{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:57:00Z","timestamp":1790445420144,"version":"4.1.0"},"reference-count":129,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007586","name":"Aix-Marseille Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.msec.2019.110354","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T19:53:41Z","timestamp":1571860421000},"page":"110354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Motor and sensitive recovery after injection of a physically cross-linked PNIPAAm-g-PEG hydrogel in rat hemisectioned spinal cord"],"prefix":"10.1016","volume":"107","author":[{"given":"Maxime","family":"Bonnet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Trimaille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Brezun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Feron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Gigmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanguy","family":"Marqueste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Decherchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2019.110354_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2017.00430","article-title":"Biomaterial-supported cell transplantation treatments for spinal cord injury: challenges and perspectives","volume":"11","author":"Liu","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.msec.2019.110354_bib2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.biomaterials.2005.07.045","article-title":"Multiple-channel scaffolds to promote spinal cord axon regeneration","volume":"27","author":"Moore","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110354_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088593","article-title":"Poly(Trimethylene carbonate-co-epsilon-caprolactone) promotes axonal growth","volume":"9","author":"Rocha","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.msec.2019.110354_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.2009.0948","article-title":"Biomaterial design strategies for the treatment of spinal cord injuries","volume":"27","author":"Straley","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.msec.2019.110354_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s12264-013-1362-7","article-title":"Biomaterials for spinal cord repair","volume":"29","author":"Haggerty","year":"2013","journal-title":"Neuroscience Bulletin"},{"key":"10.1016\/j.msec.2019.110354_bib6","doi-asserted-by":"crossref","DOI":"10.1186\/scrt480","article-title":"Repair of injured spinal cord using biomaterial scaffolds and stem cells","volume":"5","author":"Shrestha","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.msec.2019.110354_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.resp.2009.08.015","article-title":"Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds","volume":"169","author":"Madigan","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.msec.2019.110354_bib8","doi-asserted-by":"crossref","first-page":"726","DOI":"10.4103\/1673-5374.156966","article-title":"Advances in regenerative therapies for spinal cord injury: a biomaterials approach","volume":"10","author":"Tsintou","year":"2015","journal-title":"Neural Regeneration Research"},{"key":"10.1016\/j.msec.2019.110354_bib9","doi-asserted-by":"crossref","first-page":"806","DOI":"10.2741\/2721","article-title":"Biomimetic material systems for neural progenitor cell-based therapy","volume":"13","author":"Potter","year":"2008","journal-title":"Frontiers in Bioscience-Landmark"},{"key":"10.1016\/j.msec.2019.110354_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201601130","article-title":"Combinatorial therapies after spinal cord injury: how can biomaterials help?","volume":"6","author":"Fuhrmann","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.msec.2019.110354_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2017.00245","article-title":"Biomaterials for local, controlled drug delivery to the injured spinal cord","volume":"8","author":"Ziemba","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.msec.2019.110354_bib12","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/7\/1\/012001","article-title":"Injectable hydrogel materials for spinal cord regeneration: a review","volume":"7","author":"Macaya","year":"2012","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.msec.2019.110354_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2015.00013","article-title":"Hydrogels as scaffolds and delivery systems to enhance axonal regeneration after injuries","volume":"9","author":"Carballo-Molina","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.msec.2019.110354_bib14","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/adma.200802106","article-title":"Hydrogels in regenerative medicine","volume":"21","author":"Slaughter","year":"2009","journal-title":"Adv. Mater."},{"key":"10.1016\/j.msec.2019.110354_bib15","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1021\/cn200030w","article-title":"Hydrogels in spinal cord injury repair strategies","volume":"2","author":"Perale","year":"2011","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.msec.2019.110354_bib16","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/j.biomaterials.2005.11.015","article-title":"Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord","volume":"27","author":"Gupta","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110354_bib17","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.jconrel.2012.03.002","article-title":"Hydrogels for protein delivery in tissue engineering","volume":"161","author":"Censi","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.msec.2019.110354_bib18","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1021\/bi00350a005","article-title":"Basement-membrane complexes with biological-activity","volume":"25","author":"Kleinman","year":"1986","journal-title":"Biochemistry"},{"key":"10.1016\/j.msec.2019.110354_bib19","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1002\/jnr.22472","article-title":"Self-assembling