{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:27:34Z","timestamp":1768822054967,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["BMRPA53"],"award-info":[{"award-number":["BMRPA53"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPD1B0451"],"award-info":[{"award-number":["CMRPD1B0451"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPD3E0171"],"award-info":[{"award-number":["CMRPD3E0171"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.msec.2016.11.067","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T14:32:15Z","timestamp":1479479535000},"page":"150-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Ocular biocompatibility of gelatin microcarriers functionalized with oxidized hyaluronic acid"],"prefix":"10.1016","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9227-8549","authenticated-orcid":false,"given":"Jui-Yang","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Hui-Kang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2016.11.067_bb0005","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.addr.2007.03.012","article-title":"Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications","volume":"59","author":"Malafaya","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.msec.2016.11.067_bb0010","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.biomaterials.2010.12.041","article-title":"Silk fibroin in ocular tissue reconstruction","volume":"32","author":"Harkin","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2016.11.067_bb0015","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.3390\/ma7043106","article-title":"Gelatin-based materials in ocular tissue engineering","volume":"7","author":"Rose","year":"2014","journal-title":"Materials"},{"key":"10.1016\/j.msec.2016.11.067_bb0020","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3109\/02713683.2013.853803","article-title":"Review of alternative carrier materials for ocular surface reconstruction","volume":"39","author":"Feng","year":"2014","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.msec.2016.11.067_bb0025","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.reactfunctpolym.2007.07.060","article-title":"Functional biomedical polymers for corneal regenerative medicine","volume":"67","author":"Lai","year":"2007","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.msec.2016.11.067_bb0030","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1016\/j.biomaterials.2008.06.017","article-title":"PEG-stabilized carbodiimide crosslinked collagen-chitosan hydrogels for corneal tissue engineering","volume":"29","author":"Rafat","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2016.11.067_bb0035","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1167\/iovs.07-1599","article-title":"Development of a reconstructed cornea from collagen-chondroitin sulfate foams and human cell cultures","volume":"49","author":"Vrana","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.msec.2016.11.067_bb0040","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jmbbm.2013.03.001","article-title":"Composite electrospun gelatin fiber-alginate gel scaffolds for mechanically robust tissue engineered cornea","volume":"21","author":"Tonsomboon","year":"2013","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.msec.2016.11.067_bb0045","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.2147\/IJN.S28753","article-title":"Nanoscale modification of porous gelatin scaffolds with chondroitin sulfate for corneal stromal tissue engineering","volume":"7","author":"Lai","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.msec.2016.11.067_bb0050","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.colsurfb.2014.07.009","article-title":"Biofunctionalization of gelatin microcarrier with oxidized hyaluronic acid for corneal keratocyte cultivation","volume":"122","author":"Lai","year":"2014","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.msec.2016.11.067_bb0055","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/0885328211404265","article-title":"Fabrication of oxidized alginate-gelatin-BCP hydrogels and evaluation of the microstructure, material properties and biocompatibility for bone tissue regeneration","volume":"27","author":"Nguyen","year":"2012","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.msec.2016.11.067_bb0060","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/S0142-9612(98)00049-0","article-title":"In vitro and in vivo biocompatibility of dextran dialdehyde cross-linked gelatin hydrogel films","volume":"19","author":"Draye","year":"1998","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2016.11.067_bb0065","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.biomaterials.2004.06.044","article-title":"Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution","volume":"26","author":"Boontheekul","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2016.11.067_bb0070","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1016\/j.msec.2013.04.059","article-title":"Effect of chemical composition on corneal cellular response to photopolymerized materials comprising 2-hydroxyethyl methacrylate and acrylic acid","volume":"33","author":"Lai","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2016.11.067_bb0075","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.msec.2013.09.026","article-title":"Effect of chemical composition on corneal tissue response to photopolymerized materials comprising 2-hydroxyethyl methacrylate and acrylic acid","volume":"34","author":"Lai","year":"2014","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2016.11.067_bb0080","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.msec.2010.02.024","article-title":"Evaluation of cross-linked gelatin membranes as delivery carriers for retinal sheets","volume":"30","author":"Lai","year":"2010","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2016.11.067_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1163\/156856208783227695","article-title":"Carbodiimide cross-linked hyaluronic acid hydrogels as cell sheet delivery vehicles: characterization and interaction with corneal endothelial cells","volume":"19","author":"Lu","year":"2008","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.msec.2016.11.067_bb0090","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.3390\/ijms130910970","article-title":"Biocompatibility of genipin and glutaraldehyde cross-linked chitosan materials in the anterior chamber of the eye","volume":"13","author":"Lai","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.msec.2016.11.067_bb0095","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1163\/156856209X416980","article-title":"Ocular biocompatibility of carbodiimide cross-linked hyaluronic acid hydrogels for cell sheet delivery carriers","volume":"21","author":"Lai","year":"2010","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.msec.2016.11.067_bb0100","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1166\/jbn.2013.1734","article-title":"Effect of matrix nanostructure on the functionality of carbodiimide cross-linked amniotic membranes as limbal epithelial cell scaffolds","volume":"9","author":"Lai","year":"2013","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.msec.2016.11.067_bb0105","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1021\/bm801039n","article-title":"Low bloom strength gelatin as a carrier for potential use in retinal sheet encapsulation and transplantation","volume":"10","author":"Lai","year":"2009","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.msec.2016.11.067_bb0110","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1016\/j.biomaterials.2011.11.085","article-title":"A