{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:09:07Z","timestamp":1791238147899,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.msard.2026.107192","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:31:06Z","timestamp":1776238266000},"page":"107192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Depression severity and discordance between fatigue patient-reported outcomes in people with multiple sclerosis"],"prefix":"10.1016","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7642-7613","authenticated-orcid":false,"given":"Munther M.","family":"Queisi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuka","family":"Tomatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Dada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Netra","family":"Wuppalapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Posada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Wilken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hancock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Penner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Golan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Morrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Bogaardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Barerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Feinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myassar","family":"Zarif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bumstead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijean","family":"Buhse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TJ","family":"Covey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Cipriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrayr","family":"Attarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7810-4991","authenticated-orcid":false,"given":"Mark","family":"Gudesblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2026.107192_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2021.02.029","article-title":"Association between chronic fatigue syndrome and suicidality among survivors of Middle East respiratory syndrome over a 2-year follow-up period","volume":"137","author":"Ahn","year":"2021","journal-title":"J. Psychiatr. Res."},{"issue":"13","key":"10.1016\/j.msard.2026.107192_bib0002","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1177\/13524585231198746","article-title":"Depression symptoms and cognition in multiple sclerosis: longitudinal evidence of a specific link to executive control","volume":"29","author":"Anderson","year":"2023","journal-title":"Mult. Scler."},{"issue":"1","key":"10.1016\/j.msard.2026.107192_bib0003","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s40359-023-01235-x","article-title":"Impact of depression on the perception of fatigue and information processing speed in a cohort of multiple sclerosis patients","volume":"11","author":"Biasi","year":"2023","journal-title":"BMC. Psychol."},{"issue":"11","key":"10.1016\/j.msard.2026.107192_bib0004","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11910-016-0700-3","article-title":"Hypothalamic dysfunction and multiple sclerosis: implications for fatigue and weight dysregulation","volume":"16","author":"Burfeind","year":"2016","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.msard.2026.107192_bib0005","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jad.2025.04.109","article-title":"Comparative efficacy of non-pharmacological interventions on depression in people with multiple sclerosis: a systematic review and network meta-analysis","volume":"383","author":"Chang","year":"2025","journal-title":"J. Affect. Disord."},{"issue":"6","key":"10.1016\/j.msard.2026.107192_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/healthcare9060629","article-title":"Identifying and managing suicidality in myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"9","author":"Chu","year":"2021","journal-title":"Healthcare"},{"issue":"7","key":"10.1016\/j.msard.2026.107192_bib0007","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1177\/1352458517702553","article-title":"Multiple sclerosis and suicide","volume":"23","author":"Feinstein","year":"2017","journal-title":"Mult. Scler."},{"issue":"5","key":"10.1016\/j.msard.2026.107192_bib0008","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2174\/1570159X15666171123201142","article-title":"Imaging the role of inflammation in mood and anxiety-related disorders","volume":"16","author":"Felger","year":"2018","journal-title":"Curr. Neuropharmacol."},{"issue":"4","key":"10.1016\/j.msard.2026.107192_bib0009","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/135245859900500410","article-title":"Recent developments in the assessment of quality of life in multiple sclerosis (MS)","volume":"5","author":"Fischer","year":"1999","journal-title":"Mult. Scler."},{"issue":"6","key":"10.1016\/j.msard.2026.107192_bib0010","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1191\/1352458502ms839oa","article-title":"Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters","volume":"8","author":"Flachenecker","year":"2002","journal-title":"Mult. Scler."},{"issue":"9","key":"10.1016\/j.msard.2026.107192_bib0011","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10092058","article-title":"Fatigue in multiple sclerosis is associated with reduced expression of interleukin-10 and worse prospective disease activity","volume":"10","author":"Gilio","year":"2022","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.msard.2026.107192_bib0012","article-title":"The multiple sclerosis severity score: fluctuations and prognostic ability in a longitudinal cohort of patients with MS","volume":"5","author":"Gross","year":"2019","journal-title":"Mult. Scler. J. Exp. Transl. Clin."},{"issue":"1","key":"10.1016\/j.msard.2026.107192_bib0013","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s12883-021-02344-z","article-title":"The association of selected multiple sclerosis symptoms with disability and quality of life: a large Danish self-report survey","volume":"21","author":"Gustavsen","year":"2021","journal-title":"BMC. Neurol."},{"issue":"8","key":"10.1016\/j.msard.2026.107192_bib0014","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00702-024-02792-0","article-title":"Depression and anxiety in multiple sclerosis. Review of a fatal combination","volume":"131","author":"Jellinger","year":"2024","journal-title":"J. Neural Transm."},{"issue":"10","key":"10.1016\/j.msard.2026.107192_bib0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11910-019-0992-1","article-title":"Depression and suicidality in multiple sclerosis: red flags, management strategies, and ethical considerations","volume":"19","author":"Kalb","year":"2019","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"4","key":"10.1016\/j.msard.2026.107192_bib0016","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1001\/archneur.1988.00520280085020","article-title":"Fatigue in multiple sclerosis","volume":"45","author":"Krupp","year":"1988","journal-title":"Arch. Neurol."