{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:13:28Z","timestamp":1783120408640,"version":"3.54.6"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006560","name":"Yildiz Technical University","doi-asserted-by":"publisher","award":["2015-07-02-KAP01"],"award-info":[{"award-number":["2015-07-02-KAP01"]}],"id":[{"id":"10.13039\/501100006560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.msec.2018.05.056","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T21:52:39Z","timestamp":1526593959000},"page":"382-388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Biological responses of ultrafine grained pure titanium and their sand blasted surfaces"],"prefix":"10.1016","volume":"91","author":[{"given":"Asl\u0131","family":"G\u00fcnay-Bulutsuz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge","family":"Berrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Ayg\u00fcl","family":"Yeprem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif Damla","family":"Arisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Emin","family":"Yurci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2018.05.056_bb0005","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0921-5093(00)01660-9","article-title":"Improving the mechanical properties of magnesium and a magnesium alloy through severe plastic deformation","volume":"300","author":"Yamashita","year":"2001","journal-title":"Mater. Sci. Eng. A"},{"key":"10.1016\/j.msec.2018.05.056_bb0010","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/adem.200310077","article-title":"ARB (accumulative roll-bonding) and other new techniques to produce bulk ultrafine grained materials","volume":"5","author":"Tsuji","year":"2003","journal-title":"Adv. Eng. Mater."},{"key":"10.1016\/j.msec.2018.05.056_bb0015","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.pmatsci.2006.02.003","article-title":"Principles of equal-channel angular pressing as a processing tool for grain refinement","volume":"51","author":"Valiev","year":"2006","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.msec.2018.05.056_bb0020","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.scriptamat.2004.04.025","article-title":"On the homogeneity of deformation by high pressure torsion","volume":"51","author":"Vorhauer","year":"2004","journal-title":"Scr. Mater."},{"key":"10.1016\/j.msec.2018.05.056_bb0025","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1007\/s11661-017-4278-4","article-title":"Microstructure and texture evolutions of biomedical Ti-13Nb-13Zr alloy processed by hydrostatic extrusion","volume":"48","author":"Ozaltin","year":"2017","journal-title":"Metall. Mater. Trans. A Phys. Metall. Mater. Sci."},{"key":"10.1016\/j.msec.2018.05.056_bb0030","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11837-008-0031-1","article-title":"Biomedical applications of titanium and its alloys","author":"Elias","year":"2008","journal-title":"J. Miner. Met. Mater. Soc."},{"issue":"6","key":"10.1016\/j.msec.2018.05.056_bb0035","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2106\/00004623-199306000-00004","article-title":"The differences in toxicity and release of bone-resorbing mediators induced by titanium and cobalt-chromium-alloy wear particles","volume":"75","author":"Haynes","year":"1993","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.msec.2018.05.056_bb0040","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1016\/j.biomaterials.2007.05.010","article-title":"Cellular and molecular interactions between MC3T3-E1 pre-osteoblasts and nanostructured titanium produced by high-pressure torsion","volume":"28","author":"Faghihi","year":"2007","journal-title":"Biomaterials"},{"issue":"2\u20133","key":"10.1016\/j.msec.2018.05.056_bb0045","article-title":"Microstructure, mechanical and biological properties of zirconium alloyed with niobium after severe plastic deformation","volume":"44","author":"Sharkeev","year":"2013","journal-title":"Mater. Werkst."},{"key":"10.1016\/j.msec.2018.05.056_bb0050","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1016\/j.msec.2013.01.056","article-title":"Mechanical properties of a medical \u03b2-type titanium alloy with specific microstructural evolution through high-pressure torsion","volume":"33","author":"Yilmazer","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2018.05.056_bb0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4028\/www.scientific.net\/MSF.584-586.49","article-title":"Nanostructured SPD processed titanium for medical implants","volume":"584\u2013586","author":"Valiev","year":"2008","journal-title":"Mater. Sci. Forum"},{"key":"10.1016\/j.msec.2018.05.056_bb0060","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1016\/j.biomaterials.2007.06.015","article-title":"In vitro biocompatibility of an ultrafine grained zirconium","volume":"28","author":"Salda\u00f1a","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2018.05.056_bb0065","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.actbio.2010.09.033","article-title":"Accelerated stem cell attachment to ultrafine grained titanium","volume":"7","author":"Estrin","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2018.05.056_bb0070","doi-asserted-by":"crossref","first-page":"9086","DOI":"10.1016\/j.apsusc.2011.05.105","article-title":"Enhanced in vitro biocompatibility of ultrafine-grained biomedical NiTi alloy with microporous surface","volume":"257","author":"Zheng","year":"2011","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.msec.2018.05.056_bb0075","first-page":"556","article-title":"An in vivo evaluation of ultra-fine grained titanium implants","volume":"25","author":"Bindu","year":"2009","journal-title":"J. Mater. Sci. Technol."