peptide amphiphile promotes plasticity of serotonergic fibers following spinal cord injury","volume":"88","author":"Tysseling","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.msec.2019.110354_bib20","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1089\/scd.2012.0616","article-title":"Adjusting the chemical and physical properties of hydrogels leads to improved stem cell survival and tissue ingrowth in spinal cord injury reconstruction: a comparative study of four methacrylate hydrogels","volume":"22","author":"Hejcl","year":"2013","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.msec.2019.110354_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biomaterials.2014.11.017","article-title":"Creating stiffness gradient polyvinyl alcohol hydrogel using a simple gradual freezing-thawing method to investigate stem cell differentiation behaviors","volume":"40","author":"Kim","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110354_bib22","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/jbm.b.30157","article-title":"In vitro and in vivo biocompatibility evaluation of a polyalkylimide hydrogel for soft tissue augmentation","volume":"72B","author":"Ramires","year":"2005","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.msec.2019.110354_bib23","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1016\/j.biomaterials.2009.01.056","article-title":"Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the central nervous system","volume":"30","author":"Yang","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110354_bib24","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1460-9568.2008.06567.x","article-title":"Engineering angiogenesis following spinal cord injury: a coculture of neural progenitor and endothelial cells in a degradable polymer implant leads to an increase in vessel density and formation of the blood-spinal cord barrier","volume":"29","author":"Rauch","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.msec.2019.110354_bib25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/AN20120082","article-title":"The use of poly(N-[2-hydroxypropyl]-methacrylamide) hydrogel to repair a T10 spinal cord hemisection in rat: a behavioural, electrophysiological and anatomical examination","volume":"5","author":"Pertici","year":"2013","journal-title":"Asn Neuro"},{"key":"10.1016\/j.msec.2019.110354_bib26","doi-asserted-by":"crossref","first-page":"6248","DOI":"10.1016\/j.biomaterials.2014.04.020","article-title":"Repair of the injured spinal cord by implantation of a synthetic degradable block copolymer in rat","volume":"35","author":"Pertici","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110354_bib27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.nbd.2014.03.018","article-title":"Long-lasting significant functional improvement in chronic severe spinal cord injury following scar resection and polyethylene glycol implantation","volume":"67","author":"Estrada","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.msec.2019.110354_bib28","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/0142-9612(93)90205-G","article-title":"Hydrogels for neural tissue reconstruction and transplantation","volume":"14","author":"Woerly","year":"1993","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110354_bib29","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1021\/bm800234r","article-title":"Development of a sialic acid-containing hydrogel of poly[N-(2-hydroxypropyl) methacrylamide]: characterization and implantation study","volume":"9","author":"Woerly","year":"2008","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.msec.2019.110354_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1227\/01.neu.0000243297.69189.f8","article-title":"Complete spinal cord transection treated by implantation of a reinforced synthetic hydrogel channel results in syringomyelia and caudal migration of the rostral stump","volume":"59","author":"Nomura","year":"2006","journal-title":"Neurosurgery"},{"key":"10.1016\/j.msec.2019.110354_bib31","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.33549\/physiolres.931606","article-title":"Biocompatible hydrogels in spinal cord injury repair","volume":"57","author":"Hejcl","year":"2008","journal-title":"Physiol. Res."},{"key":"10.1016\/j.msec.2019.110354_bib32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3171\/SPI-08\/01\/067","article-title":"Acute and delayed implantation of positively charged 2-hydroxyethyl methacrylate scaffolds in spinal cord injury in the rat","volume":"8","author":"Hejcl","year":"2008","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.msec.2019.110354_bib33","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1007\/s10856-009-3714-4","article-title":"Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 6: 3D hydrogels with positive and negative surface charges and polyelectrolyte complexes in spinal cord injury repair","volume":"20","author":"Hejcl","year":"2009","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.msec.2019.110354_bib34","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1089\/scd.2009.0378","article-title":"HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury","volume":"19","author":"Hejcl","year":"2010","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.msec.2019.110354_bib35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/rb\/rbv012","article-title":"Bridging the lesion-engineering a permissive substrate for nerve regeneration","volume":"2","author":"Pires","year":"2015","journal-title":"Regenerative Biomaterials"},{"key":"10.1016\/j.msec.2019.110354_bib36","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1089\/0897715041269687","article-title":"Synthetic hydrogel guidance channels facilitate regeneration of adult rat brainstem motor axons after