{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:14:18Z","timestamp":1777558458749,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51103120"],"award-info":[{"award-number":["51103120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.msec.2016.06.035","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T08:08:35Z","timestamp":1465891715000},"page":"512-518","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Bi-directional controlled release of ibuprofen and Mg2+ from magnesium alloys coated by multifunctional composite"],"prefix":"10.1016","volume":"68","author":[{"given":"Hongzhou","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningning","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2016.06.035_bb0005","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.matlet.2015.03.140","article-title":"Ultrathin film coating of hydroxyapatite (HA) on a magnesium\u2013calcium alloy using RF magnetron sputtering for bioimplant applications[J]","volume":"152","author":"Surmeneva","year":"2015","journal-title":"Mater. Lett."},{"key":"10.1016\/j.msec.2016.06.035_bb0010","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.msec.2014.10.078","article-title":"Effect of nitrogen and cold working on structural and mechanical behavior of Ni-free nitrogen containing austenitic stainless steels for biomedical applications[J]","volume":"47","author":"Talha","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2016.06.035_bb0015","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.msec.2014.12.038","article-title":"Surface modification of investment cast-316L implants: microstructure effects[J]","volume":"48","author":"El-Hadad","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2016.06.035_bb0020","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.msec.2015.06.017","article-title":"MC3T3-E1 cell response to stainless steel 316L with different surface treatments[J]","volume":"56","author":"Zhang","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"issue":"6","key":"10.1016\/j.msec.2016.06.035_bb0025","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00590-013-1354-3","article-title":"Porous tantalum shells and augments for acetabular cup revisions[J]","volume":"24","author":"Moli\u010dnik","year":"2014","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"issue":"8","key":"10.1016\/j.msec.2016.06.035_bb0030","doi-asserted-by":"crossref","first-page":"5316","DOI":"10.1166\/jnn.2013.7458","article-title":"Anodic TiO2 nanotubular arrays with pre-synthesized hydroxyapatite\u2014an effective approach to enhance the biocompatibility of titanium[J]","volume":"13","author":"Wang","year":"2013","journal-title":"J. Nanosci. Nanotechnol."},{"issue":"2","key":"10.1016\/j.msec.2016.06.035_bb0035","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1600-0501.2009.01813.x","article-title":"Porous titanium granules promote bone healing and growth in rabbit tibia peri-implant osseous defects[J]","volume":"21","author":"Wohlfahrt","year":"2010","journal-title":"Clin. Oral Implants Res."},{"issue":"9","key":"10.1016\/j.msec.2016.06.035_bb0040","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.biomaterials.2005.10.003","article-title":"Magnesium and its alloys as orthopedic biomaterials: a review[J]","volume":"27","author":"Staiger","year":"2006","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.msec.2016.06.035_bb0045","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.msec.2005.01.008","article-title":"A mineralogical perspective on the apatite in bone[J]","volume":"25","author":"Wopenka","year":"2005","journal-title":"Mater. Sci. Eng. C"},{"issue":"6","key":"10.1016\/j.msec.2016.06.035_bb0050","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.biomaterials.2009.11.005","article-title":"Hierarchically microporous\/macroporous scaffold of magnesium\u2013calcium phosphate for bone tissue regeneration[J]","volume":"31","author":"Wei","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2016.06.035_bb0055","series-title":"In Vitro and In Vivo Biocompatibility Testing of Absorbable Metal Stents[C]\/\/Macromolecular Symposia","first-page":"103","volume":"253(1)","author":"Loos","year":"2007"},{"key":"10.1016\/j.msec.2016.06.035_bb0060","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.surfcoat.2014.06.031","article-title":"Functional and smart coatings for corrosion protection: a review of recent advances[J]","volume":"258","author":"Montemor","year":"2014","journal-title":"Surf. Coat. Technol."