{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:10:25Z","timestamp":1780416625259,"version":"3.54.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.msard.2026.107014","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:44:51Z","timestamp":1768520691000},"page":"107014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Virus antibody responses in patients with myelin oligodendrocyte glycoprotein antibody-associated disease and multiple sclerosis"],"prefix":"10.1016","volume":"107","author":[{"given":"JL","family":"Frederiksen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"\u017diogien\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Slibinskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Ciplys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Houen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1548-2009","authenticated-orcid":false,"given":"NH","family":"Trier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2026.107014_bib0001","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70919-w","article-title":"Progressive patterns of neurological disability in multiple sclerosis and neuromyelitis optica spectrum disorders","volume":"10","author":"Akaishi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.msard.2026.107014_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577467","article-title":"Progression pattern of neurological disability with respect to clinical attacks in anti-MOG antibody-associated disorders","volume":"351","author":"Akaishi","year":"2021","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.msard.2026.107014_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2024.106173","article-title":"Epstein-Barr nuclear antigen 1 antibody-based indices are increased in patients with multiple sclerosis","volume":"92","author":"Ali","year":"2024","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2026.107014_bib0004","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S1474-4422(22)00431-8","article-title":"Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: international MOGAD Panel proposed criteria","volume":"22","author":"Banwell","year":"2023","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.msard.2026.107014_bib0005","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.msard.2026.107014_bib0006","doi-asserted-by":"crossref","first-page":"e702","DOI":"10.1212\/NXI.0000000000000702","article-title":"HLA association in MOG-IgG- and AQP4-IgG-related disorders of the CNS in the Dutch population","volume":"7","author":"Bruijstens","year":"2020","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.msard.2026.107014_bib0007","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1471-4159.1989.tb10930.x","article-title":"Differential ultrastructural localization of myelin basic protein, myelin\/oligodendroglial glycoprotein, and 2\u2032,3\u2032-cyclic nucleotide 3\u2032-phosphodiesterase in the CNS of adult rats","volume":"52","author":"Brunner","year":"1989","journal-title":"J. Neurochem."},{"key":"10.1016\/j.msard.2026.107014_bib0008","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/WCO.0000000000000681","article-title":"Clinical spectrum of central nervous system myelin oligodendrocyte glycoprotein autoimmunity in adults","volume":"32","author":"Cobo-Calvo","year":"2019","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.msard.2026.107014_bib0009","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/ana.25909","article-title":"Clinical features and risk of relapse in children and adults with myelin oligodendrocyte glycoprotein antibody-associated disease","volume":"89","author":"Cobo-Calvo","year":"2021","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2026.107014_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1137998","article-title":"Pathophysiology of myelin oligodendrocyte glycoprotein antibody disease","volume":"14","author":"Corbali","year":"2023","journal-title":"Front. Neurol."},{"key":"10.1016\/j.msard.2026.107014_bib0012","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/ana.26890","article-title":"Epstein-Barr virus strongly associates with pediatric multiple sclerosis, but not myelin oligodendrocyte glycoprotein-antibody-associated disease","volume":"95","author":"Fadda","year":"2024","journal-title":"Ann Neurol."},{"key":"10.1016\/j.msard.2026.107014_bib0013","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.imlet.2023.02.003","article-title":"Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis","volume":"254","author":"G\u00e5sland","year":"2023","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.msard.2026.107014_bib0011","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1002\/acn3.51378","article-title":"No strong HLA association with MOG antibody disease in the UK population","volume":"8","author":"Grant-Peters","year":"2021","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.msard.2026.107014_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1260358","article-title":"Epidemiology of myelin oligodendrocyte glycoprotein antibody-associated disease: a review of prevalence and incidence worldwide","volume":"14","author":"Hor","year":"2023","journal-title":"Front. Neurol."},{"key":"10.1016\/j.msard.2026.107014_bib0015","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12987-016-0049-7","article-title":"The MRZ reaction in primary progressive multiple sclerosis","volume":"14","author":"Hottenrott","year":"2017","journal-title":"Fluids. Barriers. CNS."},{"key":"10.1016\/j.msard.2026.107014_bib0016","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1007\/s00415-018-8779-x","article-title":"The MRZ reaction and a quantitative intrathecal IgG synthesis may be helpful to differentiate between primary central nervous system lymphoma and multiple sclerosis","volume":"265","author":"Hottenrott","year":"2018","journal-title":"J. Neurol."