{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:50:13Z","timestamp":1790509813918,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.msec.2018.12.032","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T03:53:03Z","timestamp":1544500383000},"page":"377-387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Impact of simulated biological aging on physicochemical and biocompatibility properties of cyclic olefin copolymers"],"prefix":"10.1016","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4001-7435","authenticated-orcid":false,"given":"M\u00e9lisande","family":"Bernard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-4091","authenticated-orcid":false,"given":"Emile","family":"Jubeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joudi","family":"Bakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Saunier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najet","family":"Yagoubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.msec.2018.12.032_bb0005","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.snb.2011.12.011","article-title":"Thermal bonding of microfluidic devices: factors that affect interfacial strength of similar and dissimilar cyclic olefin copolymers","volume":"161","author":"Roy","year":"2012","journal-title":"Sensors Actuators B"},{"issue":"12","key":"10.1016\/j.msec.2018.12.032_bb0010","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1002\/jbm.a.36199","article-title":"Biocompatibility assessment of cyclic olefin copolymers: impact of two additives on cytotoxicity, oxidative stress, inflammatory reactions and hemocompatibility","volume":"105","author":"Bernard","year":"2017","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.msec.2018.12.032_bb0015","series-title":"parts 1\u201320: Biological Evaluation of Medical Devices","author":"ISO 10993","year":"1998"},{"key":"10.1016\/j.msec.2018.12.032_bb0020","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1039\/C8BM00518D","article-title":"Risk management-based evaluation of polymers biocompatibility: beyond standards, current approaches of in vitro studies","volume":"6","author":"Bernard","year":"2018","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.msec.2018.12.032_bb0025","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/ppap.201000120","article-title":"Surface modification of COC microfluidic devices: a comparative study of nitrogen plasma treatment and its advantages over argon and oxygen plasma treatments","volume":"8","author":"Roy","year":"2011","journal-title":"Plasma Process. Polym."},{"issue":"11","key":"10.1016\/j.msec.2018.12.032_bb0030","doi-asserted-by":"crossref","first-page":"6879","DOI":"10.1007\/s10853-017-0925-9","article-title":"Physico-chemical ageing of ethylene\u2013norbornene copolymers: a review","volume":"52","author":"Lago","year":"2017","journal-title":"J. Mater. Sci."},{"issue":"7","key":"10.1016\/j.msec.2018.12.032_bb0035","volume":"6","year":"2008","journal-title":"EFSA J."},{"key":"10.1016\/j.msec.2018.12.032_bb0040","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1016\/S0142-9612(01)00049-7","article-title":"Hydrolytic degradation of poly(carbonate)-urethanes by monocyte-derived macrophages","volume":"22","author":"Labow","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2018.12.032_bb0045","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1172\/JCI116841","article-title":"Degradation of biomaterials by phagocyte-derived oxidants","volume":"92","author":"Sutherland","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.msec.2018.12.032_bb0050","doi-asserted-by":"crossref","first-page":"448","DOI":"10.5731\/pdajpst.2013.00933","article-title":"Extractables characterization for five materials of construction representative of packaging systems used for parenteral and ophthalmic drug products","volume":"67","author":"Jenke","year":"2013","journal-title":"PDA J. Pharm. Sci. Technol."},{"issue":"1","key":"10.1016\/j.msec.2018.12.032_bb0055","doi-asserted-by":"crossref","first-page":"012822.1","DOI":"10.1063\/1.3682098","article-title":"Cyclic olefin copolymer based microfluidic devices for biochip applications: ultraviolet surface grafting using 2-methacryloyloxyethyl phosphorylcholine","volume":"6","author":"Jena","year":"2012","journal-title":"Biomicrofluidics"},{"issue":"2","key":"10.1016\/j.msec.2018.12.032_bb0060","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.snb.2010.08.043","article-title":"Surface analysis, hydrophilic enhancement, ageing behavior and flow in plasma modified cyclic olefin copolymer (COC)-based microfluidic devices","volume":"150","author":"Roy","year":"2010","journal-title":"Sensors Actuators B Chem."},{"issue":"12","key":"10.1016\/j.msec.2018.12.032_bb0065","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.vacuum.2011.03.007","article-title":"Influence of plasma surface treatment on thermal bonding and flow behaviour in Cyclic Olefin Copolymer (COC) based microfluidic devices","volume":"85","author":"Roy","year":"2011","journal-title":"Vacuum"},{"issue":"9","key":"10.1016\/j.msec.2018.12.032_bb0070","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1016\/j.bios.2011.03.005","article-title":"Toward immunoassay chips: facile immobilization of antibodies on cyclic olefin copolymer substrates through pre-activated polymer adlayers","volume":"26","author":"Sung","year":"2011","journal-title":"Biosens. Bioelectron."