{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:39:08Z","timestamp":1792514348355,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.msec.2014.11.069","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T21:34:55Z","timestamp":1417556095000},"page":"145-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Development and characterization of oral liposomes of vegetal ceramide based amphotericin B having enhanced dry solubility and solubility"],"prefix":"10.1016","volume":"48","author":[{"given":"Malika","family":"Skiba-Lahiani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Hallouard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyes","family":"Mehenni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Fessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Skiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2014.11.069_bb0005","first-page":"693-693","article-title":"Allergic reactions to amphotericin B","volume":"290","author":"Murray","year":"1974","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.msec.2014.11.069_bb0010","doi-asserted-by":"crossref","first-page":"175","DOI":"10.7326\/0003-4819-61-2-175","article-title":"Nephrotoxicity of amphotericin B: early and late effects in 81 patients","volume":"61","author":"Butler","year":"1964","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.msec.2014.11.069_bb0015","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/0002-9343(83)90353-4","article-title":"Amphotericin B nephrotoxicity in humans decreased by salt repletion","volume":"75","author":"Heidemann","year":"1983","journal-title":"Am. J. Med."},{"key":"10.1016\/j.msec.2014.11.069_bb0020","first-page":"231","article-title":"Therapeutic and hemolytic evaluation of in-situ liposomal preparation containing amphotericin-beta complexed with different chemically modified beta-cyclodextrins","volume":"6","author":"Chakraborty","year":"2003","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.msec.2014.11.069_bb0025","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijpharm.2005.11.031","article-title":"Encapsulation of amphotericin B in poly(ethylene glycol)-block-poly(epsilon-caprolactone-co-trimethylenecarbonate) polymeric micelles","volume":"309","author":"Vandermeulen","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.msec.2014.11.069_bb0030","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1016\/j.polymer.2009.07.006","article-title":"Preparation and self-assembly of amphiphilic triblock copolymers with polyrotaxane as a middle block and their application as carrier for the controlled release of amphotericin B","volume":"50","author":"Zhang","year":"2009","journal-title":"Polymer"},{"key":"10.1016\/j.msec.2014.11.069_bb0035","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ejps.2010.05.005","article-title":"Development of amphotericin B loaded polymersomes based on (PEG)(3)-PLA co-polymers: factors affecting size and in vitro evaluation","volume":"40","author":"Jain","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.msec.2014.11.069_bb0040","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2165\/00003088-199223040-00004","article-title":"Liposomal and lipid formulations of amphotericin B. Clinical pharmacokinetics","volume":"23","author":"Janknegt","year":"1992","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.msec.2014.11.069_bb0045","first-page":"1570","article-title":"The use of lipid formulations of amphotericin B for systemic fungal infections","volume":"10","author":"Leenders","year":"1996","journal-title":"Leukemia"},{"key":"10.1016\/j.msec.2014.11.069_bb0050","first-page":"319","article-title":"Lipid excipients Peceol and Gelucire 44\/14 decrease P-glycoprotein mediated efflux of rhodamine 123 partially due to modifying P-glycoprotein protein expression within Caco-2 cells","volume":"10","author":"Sachs-Barrable","year":"2007","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.msec.2014.11.069_bb0055","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ejps.2013.12.005","article-title":"Preparation and characterization of amorphous amphotericin B nanoparticles for oral administration through liquid antisolvent precipitation","volume":"53","author":"Zu","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.msec.2014.11.069_bb0060","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/infdis\/jir735","article-title":"An oral formulation of amphotericin B attached to functionalized carbon nanotubes is an effective treatment for experimental visceral leishmaniasis","volume":"205","author":"Prajapati","year":"2012","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.msec.2014.11.069_bb0065","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ijbiomac.2013.04.053","article-title":"Spray dried chitosan\u2013EDTA superior microparticles as solid substrate for the oral delivery of amphotericin B","volume":"58","author":"Singh","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.msec.2014.11.069_bb0070","first-page":"327","article-title":"Evaluating the potential of cubosomal nanoparticles for oral delivery of amphotericin B in treating fungal infection","volume":"9","author":"Yang","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.msec.2014.11.069_bb0075","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijpharm.2009.01.003","article-title":"Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans","volume":"372","author":"Wasan","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.msec.2014.11.069_bb0080","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1021\/mp300320d","article-title":"Gelatin coated hybrid lipid nanoparticles for oral delivery of amphotericin