complete spinal cord transection","volume":"21","author":"Tsai","year":"2004","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.msec.2019.110354_bib37","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.4103\/1673-5374.208597","article-title":"Polyethylene glycol as a promising synthetic material for repair of spinal cord injury","volume":"12","author":"Kong","year":"2017","journal-title":"Neural Regeneration Research"},{"key":"10.1016\/j.msec.2019.110354_bib38","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1089\/0897715041651097","article-title":"Polyethylene glycol improves function and reduces oxidative stress in synaptosomal preparations following spinal cord injury","volume":"21","author":"Luo","year":"2004","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.msec.2019.110354_bib39","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s10571-006-9007-2","article-title":"Bone marrow stem cells and polymer hydrogels-two strategies for spinal cord injury repair","volume":"26","author":"Sykova","year":"2006","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.msec.2019.110354_bib40","first-page":"367","article-title":"In vivo tracking of stem cells in brain and spinal cord injury","volume":"161","author":"Sykova","year":"2007","journal-title":"Neurotrauma: New Insights into Pathology and Treatment"},{"key":"10.1016\/j.msec.2019.110354_bib41","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1016\/S0142-9612(02)00120-5","article-title":"Manufacture of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel tubes for use as nerve guidance channels","volume":"23","author":"Dalton","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110354_bib42","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1179\/016164101101198622","article-title":"Acrylic hydrogel implants after spinal cord lesion in the adult rat","volume":"23","author":"Giannetti","year":"2001","journal-title":"Neurol. Res."},{"key":"10.1016\/j.msec.2019.110354_bib43","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/wnan.10","article-title":"Hydrogel mediated delivery of trophic factors for neural repair","volume":"1","author":"Katz","year":"2009","journal-title":"Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology"},{"key":"10.1016\/j.msec.2019.110354_bib44","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/7\/2\/024101","article-title":"Injectable hydrogels for central nervous system therapy","volume":"7","author":"Pakulska","year":"2012","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.msec.2019.110354_bib45","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.nano.2007.09.003","article-title":"Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold","volume":"3","author":"Guo","year":"2007","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.msec.2019.110354_bib46","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1523\/JNEUROSCI.0143-08.2008","article-title":"Self-assembling nanofibers inhibit glial scar formation and promote axon elongation after spinal cord injury","volume":"28","author":"Tysseling-Mattiace","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.msec.2019.110354_bib47","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1016\/j.actbio.2013.06.001","article-title":"A self-assembling peptide reduces glial scarring, attenuates post-traumatic inflammation and promotes neurological recovery following spinal cord injury","volume":"9","author":"Liu","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2019.110354_bib48","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.expneurol.2006.04.020","article-title":"An injectable, biodegradable hydrogel for trophic factor delivery enhances axonal rewiring and improves performance after spinal cord injury","volume":"201","author":"Piantino","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.msec.2019.110354_bib49","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejpb.2007.02.025","article-title":"Thermoresponsive hydrogels in biomedical applications","volume":"68","author":"Klouda","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.msec.2019.110354_bib50","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.colsurfb.2016.05.094","article-title":"Evaluation of hydrogel composing of Pluronic F127 and carboxymethyl hexanoyl chitosan as injectable scaffold for tissue engineering applications","volume":"146","author":"Yap","year":"2016","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"10.1016\/j.msec.2019.110354_bib51","doi-asserted-by":"crossref","DOI":"10.1007\/s10856-015-5493-4","article-title":"Pluronic F-127 hydrogel as a promising scaffold for encapsulation of dental-derived mesenchymal stem cells","volume":"26","author":"Diniz","year":"2015","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.msec.2019.110354_bib52","first-page":"151","article-title":"Thermoreversible Pluronic (R) F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies","volume":"6","author":"Nie","year":"2011","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.msec.2019.110354_bib53","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0378-5173(99)00119-2","article-title":"Absorption of insulin from Pluronic F-127 gels following subcutaneous administration in rats","volume":"184","author":"Barichello","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.msec.2019.110354_bib54","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0378-5173(92)90269-8","article-title":"Polyoxyethylene-polyoxypropylene block copolymer gels as sustained-release vehicles for subcutaneous drug administration","volume":"80","author":"Guzman","year":"1992","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.msec.2019.110354_bib55","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jconrel.2009.01.007","article-title":"A novel mixed micelle gel with thermo-sensitive property for the local delivery of