{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:55:53Z","timestamp":1781510153260,"version":"3.54.1"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008522","name":"University of Illinois Chicago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008522","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["F32HD113333"],"award-info":[{"award-number":["F32HD113333"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.msard.2025.106930","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T16:27:32Z","timestamp":1765556852000},"page":"106930","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Feasibility and efficacy of peak-velocity interval training vs. moderate-intensity walking training in people with multiple sclerosis with severe fatigue and walking impairment: A pilot randomized controlled trial"],"prefix":"10.1016","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8227-6876","authenticated-orcid":false,"given":"Brice Thomas","family":"Cleland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Jeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalya","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Motl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeetha","family":"Madhavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.msard.2025.106930_bib0001","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1177\/1352458511401120","article-title":"The effect of exercise therapy on fatigue in multiple sclerosis","volume":"17","author":"Andreasen","year":"2011","journal-title":"Mult. Scler."},{"issue":"1","key":"10.1016\/j.msard.2025.106930_bib0002","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/cercor\/bhz075","article-title":"Intensity matters: high-intensity interval exercise enhances motor cortex plasticity more than moderate exercise","volume":"30","author":"Andrews","year":"2020","journal-title":"Cereb. Cortex."},{"key":"10.1016\/j.msard.2025.106930_bib0003","article-title":"Feasibility of a new intervention addressing group-based balance and high-intensity training, physical activity, and employment in individuals with multiple sclerosis: a pilot randomized controlled trial","volume":"4","author":"Arntzen","year":"2023","journal-title":"Front. Rehabil. Sci."},{"key":"10.1016\/j.msard.2025.106930_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.104748","article-title":"High intensity exercise training on functional outcomes in persons with multiple sclerosis: a systematic review","volume":"75","author":"Bae","year":"2023","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"5","key":"10.1016\/j.msard.2025.106930_bib0005","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1177\/1352458517690821","article-title":"Validity of the symbol digit Modalities Test as a cognition performance outcome measure for multiple sclerosis","volume":"23","author":"Benedict","year":"2017","journal-title":"Mult. Scler."},{"issue":"10","key":"10.1016\/j.msard.2025.106930_bib0006","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.2522\/ptj.20150277","article-title":"High-intensity interval training and moderate-intensity continuous training in ambulatory chronic stroke: feasibility study","volume":"96","author":"Boyne","year":"2016","journal-title":"Phys. Ther."},{"issue":"5","key":"10.1016\/j.msard.2025.106930_bib0007","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1191\/1352458503ms957oa","article-title":"Symptomatic medication use in multiple sclerosis","volume":"9","author":"Brichetto","year":"2003","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2025.106930_bib0008","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.msard.2018.06.005","article-title":"High intensity interval training for people with multiple sclerosis: a systematic review","volume":"24","author":"Campbell","year":"2018","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"12","key":"10.1016\/j.msard.2025.106930_bib0009","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S1474-4422(08)70259-X","article-title":"Cognitive impairment in multiple sclerosis","volume":"7","author":"Chiaravalloti","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.msard.2025.106930_bib0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s11556-017-0183-5","article-title":"The effect of three different exercise training modalities on cognitive and physical function in a healthy older population","volume":"14","author":"Coetsee","year":"2017","journal-title":"Eur. Rev. Aging Phys. Act."},{"issue":"9648","key":"10.1016\/j.msard.2025.106930_bib0011","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.msard.2025.106930_bib0012","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s11910-019-1002-3","article-title":"Exercise as medicine in Multiple sclerosis-time for a paradigm shift: preventive, symptomatic, and disease-modifying aspects and perspectives","volume":"19","author":"Dalgas","year":"2019","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.msard.2025.106930_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2020.106265","article-title":"Perceived fatigue in multiple sclerosis: the importance of highlighting its impact on quality of life, social network and cognition","volume":"199","author":"Eizaguirre","year":"2020","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"6","key":"10.1016\/j.msard.2025.106930_bib62","first-page":"765","article-title":"Cardiovascular adaptation in people with multiple sclerosis following a twelve week exercise programme suggest deconditioning rather than autonomic dysfunction caused by the disease. Results from a randomized controlled trial","volume":"49","author":"Feltham","year":"2013","journal-title":"Eur J Phys Rehabil Med"},{"issue":"Suppl 1","key":"10.1016\/j.msard.2025.106930_bib0014","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1093\/clinids\/18.Supplement_1.S79","article-title":"Measuring the functional impact of fatigue: initial validation of the fatigue impact scale","volume":"18","author":"Fisk","year":"1994","journal-title":"Clin. Infect. Dis."