},{"issue":"15","key":"10.1016\/j.msec.2018.12.032_bb0075","doi-asserted-by":"crossref","first-page":"8841","DOI":"10.1073\/pnas.95.15.8841","article-title":"Mast cells mediate acute inflammatory responses to implanted biomaterials","volume":"95","author":"Tang","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.msec.2018.12.032_bb0080","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/pi.4408","article-title":"Which is more effective for protein adsorption: surface roughness, surface wettability or swelling? Case study of polyurethane films prepared from castor oil and poly(ethylene glycol)","volume":"62","author":"Akkas","year":"2013","journal-title":"Polym. Int."},{"issue":"27","key":"10.1016\/j.msec.2018.12.032_bb0085","doi-asserted-by":"crossref","first-page":"17631","DOI":"10.1021\/acsami.6b03644","article-title":"Effect of extreme wettability on platelet adhesion on metallic implants: from superhydrophilicity to superhydrophobicity","volume":"8","author":"Moradi","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"4","key":"10.1016\/j.msec.2018.12.032_bb0090","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2174\/156802608783790901","article-title":"Surface chemistry influences implant biocompatibility","volume":"8","author":"Thevenot","year":"2008","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.msec.2018.12.032_bb0095","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1002\/jbm.a.35837","article-title":"Exudation of additives to the surface of medical devices: impact on biocompatibility in the case of polyurethane used in implantable catheters","volume":"104","author":"Nouman","year":"2016","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"1\u20132","key":"10.1016\/j.msec.2018.12.032_bb0100","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ijpharm.2012.07.060","article-title":"Blooming of Irganox 3114\u00ae antioxidant onto a medical grade elastomer. Impact of the recrystallization conditions on the antioxidant polymorphism, on the film wettability and on the antioxidant leachability","volume":"437","author":"Saunier","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.msec.2018.12.032_bb0105","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1080\/03602559.2014.935400","article-title":"Thermo-oxidative stability of cyclic olefin copolymers in the presence of Fe, Co and Mn stearates as pro-degradant additives","volume":"53","author":"Guti\u00e9rrez-Villarreal","year":"2014","journal-title":"Polym.-Plast. Technol. Eng."},{"issue":"24","key":"10.1016\/j.msec.2018.12.032_bb0110","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.1039\/C6AN01448H","article-title":"Characterization of activated cyclic olefin copolymer: effects of ethylene\/norbornene content on the physiochemical properties","volume":"141","author":"O Neil","year":"2016","journal-title":"Analyst"},{"key":"10.1016\/j.msec.2018.12.032_bb0115","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10404-010-0605-4","article-title":"Cyclic olefin polymers: emerging materials for lab-on-a-chip applications","volume":"9","author":"Nunes","year":"2010","journal-title":"Microfluid. Nanofluid."},{"issue":"1","key":"10.1016\/j.msec.2018.12.032_bb0120","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ijpharm.2013.07.065","article-title":"Modification of a cyclo-olefin surface by radio-sterilization: is there any effect on the interaction with drug solutions?","volume":"456","author":"Barakat","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.msec.2018.12.032_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/app.43498","article-title":"Electron beam sterilization of cyclo olefin polymer leads to polymer degradation and production of alkyl radicals","volume":"133","author":"Kiminami","year":"2016","journal-title":"J. Appl. Polym. Sci."},{"issue":"4","key":"10.1016\/j.msec.2018.12.032_bb0130","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.freeradbiomed.2009.05.018","article-title":"Regulation of superoxide dismutase genes: implications in diseases","volume":"47","author":"Miao","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.msec.2018.12.032_bb0135","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1002\/jps.20984","article-title":"Evaluation of the chemical compatibility of plastic contact materials and pharmaceutical products; safety considerations related to extractables and leachables","volume":"96","author":"Jenke","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.msec.2018.12.032_bb0140","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.apsusc.2014.12.060","article-title":"Surface functionalization of cyclic olefin copolymer with aryldiazonium salts: a covalent grafting method","volume":"329","author":"Brisset","year":"2015","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.msec.2018.12.032_bb0145","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1002\/jbm.a.35528","article-title":"Interaction of intraocular lenses with fibronectin and human lens epithelial cells: effect of chemical composition and aging","volume":"103A","author":"Tortolano","year":"2015","journal-title":"J. Biomed. Mater. Res. A"}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493118310440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493118310440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T17:31:03Z","timestamp":1548264663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493118310440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":29,"alternative-id":["S0928493118310440"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2018.12.032","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of simulated biological aging on physicochemical and biocompatibility properties of cyclic olefin copolymers","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2018.12.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}