docetaxel","volume":"135","author":"Yang","year":"2009","journal-title":"J. Control. Release"},{"key":"10.1016\/j.msec.2019.110354_bib56","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/adhm.201600055","article-title":"An in situ gelling drug delivery system for improved recovery after spinal cord injury","volume":"5","author":"Liu","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.msec.2019.110354_bib57","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jconrel.2015.03.003","article-title":"A functionalized, injectable hydrogel for localized drug delivery with tunable thermosensitivity: synthesis and characterization of physical and toxicological properties","volume":"208","author":"Elias","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.msec.2019.110354_bib58","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1021\/acsbiomaterials.5b00153","article-title":"Thermoresponsive copolypeptide hydrogel vehicles for central nervous system cell delivery","volume":"1","author":"Zhang","year":"2015","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.msec.2019.110354_bib59","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10118-016-1740-5","article-title":"An injectable hydrogel with or without drugs for prevention of epidural scar adhesion after laminectomy in rats","volume":"34","author":"Chen","year":"2016","journal-title":"Chin. J. Polym. Sci."},{"key":"10.1016\/j.msec.2019.110354_bib60","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-00583-8","article-title":"An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling","volume":"8","author":"Hong","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.msec.2019.110354_bib61","article-title":"Functional test scales for evaluating cell-based therapies in animal models of spinal cord injury","volume":"2017","author":"Kim","year":"2017","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.msec.2019.110354_bib62","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.actbio.2010.12.027","article-title":"Thermoresponsive, in situ cross-linkable hydrogels based on N-isopropylacrylamide: fabrication, characterization and mesenchymal stem cell encapsulation","volume":"7","author":"Klouda","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2019.110354_bib63","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/jbm.b.30844","article-title":"Evaluation of novel injectable hydrogels for nucleus pulposus replacement","volume":"84B","author":"Vernengo","year":"2008","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.msec.2019.110354_bib64","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1021\/j100345a085","article-title":"Phase-transition of aqueous-solutions of poly(N-isopropylacrylamide) and poly(N-isopropylmethacrylamide)","volume":"93","author":"Fujishige","year":"1989","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.msec.2019.110354_bib65","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.progpolymsci.2004.08.003","article-title":"Stimuli-reponsive polymers and their bioconjugates","volume":"29","author":"Gil","year":"2004","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.msec.2019.110354_bib66","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1021\/bm025692t","article-title":"Copolymerization of 2-carboxyisopropylacrylamide with N-isopropylacrylamide accelerates cell detachment from grafted surfaces by reducing temperature","volume":"4","author":"Ebara","year":"2003","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.msec.2019.110354_bib67","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/adfm.201404247","article-title":"Conductive \"smart\" hybrid hydrogels with PNIPAM and nanostructured conductive polymers","volume":"25","author":"Shi","year":"2015","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.msec.2019.110354_bib68","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1016\/j.biomaterials.2006.02.042","article-title":"Preparation, properties and controlled release behaviors of pH-induced thermosensitive amphiphilic gels","volume":"27","author":"Liu","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110354_bib69","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1016\/j.biomaterials.2006.05.019","article-title":"Bio-functionalized thermoresponsive interfaces facilitating cell adhesion and proliferation","volume":"27","author":"Hatakeyama","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110354_bib70","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jconrel.2006.07.007","article-title":"Molecular design of biodegradable polymeric micelles for temperature-responsive drug release","volume":"115","author":"Nakayama","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.msec.2019.110354_bib71","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jconrel.2004.04.014","article-title":"Effect of drug physicochemical properties on swelling\/deswelling kinetics and pulsatile drug release from thermoresponsive poly(N-isopropylacrylamide) hydrogels","volume":"98","author":"Coughlan","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.msec.2019.110354_bib72","doi-asserted-by":"crossref","first-page":"5951","DOI":"10.1016\/j.biomaterials.2006.08.012","article-title":"Delivery of dexamethasone, ascorbate, and growth factor (TGF beta-3) in thermo-reversible hydrogel constructs embedded with rabbit chondrocytes","volume":"27","author":"Na","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110354_bib73","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0169-409X(02)00041-8","article-title":"Targeted drug delivery by thermally responsive polymers","volume":"54","author":"Chilkoti","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.msec.2019.110354_bib74","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1021\/bm0507812","article-title":"Poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers that respond sharply to temperature and