{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:21:16Z","timestamp":1786994476074,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.msec.2018.04.023","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T14:01:25Z","timestamp":1523541685000},"page":"387-400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Doxorubicin-DNA adduct entrenched and motif tethered artificial virus encased in pH-responsive polypeptide complex for targeted cancer therapy"],"prefix":"10.1016","volume":"89","author":[{"given":"K.C.","family":"Ajithkumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-3369","authenticated-orcid":false,"given":"K.","family":"Pramod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2018.04.023_bb0005","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrc1781","article-title":"Predicting the future burden of cancer","volume":"6","author":"Brayand","year":"2006","journal-title":"Nat. Rev. Cancer"},{"issue":"e169","key":"10.1016\/j.msec.2018.04.023_bb0010","first-page":"1","article-title":"Nuclease-resistant synthetic drug-DNA adducts: programmable drug-DNA conjugation for targeted anticancer drug delivery","volume":"7","author":"Zhu","year":"2015","journal-title":"NPG Asia Mater."},{"key":"10.1016\/j.msec.2018.04.023_bb0015","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1021\/bc4005427","article-title":"Site-specific DNA\u2212doxorubicin conjugates display enhanced cytotoxicity to breast cancer cells","volume":"25","author":"Stuart","year":"2014","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.msec.2018.04.023_bb0020","doi-asserted-by":"crossref","first-page":"6807","DOI":"10.1039\/C4RA12802H","article-title":"A self-assembled albumin based multiple drug delivery nanosystem to overcome multidrug resistance","volume":"5","author":"Chen","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.msec.2018.04.023_bb0025","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2147\/OTT.S3863","article-title":"Targeted delivery of albumin bound paclitaxel in the treatment of advanced breast cancer","volume":"2","author":"Costanzo","year":"2009","journal-title":"OncoTarget. Ther."},{"key":"10.1016\/j.msec.2018.04.023_bb0030","first-page":"1496","article-title":"Investigation of the interaction of the synthesized chitosan-5-fluorouracil with bovine serum albumin using spectroscopy","volume":"5","author":"Lou","year":"2013","journal-title":"J. Chem. Pharm. Res."},{"key":"10.1016\/j.msec.2018.04.023_bb0035","first-page":"669","article-title":"Preparation, characterization, and in vitro targeted delivery of folate-decorated paclitaxel-loaded bovine serum albumin nanoparticles","volume":"5","author":"Zhao","year":"2010","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.msec.2018.04.023_bb0040","doi-asserted-by":"crossref","DOI":"10.1038\/nnano.2014.169","article-title":"Design and self-assembly of simple coat proteins for artificial viruses","author":"Hernandez-Garcia","year":"2014","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.msec.2018.04.023_bb0045","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/ijc.2910570719","article-title":"New anti-lung-cancer antibody cluster 12 reacts with human folate receptors present on adenocarcinoma","volume":"57","author":"Franklin","year":"1994","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.msec.2018.04.023_bb0050","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0169-409X(02)00042-X","article-title":"Folate-mediated delivery of macromolecular anticancer therapeutic agents","volume":"54","author":"Lu","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.msec.2018.04.023_bb0055","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/1520-6017(200011)89:11<1452::AID-JPS8>3.0.CO;2-P","article-title":"Design of folic acid-conjugated nanoparticles for drug targeting","volume":"89","author":"Stella","year":"2000","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.msec.2018.04.023_bb0060","doi-asserted-by":"crossref","first-page":"8481","DOI":"10.1074\/jbc.271.14.8481","article-title":"Folate-targeted, anionic liposomeentrapped polylysine-condensed DNA for tumor cell-specific gene transfer","volume":"271","author":"Lee","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.msec.2018.04.023_bb0065","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0378-5173(02)00587-2","article-title":"Influence of formulation parameters on gadolinium entrapment and tumor cell uptake using folate-coated nanoparticles","volume":"251","author":"Oyewumi","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.msec.2018.04.023_bb0070","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.2147\/IJN.S67210","article-title":"Preparation of folic acid-conjugated, doxorubicin-loaded, magnetic bovine serum albumin nanospheres and their antitumor effects in vitro and in vivo","volume":"9","author":"Yang","year":"2014","journal-title":"Int. J. Nanomedicine"},{"issue":"89","key":"10.1016\/j.msec.2018.04.023_bb0075","first-page":"1","article-title":"Acidic extracellular microenvironment and cancer","volume":"13","author":"Kato","year":"2013","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.msec.2018.04.023_bb0080","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1021\/mz500529v","article-title":"Protein encapsulation via polypeptide complex coacervation","volume":"3","author":"Black","year":"2014","journal-title":"ACS Macro Lett."