{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:14:33Z","timestamp":1789834473830,"version":"4.0.1"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006673","name":"L\u00e9on Fredericq Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006673","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.msard.2026.107196","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:16:05Z","timestamp":1775754965000},"page":"107196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Eccentric exercise training in multiple sclerosis management -a scoping review"],"prefix":"10.1016","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6748-5630","authenticated-orcid":false,"given":"B.","family":"Vandenbroeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2599-3446","authenticated-orcid":false,"given":"J.","family":"Slomian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6616-7688","authenticated-orcid":false,"given":"H.","family":"Cassol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1939-3652","authenticated-orcid":false,"given":"J.F.","family":"Kaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2678-1373","authenticated-orcid":false,"given":"F.","family":"Schleich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-3725","authenticated-orcid":false,"given":"S.","family":"Hody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.msard.2026.107196_bib0038","doi-asserted-by":"crossref","first-page":"381\u2011407","DOI":"10.1007\/s00421-020-04548-6","article-title":"Moving forward with backward pedaling: a review on eccentric cycling","volume":"121","author":"Barreto","year":"2021","journal-title":"Eur. J. Appl. Physiol."},{"issue":"4","key":"10.1016\/j.msard.2026.107196_bib0035","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.3390\/ijerph20042861","article-title":"Chronic adaptations to eccentric cycling training: A systematic review and meta-analysis","volume":"20","author":"Barreto","year":"2023","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"1","key":"10.1016\/j.msard.2026.107196_bib0022","doi-asserted-by":"crossref","first-page":"30\u201140","DOI":"10.1016\/j.rehab.2013.01.003","article-title":"Eccentric training in chronic heart failure: Feasibility and functional effects. Results of a comparative study","volume":"56","author":"Besson","year":"2013","journal-title":"Ann. Phys. Rehabil. Med."},{"issue":"4","key":"10.1016\/j.msard.2026.107196_bib0016","doi-asserted-by":"crossref","first-page":"468\u201177","DOI":"10.1177\/1352458510391339","article-title":"Effects of long-term resistance training and simultaneous electro-stimulation on muscle strength and functional mobility in multiple sclerosis","volume":"17","author":"Broekmans","year":"2011","journal-title":"Mult. Scler. J."},{"issue":"2","key":"10.1016\/j.msard.2026.107196_bib0012","first-page":"126","article-title":"Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research","volume":"100","author":"Caspersen","year":"1985","journal-title":"Public Health Rep."},{"issue":"1-2","key":"10.1016\/j.msard.2026.107196_bib0062","doi-asserted-by":"crossref","first-page":"85\u201191","DOI":"10.1016\/j.jns.2007.12.030","article-title":"Serum brain-derived neurotrophic factor response to aerobic exercise in multiple sclerosis","volume":"269","author":"Castellano","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.msard.2026.107196_bib0009","doi-asserted-by":"crossref","first-page":"169\u201177","DOI":"10.1016\/j.msard.2018.01.021","article-title":"Physical activity and disability outcomes in multiple sclerosis: A systematic review (2011\u20132016)","volume":"20","author":"Charron","year":"2018","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"4","key":"10.1016\/j.msard.2026.107196_bib0023","doi-asserted-by":"crossref","first-page":"646\u201151","DOI":"10.1249\/MSS.0000000000001151","article-title":"Eccentric cycling: a promising modality for patients with chronic heart failure","volume":"49","author":"Chasland","year":"2017","journal-title":"Med. Sci. Sports Exerc."},{"issue":"8","key":"10.1016\/j.msard.2026.107196_bib0025","doi-asserted-by":"crossref","first-page":"1614\u201122","DOI":"10.1249\/MSS.0000000000001267","article-title":"Effects of descending stair walking on health and fitness of elderly obese women","volume":"49","author":"Chen","year":"2017","journal-title":"Med. Sci. Sports Exerc."