{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:57:08Z","timestamp":1792789028830,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.msec.2019.110098","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T11:49:55Z","timestamp":1565956195000},"page":"110098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":117,"special_numbering":"C","title":["Metal-organic frameworks for on-demand pH controlled delivery of vancomycin from chitosan scaffolds"],"prefix":"10.1016","volume":"105","author":[{"given":"Ay\u015fe","family":"Karake\u00e7ili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna","family":"Topuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Korpayev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mert","family":"Erdek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2019.110098_bb0005","doi-asserted-by":"crossref","first-page":"6260","DOI":"10.1002\/anie.201000048","article-title":"BioMOFs: metal-organic frameworks for biological and medical applications","volume":"49","author":"McKinlay","year":"2010","journal-title":"Angewandte Chemie - International Edition"},{"key":"10.1016\/j.msec.2019.110098_bb0010","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1021\/ie101312k","article-title":"Biomedical applications of metal organic frameworks","volume":"50","author":"Keskin","year":"2011","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.msec.2019.110098_bb0015","doi-asserted-by":"crossref","first-page":"6906","DOI":"10.1039\/c2dt30357d","article-title":"Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle","volume":"41","author":"Sun","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.msec.2019.110098_bb0020","doi-asserted-by":"crossref","DOI":"10.1038\/srep37705","article-title":"Fabrication of functional hollow microspheres constructed from MOF shells: promising drug delivery systems with high loading capacity and targeted transport","volume":"6","author":"Gao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.msec.2019.110098_bb0025","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1021\/nn406590q","article-title":"Optimized metal-organic-framework nanospheres for drug delivery: evaluation of small-molecule encapsulation","volume":"8","author":"Zhuang","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.msec.2019.110098_bb0030","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1021\/jacs.5b11720","article-title":"One-pot synthesis of metal-organic frameworks with encapsulated target molecules and their applications for controlled drug delivery","volume":"138","author":"Zheng","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.msec.2019.110098_bb0035","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.biotechadv.2016.09.005","article-title":"Understanding osteomyelitis and its treatment through local drug delivery system","volume":"34","author":"Nandi","year":"2016","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.msec.2019.110098_bb0040","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1016\/j.msec.2013.05.036","article-title":"Systematic approach to treat chronic osteomyelitis through localized drug delivery system: bench to bed side","volume":"33","author":"Bhattacharya","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2019.110098_bb0045","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.biomaterials.2015.12.012","article-title":"Biomaterials approaches to treating implant-associated osteomyelitis","volume":"81","author":"Inzana","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110098_bb0050","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1039\/c3tb20261e","article-title":"Controlled release of gentamicin from gelatin\/genipin reinforced beta-tricalcium phosphate scaffold for the treatment of osteomyelitis","volume":"1","author":"Wu","year":"2013","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.msec.2019.110098_bb0055","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/adhm.201400158","article-title":"Inflammation-induced drug release by using a pH-responsive gas-generating hollow-microsphere system for the treatment of osteomyelitis","volume":"3","author":"Chung","year":"2014","journal-title":"Advanced Healthcare Materials"},{"key":"10.1016\/j.msec.2019.110098_bb0060","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.ijbiomac.2016.12.046","article-title":"Chitosan based nanofibers in bone tissue engineering","volume":"104","author":"Balagangadharan","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.msec.2019.110098_bb0065","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.actbio.2009.07.012","article-title":"New poly(\u03b5\u2011caprolactone)\/chitosan blend fibers for tissue engineering applications","volume":"6","author":"Malheiro","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2019.110098_bb0070","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/mabi.200300100","article-title":"Production and characterization of chitosan fibers and 3-D fiber mesh scaffolds for tissue engineering applications","volume":"4","author":"Tuzlakoglu","year":"2004","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.msec.2019.110098_bb0075","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/aa57af","article-title":"One-pot synthesis of multifunctional nanoscale metal-organic frameworks as an effective antibacterial agent against multidrug-resistant Staphylococcus aureus","volume":"28","author":"Chowdhuri","year":"2017","journal-title":"Nanotechnology"},{"key":"10.1016\/j.msec.2019.110098_bb0080","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1021\/acsami.7b17375","article-title":"Antimicrobial properties and osteogenicity of vancomycin-loaded synthetic scaffolds obtained by supercritical foaming","volume":"10","author":"Garc\u00eda-Gonz\u00e1lez","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.msec.2019.110098_bb0085","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.micromeso.2017.11.020","article-title":"Synthesis of ZIF-7, ZIF-8, ZIF-67 and ZIF-L from recycled mother liquors","volume":"261","author":"\u015eahin","year":"2018","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.msec.2019.110098_bb0090","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.msec.2014.10.004","article-title":"Antibacterial activity on electrospun poly(lactide\u2011co\u2011glycolide) based membranes via Magainin II