},{"issue":"13","key":"10.1016\/j.msard.2025.106930_bib0015","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1177\/1352458520917935","article-title":"Exercise training and cognitive performance in persons with multiple sclerosis: a systematic review and multilevel meta-analysis of clinical trials","volume":"27","author":"Gharakhanlou","year":"2021","journal-title":"Mult. Scler."},{"issue":"5","key":"10.1016\/j.msard.2025.106930_bib0016","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1113\/jphysiol.2011.224725","article-title":"Physiological adaptations to low-volume, high-intensity interval training in health and disease","volume":"590","author":"Gibala","year":"2012","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.msard.2025.106930_bib0017","article-title":"Which symptoms contribute the most to patients' perception of health in multiple sclerosis?","volume":"3","author":"Green","year":"2017","journal-title":"Mult. Scler. J. Exp. Transl. Clin."},{"issue":"3","key":"10.1016\/j.msard.2025.106930_bib0018","first-page":"426","article-title":"Feasibility and effects of structured physical exercise interventions in adults with relapsing-remitting multiple sclerosis: a pilot study","volume":"17","author":"Guillam\u00f3","year":"2018","journal-title":"J. Sports Sci. Med."},{"issue":"1","key":"10.1016\/j.msard.2025.106930_bib0019","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12883-017-0960-9","article-title":"Exercise prescription for patients with multiple sclerosis; potential benefits and practical recommendations","volume":"17","author":"Halabchi","year":"2017","journal-title":"BMC Neurol."},{"issue":"9","key":"10.1016\/j.msard.2025.106930_bib0020","article-title":"Exercise therapy for fatigue in multiple sclerosis","volume":"2015","author":"Heine","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"2","key":"10.1016\/j.msard.2025.106930_bib0021","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1212\/WNL.45.2.251","article-title":"Disease steps in multiple sclerosis: a simple approach to evaluate disease progression","volume":"45","author":"Hohol","year":"1995","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.msard.2025.106930_bib0022","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1177\/135245859900500508","article-title":"Disease steps in multiple sclerosis: a longitudinal study comparing disease steps and EDSS to evaluate disease progression","volume":"5","author":"Hohol","year":"1999","journal-title":"Mult. Scler."},{"issue":"10","key":"10.1016\/j.msard.2025.106930_bib0023","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.apmr.2011.05.017","article-title":"Is there a relationship between fatigue questionnaires and gait mechanics in persons with multiple sclerosis?","volume":"92","author":"Huisinga","year":"2011","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"5","key":"10.1016\/j.msard.2025.106930_bib0024","doi-asserted-by":"crossref","DOI":"10.12968\/ijtr.2021.0073","article-title":"High-intensity interval training in people with mild multiple sclerosis: a mixed-methods feasibility study","volume":"29","author":"Humphreys","year":"2022","journal-title":"Int. J. Ther. Rehabil."},{"issue":"1","key":"10.1016\/j.msard.2025.106930_bib0025","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0022-510X(02)00312-X","article-title":"Quality of life in patients with multiple sclerosis: the impact of fatigue and depression","volume":"205","author":"Janardhan","year":"2002","journal-title":"J. Neurol. Sci."},{"issue":"4","key":"10.1016\/j.msard.2025.106930_bib0026","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s40263-025-01159-7","article-title":"Maintaining mobility and balance in multiple sclerosis: a systematic review examining potential impact of symptomatic pharmacotherapy","volume":"39","author":"Jones","year":"2025","journal-title":"CNS Drugs"},{"key":"10.1016\/j.msard.2025.106930_bib63","doi-asserted-by":"crossref","first-page":"102782","DOI":"10.1016\/j.msard.2021.102782","article-title":"Periodized versus classic exercise therapy in Multiple Sclerosis: a randomized controlled trial","volume":"49","author":"Keytsman","year":"2021","journal-title":"Mult Scler Relat Disord"},{"issue":"4","key":"10.1016\/j.msard.2025.106930_bib0027","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2165\/00023210-200317040-00002","article-title":"Fatigue in multiple sclerosis: definition, pathophysiology and treatment","volume":"17","author":"Krupp","year":"2003","journal-title":"CNS Drugs"},{"issue":"7","key":"10.1016\/j.msard.2025.106930_bib0028","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1212\/WNL.55.7.934","article-title":"Fatigue and declines in cognitive functioning in multiple sclerosis","volume":"55","author":"Krupp","year":"2000","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.msard.2025.106930_bib0029","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/archneur.1989.00520460115022","article-title":"The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus","volume":"46","author":"Krupp","year":"1989","journal-title":"Arch. Neurol."},{"issue":"6","key":"10.1016\/j.msard.2025.106930_bib0030","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1177\/1352458511431076","article-title":"Recommendations for a brief international cognitive assessment for Multiple sclerosis (BICAMS)","volume":"18","author":"Langdon","year":"2012","journal-title":"Mult. Scler."