{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:47:12Z","timestamp":1789026432399,"version":"build-2803163510"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Uka Tarsadia University","award":["UTU\/RPS\/2693\/2017"],"award-info":[{"award-number":["UTU\/RPS\/2693\/2017"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.msec.2020.110885","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T20:13:03Z","timestamp":1584994383000},"page":"110885","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"special_numbering":"C","title":["Multiple drug delivery from the drug-implants-laden silicone contact lens: Addressing the issue of burst drug release"],"prefix":"10.1016","volume":"112","author":[{"given":"Ankita R.","family":"Desai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furqan A.","family":"Maulvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditixa M.","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish R.","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketan M.","family":"Ranch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavin A.","family":"Vyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh A.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Sandeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh O.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.msec.2020.110885_bb0005","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/112067210901900110","article-title":"Efficacy of the fixed combinations of bimatoprost or latanoprost plus timolol in patients uncontrolled with prostaglandin monotherapy: a multicenter, randomized, investigator-masked, clinical study","volume":"19","author":"Centofanti","year":"2009","journal-title":"Eur. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.msec.2020.110885_bb0010","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/IJG.0b013e3181507313","article-title":"Bimatoprost\/timolol fixed combination: a 3-month double-masked, randomized parallel comparison to its individual components in patients with glaucoma or ocular hypertension","volume":"17","author":"Brandt","year":"2008","journal-title":"J. Glaucoma"},{"issue":"1","key":"10.1016\/j.msec.2020.110885_bb0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/112067210701700108","article-title":"A double-masked, randomized, parallel comparison of a fixed combination of bimatoprost 0.03%\/timolol 0.5% with non-fixed combination use in patients with glaucoma or ocular hypertension","volume":"17","author":"Hommer","year":"2007","journal-title":"Eur. J. Ophthalmol."},{"issue":"11","key":"10.1016\/j.msec.2020.110885_bb0020","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.addr.2006.07.027","article-title":"Challenges and obstacles of ocular pharmacokinetics and drug delivery","volume":"58","author":"Urtti","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.msec.2020.110885_bb0025","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1001\/archopht.1975.01010020046008","article-title":"Effects of drug vehicles on ocular contact time","volume":"93","author":"Hardberger","year":"1975","journal-title":"Arch. Ophthalmol."},{"issue":"2","key":"10.1016\/j.msec.2020.110885_bb0030","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1517\/17425247.3.2.275","article-title":"Ocular drug delivery","volume":"3","author":"Ghate","year":"2006","journal-title":"Expert opinion on drug delivery"},{"issue":"3","key":"10.1016\/j.msec.2020.110885_bb0035","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s12325-008-0029-7","article-title":"A multicentre evaluation of the effect of patient education on acceptance of hyperaemia associated with bimatoprost therapy for glaucoma or ocular hypertension","volume":"25","author":"Trattler","year":"2008","journal-title":"Adv. Ther."},{"issue":"6","key":"10.1016\/j.msec.2020.110885_bb0040","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s00417-002-0462-2","article-title":"Systemic bioavailability and cardiopulmonary effects of 0.5% timolol eyedrops","volume":"240","author":"Korte","year":"2002","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"11","key":"10.1016\/j.msec.2020.110885_bb0045","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0161-6420(84)34141-0","article-title":"Plasma timolol in glaucoma patients","volume":"91","author":"Passo","year":"1984","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.msec.2020.110885_bb0050","first-page":"137","article-title":"Diagnosis and management of red eye in primary care","volume":"81","author":"Cronau","year":"2010","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.msec.2020.110885_bb0055","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ijpharm.2018.11.016","article-title":"Optimization of a novel in situ gel for sustained ocular drug delivery using Box-Behnken design: in vitro, ex vivo, in vivo and human studies","volume":"554","author":"Ranch","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.msec.2020.110885_bb0060","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1773-2247(11)50062-0","article-title":"Controlled drug release from contact lenses: a comprehensive review from 1965-present","volume":"21","author":"White","year":"2011","journal-title":"Journal of drug delivery science and technology"},{"issue":"7","key":"10.1016\/j.msec.2020.110885_bb0065","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1167\/iovs.03-0959","article-title":"Ophthalmic drug delivery through contact lenses","volume":"45","author":"Gulsen","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.msec.2020.110885_bb0070","series-title":"Seminars in