},{"issue":"11","key":"10.1016\/j.msard.2026.107192_bib0017","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1212\/WNL.45.11.1956","article-title":"Fatigue therapy in multiple sclerosis: results of a double-blind, randomized, parallel trial of amantadine, pemoline, and placebo","volume":"45","author":"Krupp","year":"1995","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.msard.2026.107192_bib0018","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/archneur.1989.00520460115022","article-title":"The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus","volume":"46","author":"Krupp","year":"1989","journal-title":"Arch. Neurol."},{"issue":"1","key":"10.1016\/j.msard.2026.107192_bib0019","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s40120-021-00239-2","article-title":"Comprehensive approach to management of multiple sclerosis: addressing invisible symptoms-A narrative review","volume":"10","author":"Lakin","year":"2021","journal-title":"Neurol. Ther."},{"issue":"9","key":"10.1016\/j.msard.2026.107192_bib0020","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.apmr.2013.04.020","article-title":"Effects of exercise training on fitness, mobility, fatigue, and health-related quality of life among adults with multiple sclerosis: a systematic review to inform guideline development","volume":"94","author":"Latimer-Cheung","year":"2013","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"13","key":"10.1016\/j.msard.2026.107192_bib0021","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1177\/1352458513483890","article-title":"The reliability, precision and clinically meaningful change of walking assessments in multiple sclerosis","volume":"19","author":"Learmonth","year":"2013","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2026.107192_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2024.105677","article-title":"Suicidal ideation in people with multiple sclerosis and its association with coping self-efficacy","volume":"87","author":"Mikula","year":"2024","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"1","key":"10.1016\/j.msard.2026.107192_bib0023","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/qjmed\/hcm122","article-title":"A medical definition of fatigue in multiple sclerosis","volume":"101","author":"Mills","year":"2008","journal-title":"QJM"},{"issue":"1","key":"10.1016\/j.msard.2026.107192_bib0024","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000335076","article-title":"Sleep disorders and multiple sclerosis: a clinical and polysomnography study","volume":"68","author":"Neau","year":"2012","journal-title":"Eur. Neurol."},{"issue":"1","key":"10.1016\/j.msard.2026.107192_bib0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neulet.2010.02.062","article-title":"CSF hypocretin-1 concentrations correlate with the level of fatigue in multiple sclerosis patients","volume":"474","author":"Papuc","year":"2010","journal-title":"Neurosci. Lett."},{"issue":"10","key":"10.1016\/j.msard.2026.107192_bib0026","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.70984","article-title":"Orexin deficiency in narcolepsy: molecular mechanisms, clinical phenotypes, and emerging therapeutic frontiers","volume":"15","author":"Rauf","year":"2025","journal-title":"Brain Behav."},{"key":"10.1016\/j.msard.2026.107192_bib0027","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.msard.2019.07.028","article-title":"Minimally important difference of the fatigue severity scale and modified fatigue impact scale in people with multiple sclerosis","volume":"35","author":"Rooney","year":"2019","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"4","key":"10.1016\/j.msard.2026.107192_bib0028","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/ene.12932","article-title":"Psychometric properties and validity of beck depression inventory ii in multiple sclerosis","volume":"23","author":"Sacco","year":"2016","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.msard.2026.107192_bib0029","article-title":"The relationship between objective parameters of sleep and measures of fatigue, depression, and cognition in multiple sclerosis","volume":"1","author":"Sater","year":"2015","journal-title":"Mult. Scler. J. Exp. Transl. Clin."},{"key":"10.1016\/j.msard.2026.107192_bib0030","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.msard.2019.06.012","article-title":"Association between suicide and multiple sclerosis: an updated meta-analysis","volume":"34","author":"Shen","year":"2019","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"2","key":"10.1016\/j.msard.2026.107192_bib0031","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s40263-018-0489-5","article-title":"Depression in multiple sclerosis: epidemiology, aetiology, diagnosis and treatment","volume":"32","author":"Solaro","year":"2018","journal-title":"CNS. Drugs"},{"key":"10.1016\/j.msard.2026.107192_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.105017","article-title":"Systematic review of cognitive reserve in multiple sclerosis: accounting for physical disability, fatigue, depression, and anxiety","volume":"79","author":"Stein","year":"2023","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2026.107192_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2020.102576","article-title":"Tired of not knowing what that fatigue score means? Normative data of the modified fatigue impact scale (MFIS)","volume":"46","author":"Strober","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"8","key":"10.1016\/j.msard.2026.107192_bib0034","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.apmr.2011.02.018","article-title":"Is fatigue associated with suicidality in stroke?","volume":"92","author":"Tang","year":"2011","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"4","key":"10.1016\/j.msard.2026.107192_bib0035","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1590\/0004-282x20190035","article-title":"Disability as a determinant of fatigue in MS patients","volume":"77","author":"Taveira","year":"2019","journal-title":"Arq. Neuropsiquiatr."},{"issue":"2","key":"10.1016\/j.msard.2026.107192_bib0036","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1191\/1352458505ms1148oa","article-title":"Does the modified fatigue impact scale offer a more comprehensive assessment of fatigue in MS?","volume":"11","author":"Tellez","year":"2005","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2026.107192_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.104842","article-title":"Exploring the relation between reserve and fatigue in multiple sclerosis","volume":"76","author":"Tranfa","year":"2023","journal-title":"Mult. Scler. Relat. Disord."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034826002282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034826002282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:25:24Z","timestamp":1780327524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034826002282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":37,"alternative-id":["S2211034826002282"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2026.107192","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Depression severity and discordance between fatigue patient-reported outcomes in people with multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2026.107192","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107192"}}