{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:55:32Z","timestamp":1781528132733,"version":"3.54.1"},"reference-count":11,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.msard.2026.107149","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:39:37Z","timestamp":1773826777000},"page":"107149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Impact of autoimmune comorbidity on inflammatory activity and disability accumulation in multiple sclerosis"],"prefix":"10.1016","volume":"109","author":[{"given":"Shai","family":"Shabo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviv","family":"Yafa Lazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofir","family":"Zmira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.msard.2026.107149_bib0001","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/ana.25463","article-title":"Silent progression in disease activity\u2013free relapsing multiple sclerosis","volume":"85","author":"Cree","year":"2019","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.msard.2026.107149_bib0002","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s00401-024-02742-w","article-title":"Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions","volume":"147","author":"de Boer","year":"2024","journal-title":"Acta Neuropathol."},{"issue":"4","key":"10.1016\/j.msard.2026.107149_bib0003","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1474-4422(20)30067-3","article-title":"Timing of high-efficacy therapy for multiple sclerosis: a retrospective observational cohort study","volume":"19","author":"He","year":"2020","journal-title":"Lancet Neurol."},{"issue":"9","key":"10.1016\/j.msard.2026.107149_bib0004","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/jamaneurol.2020.1568","article-title":"Contribution of relapse-independent progression vsrelapse-associated worsening to overall disability accumulation in MS","volume":"77","author":"Kappos","year":"2020","journal-title":"JAMa Neurol."},{"issue":"3","key":"10.1016\/j.msard.2026.107149_bib0005","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028936","article-title":"Multiple sclerosis pathology","volume":"8","author":"Lassmann","year":"2018","journal-title":"Cold. Spring. Harb. Perspect. Med."},{"issue":"2","key":"10.1016\/j.msard.2026.107149_bib0006","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1212\/01.wnl.0000333252.78173.5f","article-title":"Comorbidity delays diagnosis and increases disability at diagnosis in multiple sclerosis","volume":"72","author":"Marrie","year":"2009","journal-title":"Neurology."},{"issue":"8","key":"10.1016\/j.msard.2026.107149_bib0007","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S1474-4422(10)70135-6","article-title":"Emerging effects of comorbidities on multiple sclerosis","volume":"9","author":"Marrie","year":"2010","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.msard.2026.107149_bib0008","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1177\/1352458514564490","article-title":"A systematic review of the incidence and prevalence of autoimmune disease in multiple sclerosis","volume":"21","author":"Marrie","year":"2015","journal-title":"Mult. Scler."},{"issue":"3","key":"10.1016\/j.msard.2026.107149_bib0009","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/1352458514564491","article-title":"A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis","volume":"21","author":"Marrie","year":"2015","journal-title":"Mult. Scler. J."},{"issue":"7","key":"10.1016\/j.msard.2026.107149_bib0010","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/S1474-4422(07)70132-1","article-title":"Autoimmune disease in families with multiple sclerosis: a population-based study","volume":"6","author":"Ramagopalan","year":"2007","journal-title":"Lancet Neurol."},{"issue":"7","key":"10.1016\/j.msard.2026.107149_bib0011","first-page":"875","article-title":"Risk factors related to multiple sclerosis progression and disability accumulation: asystematic review","volume":"19","author":"Wens","year":"2013","journal-title":"Mult. Scler. J."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034826001859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034826001859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:22:15Z","timestamp":1781526135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034826001859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":11,"alternative-id":["S2211034826001859"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2026.107149","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of autoimmune comorbidity on inflammatory activity and disability accumulation in multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2026.107149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107149"}}