B","volume":"9","author":"Jain","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.msec.2014.11.069_bb0085","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1166\/jbn.2012.1414","article-title":"Evaluating the potential of polyester nanoparticles for per oral delivery of amphotericin B in treating visceral leishmaniasis","volume":"8","author":"Italia","year":"2012","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.msec.2014.11.069_bb0090","doi-asserted-by":"crossref","first-page":"13340","DOI":"10.3390\/molecules181113340","article-title":"Preparation and optimization of triptolide-loaded solid lipid nanoparticles for oral delivery with reduced gastric irritation","volume":"18","author":"Zhang","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.msec.2014.11.069_bb0095","series-title":"New Systems and Trends in Their Applications","author":"Puisieux","year":"1995"},{"key":"10.1016\/j.msec.2014.11.069_bb0100","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0021-9797(81)90382-9","article-title":"Synthetic bilayer membranes prepared from dialkyl amphiphiles with nonionic and zwitterionic head groups","volume":"82","author":"Okahata","year":"1982","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.msec.2014.11.069_bb0105","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1001\/archinte.1989.00390110097022","article-title":"Treatment of systemic fungal infections with liposomal amphotericin B","volume":"149","author":"Lopez-Berestein","year":"1989","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.msec.2014.11.069_bb0110","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0005-2736(89)90336-2","article-title":"Physical biochemistry of a liposomal amphotericin B mixture used for patient treatment","volume":"984","author":"Grant","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.msec.2014.11.069_bb0115","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/BF03258404","article-title":"Early pharmacokinetic and clinical results from a noncomparative multicentre trial of amphotericin B encapsulated in a small unilamellar liposome (AmBisome\u00ae)","volume":"4","author":"Tollemar","year":"1992","journal-title":"Drug Invest."},{"key":"10.1016\/j.msec.2014.11.069_bb0120","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1128\/AAC.35.7.1303","article-title":"Limited protection by small unilamellar liposomes against the renal tubular toxicity induced by repeated amphotericin B infusions in rats","volume":"35","author":"Longuet","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.msec.2014.11.069_bb0125","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1128\/AAC.36.12.2656","article-title":"Efficacy and safety of amphotericin B colloidal dispersion compared with those of amphotericin B deoxycholate suspension for treatment of disseminated murine cryptococcosis","volume":"36","author":"Hostetler","year":"1992","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.msec.2014.11.069_bb0130","series-title":"Proc\u00e9d\u00e9 depr\u00e9paration de syst\u00e8mes colloidaux dispersibles de lipides amphiphiles sous forme de liposomes submicroniques, FR 2634375","author":"Devissaguet","year":"1990"},{"key":"10.1016\/j.msec.2014.11.069_bb0135","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/jps.2600830709","article-title":"Interactions of cimetidine and ranitidine with aluminum-containing antacids and a clay-containing gastric-protective drug in an \u201cartificial stomach\u2013duodenum\u201d model","volume":"83","author":"Vatier","year":"1994","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.msec.2014.11.069_bb0140","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1248\/cpb.36.1508","article-title":"A two-step model of disintegration kinetics of liposomes in bile salts","volume":"36","author":"Nagata","year":"1988","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.msec.2014.11.069_bb0145","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1042\/bst0071129","article-title":"Epidermal lipid liposomes: a novel non-phospholipid membrane system [proceedings]","volume":"7","author":"Gray","year":"1979","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.msec.2014.11.069_bb0150","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/1523-1747.ep12455832","article-title":"Preparation of liposomes from stratum corneum lipids","volume":"87","author":"Wertz","year":"1986","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.msec.2014.11.069_bb0155","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0165-2478(93)90070-I","article-title":"Enhancement of systemic and mucosal immune responses following oral administration of liposomes","volume":"36","author":"Fujii","year":"1993","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.msec.2014.11.069_bb0160","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1023\/A:1018936806278","article-title":"Stability of liposomes in vitro and their uptake by rat Peyer's patches following oral administration","volume":"10","author":"Aramaki","year":"1993","journal-title":"Pharm. Res."}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493114007954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493114007954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T08:27:08Z","timestamp":1538036828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493114007954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":32,"alternative-id":["S0928493114007954"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2014.11.069","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and characterization of oral liposomes of vegetal ceramide based amphotericin B having enhanced dry solubility and solubility","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2014.11.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}