},{"issue":"4","key":"10.1016\/j.msard.2026.107196_bib0011","doi-asserted-by":"crossref","first-page":"e411","DOI":"10.1097\/MD.0000000000000411","article-title":"A systematic review and meta-analysis of strength training in individuals with multiple sclerosis or parkinson disease","volume":"94","author":"Cruickshank","year":"2015","journal-title":"Medicine"},{"issue":"1","key":"10.1016\/j.msard.2026.107196_bib0005","first-page":"27\u201140","article-title":"Multiple sclerosis \u2013 a review","volume":"26","author":"Dobson","year":"2019","journal-title":"Eur. J. Neurol. Janv."},{"issue":"5","key":"10.1016\/j.msard.2026.107196_bib0060","doi-asserted-by":"crossref","first-page":"917\u201141","DOI":"10.1007\/s40279-016-0628-4","article-title":"Chronic adaptations to eccentric training: a systematic review","volume":"47","author":"Douglas","year":"2017","journal-title":"Sports Med."},{"issue":"2","key":"10.1016\/j.msard.2026.107196_bib0040","doi-asserted-by":"crossref","first-page":"197\u2011204","DOI":"10.1242\/jeb.123158","article-title":"Neural control of lengthening contractions. Lindstedt SL, Hoppeler HH, \u00e9diteurs","volume":"219","author":"Duchateau","year":"2016","journal-title":"J. Exp. Biol."},{"issue":"12","key":"10.1016\/j.msard.2026.107196_bib0042","doi-asserted-by":"crossref","first-page":"1440\u201150","DOI":"10.1152\/japplphysiol.00489.2014","article-title":"Specific modulation of spinal and cortical excitabilities during lengthening and shortening submaximal and maximal contractions in plantar flexor muscles","volume":"117","author":"Duclay","year":"2014","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.msard.2026.107196_bib0003","first-page":"31\u20119","article-title":"The effect of exercise training in adults with multiple sclerosis with severe mobility disability: A systematic review and future research directions","volume":"16","author":"Edwards","year":"2017","journal-title":"Mult. Scler. Relat. Disord. Ao\u00fbt"},{"issue":"6","key":"10.1016\/j.msard.2026.107196_bib0039","doi-asserted-by":"crossref","first-page":"2339\u201146","DOI":"10.1152\/jappl.1996.81.6.2339","article-title":"Eccentric contractions require unique activation strategies by the nervous system","volume":"81","author":"Enoka","year":"1996","journal-title":"J. Appl. Physiol."},{"issue":"2","key":"10.1016\/j.msard.2026.107196_bib0047","doi-asserted-by":"crossref","first-page":"130\u20112","DOI":"10.1016\/j.mehy.2009.03.009","article-title":"Physical activity, eccentric contractions of plantar flexors, and neurogenesis: Therapeutic potential of flat shoes in psychiatric and neurological disorders","volume":"73","author":"Flensmark","year":"2009","journal-title":"Med. Hypotheses."},{"key":"10.1016\/j.msard.2026.107196_bib0006","unstructured":"Goldenberg MM. Multiple sclerosis review. 2012."},{"issue":"4","key":"10.1016\/j.msard.2026.107196_bib0041","doi-asserted-by":"crossref","first-page":"2030\u201140","DOI":"10.1152\/jn.91104.2008","article-title":"Excitability at the motoneuron pool and motor cortex is specifically modulated in lengthening compared to isometric contractions","volume":"101","author":"Gruber","year":"2009","journal-title":"J. Neurophysiol."},{"issue":"1","key":"10.1016\/j.msard.2026.107196_bib0004","first-page":"2\u201110","article-title":"Effects of high-intensity resistance training on strength, mobility, balance, and fatigue in individuals with multiple sclerosis: A randomized controlled trial","volume":"35","author":"Hayes","year":"2011","journal-title":"J. Neurol. Phys. Ther. Mars."},{"key":"10.1016\/j.msard.2026.107196_bib0019","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3389\/fphys.2019.00536","article-title":"Eccentric muscle contractions: risks and benefits","volume":"10","author":"Hody","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.msard.2026.107196_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2016.00483","article-title":"Moderate load eccentric exercise; a distinct novel training modality","volume":"7","author":"Hoppeler","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.msard.2026.107196_bib0054","doi-asserted-by":"crossref","first-page":"73\u201180","DOI":"10.1016\/j.neuroscience.2018.09.007","article-title":"The short-term effect of slope walking on soleus h-reflexes in people with multiple sclerosis","volume":"391","author":"Hoque","year":"2018","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.msard.2026.107196_bib0053","doi-asserted-by":"crossref","first-page":"587\u201197","DOI":"10.3233\/NRE-192701","article-title":"Effects of downslope walking on Soleus H-reflexes and walking function in individuals with multiple sclerosis: A preliminary study","volume":"44","author":"Hoque","year":"2019","journal-title":"NeuroRehabilitation."