},{"issue":"18","key":"10.1016\/j.msec.2016.06.035_bb0065","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1002\/smll.201302880","article-title":"A poly (lactide) stereocomplex structure with modified magnesium oxide and its effects in enhancing the mechanical properties and suppressing inflammation[J]","volume":"10","author":"Kum","year":"2014","journal-title":"Small"},{"issue":"11","key":"10.1016\/j.msec.2016.06.035_bb0070","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.biomaterials.2005.11.031","article-title":"Drug\/device combinations for local drug therapies and infection prophylaxis[J]","volume":"27","author":"Wu","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2016.06.035_bb0075","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.msec.2015.09.050","article-title":"Effect of the addition CNTs on performance of CaP\/chitosan\/coating deposited on magnesium alloy by electrophoretic deposition[J]","volume":"58","author":"Zhang","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2016.06.035_bb0080","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.msec.2014.08.059","article-title":"Gentamicin release from biodegradable poly-l-lactide based composites for novel intramedullary nails[J]","volume":"45","author":"Morawska-Choch\u00f3\u0142","year":"2014","journal-title":"Mater. Sci. Eng. C"},{"issue":"2","key":"10.1016\/j.msec.2016.06.035_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10856-015-5389-3","article-title":"Investigation of the antimicrobial activity and biocompatibility of magnesium alloy coated with HA and antimicrobial peptide[J]","volume":"26","author":"Tian","year":"2015","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"1","key":"10.1016\/j.msec.2016.06.035_bb0090","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.actbio.2010.09.006","article-title":"Electrochemical deposition of conducting polymer coatings on magnesium surfaces in ionic liquid[J]","volume":"7","author":"Luo","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2016.06.035_bb0095","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.msec.2015.03.054","article-title":"Blood compatibility of a ferulic acid (FA)-eluting PHBHHx system for biodegradable magnesium stent application[J]","volume":"52","author":"Zhang","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"issue":"37","key":"10.1016\/j.msec.2016.06.035_bb0100","doi-asserted-by":"crossref","first-page":"5329","DOI":"10.1002\/adma.201301732","article-title":"ZnO nanoparticles applied to bioimaging and drug delivery[J]","volume":"25","author":"Xiong","year":"2013","journal-title":"Adv. Mater."},{"issue":"51","key":"10.1016\/j.msec.2016.06.035_bb0105","doi-asserted-by":"crossref","first-page":"25850","DOI":"10.1021\/jp0659296","article-title":"Conversion of ZnO nanorod arrays into ZnO\/ZnS nanocable and ZnS nanotube arrays via an in situ chemistry strategy[J]","volume":"110","author":"Yan","year":"2006","journal-title":"J. Phys. Chem. B"},{"issue":"1","key":"10.1016\/j.msec.2016.06.035_bb0110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cbi.2012.04.007","article-title":"Association of zinc ion release and oxidative stress induced by intratracheal instillation of ZnO nanoparticles to rat lung[J]","volume":"198","author":"Fukui","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.msec.2016.06.035_bb0115","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhazmat.2014.01.043","article-title":"Effect of ZnO nanoparticles aggregation on the toxicity in RAW 264.7 murine macrophage[J]","volume":"270","author":"Tripathy","year":"2014","journal-title":"J. Hazard. Mater."},{"issue":"7","key":"10.1016\/j.msec.2016.06.035_bb0120","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.polymdegradstab.2005.10.016","article-title":"Long term degradation of poly (\u025b-caprolactone) films in biologically related fluids[J]","volume":"91","author":"Pe\u00f1a","year":"2006","journal-title":"Polym. Degrad. Stab."},{"issue":"19","key":"10.1016\/j.msec.2016.06.035_bb0125","doi-asserted-by":"crossref","first-page":"7589","DOI":"10.1016\/j.apsusc.2012.04.094","article-title":"Fabrication and properties of porous scaffold of magnesium phosphate\/polycaprolactone biocomposite for bone tissue engineering[J]","volume":"258","author":"Wu","year":"2012","journal-title":"Appl. Surf. Sci."},{"issue":"4","key":"10.1016\/j.msec.2016.06.035_bb0130","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.corsci.2007.01.001","article-title":"Control of biodegradation of biocompatable magnesium alloys[J]","volume":"49","author":"Song","year":"2007","journal-title":"Corros. Sci."},{"issue":"7","key":"10.1016\/j.msec.2016.06.035_bb0135","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1002\/jps.23580","article-title":"Sustained ibuprofen release using composite poly (lactic-co-glycolic acid)\/titanium dioxide nanotubes from Ti implant surface[J]","volume":"102","author":"Jia","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.msec.2016.06.035_bb0140","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.electacta.2015.04.013","article-title":"\u201cIn-vitro\u201d corrosion behaviour of the magnesium alloy with Al and Zn (AZ31) protected with a biodegradable polycaprolactone coating loaded with hydroxyapatite and cephalexin[J]","volume":"179","author":"Zomorodian","year":"2015","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.msec.2016.06.035_bb0145","series-title":"Standard Test Methods for Measuring Adhesion by Tape Test","author":"ASTM D3359-09","year":"2009"},{"key":"10.1016\/j.msec.2016.06.035_bb0150","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.corsci.2013.06.037","article-title":"Electrolytic MgO\/ZrO2 duplex-layer coating on AZ91D magnesium alloy for corrosion resistance[J]","volume":"76","author":"Wang","year":"2013","journal-title":"Corros. Sci."