},{"key":"10.1016\/j.msec.2018.05.056_bb0080","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10856-007-3204-5","article-title":"In vitro fibroblast response to ultrafine grained titanium produced by a severe plastic deformation process","volume":"19","author":"Kim","year":"2008","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.msec.2018.05.056_bb0085","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1016\/j.biomaterials.2008.05.012","article-title":"Advancing dental implant surface technology - from micron- to nanotopography","volume":"29","author":"Mendon\u00e7a","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2018.05.056_bb0090","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/clr.12213","article-title":"Nanostructures and hydrophilicity influence osseointegration: a biomechanical study in the rabbit tibia","volume":"25","author":"Wennerberg","year":"2014","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.msec.2018.05.056_bb0095","doi-asserted-by":"crossref","first-page":"625","DOI":"10.12693\/APhysPolA.129.625","article-title":"Influence of surface modification methods on the topography of dental implants by using metrological observation techniques","volume":"129","author":"Bulutsuz","year":"2016","journal-title":"Acta Phys. Pol. A"},{"key":"10.1016\/j.msec.2018.05.056_bb0100","doi-asserted-by":"crossref","first-page":"484","DOI":"10.12693\/APhysPolA.125.484","article-title":"Importance of measurement parameters for the dental implant surface characterization","volume":"125","author":"Gunay","year":"2014","journal-title":"Acta Phys. Pol. A"},{"key":"10.1016\/j.msec.2018.05.056_bb0105","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.dental.2006.06.025","article-title":"Surface treatments of titanium dental implants for rapid osseointegration","volume":"23","author":"Le Gu\u00e9hennec","year":"2007","journal-title":"Dent. Mater."},{"key":"10.1016\/j.msec.2018.05.056_bb0110","first-page":"544","article-title":"Oral implant surfaces. Part 2. Review focusing on clinical knowledge of different surfaces","volume":"17","author":"Albrektsson","year":"2004","journal-title":"Int. J. Prosthodont."},{"key":"10.1016\/j.msec.2018.05.056_bb0115","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1016\/j.biomaterials.2010.01.071","article-title":"The influence of nano-scale surface roughness on bacterial adhesion to ultrafine-grained titanium","volume":"31","author":"Truong","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2018.05.056_bb0120","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/jbm.a.34831","article-title":"Dependence of cellular activity at protein adsorbed biointerfaces with nano- to microscale dimensionality","volume":"102","author":"Nune","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.msec.2018.05.056_bb0125","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/adem.200800026","article-title":"Nanostructured titanium for biomedical applications","volume":"10","author":"Valiev","year":"2008","journal-title":"Adv. Eng. Mater."},{"key":"10.1016\/j.msec.2018.05.056_bb0130","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.msec.2016.10.035","article-title":"Combined effect of grain refinement and surface modification of pure titanium on the attachment of mesenchymal stem cells and osteoblast-like SaOS-2 cells","volume":"71","author":"Medvedev","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2018.05.056_bb0135","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1163\/156855409X447174","article-title":"The structure and physical and mechanical properties of a novel biocomposite material, nanostructured titanium\u2013calcium-phosphate coating","volume":"16","author":"Sharkeev","year":"2009","journal-title":"Compos. Interfaces"},{"key":"10.1016\/j.msec.2018.05.056_bb0140","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0142-9612(03)00571-4","article-title":"Influence of titanium surfaces on attachment of osteoblast-like cells in vitro","volume":"25","author":"Jayaraman","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2018.05.056_bb0145","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.biomaterials.2003.08.015","article-title":"Roughness induced dynamic changes of wettability of acid etched titanium implant modifications","volume":"25","author":"Rupp","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2018.05.056_bb0150","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jmbbm.2007.12.002","article-title":"Relationship between surface properties (roughness, wettability and morphology) of titanium and dental implant removal torque","volume":"1","author":"Elias","year":"2008","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.msec.2018.05.056_bb0155","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.dental.2006.06.025","article-title":"Surface treatments of titanium dental implants for rapid osseointegration","volume":"23","author":"Le Gu\u00e9hennec","year":"2007","journal-title":"Dent. Mater."