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Sci."},{"key":"10.1016\/j.msec.2017.02.070_bb0550","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1016\/j.polymer.2004.03.004","article-title":"Creep resistant polymeric nanocomposites","volume":"45","author":"Zhang","year":"2004","journal-title":"Polymer"},{"issue":"2","key":"10.1016\/j.msec.2017.02.070_bb0555","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.polymertesting.2005.10.005","article-title":"Tribological behaviour of UHMWPE\/HDPE blends reinforced with multi-wall carbon nanotubes","volume":"25","author":"Xue","year":"2006","journal-title":"Polym. Test."},{"key":"10.1016\/j.msec.2017.02.070_bb0560","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/(SICI)1097-4628(20000321)75:12<1503::AID-APP9>3.0.CO;2-X","article-title":"Binary and ternary particulated composites: UHMWPE\/CaCO3\/HDPE","volume":"75","author":"Suwanprateeb","year":"2000","journal-title":"J. Appl. Polym. 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Sci."},{"key":"10.1016\/j.msec.2017.02.070_bb0720","series-title":"Biocompatibility Studies of HDPE \u2013 HA Composites with Different HA Content","first-page":"3083","author":"Herman","year":"2015"},{"key":"10.1016\/j.msec.2017.02.070_bb0725","doi-asserted-by":"crossref","unstructured":"M St\u00fcrzel, F Kempe, Y Thomann, S Mark, M Enders, & R M\u00fclhaupt, Novel graphene UHMWPE nanocomposites prepared by polymerization filling using single-site catalysts supported on functionalized graphene nanosheet dispersions. Macromolecules, 45(2012), 6878\u20136887. doi\/abs\/10.1021\/ma301376q","DOI":"10.1021\/ma301376q"},{"key":"10.1016\/j.msec.2017.02.070_bb0730","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1021\/am300244s","article-title":"Graphene nanoplatelet-induced strengthening of ultrahigh molecular weight polyethylene and biocompatibility in vitro","volume":"4","author":"Lahiri","year":"2012","journal-title":"ACS Appl. Mater. 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Sci."},{"key":"10.1016\/j.msec.2017.02.070_bb0740","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1016\/j.biomaterials.2004.11.022","article-title":"Process and kinetics of bonelike apatite formation on sintered hydroxyapatite in a simulated body fluid","volume":"26","author":"Kim","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2017.02.070_bb0745","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1100\/2012\/474851","article-title":"Mechanical, rheological, and bioactivity properties of ultra high-molecular-weight polyethylene bioactive composites containing polyethylene glycol and hydroxyapatite","volume":"2012","author":"Ahmad","year":"2012","journal-title":"Sci. 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