},{"issue":"6","key":"10.1016\/j.msard.2025.106930_bib0031","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s40279-015-0307-x","article-title":"Aerobic capacity in persons with multiple sclerosis: a systematic review and meta-analysis","volume":"45","author":"Langeskov-Christensen","year":"2015","journal-title":"Sports Med."},{"issue":"9","key":"10.1016\/j.msard.2025.106930_bib0032","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.apmr.2013.04.020","article-title":"Effects of exercise training on fitness, mobility, fatigue, and health-related quality of life among adults with multiple sclerosis: a systematic review to inform guideline development","volume":"94","author":"Latimer-Cheung","year":"2013","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"1","key":"10.1016\/j.msard.2025.106930_bib0033","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2165\/00007256-200232010-00003","article-title":"The scientific basis for high-intensity interval training: optimising training programmes and maximising performance in highly trained endurance athletes","volume":"32","author":"Laursen","year":"2002","journal-title":"Sports Med."},{"issue":"1\u20132","key":"10.1016\/j.msard.2025.106930_bib0034","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jns.2013.05.023","article-title":"Psychometric properties of the fatigue Severity Scale and the Modified fatigue Impact Scale","volume":"331","author":"Learmonth","year":"2013","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.msard.2025.106930_bib0035","doi-asserted-by":"crossref","first-page":"20","DOI":"10.46439\/rehabilitation.6.035","article-title":"Tailoring interval training in stroke rehabilitation: the role of peak velocity","volume":"6","author":"Madhavan","year":"2025","journal-title":"J. Rehab. Res. Pract."},{"issue":"1","key":"10.1016\/j.msard.2025.106930_bib0036","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1038\/s41598-018-37982-w","article-title":"Effects of high intensity speed-based treadmill training on ambulatory function in people with chronic stroke: a preliminary study with long-term follow-up","volume":"9","author":"Madhavan","year":"2019","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.msard.2025.106930_bib0037","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/PHM.0000000000002676","article-title":"High-intensity interval Training effects on people with Multiple sclerosis: a systematic review and meta-analyses for exercise capacity and fatigue","volume":"104","author":"Martin-Nunez","year":"2025","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"10.1016\/j.msard.2025.106930_bib0038","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jns.2017.08.012","article-title":"The pharmacological and non-pharmacological interventions for the management of fatigue related multiple sclerosis","volume":"381","author":"Miller","year":"2017","journal-title":"J. Neurol. Sci."},{"issue":"3","key":"10.1016\/j.msard.2025.106930_bib0039","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.nic.2024.03.010","article-title":"Cognitive impairment in Multiple sclerosis: past, present, and future","volume":"34","author":"Morrow","year":"2024","journal-title":"NeuroimAging Clin. N. Am."},{"key":"10.1016\/j.msard.2025.106930_bib0040","doi-asserted-by":"crossref","first-page":"767","DOI":"10.2147\/NDT.S10480","article-title":"Walking impairment in patients with multiple sclerosis: exercise training as a treatment option","volume":"6","author":"Motl","year":"2010","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"2","key":"10.1016\/j.msard.2025.106930_bib0041","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10072-010-0396-0","article-title":"Oxygen cost of treadmill and over-ground walking in mildly disabled persons with multiple sclerosis","volume":"32","author":"Motl","year":"2011","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.msard.2025.106930_bib0042","series-title":"ACSM's Resources For Clinical Exercise Physiology : musculoskeletal, neuromuscular, neoplastic, immunologic, and Hematologic Conditions","article-title":"American College of Sports Medicine","author":"Myers","year":"2010"},{"issue":"10","key":"10.1016\/j.msard.2025.106930_bib0043","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1517\/14656566.2011.586338","article-title":"Treatment of walking impairment in multiple sclerosis: an unmet need for a disease-specific disability","volume":"12","author":"Panitch","year":"2011","journal-title":"Expert. Opin. PharmacOther"},{"issue":"7","key":"10.1016\/j.msard.2025.106930_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.apmr.2015.02.011","article-title":"Exercise as a therapy for improvement of walking ability in adults with multiple sclerosis: a meta-analysis","volume":"96","author":"Pearson","year":"2015","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"6","key":"10.1016\/j.msard.2025.106930_bib0045","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/PSY.0b013e31829b4525","article-title":"Effects of exercise training on fatigue in multiple sclerosis: a meta-analysis","volume":"75","author":"Pilutti","year":"2013","journal-title":"Psychosom. Med."},{"issue":"4","key":"10.1016\/j.msard.2025.106930_bib0046","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0895-4356(95)00027-5","article-title":"Psychosocial and neurological predictors of mental health in multiple sclerosis patients","volume":"49","author":"Ritvo","year":"1996","journal-title":"J. Clin. Epidemiol."