},{"issue":"2","key":"10.1016\/j.msard.2026.107196_bib0027","doi-asserted-by":"crossref","first-page":"489\u2011502","DOI":"10.1007\/s00421-021-04850-x","article-title":"Effects of eccentric vs concentric cycling training on patients with moderate COPD","volume":"122","author":"Inostroza","year":"2022","journal-title":"Eur. J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.msard.2026.107196_bib0026","doi-asserted-by":"crossref","first-page":"4\u201115","DOI":"10.1111\/sms.13301","article-title":"Eccentric cycling is more efficient in reducing fat mass than concentric cycling in adolescents with obesity","volume":"29","author":"Julian","year":"2019","journal-title":"Scand. J. Med. Sci. Sports"},{"issue":"1","key":"10.1016\/j.msard.2026.107196_bib0055","first-page":"10\u20119","article-title":"Multipl sklerozda eksentrik ve konsentrik egzersiz e\u011fitiminin hemodinamik yanitlar, fonksiyonel kapasite ve yorgunluk \u00fczerine etkilerinin kar\u015fila\u015ftirilmASI","volume":"32","author":"Katirci Kirmaci","year":"2021","journal-title":"T\u00fcrk Fiz Ve Rehabil Derg"},{"issue":"2","key":"10.1016\/j.msard.2026.107196_bib0010","doi-asserted-by":"crossref","first-page":"353\u201167","DOI":"10.1016\/j.apmr.2016.04.016","article-title":"Rehabilitation in multiple sclerosis: a systematic review of systematic reviews","volume":"98","author":"Khan","year":"2017","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"4","key":"10.1016\/j.msard.2026.107196_bib0014","first-page":"709\u201115","article-title":"Rehabilitation in multiple sclerosis","volume":"26","author":"Kubsik-Gidlewska","year":"2017","journal-title":"Adv. Clin. Exp. Med."},{"issue":"2","key":"10.1016\/j.msard.2026.107196_bib0033","doi-asserted-by":"crossref","first-page":"367\u201180","DOI":"10.1007\/s41999-021-00571-8","article-title":"Effectiveness of eccentric-biased exercise interventions in reducing the incidence of falls and improving functional performance in older adults: a systematic review","volume":"13","author":"Kulkarni","year":"2022","journal-title":"Eur. Geriatr. Med."},{"issue":"3","key":"10.1016\/j.msard.2026.107196_bib0044","doi-asserted-by":"crossref","first-page":"253\u20119","DOI":"10.3233\/NRE-2011-0701","article-title":"Different cortical activation patterns during voluntary eccentric and concentric muscle contractions: An fMRI study","volume":"29","author":"Kwon","year":"2011","journal-title":"NeuroRehabilitation"},{"issue":"6","key":"10.1016\/j.msard.2026.107196_bib0015","doi-asserted-by":"crossref","first-page":"905\u201123","DOI":"10.1007\/s40279-015-0307-x","article-title":"Aerobic capacity in persons with multiple sclerosis: a systematic review and meta-analysis","volume":"45","author":"Langeskov-Christensen","year":"2015","journal-title":"Sports Med."},{"issue":"5","key":"10.1016\/j.msard.2026.107196_bib0032","doi-asserted-by":"crossref","first-page":"M419\u201124","DOI":"10.1093\/gerona\/58.5.M419","article-title":"The positive effects of negative work: increased muscle strength and decreased fall risk in a frail elderly population","volume":"58","author":"LaStayo","year":"2003","journal-title":"J. Gerontol. a Biol. Sci. Med. Sci."},{"issue":"6","key":"10.1016\/j.msard.2026.107196_bib0020","doi-asserted-by":"crossref","first-page":"256\u201161","DOI":"10.1152\/physiologyonline.2001.16.6.256","article-title":"When active muscles lengthen: properties and consequences of eccentric contractions","volume":"16","author":"Lindstedt","year":"2001","journal-title":"Physiology"},{"issue":"5","key":"10.1016\/j.msard.2026.107196_bib0036","doi-asserted-by":"crossref","first-page":"947\u201157","DOI":"10.1007\/s00421-018-3826-y","article-title":"Cardio-pulmonary responses to incremental eccentric and concentric cycling tests to task failure","volume":"118","author":"Lipski","year":"2018","journal-title":"Eur. J. Appl. Physiol."},{"issue":"3","key":"10.1016\/j.msard.2026.107196_bib0061","first-page":"461\u20116","article-title":"Differential response of heat shock proteins to uphill and downhill exercise in heart, skeletal muscle, lung and kidney tissues","volume":"12","author":"Lollo","year":"2013","journal-title":"J. Sports Sci. Med."},{"key":"10.1016\/j.msard.2026.107196_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00114","article-title":"Eccentric ergometer training promotes locomotor muscle strength but not mitochondrial adaptation in patients with severe chronic obstructive pulmonary disease","volume":"8","author":"MacMillan","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.msard.2026.107196_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1385042","article-title":"The relevance of BDNF for neuroprotection and neuroplasticity in multiple sclerosis","volume":"15","author":"Maiworm","year":"2024","journal-title":"Front. Neurol."