},{"key":"10.1016\/j.msec.2018.04.023_bb0085","series-title":"Biological Procedures Online","article-title":"Chicken chorioallntaoic membrane as a reliable model to evaluate osteosacroma-an experimental approach using SaOS2 cell line","author":"Reji","year":"2015"},{"key":"10.1016\/j.msec.2018.04.023_bb0090","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1039\/C0AN00424C","article-title":"Fluorescent gold cludters as nanosensors for copper ions in live cell","volume":"136","author":"Durgadas","year":"2011","journal-title":"Analyst"},{"key":"10.1016\/j.msec.2018.04.023_bb0095","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/24\/3\/035103","article-title":"Drug loading and release on tumor cells using silk fibroin\u2013albumin nanoparticles as carriers","volume":"24","author":"Subia","year":"2013","journal-title":"Nanotechnology"},{"key":"10.1016\/j.msec.2018.04.023_bb0100","doi-asserted-by":"crossref","first-page":"10076","DOI":"10.1039\/c3ra46209a","article-title":"Controlled design and construction of multifunctional nanoparticles by molecular self-assembly","volume":"4","author":"Suthiwangcharoen","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.msec.2018.04.023_bb0105","article-title":"A novel strategy to fabricate doxorubicin\/bovine serum albumin\/porous silicon nanocomposites with pH-triggered drug delivery for cancer therapy in vitro","volume":"32","author":"Xia","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.msec.2018.04.023_bb0110","first-page":"51","article-title":"Endocytosis and exocytosis of nanoparticles in mammalian cells","volume":"1","author":"Oh","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.msec.2018.04.023_bb0115","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3389\/fphys.2013.00370","article-title":"pH sensing and regulation in cancer","volume":"4","author":"Damaghi","year":"2013","journal-title":"Front. Physiol."},{"issue":"11","key":"10.1016\/j.msec.2018.04.023_bb0120","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0891-5849(01)00480-4","article-title":"Redox environment of the cell as viewed through the redox state of the glutathione disulfide\/glutathione couple","volume":"30","author":"Schafer","year":"2001","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.msec.2018.04.023_bb0125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jconrel.2003.06.001","article-title":"A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs","volume":"93","author":"Bulmus","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.msec.2018.04.023_bb0130","first-page":"457","article-title":"Glutathione-sensitive nanogels for drug release","volume":"38","author":"Adamo","year":"2014","journal-title":"Chem. Eng. Trans."},{"key":"10.1016\/j.msec.2018.04.023_bb0135","doi-asserted-by":"crossref","DOI":"10.3791\/3612","article-title":"Therapeutic gene delivery and transfection in human pancreatic cancer cells using epidermal growth factor receptor-targeted gelatin nanoparticles","author":"Xu","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.msec.2018.04.023_bb0140","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.2147\/IJN.S108689","article-title":"Enhanced tumor delivery and antitumor response of doxorubicin-loaded albumin nanoparticles formulated based on a schiffbase","volume":"11","author":"Li","year":"2016","journal-title":"Int. J. Nanomedicine"},{"issue":"16","key":"10.1016\/j.msec.2018.04.023_bb0145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/sonc.2002.37263","article-title":"Role of angiogenesis in tumor growth and metastasis","volume":"29","author":"Folkman","year":"2002","journal-title":"Semin. Oncol."},{"issue":"12","key":"10.1016\/j.msec.2018.04.023_bb0150","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.exphem.2006.07.005","article-title":"A novel and rapid in vivo system for testing therapeutics on human leukemias","volume":"34","author":"Taizi","year":"2006","journal-title":"Exp. Hematol."},{"issue":"2","key":"10.1016\/j.msec.2018.04.023_bb0155","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000265166","article-title":"Doxorubicin cardiomyopathy","volume":"115","author":"Chatterjee","year":"2010","journal-title":"Cardiology"}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493117335415?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493117335415?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T20:54:12Z","timestamp":1550004852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493117335415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":31,"alternative-id":["S0928493117335415"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2018.04.023","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Doxorubicin-DNA adduct entrenched and motif tethered artificial virus encased in pH-responsive polypeptide complex for targeted cancer therapy","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2018.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}