pH","volume":"7","author":"Yin","year":"2006","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.msec.2019.110354_bib75","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ejpb.2014.07.005","article-title":"Polyethylene glycol (PEG)-Poly(N-isopropylacrylamide) (PNIPAAm) based thermosensitive injectable hydrogels for biomedical applications","volume":"88","author":"Alexander","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.msec.2019.110354_bib76","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.actbio.2008.10.008","article-title":"In vitro analysis of PNIPAAm-PEG, a novel, injectable scaffold for spinal cord repair","volume":"5","author":"Comolli","year":"2009","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2019.110354_bib77","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.2116\/analsci.32.1203","article-title":"Design of tetra-arm PEG-crosslinked thermoresponsive hydrogel for 3D cell culture","volume":"32","author":"Akimoto","year":"2016","journal-title":"Anal. Sci."},{"key":"10.1016\/j.msec.2019.110354_bib78","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3171\/2011.7.SPINE11194","article-title":"A pilot study of poly(N-isopropylacrylamide)-g-polyethylene glycol and poly(N-isopropylacrylamide)-g-methylcellulose branched copolymers as injectable scaffolds for local delivery of neurotrophins and cellular transplants into the injured spinal cord","volume":"15","author":"Conova","year":"2011","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.msec.2019.110354_bib79","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3171\/2013.3.SPINE12874","article-title":"Implications of poly(N-isopropylacrylamide)-g-poly(ethylene glycol) with codissolved brain-derived neurotrophic factor injectable scaffold on motor function recovery rate following cervical dorsolateral funiculotomy in the rat","volume":"18","author":"Grous","year":"2013","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.msec.2019.110354_bib80","first-page":"1","article-title":"Isolating nasal olfactory stem cells from rodents or humans","volume":"54","author":"Girard","year":"2011","journal-title":"Jove-Journal of Visualized Experiments"},{"key":"10.1016\/j.msec.2019.110354_bib81","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jsbmb.2015.06.007","article-title":"Cholecalciferol (vitamin D-3) improves functional recovery when delivered during the acute phase after a spinal cord trauma","volume":"154","author":"Gueye","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.msec.2019.110354_bib82","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/jbm.a.36067","article-title":"Thermogelling chitosan lactate hydrogel improves functional recovery after a C2 spinal cord hemisection in rat","volume":"105","author":"Nawrotek","year":"2017","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.msec.2019.110354_bib83","series-title":"Anatomy of Descending Pathways. Comprehensive Physiology","first-page":"597","author":"Kuypers","year":"1981"},{"key":"10.1016\/j.msec.2019.110354_bib84","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0304-3940(84)90322-7","article-title":"Labeling of interneurones by retrograde transsynaptic transport of horseradish-peroxidase from motoneurones in rats and cats","volume":"45","author":"Harrison","year":"1984","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.msec.2019.110354_bib85","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0306-4522(02)00052-0","article-title":"Regeneration of acutely and chronically injured descending respiratory pathways within post-traumatic nerve grafts","volume":"112","author":"Decherchi","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.msec.2019.110354_bib86","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1089\/neu.2008.0717","article-title":"A new rating scale for open-field evaluation of behavioral recovery after cervical spinal cord injury in rats","volume":"26","author":"Martinez","year":"2009","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.msec.2019.110354_bib87","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1523\/JNEUROSCI.23-03-00727.2003","article-title":"Transplantation of olfactory ensheathing cells into spinal cord lesions restores breathing and climbing","volume":"23","author":"Li","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.msec.2019.110354_bib88","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0165-0270(02)00012-2","article-title":"Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination","volume":"115","author":"Metz","year":"2002","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.msec.2019.110354_bib89","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.expneurol.2005.02.006","article-title":"Quantitative assessment of forelimb motor function after cervical spinal cord injury in rats: relationship to the corticospinal tract","volume":"194","author":"Anderson","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.msec.2019.110354_bib90","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00423313","article-title":"Tape test as a simple new method for study of compounds increasing problem-solving ability of rat","volume":"48","author":"Ezer","year":"1976","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.msec.2019.110354_bib91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150141","article-title":"Evaluation of five tests for sensitivity to functional deficits following cervical or thoracic dorsal column transection in the rat","volume":"11","author":"Fagoe","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.msec.2019.110354_bib92","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.neuroscience.2011.04.066","article-title":"Vitamin D-3 improves respiratory adjustment to fatigue and H-reflex responses in paraplegic adult rats","volume":"188","author":"Bianco","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.msec.2019.110354_bib93","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neurobiolaging.2016.02.022","article-title":"Restoration