},{"issue":"7","key":"10.1016\/j.msard.2026.107196_bib0058","doi-asserted-by":"crossref","first-page":"1142\u201152","DOI":"10.1093\/ptj\/pzaa055","article-title":"Effect of eccentric strength training on elbow flexor spasticity and muscle weakness in people with multiple sclerosis: proof-of-concept single-system case series","volume":"100","author":"Manca","year":"2020","journal-title":"Phys. Ther."},{"issue":"1","key":"10.1016\/j.msard.2026.107196_bib0048","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12984-025-01684-y","article-title":"Wristful thinking: exploring the effects of robotic rehabilitation and cross-education for persons with multiple sclerosis","volume":"22","author":"Mannella","year":"2025","journal-title":"J. NeuroEng. Rehabil."},{"issue":"6","key":"10.1016\/j.msard.2026.107196_bib0031","doi-asserted-by":"crossref","first-page":"528\u201138","DOI":"10.1159\/000323267","article-title":"Different molecular and structural adaptations with eccentric and conventional strength training in elderly men and women","volume":"57","author":"Mueller","year":"2011","journal-title":"Gerontology"},{"issue":"1","key":"10.1016\/j.msard.2026.107196_bib0049","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12874-018-0611-x","article-title":"Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach","volume":"18","author":"Munn","year":"2018","journal-title":"BMC. Med. Res. Methodol."},{"key":"10.1016\/j.msard.2026.107196_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2021.103706","article-title":"Ventilatory adaptation during eccentric cycling in patients with severe COPD: Potential implications for exercise training","volume":"292","author":"Nahmias","year":"2021","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"9","key":"10.1016\/j.msard.2026.107196_bib0018","doi-asserted-by":"crossref","first-page":"8447","DOI":"10.3390\/ijms24098447","article-title":"The role of BDNF in multiple sclerosis neuroinflammation","volume":"24","author":"Nociti","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.msard.2026.107196_bib0034","doi-asserted-by":"crossref","first-page":"1125\u201136","DOI":"10.1007\/s40279-023-01851-y","article-title":"The eccentric:concentric strength ratio of human skeletal muscle in vivo: meta-analysis of the influences of sex, age, joint action, and velocity","volume":"53","author":"Nuzzo","year":"2023","journal-title":"Sports Med."},{"issue":"3","key":"10.1016\/j.msard.2026.107196_bib0024","doi-asserted-by":"crossref","first-page":"241\u20114","DOI":"10.1016\/j.rehab.2019.09.007","article-title":"Progressively increasing the intensity of eccentric cycling over four training sessions: A feasibility study in coronary heart disease patients","volume":"63","author":"Pageaux","year":"2020","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"10.1016\/j.msard.2026.107196_bib0063","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3390\/ijms21031170","article-title":"BDNF as a promising therapeutic agent in Parkinson\u2019s disease","author":"Palasz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.msard.2026.107196_bib0059","doi-asserted-by":"crossref","first-page":"819\u201125","DOI":"10.1016\/j.apmr.2017.10.021","article-title":"Effects of classic progressive resistance training versus eccentric-enhanced resistance training in people with multiple sclerosis","volume":"99","author":"Patrocinio De Oliveira","year":"2018","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"4","key":"10.1016\/j.msard.2026.107196_bib0037","doi-asserted-by":"crossref","first-page":"884\u201193","DOI":"10.1152\/japplphysiol.00536.2016","article-title":"Factors contributing to lower metabolic demand of eccentric compared with concentric cycling","volume":"123","author":"Pe\u00f1ailillo","year":"2017","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.msard.2026.107196_bib0029","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s12890-022-02061-4","article-title":"Effects of eccentric, concentric and eccentric\/concentric training on muscle function and mass, functional performance, cardiometabolic health, quality of life and molecular adaptations of skeletal muscle in COPD patients: a multicentre randomised trial","volume":"22","author":"Pe\u00f1ailillo","year":"2022","journal-title":"BMC. Pulm. Med."},{"issue":"1","key":"10.1016\/j.msard.2026.107196_bib0043","doi-asserted-by":"crossref","first-page":"75\u201182","DOI":"10.1080\/17461391.2017.1391334","article-title":"Brain activation associated with eccentric movement: A narrative review of the literature","volume":"18","author":"Perrey","year":"2018","journal-title":"Eur. J. Sport Sci."