{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:11:20Z","timestamp":1783674680816,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["105-2314-B-350-002"],"award-info":[{"award-number":["105-2314-B-350-002"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107-3017-F-007-002"],"award-info":[{"award-number":["107-3017-F-007-002"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI-EX107-10522EI"],"award-info":[{"award-number":["NHRI-EX107-10522EI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["MOE 107QR001I5"],"award-info":[{"award-number":["MOE 107QR001I5"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.msec.2019.109954","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T11:24:23Z","timestamp":1563276263000},"page":"109954","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["An in situ slow-releasing H2S donor depot with long-term therapeutic effects for treating ischemic diseases"],"prefix":"10.1016","volume":"104","author":[{"given":"Meng-Hsuan","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Wen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Ju","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Yu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Yi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Ji","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsing-Wen","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2019.109954_bb0005","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrcardio.2013.70","article-title":"Therapeutic angiogenesis for critical limb ischaemia","volume":"10","author":"Annex","year":"2013","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.msec.2019.109954_bb0010","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1161\/CIRCRESAHA.115.303565","article-title":"Modulating the vascular response to limb ischemia: angiogenic and cell therapies","volume":"116","author":"Cooke","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.msec.2019.109954_bb0015","doi-asserted-by":"crossref","first-page":"801","DOI":"10.7150\/thno.4419","article-title":"Therapeutic angiogenesis for treating cardiovascular diseases","volume":"2","author":"Deveza","year":"2012","journal-title":"Theranostics"},{"key":"10.1016\/j.msec.2019.109954_bb0020","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.atherosclerosis.2013.05.029","article-title":"Critical limb ischaemia is characterised by an increased production of whole blood reactive oxygen species and expression of TREM-1 on neutrophils","volume":"229","author":"Dopheide","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.msec.2019.109954_bb0025","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3390\/antiox3030472","article-title":"Oxidative stress and the use of antioxidants in stroke","volume":"3","author":"Shirley","year":"2014","journal-title":"Antioxid"},{"key":"10.1016\/j.msec.2019.109954_bb0030","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1177\/1538574407311106","article-title":"The myopathy of peripheral arterial occlusive disease: part 1. Functional and histomorphological changes and evidence for mitochondrial dysfunction","volume":"41","author":"Pipinos","year":"2008","journal-title":"Vasc. Endovasc. Surg."},{"key":"10.1016\/j.msec.2019.109954_bb0035","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1089\/ars.2011.4401","article-title":"A practical look at the chemistry and biology of hydrogen sulfide","volume":"17","author":"Olson","year":"2012","journal-title":"Antioxid. Redox. Sign."},{"key":"10.1016\/j.msec.2019.109954_bb0040","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen sulfide is an endogenous stimulator of angiogenesis","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S."},{"key":"10.1016\/j.msec.2019.109954_bb0045","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/CIRCULATIONAHA.109.920991","article-title":"Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice","volume":"122","author":"Calvert","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.msec.2019.109954_bb0050","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/labinvest.3700391","article-title":"Hydrogen sulfide prevents apoptosis of human PMN via inhibition of p38 and caspase 3","volume":"86","author":"Rinaldi","year":"2006","journal-title":"Lab. Investig."},{"key":"10.1016\/j.msec.2019.109954_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.08.023","article-title":"In situ depot comprising phase-change materials that can sustainably release a gasotransmitter H2S to treat diabetic wounds","volume":"145","author":"Lin","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.109954_bb0060","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/toxsci\/kfu272","article-title":"Antioxidant effects of hydrogen sulfide on left ventricular remodeling in smoking rats are mediated via PI3K\/Akt-dependent activation of Nrf2","volume":"144","author":"Zhou","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.msec.2019.109954_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/768607","article-title":"The cardioprotective actions of hydrogen sulfide in acute myocardial infarction and heart failure","volume":"2014","author":"Polhemus","year":"2014","journal-title":"Scientifica"},{"key":"10.1016\/j.msec.2019.109954_bb0070","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1089\/ars.2007.1656","article-title":"Hydrogen sulfide raises cytosolic calcium in neurons through activation of L-type Ca2+ channels","volume":"10","author":"Garc\u00eda-Bereguia\u00edn","year":"2008","journal-title":"Antioxid. Redox. Sign."},{"key":"10.1016\/j.msec.2019.109954_bb0075","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/CIRCRESAHA.114.300505","article-title":"Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease","volume":"114","author":"Polhemus","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.msec.2019.109954_bb0080","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bcp.2017.11.014","article-title":"A review of hydrogen sulfide (H2S) donors: chemistry and potential therapeutic applications","volume":"114","author":"Powell","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.msec.2019.109954_bb0085","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1021\/acs.orglett.5b01962","article-title":"Diallyl trisulfide is a fast H2S donor, but diallyl disulfide is a slow one: the reaction pathways and intermediates of glutathione with polysulfides","volume":"17","author":"Liang","year":"2015","journal-title":"Org. Lett."},{"key":"10.1016\/j.msec.2019.109954_bb0090","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1039\/C5TB00354G","article-title":"Mesoporous silica nanoparticles for glutathione-triggered long-range and stable release of hydrogen sulfide","volume":"3","author":"Sun","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.msec.2019.109954_bb0095","first-page":"870","article-title":"Diallyl trisulfide augments ishemica-induced angiogenesis via an endothelial nitric oxide synthase-dependent mechanism","volume":"81","author":"Hayashida","year":"2017","journal-title":"Circ"},{"key":"10.1016\/j.msec.2019.109954_bb0100","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.msec.2017.12.036","article-title":"Recent advances of PLGA micro\/nanoparticles for the delivery of biomacromolecular therapeutics","volume":"92","author":"Ding","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2019.109954_bb0105","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.msec.2018.08.037","article-title":"VEGF delivery by smart polymeric PNIPAM nanoparticles affects both osteogenic and angiogenic capacities of human bone marrow stem cells","volume":"93","author":"Adibfar","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2019.109954_bb0110","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0021-9673(00)00381-2","article-title":"Sensitive