Ophthalmology","first-page":"156","article-title":"Contact lenses for drug delivery","author":"Ciolino","year":"2009"},{"issue":"11","key":"10.1016\/j.msec.2020.110885_bb0075","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.13-13166","article-title":"The TFOS international workshop on contact lens discomfort: report of the management and therapy subcommittee management and treatment of CLD","volume":"54","author":"Papas","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.msec.2020.110885_bb0080","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S1773-2247(14)50021-4","article-title":"Review of ophthalmic drug delivery by contact lenses","volume":"24","author":"Hsu","year":"2014","journal-title":"Journal of drug delivery science and technology"},{"issue":"11","key":"10.1016\/j.msec.2020.110885_bb0085","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1517\/17425247.2013.821462","article-title":"Contact lenses as a platform for ocular drug delivery","volume":"10","author":"Bengani","year":"2013","journal-title":"Expert Opinion on Drug Delivery"},{"issue":"10","key":"10.1016\/j.msec.2020.110885_bb0090","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1517\/13543776.2015.1057501","article-title":"Therapeutic contact lenses: a patent review","volume":"25","author":"Dixon","year":"2015","journal-title":"Expert Opinion on Therapeutic Patents"},{"key":"10.1016\/j.msec.2020.110885_bb0095","series-title":"Supercritical Fluid Technology: A Promising Approach to Enhance the Drug Solubility","first-page":"1","author":"Thakkar","year":"2009"},{"issue":"3","key":"10.1016\/j.msec.2020.110885_bb0100","first-page":"101","article-title":"Development of in situ ophthalmic gel of dexamethasone sodium phosphate and chloramphenicol: a viable alternative to conventional eye drops","volume":"7","author":"Ranch","year":"2017","journal-title":"Journal of Applied Pharmaceutical Science"},{"key":"10.1016\/j.msec.2020.110885_bb0105","first-page":"44","article-title":"Application of 3D printing technology in the development of novel drug delivery systems","author":"Maulvi","year":"2017","journal-title":"International Journal of Drug Development and Research"},{"issue":"1","key":"10.1016\/j.msec.2020.110885_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1874844901502010001","article-title":"Extended release of timolol from ethyl cellulose microparticles laden hydrogel contact lenses","volume":"2","author":"Maulvi","year":"2015","journal-title":"Open Pharmaceutical Sciences Journal"},{"key":"10.1016\/j.msec.2020.110885_bb0115","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jconrel.2015.01.023","article-title":"Sustained drug release by contact lenses for glaucoma treatment\u2014a review","volume":"202","author":"Carvalho","year":"2015","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.msec.2020.110885_bb0120","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.clae.2007.09.002","article-title":"Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: a review","volume":"31","author":"Xinming","year":"2008","journal-title":"Contact Lens and Anterior Eye"},{"issue":"14","key":"10.1016\/j.msec.2020.110885_bb0125","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1016\/j.biomaterials.2010.01.113","article-title":"Extended delivery of hydrophilic drugs from silicone-hydrogel contact lenses containing vitamin E diffusion barriers","volume":"31","author":"Peng","year":"2010","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.msec.2020.110885_bb0130","first-page":"44","article-title":"Application of 3D printing technology in the development of novel drug delivery systems","volume":"9","author":"Maulvi","year":"2017","journal-title":"International Journal of Drug Development and Research"},{"issue":"8","key":"10.1016\/j.msec.2020.110885_bb0135","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.3109\/10717544.2016.1138342","article-title":"A review on therapeutic contact lenses for ocular drug delivery","volume":"23","author":"Maulvi","year":"2016","journal-title":"Drug delivery"},{"key":"10.1016\/j.msec.2020.110885_bb0140","series-title":"The 2005 Annual Meeting","article-title":"Ophthalmic drug delivery of timolol by soaked contact lenses","author":"Li","year":"2005"},{"issue":"2","key":"10.1016\/j.msec.2020.110885_bb0145","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.actbio.2009.07.021","article-title":"Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release","volume":"6","author":"Xu","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2020.110885_bb0150","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ejpb.2015.06.001","article-title":"Dual drug delivery from vitamin E loaded contact lenses for glaucoma therapy","volume":"94","author":"Hsu","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"10.1016\/j.msec.2020.110885_bb0155","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jconrel.2012.10.010","article-title":"Glaucoma therapy by extended release of timolol from nanoparticle loaded silicone-hydrogel contact lenses","volume":"165","author":"Jung","year":"2013","journal-title":"J. Control. Release"},{"issue":"11","key":"10.1016\/j.msec.2020.110885_bb0160","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.biomaterials.2004.04.030","article-title":"Ocular release of timolol from molecularly imprinted soft contact lenses","volume":"26","author":"Hiratani","year":"2005","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.msec.2020.110885_bb0165","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.biomaterials.2013.09.032","article-title":"In vivo