},{"issue":"1","key":"10.1016\/j.msec.2016.06.035_bb0155","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.porgcoat.2013.08.015","article-title":"Epoxy\/polyaniline\u2013ZnO nanorods hybrid nanocomposite coatings: synthesis, characterization and corrosion protection performance of conducting paints[J]","volume":"77","author":"Mostafaei","year":"2014","journal-title":"Prog. Org. Coat."},{"issue":"11","key":"10.1016\/j.msec.2016.06.035_bb0160","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.wear.2010.01.024","article-title":"Effect of the addition of room temperature ionic liquid and ZnO nanoparticles on the wear and scratch resistance of epoxy resin[J]","volume":"268","author":"Sanes","year":"2010","journal-title":"Wear"},{"issue":"13","key":"10.1016\/j.msec.2016.06.035_bb0165","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.compscitech.2010.07.017","article-title":"Characterization of calcium phosphate layers grown on polycaprolactone for tissue engineering purposes[J]","volume":"70","author":"Lebourg","year":"2010","journal-title":"Compos. Sci. Technol."},{"key":"10.1016\/j.msec.2016.06.035_bb0170","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.msec.2015.09.050","article-title":"Effect of the addition CNTs on performance of CaP\/chitosan\/coating deposited on magnesium alloy by electrophoretic deposition[J]","volume":"58","author":"Zhang","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"issue":"22","key":"10.1016\/j.msec.2016.06.035_bb0175","doi-asserted-by":"crossref","first-page":"6038","DOI":"10.1007\/s10853-010-4688-9","article-title":"In vitro degradation and cell attachment of a PLGA coated biodegradable Mg\u20136Zn based alloy[J]","volume":"45","author":"Li","year":"2010","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.msec.2016.06.035_bb0180","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.msec.2015.09.065","article-title":"Biocorrosion behavior of biodegradable nanocomposite fibers coated layer-by-layer on AM50 magnesium implant[J]","volume":"58","author":"Abdal-hay","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"issue":"14","key":"10.1016\/j.msec.2016.06.035_bb0185","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1016\/j.electacta.2009.02.004","article-title":"Electrochemical corrosion behaviour of plasma electrolytic oxidation coatings on AM50 magnesium alloy formed in silicate and phosphate based electrolytes[J]","volume":"54","author":"Liang","year":"2009","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.msec.2016.06.035_bb0190","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.colsurfa.2012.12.009","article-title":"Influence of electrospinning and dip-coating techniques on the degradation and cytocompatibility of Mg-based alloy[J]","volume":"420","author":"Abdal-hay","year":"2013","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"issue":"12","key":"10.1016\/j.msec.2016.06.035_bb0195","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.addr.2006.09.004","article-title":"Hydrogels in controlled release formulations: network design and mathematical modeling[J]","volume":"58","author":"Lin","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.msec.2016.06.035_bb0200","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.carbpol.2014.04.002","article-title":"Porous silicon-cyclodextrin based polymer composites for drug delivery applications[J]","volume":"110","author":"Hernandez-Montelongo","year":"2014","journal-title":"Carbohydr. Polym."},{"issue":"8","key":"10.1016\/j.msec.2016.06.035_bb0205","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1039\/C4TB01683A","article-title":"Controlled release and corrosion protection by self-assembled colloidal particles electrodeposited onto magnesium alloys[J]","volume":"3","author":"Sun","year":"2015","journal-title":"J. Mater. Chem. B"}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092849311630604X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092849311630604X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T12:16:00Z","timestamp":1572437760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092849311630604X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":41,"alternative-id":["S092849311630604X"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2016.06.035","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bi-directional controlled release of ibuprofen and Mg2+ from magnesium alloys coated by multifunctional composite","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2016.06.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}