},{"key":"10.1016\/j.msard.2026.107014_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577314","article-title":"Antibodies to epstein-barr virus and neurotropic viruses in multiple sclerosis and optic neuritis","volume":"346","author":"Houen","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.msard.2026.107014_bib0018","article-title":"Epstein-Barr virus and multiple sclerosis. Front","volume":"11","author":"Houen","year":"2020","journal-title":"Immunol."},{"key":"10.1016\/j.msard.2026.107014_bib0019","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1742-2094-9-14","article-title":"Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: a multicentre study of 175 patients","volume":"9","author":"Jarius","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.msard.2026.107014_bib0020","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/acn3.51609","article-title":"SARS-COV-2 a trigger of myelin oligodendrocyte glycoprotein-associated disorder","volume":"9","author":"Johnsson","year":"2022","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.msard.2026.107014_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.970383","article-title":"COVID-19 and the risk of CNS demyelinating diseases: a systematic review","volume":"13","author":"Lotan","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.msard.2026.107014_bib0022","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/13524585241298065","article-title":"Epstein-Barr virus infection in patients with MOGAD","volume":"31","author":"Maniscalco","year":"2025","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2026.107014_bib0023","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/S1474-4422(21)00218-0","article-title":"Myelin-oligodendrocyte glycoprotein antibody-associated disease","volume":"20","author":"Marignier","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.msard.2026.107014_bib0024","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/jnnp-2024-335689","article-title":"Strong association with remote EBV infection in children with MS as opposed to other acquired demyelinating disorders","volume":"96","author":"Molenaar","year":"2025","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"key":"10.1016\/j.msard.2026.107014_bib0025","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1177\/1352458511408991","article-title":"Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel","volume":"17","author":"Munger","year":"2011","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2026.107014_bib0026","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12896-015-0187-z","article-title":"Production of recombinant VP1-derivedvirus-like particles from novel human polyomaviruses in yeast","volume":"15","author":"Norkiene","year":"2015","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.msard.2026.107014_bib0027","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3389\/fimmu.2017.00529","article-title":"Myelin oligodendrocyte glycoprotein: deciphering a target in inflammatory demyelinating diseases","volume":"8","author":"Peschl","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.msard.2026.107014_bib0028","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1159\/000067922","article-title":"Generation of recombinant virus-like particles of human and non-human polyomaviruses in yeast Saccharomyces cerevisiae","volume":"45","author":"Sasnauskas","year":"2002","journal-title":"Intervirology"},{"issue":"5","key":"10.1016\/j.msard.2026.107014_bib0029","article-title":"Factors associated with relapse and treatment of myelin oligodendrocyte glycoprotein antibody-associated disease in the United Kingdom","volume":"2022","author":"Satukijchai","year":"2022","journal-title":"JAMA Netw. Open."},{"key":"10.1016\/j.msard.2026.107014_bib0030","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jneuroim.2016.05.012","article-title":"Fine specificity of the antibody response to Epstein-Barr nuclear antigen-2 and other Epstein-Barr virus proteins in patients with clinically isolated syndrome: a peptide microarray-based case-control study","volume":"297","author":"Schlemm","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.msard.2026.107014_bib0031","first-page":"375","article-title":"Detection of oligoclonal bands in patients with neurologic diseases: comparison between agarose gel-, immunofixation- and isoelectric-focusing electrophoresis","volume":"61","author":"Shan","year":"1998","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.msard.2026.107014_bib0032","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1136\/jnnp-2019-322115","article-title":"Myelin oligodendrocyte glycoprotein-associated disorders are associated with HLA subtypes in a Chinese paediatric-onset cohort","volume":"91","author":"Sun","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"key":"10.1016\/j.msard.2026.107014_bib0033","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet. Neurol."},{"key":"10.1016\/j.msard.2026.107014_bib0034","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1016\/j.cell.2023.11.015","article-title":"Ineffective control of Epstein-Barr-virus-induced autoimmunity increases the risk for multiple sclerosis","volume":"186","author":"Vietzen","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.msard.2026.107014_bib0035","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000200035","article-title":"Temporal dynamics of MOG antibodies in children with acquired demyelinating syndrome","volume":"9","author":"Wendel","year":"2022","journal-title":"Neurol Neuroimmunol. Neuroinflamm."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034826000507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034826000507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:55:27Z","timestamp":1780415727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034826000507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":35,"alternative-id":["S2211034826000507"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2026.107014","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Virus antibody responses in patients with myelin oligodendrocyte glycoprotein antibody-associated disease and multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2026.107014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107014"}}