of post-activation depression of the H-reflex by treadmill exercise in aged rats","volume":"42","author":"Caron","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.msec.2019.110354_bib94","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1152\/jn.1992.68.5.1473","article-title":"Altered patterns of reflex excitability subsequent to contusion injury of the rat spinal-cord","volume":"68","author":"Thompson","year":"1992","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.msec.2019.110354_bib95","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0006-8993(96)00556-2","article-title":"Effects of exercise and fetal spinal cord implants on the H-reflex in chronically spinalized adult rats","volume":"729","author":"Skinner","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.msec.2019.110354_bib96","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.expneurol.2008.12.009","article-title":"Better functional outcome of compression spinal cord injury in mice is associated with enhanced H-reflex responses","volume":"216","author":"Lee","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.msec.2019.110354_bib97","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.expneurol.2005.08.018","article-title":"Effect of spinal cord injury severity on alterations of the H-reflex","volume":"196","author":"Lee","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.msec.2019.110354_bib98","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/sj.sc.3101810","article-title":"Restoration of frequency-dependent depression of the H-reflex by passive exercise in spinal rats","volume":"44","author":"Reese","year":"2006","journal-title":"Spinal Cord"},{"key":"10.1016\/j.msec.2019.110354_bib99","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00221-007-1044-7","article-title":"Respiratory and cardiovascular responses evoked by tibialis anterior muscle afferent fibers in rats","volume":"183","author":"Decherchi","year":"2007","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.msec.2019.110354_bib100","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1021\/bm8000414","article-title":"Synthesis and characterization of injectable, thermally and chemically gelable, amphiphilic poly(N-isopropylacrylamide)-based macromers","volume":"9","author":"Hacker","year":"2008","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.msec.2019.110354_bib101","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0169-409X(03)00108-X","article-title":"Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates","volume":"55","author":"Caliceti","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.msec.2019.110354_bib102","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jchemneu.2017.07.004","article-title":"Mechanical properties of the human spinal cord under the compressive loading","volume":"86","author":"Karimi","year":"2017","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.msec.2019.110354_bib103","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1007\/s11051-008-9526-5","article-title":"Cytotoxic evaluation of N-isopropylacrylamide monomers and temperature-sensitive poly(N-isopropylacrylamide) nanoparticles","volume":"11","author":"Wadajkar","year":"2009","journal-title":"J. Nanoparticle Res."},{"key":"10.1016\/j.msec.2019.110354_bib104","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1016\/j.biomaterials.2004.09.008","article-title":"Cytotoxicity of thermosensitive polymers poly(N-isopropylacrylamide), poly(N-vinylcaprolactam) and amphiphilically modified poly(N-vinylcaprolactam)","volume":"26","author":"Vihola","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110354_bib105","series-title":"I materiali biocompatibili per la medicina","article-title":"Development and analysis of PNIPAAM and PNIPAL\/PEG hydrogels for brain neurodegeneration","author":"Tunesi","year":"2014"},{"key":"10.1016\/j.msec.2019.110354_bib106","article-title":"hESC-derived striatal cells generated in a 3D hydrogel promote recovery in a huntington's disease mouse model","volume":"26","author":"Adil","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.msec.2019.110354_bib107","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.stemcr.2018.03.007","article-title":"hPSC-derived striatal cells generated using a scalable 3D hydrogel promote recovery in a Huntington disease mouse model","volume":"10","author":"Adil","year":"2018","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.msec.2019.110354_bib108","doi-asserted-by":"crossref","DOI":"10.1038\/srep40573","article-title":"Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform","volume":"7","author":"Adil","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.msec.2019.110354_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.05.008","article-title":"Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons","volume":"136","author":"Adil","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2019.110354_bib110","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s11064-013-0991-6","article-title":"Spinal cord injury: a review of current therapy, future treatments, and basic science frontiers","volume":"38","author":"Varma","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.msec.2019.110354_bib111","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pneurobio.2013.11.002","article-title":"From basics to clinical: a comprehensive review on spinal cord injury","volume":"114","author":"Silva","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.msec.2019.110354_bib112","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1093\/neuros\/nyw080","article-title":"Traumatic spinal cord injury-repair and regeneration","volume":"80","author":"Ahuja","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1016\/j.msec.2019.110354_bib113","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.18","article-title":"Traumatic