grafting","volume":"45","author":"Y\u00fcksel","year":"2014","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2019.110098_bb0095","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.biomaterials.2010.09.073","article-title":"Chitosan\/poly(e{open}\u2011caprolactone) blend scaffolds for cartilage repair","volume":"32","author":"Neves","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110098_bb0100","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1021\/acsbiomaterials.7b00103","article-title":"Metal ion coordination polymer-capped pH-triggered drug release system on titania nanotubes for enhancing self-antibacterial capability of Ti implants","volume":"3","author":"Wang","year":"2017","journal-title":"ACS Biomaterials Science and Engineering"},{"key":"10.1016\/j.msec.2019.110098_bb0105","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1021\/bm301524e","article-title":"Combined effects of Ag nanoparticles and oxygen plasma treatment on PLGA morphological, chemical, and antibacterial properties","volume":"14","author":"Fortunati","year":"2013","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.msec.2019.110098_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2015.00372","article-title":"Chitosan nanoparticles loaded with the antimicrobial peptide temporin B exert a long-term antibacterial activity in vitro against clinical isolates of Staphylococcus epidermidis","volume":"6","author":"Piras","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.msec.2019.110098_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10856-015-5626-9","article-title":"Combined delivery of PDGF-BB and BMP-6 for enhanced osteoblastic differentiation","volume":"27","author":"Demirta\u015f","year":"2016","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.msec.2019.110098_bb0120","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/aa7b1d","article-title":"A bioprintable form of chitosan hydrogel for bone tissue engineering","volume":"9","author":"Demirta\u015f","year":"2017","journal-title":"Biofabrication"},{"key":"10.1016\/j.msec.2019.110098_bb0125","doi-asserted-by":"crossref","first-page":"8886","DOI":"10.1039\/C6RA26020A","article-title":"Enhanced proliferation and osteogenic differentiation of MC3T3-E1 pre-osteoblasts on graphene oxide-impregnated PLGA-gelatin nanocomposite fibrous membranes","volume":"7","author":"Fu","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.msec.2019.110098_bb0130","doi-asserted-by":"crossref","first-page":"10186","DOI":"10.1073\/pnas.0602439103","article-title":"Exceptional chemical and thermal stability of zeolitic imidazolate frameworks","volume":"103","author":"Park","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.msec.2019.110098_bb0135","doi-asserted-by":"crossref","first-page":"8779","DOI":"10.1039\/C4CC02570A","article-title":"Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release","volume":"50","author":"Zhu","year":"2014","journal-title":"Chem. Commun."},{"key":"10.1016\/j.msec.2019.110098_bb0140","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/adma.200401085","article-title":"Incorporation of highly dispersed gold nanoparticles into the pore channels of mesoporous silica thin films and their ultrafast nonlinear optical response","volume":"17","author":"Gu","year":"2005","journal-title":"Adv. Mater."},{"key":"10.1016\/j.msec.2019.110098_bb0145","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1039\/c2nj40482f","article-title":"Calcium doped mesoporous silica nanoparticles as efficient alendronate delivery vehicles","volume":"36","author":"Gu","year":"2012","journal-title":"New J. Chem."},{"key":"10.1016\/j.msec.2019.110098_bb0150","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.ijbiomac.2016.06.039","article-title":"Antibacterial electrospun chitosan-polyethylene oxide nanocomposite mats containing ZIF-8 nanoparticles","volume":"91","author":"Kohsari","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.msec.2019.110098_bb0155","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.carbpol.2016.07.081","article-title":"Preparation of pure chitosan film using ternary solvents and its super absorbency","volume":"153","author":"Wang","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.msec.2019.110098_bb0160","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/jbm.a.30533","article-title":"Preparation and swelling behavior of chitosan-based superporous hydrogels for gastric retention application","volume":"76","author":"Park","year":"2006","journal-title":"Journal of Biomedical Materials Research - Part A"},{"key":"10.1016\/j.msec.2019.110098_bb0165","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.actbio.2011.03.005","article-title":"Inhibition of bacterial adhesion on biocompatible zwitterionic SBA-15 mesoporous materials","volume":"7","author":"Izquierdo-Barba","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2019.110098_bb0170","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/jbm.a.35960","article-title":"Osteogenic activity and antibacterial effect of porous titanium modified with metal-organic framework films","volume":"105","author":"Chen","year":"2017","journal-title":"Journal of Biomedical Materials Research - Part A"},{"key":"10.1016\/j.msec.2019.110098_bb0175","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1039\/C3TB20832J","article-title":"Cytotoxicity of nanoscaled metal\u2013organic frameworks","volume":"2","author":"Tamames-Tabar","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.msec.2019.110098_bb0180","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1039\/C5RA24336J","article-title":"Surface defection reduces cytotoxicity of Zn(2\u2011methylimidazole)2(ZIF-8) without compromising its drug delivery capacity","volume":"6","author":"Shearier","year":"2016","journal-title":"RSC Adv."}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493119304734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493119304734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:48:03Z","timestamp":1760532483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493119304734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":36,"alternative-id":["S0928493119304734"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2019.110098","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metal-organic frameworks for on-demand pH controlled delivery of vancomycin from chitosan scaffolds","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2019.110098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110098"}}