phys. Act. Q"},{"key":"10.1016\/j.msard.2025.106821_bib0027","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.3390\/s140203362","article-title":"Gait analysis methods: an overview of wearable and non-wearable systems, highlighting clinical applications","volume":"14","author":"Muro-de-la-Herran","year":"2014","journal-title":"Sensors"},{"key":"10.1016\/j.msard.2025.106821_bib0028","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.gaitpost.2017.08.023","article-title":"Smoothness of gait detects early alterations of walking in persons with multiple sclerosis without disability","volume":"58","author":"Pau","year":"2017","journal-title":"Gait. Posture."},{"key":"10.1016\/j.msard.2025.106821_bib0029","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1532-5415.1991.tb01616.x","article-title":"The timed \u201cUp & Go\u201d: a test of basic functional mobility for frail elderly persons","volume":"39","author":"Podsiadlo","year":"1991","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.msard.2025.106821_bib0030","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41746-021-00513-5","article-title":"Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes","volume":"4","author":"Polhemus","year":"2021","journal-title":"npj. Digit. Med."},{"key":"10.1016\/j.msard.2025.106821_bib0031","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-038704","article-title":"Walking-related digital mobility outcomes as clinical trial endpoint measures: protocol for a scoping review","volume":"10","author":"Polhemus","year":"2020","journal-title":"BMJ. Open"},{"key":"10.1016\/j.msard.2025.106821_bib0032","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1097\/00005768-200009000-00012","article-title":"Age-related decline in physical activity: a synthesis of human and animal studies","volume":"32","author":"Sallis","year":"2000","journal-title":"Med. Sci. Sports. Exerc."},{"key":"10.1016\/j.msard.2025.106821_bib0033","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jns.2014.02.024","article-title":"Accelerometer cut-points derived during over-ground walking in persons with mild, moderate, and severe multiple sclerosis","volume":"340","author":"Sandroff","year":"2014","journal-title":"J. Neurol. Sci"},{"key":"10.1016\/j.msard.2025.106821_bib0034","first-page":"03","article-title":"Diagn\u00f3stico de esclerose m\u00faltipla por resson\u00e2ncia magn\u00e9tica","volume":"3","author":"Santos","year":"2018","journal-title":"Revista Remecs - Revista Multidisciplinar de Estudos Cient\u00ed\u00adficos em Sa\u00fade"},{"key":"10.1016\/j.msard.2025.106821_bib0035","doi-asserted-by":"crossref","first-page":"110","DOI":"10.12820\/rbafs.v.22n2p110-126","article-title":"Orienta\u00e7\u00f5es para utiliza\u00e7\u00e3o de aceler\u00f4metros no Brasil","volume":"22","author":"Sasaki","year":"2017","journal-title":"Revista Brasileira de Atividade F\u00edsica & Sa\u00fade"},{"key":"10.1016\/j.msard.2025.106821_bib0036","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph191811839","article-title":"Pedometers and accelerometers in multiple sclerosis: current and new applications","volume":"19","author":"Sasaki","year":"2022","journal-title":"Int. J. Env. Res. Public. Health"},{"key":"10.1016\/j.msard.2025.106821_bib0037","series-title":"Computer-Assisted and Web-Based Innovations in Psychology, Special Education, and Health","first-page":"33","article-title":"Measurement of physical activity using accelerometers","author":"Sasaki","year":"2016"},{"key":"10.1016\/j.msard.2025.106821_bib0038","series-title":"Encyclopedia of Sensors and Biosensors","first-page":"111","article-title":"Physical sensors: motion sensors for physical activity assessment","author":"Sasaki","year":"2023"},{"key":"10.1016\/j.msard.2025.106821_bib0039","series-title":"Reference Module in Biomedical Sciences","article-title":"Motion sensors for physical activity assessment: review of applications","author":"Sasaki","year":"2021"},{"key":"10.1016\/j.msard.2025.106821_bib0040","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1080\/17434440.2017.1386550","article-title":"Motion sensors in multiple sclerosis: narrative review and update of applications","volume":"14","author":"Sasaki","year":"2017","journal-title":"Expert. Rev. Med. Devices"},{"key":"10.1016\/j.msard.2025.106821_bib0041","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/00005768-200205000-00018","article-title":"Validation of the godin-shephard questionnaire in prepubertal girls","volume":"34","author":"Scerpella","year":"2002","journal-title":"Med. Sci. Sports. Exerc"},{"key":"10.1016\/j.msard.2025.106821_bib0042","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.apmr.2015.12.031","article-title":"Validity of the timed up and go test as a measure of functional mobility in persons with multiple sclerosis","volume":"97","author":"Sebasti\u00e3o","year":"2016","journal-title":"Arch. Phys. Med. Rehabil"},{"key":"10.1016\/j.msard.2025.106821_bib0043","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4300\/JGME-D-12-00156.1","article-title":"Using effect size\u2014or why the p value is not enough","volume":"4","author":"Sullivan","year":"2012","journal-title":"J. Gr. Med. Educ"},{"key":"10.1016\/j.msard.2025.106821_bib0044","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1136\/bjsports-2014-093546","article-title":"Evolution of accelerometer methods for physical activity research","volume":"48","author":"Troiano","year":"2014","journal-title":"Br. J. Sports. Med"},{"key":"10.1016\/j.msard.2025.106821_bib0045","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1123\/jpah.9.8.1125","article-title":"Peak stepping cadence in free-living adults: 2005-2006 NHANES","volume":"9","author":"Tudor-Locke","year":"2012","journal-title":"J. Phys. Act. Health"},{"key":"10.1016\/j.msard.2025.106821_bib0046","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2165\/11599170-000000000-00000","article-title":"Using cadence to study free-living ambulatory behaviour","volume":"42","author":"Tudor-Locke","year":"2012","journal-title":"Sports. Med."},{"key":"10.1016\/j.msard.2025.106821_bib0047","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1093\/gerona\/glac013","article-title":"Free-living gait cadence measured by wearable accelerometer: a promising alternative to traditional measures of mobility for assessing fall risk","volume":"78","author":"Urbanek","year":"2023","journal-title":"J. Gerontol."},{"key":"10.1016\/j.msard.2025.106821_bib0048","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1177\/15459683231206741","article-title":"Free-living peak cadence in multiple sclerosis: a new measure of real-world walking?","volume":"37","author":"Zheng","year":"2023","journal-title":"Neurorehabil. Neural. Repair."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825005632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825005632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:24:31Z","timestamp":1784345071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034825005632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":48,"alternative-id":["S2211034825005632"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2025.106821","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peak 30-minute cadence as a digital biomarker of real-world mobility in people with multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2025.106821","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106821"}}