gelatin-g-poly(N-isopropylacrylamide) biodegradable in situ gelling delivery system for the intracameral administration of pilocarpine","volume":"33","author":"Lai","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2016.11.067_bb0115","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.carbpol.2013.09.060","article-title":"Relationship between structure and cytocompatibility of divinyl sulfone cross-linked hyaluronic acid","volume":"101","author":"Lai","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.msec.2016.11.067_bb0120","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1039\/C1JM14211A","article-title":"Synthesis, characterization and ocular biocompatibility of potential keratoprosthetic hydrogels based on photopolymerized poly(2-hydroxyethyl methacrylate)-co-poly(acrylic acid)","volume":"22","author":"Lai","year":"2012","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.msec.2016.11.067_bb0125","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10856-007-3192-5","article-title":"In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: extraction studies","volume":"19","author":"Huhtala","year":"2008","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.msec.2016.11.067_bb0130","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/(SICI)1097-4652(199812)177:3<465::AID-JCP9>3.0.CO;2-5","article-title":"Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix","volume":"177","author":"Greco","year":"1998","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.msec.2016.11.067_bb0135","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jmbbm.2010.09.014","article-title":"The effect of keratoconus on the structural, mechanical, and optical properties of the cornea","volume":"4","author":"Ambekar","year":"2011","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.msec.2016.11.067_bb0140","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/jbm.a.31619","article-title":"A methodology based on the \u201canterior chamber of rabbit eyes\u201d model for noninvasively determining the biocompatibility of biomaterials in an immune privileged site","volume":"86","author":"Lu","year":"2008","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.msec.2016.11.067_bb0145","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1007\/s10856-010-4035-3","article-title":"Biocompatibility of chemically cross-linked gelatin hydrogels for ophthalmic use","volume":"21","author":"Lai","year":"2010","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.msec.2016.11.067_bb0150","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/0883911506074025","article-title":"Three-dimensional gelatin and gelatin\/hyaluronan hydrogel structures for traumatic brain injury","volume":"22","author":"Zhang","year":"2007","journal-title":"J. Bioact. Compat. Polym."},{"key":"10.1016\/j.msec.2016.11.067_bb0155","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/jbm.a.31491","article-title":"Self-crosslinkable hydrogels composed of partially oxidized hyaluronan and gelatin: in vitro and in vivo responses","volume":"85","author":"Weng","year":"2008","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.msec.2016.11.067_bb0160","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1089\/ten.tea.2009.0798","article-title":"Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting","volume":"16","author":"Skardal","year":"2010","journal-title":"Tissue Eng. A"},{"key":"10.1016\/j.msec.2016.11.067_bb0165","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/mabi.201100335","article-title":"Characterization of a hierarchical network of hyaluronic acid\/gelatin composite for use as a smart injectable biomaterial","volume":"12","author":"Heris","year":"2012","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.msec.2016.11.067_bb0170","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/mabi.200800141","article-title":"Rheological properties of cross-linked hyaluronan-gelatin hydrogels for tissue engineering","volume":"9","author":"Vanderhooft","year":"2009","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.msec.2016.11.067_bb0175","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3109\/08977194.2010.508456","article-title":"Neovascularization by bFGF releasing hyaluronic acid-gelatin microspheres: in vitro and in vivo studies","volume":"28","author":"Demird\u00f6gen","year":"2010","journal-title":"Growth Factors"},{"key":"10.1016\/j.msec.2016.11.067_bb0180","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ijbiomac.2011.01.012","article-title":"Fabrication of gelatin-hyaluronic acid hybrid scaffolds with tunable porous structures for soft tissue engineering","volume":"48","author":"Zhang","year":"2011","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.msec.2016.11.067_bb0185","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1089\/ten.tea.2013.0352","article-title":"A combination of biphasic calcium phosphate scaffold with hyaluronic acid-gelatin hydrogel as a new tool for bone regeneration","volume":"20","author":"Nguyen","year":"2014","journal-title":"Tissue Eng. A"},{"key":"10.1016\/j.msec.2016.11.067_bb0190","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.actbio.2011.11.012","article-title":"Adhesion, phenotypic expression, and biosynthetic capacity of corneal keratocytes on surfaces coated with hyaluronic acid of different molecular weights","volume":"8","author":"Lai","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2016.11.067_bb0195","article-title":"Characterization of cross-linked porous gelatin carriers and their interaction with corneal endothelium: biopolymer concentration effect","volume":"8","author":"Lai","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.msec.2016.11.067_bb0200","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1021\/acs.biomac.5b00854","article-title":"Antioxidant gallic acid-functionalized biodegradable in situ gelling copolymers for cytoprotective antiglaucoma drug delivery systems","volume":"16","author":"Lai","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.msec.2016.11.067_bb0205","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0142-9612(00)00169-1","article-title":"Biocompatibility and biodegradation of intravitreal hyaluronan implants in rabbits","volume":"22","author":"Avitabile","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2016.11.067_bb0210","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1016\/S0142-9612(02)00209-0","article-title":"Synthesis and biodegradation of arabinogalactan sponges prepared by reductive amination","volume":"23","author":"Ehrenfreund-Kleinman","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2016.11.067_bb0215","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1016\/j.actbio.2013.02.017","article-title":"In vitro and in vivo evaluation of biodegradable embolic microspheres with tunable anticancer drug release","volume":"9","author":"Weng","year":"2013","journal-title":"Acta Biomater."}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493116322408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493116322408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T11:29:28Z","timestamp":1536233368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493116322408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":43,"alternative-id":["S0928493116322408"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2016.11.067","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ocular biocompatibility of gelatin microcarriers functionalized with oxidized hyaluronic acid","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2016.11.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}