},{"issue":"2","key":"10.1016\/j.msard.2025.106930_bib0047","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0003-9993(96)90162-8","article-title":"Psychosocial correlates of fatigue in multiple sclerosis","volume":"77","author":"Schwartz","year":"1996","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.msard.2025.106930_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2024.105695","article-title":"Results of a feasibility and initial efficacy clinical trial of a high-intensity interval training program using adaptive equipment in persons with multiple sclerosis who have walking disability","volume":"87","author":"Silveira","year":"2024","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"5","key":"10.1016\/j.msard.2025.106930_bib0049","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1177\/1352458513505351","article-title":"Endurance training is feasible in severely disabled patients with progressive multiple sclerosis","volume":"20","author":"Skjerb\u00e6k","year":"2014","journal-title":"Mult. Scler."},{"issue":"2","key":"10.1016\/j.msard.2025.106930_bib0050","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1177\/1545968308320641","article-title":"Effect of exercise training on walking mobility in multiple sclerosis: a meta-analysis","volume":"23","author":"Snook","year":"2009","journal-title":"Neurorehabil. Neural Repair"},{"issue":"2","key":"10.1016\/j.msard.2025.106930_bib0051","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/13854040903266910","article-title":"Validity of the California verbal Learning Test-II in multiple sclerosis","volume":"24","author":"Stegen","year":"2010","journal-title":"Clin. Neuropsychol."},{"key":"10.1016\/j.msard.2025.106930_bib0052","unstructured":"Taskforce, A.P.T.A.M.S. (2011) Multiple sclerosis outcome measures recommendations."},{"issue":"1","key":"10.1016\/j.msard.2025.106930_bib0053","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166299","article-title":"High-intensity interval training elicits higher enjoyment than moderate intensity continuous exercise","volume":"12","author":"Thum","year":"2017","journal-title":"PLoS One"},{"issue":"26","key":"10.1016\/j.msard.2025.106930_bib0054","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.3109\/09638288.2012.680649","article-title":"Walking tests for stroke survivors: a systematic review of their measurement properties","volume":"34","author":"van Bloemendaal","year":"2012","journal-title":"Disabil. Rehabil."},{"issue":"10","key":"10.1016\/j.msard.2025.106930_bib0055","doi-asserted-by":"crossref","first-page":"e1029","DOI":"10.1212\/WNL.0000000000007035","article-title":"The prevalence of MS in the United States: a population-based estimate using health claims data","volume":"92","author":"Wallin","year":"2019","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.msard.2025.106930_bib0056","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115541","article-title":"Clinically significant fatigue: prevalence and associated factors in an international sample of adults with multiple sclerosis recruited via the internet","volume":"10","author":"Weiland","year":"2015","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.msard.2025.106930_bib0057","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133697","article-title":"High intensity exercise in multiple sclerosis: effects on muscle contractile characteristics and exercise capacity, a randomised controlled trial","volume":"10","author":"Wens","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.msard.2025.106930_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2021.117437","article-title":"Quality of life in multiple sclerosis is dominated by fatigue, disability and self-efficacy","volume":"426","author":"Young","year":"2021","journal-title":"J. Neurol. Sci."},{"issue":"8","key":"10.1016\/j.msard.2025.106930_bib0059","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.apmr.2023.12.012","article-title":"Is high-intensity interval training more effective than moderate continuous training in rehabilitation of multiple sclerosis: a comprehensive systematic review and meta-analysis","volume":"105","author":"Youssef","year":"2024","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"11","key":"10.1016\/j.msard.2025.106930_bib0060","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9113592","article-title":"New strategies for rehabilitation and pharmacological treatment of fatigue syndrome in multiple sclerosis","volume":"9","author":"Zieli\u0144ska-Nowak","year":"2020","journal-title":"J. Clin. Med."},{"issue":"12","key":"10.1016\/j.msard.2025.106930_bib61","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1177\/1352458517728342","article-title":"High-intensity interval exercise improves cognitive performance and reduces matrix metalloproteinases-2 serum levels in persons with multiple sclerosis: A randomized controlled trial","volume":"24","author":"Zimmer","year":"2018","journal-title":"Mult. Scler."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825006686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034825006686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:46:44Z","timestamp":1781509604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034825006686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":63,"alternative-id":["S2211034825006686"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2025.106930","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Feasibility and efficacy of peak-velocity interval training vs. moderate-intensity walking training in people with multiple sclerosis with severe fatigue and walking impairment: A pilot randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2025.106930","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106930"}}