},{"issue":"10","key":"10.1016\/j.msard.2026.107196_bib0050","first-page":"2119\u201126","article-title":"Updated methodological guidance for the conduct of scoping reviews","volume":"18","author":"Peters","year":"2020","journal-title":"JBI. Evid. Synth."},{"issue":"3","key":"10.1016\/j.msard.2026.107196_bib0046","doi-asserted-by":"crossref","first-page":"114\u201122","DOI":"10.2519\/jospt.1992.16.3.114","article-title":"Concentric and eccentric isokinetic lower extremity strength in persons with multiple sclerosis","volume":"16","author":"Ponichtera","year":"1992","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"10.1016\/j.msard.2026.107196_bib0064","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.645220","article-title":"The brain-derived neurotrophic factor val66met polymorphism can protect against cognitive impairment in multiple sclerosis","volume":"12","author":"Portaccio","year":"2021","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.msard.2026.107196_bib0056","doi-asserted-by":"crossref","first-page":"31\u20116","DOI":"10.7224\/1537-2073.2019-022","article-title":"Safety, feasibility, and efficacy of an eccentric exercise intervention in people with multiple sclerosis with ankle contractures","volume":"23","author":"Psarakis","year":"2021","journal-title":"Int. J. MS. Care"},{"issue":"1","key":"10.1016\/j.msard.2026.107196_bib0052","first-page":"29\u201133","article-title":"Renforcement musculaire isocin\u00e9tique excentrique des ischiojambiers chez des patients atteints de scl\u00e9rose en plaque","volume":"48","author":"Robineau","year":"2005","journal-title":"Ann R\u00e9adapt M\u00e9decine Phys."},{"issue":"5","key":"10.1016\/j.msard.2026.107196_bib0008","doi-asserted-by":"crossref","first-page":"483\u201198","DOI":"10.1080\/14656566.2018.1446944","article-title":"Managing the side effects of multiple sclerosis therapy: pharmacotherapy options for patients","volume":"19","author":"Rommer","year":"2018","journal-title":"Expert. Opin. PharmacOther"},{"issue":"1","key":"10.1016\/j.msard.2026.107196_bib0057","doi-asserted-by":"crossref","first-page":"34\u201141","DOI":"10.7224\/1537-2073.2014-072","article-title":"Uphill and downhill walking in multiple sclerosis","volume":"18","author":"Samaei","year":"2016","journal-title":"Int. J. MS. Care"},{"issue":"1","key":"10.1016\/j.msard.2026.107196_bib0007","doi-asserted-by":"crossref","first-page":"683\u2011747","DOI":"10.1146\/annurev.immunol.23.021704.115707","article-title":"Immunology of multiple sclerosis","volume":"23","author":"Sospedra","year":"2005","journal-title":"Annu. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.msard.2026.107196_bib0001","doi-asserted-by":"crossref","first-page":"344\u201181","DOI":"10.1016\/S1474-4422(24)00038-3","article-title":"Global, regional, and national burden of disorders affecting the nervous system, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"23","author":"Steinmetz","year":"2024","journal-title":"Lancet Neurol."},{"issue":"5","key":"10.1016\/j.msard.2026.107196_bib0013","doi-asserted-by":"crossref","first-page":"1007\u201114","DOI":"10.1249\/MSS.0000000000002228","article-title":"Exercise effects on multiple sclerosis quality of life and clinical\u2013motor symptoms","volume":"52","author":"Toll\u00e1r","year":"2020","journal-title":"Med. Sci. Sports Exerc."},{"issue":"7","key":"10.1016\/j.msard.2026.107196_bib0051","doi-asserted-by":"crossref","first-page":"467\u201173","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for scoping reviews (PRISMA-ScR): checklist and explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.msard.2026.107196_bib0045","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2014.00086","article-title":"Aging interferes central control mechanism for eccentric muscle contraction","volume":"6","author":"Yao","year":"2014","journal-title":"Front. Aging Neurosci."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034826002324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034826002324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:25:58Z","timestamp":1780327558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034826002324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":63,"alternative-id":["S2211034826002324"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2026.107196","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Eccentric exercise training in multiple sclerosis management -a scoping review","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2026.107196","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107196"}}