spinal cord injury","volume":"3","author":"Ahuja","year":"2017","journal-title":"Nature Reviews Disease Primers"},{"key":"10.1016\/j.msec.2019.110354_bib114","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.052678899","article-title":"Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells (vol 99, pg 3024, 2002)","volume":"99","author":"Teng","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.msec.2019.110354_bib115","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1007\/s00221-018-5344-x","article-title":"Effects of bioengineered scaffold loaded with neurotrophins and locomotor training in restoring H-reflex responses after spinal cord injury","volume":"236","author":"Tom","year":"2018","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.msec.2019.110354_bib116","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1021\/cr000108x","article-title":"Hydrogels for tissue engineering","volume":"101","author":"Lee","year":"2001","journal-title":"Chem. Rev."},{"key":"10.1016\/j.msec.2019.110354_bib117","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jbm.a.31063","article-title":"Fabrication and characterization of a novel composite PNIPAAm hydrogel for controlled drug release","volume":"81A","author":"Xu","year":"2007","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.msec.2019.110354_bib118","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1163\/156856200743896","article-title":"Calcification of poly(2-hydroxyethyl methacrylate) hydrogel sponges implanted in the rabbit cornea: a 3-month study","volume":"11","author":"Vijayasekaran","year":"2000","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.msec.2019.110354_bib119","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1212\/WNL.54.8.1574","article-title":"From spinal shock to spasticity - neuronal adaptations to a spinal cord injury","volume":"54","author":"Hiersemenzel","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.msec.2019.110354_bib120","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0079-6123(06)57016-5","article-title":"Functional plasticity following spinal cord lesions","volume":"157","author":"Frigon","year":"2006","journal-title":"Reprogramming the Brain"},{"key":"10.1016\/j.msec.2019.110354_bib121","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/16501960310010142","article-title":"Changes in neuronal properties and spinal reflexes during development of spasticity following spinal cord lesions and stroke: studies in animal models and patients","volume":"35","author":"Hultborn","year":"2003","journal-title":"J. Rehabil. Med."},{"key":"10.1016\/j.msec.2019.110354_bib122","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1152\/jn.00236.2003","article-title":"Persistent sodium and calcium currents cause plateau potentials in motoneurons of chronic spinal rats","volume":"90","author":"Li","year":"2003","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.msec.2019.110354_bib123","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1113\/jphysiol.1968.sp008403","article-title":"Reticulospinal inhibition of interneurons","volume":"194","author":"Engberg","year":"1968","journal-title":"J. Physiol."},{"key":"10.1016\/j.msec.2019.110354_bib124","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1113\/jphysiol.1968.sp008402","article-title":"Reticulospinal inhibition of transmission in reflex pathway","volume":"194","author":"Engberg","year":"1968","journal-title":"J. Physiol."},{"key":"10.1016\/j.msec.2019.110354_bib125","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3171\/spi.2004.1.3.0322","article-title":"Mechanically engineered hydrogel scaffolds for axonal growth and angiogenesis after transplantation in spinal cord injury","volume":"1","author":"Bakshi","year":"2004","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.msec.2019.110354_bib126","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1089\/08977150151070937","article-title":"Grafting of encapsulated BDNF-producing fibroblasts into the injured spinal cord without immune suppression in adult rats","volume":"18","author":"Tobias","year":"2001","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.msec.2019.110354_bib127","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1089\/neu.2005.22.138","article-title":"Alginate encapsulated BDNF-producing fibroblast grafts permit recovery of function after spinal cord injury in the absence of immune suppression","volume":"22","author":"Tobias","year":"2005","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.msec.2019.110354_bib128","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.actbio.2017.07.024","article-title":"Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury","volume":"60","author":"Liu","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2019.110354_bib129","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/10717544.2016.1256003","article-title":"Effective improvement of the neuroprotective activity after spinal cord injury by synergistic effect of glucocorticoid with biodegradable amphipathic nanomicelles","volume":"24","author":"Wang","year":"2017","journal-title":"Drug Deliv."}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493119314730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493119314730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:44:58Z","timestamp":1760532298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493119314730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":129,"alternative-id":["S0928493119314730"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2019.110354","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Motor and sensitive recovery after injection of a physically cross-linked PNIPAAm-g-PEG hydrogel in rat hemisectioned spinal cord","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2019.110354","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110354"}}