determination of dissolved sulfide in estuarine water by solid-phase extraction and high-performance liquid chromatography of methylene blue","volume":"883","author":"Tang","year":"2000","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.msec.2019.109954_bb0115","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1161\/CIRCHEARTFAILURE.113.000299","article-title":"Hydrogen sulfide attenuates cardiac dysfunction after heart failure via induction of angiogenesis","volume":"6","author":"Polhemus","year":"2013","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.msec.2019.109954_bb0120","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.redox.2017.04.017","article-title":"Peripheral artery disease, redox signaling, oxidative stress-basic and clinical aspects","volume":"12","author":"Steven","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.msec.2019.109954_bb0125","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1021\/jacs.6b01784","article-title":"An implantable depot that can generate oxygen in situ for overcoming hypoxia-induced resistance to anticancer drugs in chemotherapy","volume":"138","author":"Huang","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.msec.2019.109954_bb0130","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1089\/ten.tea.2011.0193","article-title":"Three-dimensional cell grafting enhances the angiogenic efficacy of human umbilical vein endothelial cells","volume":"18","author":"Bhang","year":"2012","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.msec.2019.109954_bb0135","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/exnr.2000.7614","article-title":"Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions","volume":"170","author":"Lee","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.msec.2019.109954_bb0140","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/chem.201303757","article-title":"Fluorescent probes based on nucleophilic substitution-cyclization for hydrogen sulfide detection and bioimaging","volume":"20","author":"Peng","year":"2014","journal-title":"Eur. J."},{"key":"10.1016\/j.msec.2019.109954_bb0145","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.biomaterials.2015.09.043","article-title":"Enhancement of cell adhesion, retention, and survival of HUVEC\/cbMSC aggregates that are transplanted in ischemic tissues by concurrent delivery of an antioxidant for therapeutic angiogenesis","volume":"74","author":"Huang","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.109954_bb0150","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/jcbfm.2011.150","article-title":"Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives","volume":"32","author":"Zille","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.msec.2019.109954_bb0155","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.msec.2016.08.037","article-title":"Development of novel biocompatible hybrid nanocomposites based on polyurethane-silica prepared by sol gel process","volume":"69","author":"Rashti","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2019.109954_bb0160","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1073\/pnas.0905432106","article-title":"Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles","volume":"107","author":"Yang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.msec.2019.109954_bb0165","doi-asserted-by":"crossref","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen sulfide mediates the vasoactivity of garlic","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.msec.2019.109954_bb0170","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1113\/expphysiol.2011.059725","article-title":"Cytoprotective actions of hydrogen sulfide in ischaemia-reperfusion injury","volume":"96","author":"King","year":"2011","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.msec.2019.109954_bb0175","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCRESAHA.109.199919","article-title":"Hydrogen sulfide mediates cardioprotection through Nrf2 signaling","volume":"105","author":"Calvert","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.msec.2019.109954_bb0180","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/864946","article-title":"Molecular characterization of reactive oxygen species in myocardial ischemia-reperfusion injury","volume":"2015","author":"Zhou","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.msec.2019.109954_bb0185","first-page":"1","article-title":"Antioxidant and cell-signaling functions of hydrogen sulfide in the central nervous system","volume":"2018","author":"Shefa","year":"2018","journal-title":"Oxi. Med. Cell Longev."},{"key":"10.1016\/j.msec.2019.109954_bb0190","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molcel.2011.10.021","article-title":"Hydrogen sulfide-linked sulfhydration of NF-\u03baB mediates its antiapoptotic actions","volume":"45","author":"Sen","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.msec.2019.109954_bb0195","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1089\/ars.2009.2945","article-title":"The hydrogen sulfide donor NaHS promotes angiogenesis in a rat model of hind limb ischemia","volume":"12","author":"Wang","year":"2010","journal-title":"Antioxid. Redox. Sign."},{"key":"10.1016\/j.msec.2019.109954_bb0200","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.msec.2018.09.055","article-title":"In situ preparation of multicomponent polymer composite nanofibrous scaffolds with enhanced osteogenic and angiogenic activities","volume":"94","author":"Meka","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2019.109954_bb0205","first-page":"10205","article-title":"Pharmacological actions of hydrogen sulfide donors on sympathetic neurotransmission in the bovine anterior uvea, in vitro","volume":"4","author":"Salvi","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.msec.2019.109954_bb0210","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3233\/CH-152019","article-title":"Sympathetic nerves: how do they affect angiogenesis, particularly during wound healing of soft tissues?","volume":"62","author":"Pan","year":"2016","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"10.1016\/j.msec.2019.109954_bb0215","doi-asserted-by":"crossref","first-page":"6705","DOI":"10.1039\/C8TB02020E","article-title":"Islet encapsulation","volume":"6","author":"Ernst","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.msec.2019.109954_bb0220","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1016\/j.actbio.2012.09.034","article-title":"Injectable and biodegradable thermosensitive hydrogels loaded with PHBHHx nanoparticles for the sustained and controlled release of insulin","volume":"9","author":"Peng","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2019.109954_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2016.11.045","article-title":"Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection","volume":"116","author":"Korupalli","year":"2017","journal-title":"Biomaterials"}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493119307015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493119307015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:57:17Z","timestamp":1760533037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493119307015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":45,"alternative-id":["S0928493119307015"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2019.109954","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An in situ slow-releasing H2S donor depot with long-term therapeutic effects for treating ischemic diseases","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2019.109954","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109954"}}