},{"key":"10.1016\/j.msec.2018.05.056_bb0160","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0142-9612(01)00317-9","article-title":"Adsorption and dissolution behavior of human plasma fibronectin on thermally and chemically modified titanium dioxide particles","volume":"23","author":"MacDonald","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2018.05.056_bb0165","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1163\/156856195X00347","article-title":"The effect of substrate roughness characteristics on wettability and on the mechanical properties of adhesive joints loaded at high strain rates","volume":"9","author":"Keisler","year":"1995","journal-title":"J. Adhes. Sci. Technol."},{"key":"10.1016\/j.msec.2018.05.056_bb0170","series-title":"The Physics of Microdroplets","first-page":"201","author":"Berthier","year":"2012"},{"key":"10.1016\/j.msec.2018.05.056_bb0175","first-page":"1163","article-title":"Properties and performance of ultrafine grained titanium for biomedical applications 2","volume":"18","author":"Jogaib","year":"2015","journal-title":"Dental Implants"},{"key":"10.1016\/j.msec.2018.05.056_bb0180","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1016\/j.biomaterials.2011.01.029","article-title":"The effects of combined micron-\/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation","volume":"32","author":"Gittens","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2018.05.056_bb0185","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5757\/ASCT.2016.25.3.51","article-title":"Surface treatment of a titanium implant using a low temperature atmospheric pressure plasma jet","volume":"25","author":"Lee","year":"2016","journal-title":"Appl. Sci. Converg. Technol."},{"key":"10.1016\/j.msec.2018.05.056_bb0190","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.actbio.2007.12.002","article-title":"Osteoblastic cell behaviour on different titanium implant surfaces","volume":"4","author":"Le Guehennec","year":"2008","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2018.05.056_bb0195","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/jbm.820290314","article-title":"Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63)","volume":"29","author":"Martin","year":"1995","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.msec.2018.05.056_bb0200","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1097-4636(199602)30:2<145::AID-JBM3>3.0.CO;2-R","article-title":"Effect of titanium surface roughness on chondrocyte proliferation, matrix production, and differentiation depends on the state of cell maturation","volume":"30","author":"Schwartz","year":"1996","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.msec.2018.05.056_bb0205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/(SICI)1097-4636(199609)32:1<55::AID-JBM7>3.0.CO;2-O","article-title":"Surface roughness modulates the local production of growth factors and cytokines by osteoblast- like MG-63 cells","volume":"32","author":"Kieswetter","year":"1996","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.msec.2018.05.056_bb0210","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1016\/j.biomaterials.2003.12.002","article-title":"Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo","volume":"25","author":"Webster","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2018.05.056_bb0215","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/jbm.a.32174","article-title":"Accelerated growth of preosteoblastic cells on ultrafine grained titanium","volume":"90","author":"Estrin","year":"2009","journal-title":"J. Biomed. Mater. Res. A"}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493117324608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493117324608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:28:19Z","timestamp":1760531299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493117324608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":43,"alternative-id":["S0928493117324608"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2018.05.056","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biological responses of ultrafine grained pure titanium and their sand blasted surfaces","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2018.05.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}