performance of a drug-eluting contact lens to treat glaucoma for a month","volume":"35","author":"Ciolino","year":"2014","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.msec.2020.110885_bb0170","doi-asserted-by":"crossref","first-page":"6286","DOI":"10.1167\/iovs.10-6935","article-title":"A prototype antifungal contact lens","volume":"52","author":"Ciolino","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1\u20133","key":"10.1016\/j.msec.2020.110885_bb0175","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.supflu.2010.02.007","article-title":"Anti-glaucoma drug-loaded contact lenses prepared using supercritical solvent impregnation","volume":"53","author":"Costa","year":"2010","journal-title":"J. Supercrit. Fluids"},{"issue":"1","key":"10.1016\/j.msec.2020.110885_bb0180","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ijpharm.2017.09.029","article-title":"Development and characterisation of electrospun timolol maleate-loaded polymeric contact lens coatings containing various permeation enhancers","volume":"532","author":"Mehta","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"10","key":"10.1016\/j.msec.2020.110885_bb0185","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.ophtha.2017.04.022","article-title":"Long-term safety and efficacy of a sustained-release bimatoprost ocular ring","volume":"124","author":"Brandt","year":"2017","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1016\/j.msec.2020.110885_bb0190","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.ophtha.2016.04.026","article-title":"Six-month intraocular pressure reduction with a topical bimatoprost ocular insert: results of a phase II randomized controlled study","volume":"123","author":"Brandt","year":"2016","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.msec.2020.110885_bb0195","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1089\/jop.2012.0212","article-title":"Contact lenses: promising devices for ocular drug delivery","volume":"29","author":"Guzman-Aranguez","year":"2013","journal-title":"J. Ocul. Pharmacol. Ther."},{"issue":"9","key":"10.1016\/j.msec.2020.110885_bb0200","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/S0161-6420(95)30862-7","article-title":"Acanthamoeba keratitis: contact lens and noncontact lens characteristics","volume":"102","author":"Chynn","year":"1995","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1016\/j.msec.2020.110885_bb0205","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1056\/NEJM198909213211201","article-title":"The relative risk of ulcerative keratitis among users of daily-wear and extended-wear soft contact lenses","volume":"321","author":"Schein","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.msec.2020.110885_bb0210","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jconrel.2016.02.012","article-title":"In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery","volume":"226","author":"Maulvi","year":"2016","journal-title":"J. Control. Release"},{"issue":"15","key":"10.1016\/j.msec.2020.110885_bb0215","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1080\/09205063.2015.1072902","article-title":"Extended release of hyaluronic acid from hydrogel contact lenses for dry eye syndrome","volume":"26","author":"Maulvi","year":"2015","journal-title":"J. Biomater. Sci. Polym. Ed."},{"issue":"6","key":"10.1016\/j.msec.2020.110885_bb0220","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1039\/C8BM00212F","article-title":"Co-delivery of timolol and hyaluronic acid from semi-circular ring-implanted contact lenses for the treatment of glaucoma: in vitro and in vivo evaluation","volume":"6","author":"Desai","year":"2018","journal-title":"Biomaterials science"},{"key":"10.1016\/j.msec.2020.110885_bb0225","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.actbio.2017.01.063","article-title":"Design and optimization of a novel implantation technology in contact lenses for the treatment of dry eye syndrome: in vitro and in vivo evaluation","volume":"53","author":"Maulvi","year":"2017","journal-title":"Acta Biomater."},{"issue":"1\u20132","key":"10.1016\/j.msec.2020.110885_bb0230","first-page":"205","article-title":"Dexamethasone transport and ocular delivery from poly (hydroxyethyl methacrylate) gels","volume":"353","author":"Kim","year":"2008","journal-title":"Int. J. Pharm."},{"issue":"10","key":"10.1016\/j.msec.2020.110885_bb0235","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1002\/jps.10209","article-title":"Soft contact lenses capable of sustained delivery of timolol","volume":"91","author":"Alvarez Lorenzo","year":"2002","journal-title":"J. Pharm. Sci."},{"issue":"4","key":"10.1016\/j.msec.2020.110885_bb0240","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/jps.20761","article-title":"Improving the loading and release of NSAIDs from pHEMA hydrogels by copolymerization with functionalized monomers","volume":"96","author":"Andrade Vivero","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.msec.2020.110885_bb0245","first-page":"1429","article-title":"Development and validation of stability indicating reverse phase high performance liquid chromatography method for timolol maleate","volume":"6","author":"Laddha","year":"2014","journal-title":"Int J PharmTech Res"},{"key":"10.1016\/j.msec.2020.110885_bb0250","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1016\/S0039-6257(02)00323-5","article-title":"The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist","volume":"47","author":"Maxey","year":"2002","journal-title":"Surv. Ophthalmol."},{"issue":"10","key":"10.1016\/j.msec.2020.110885_bb0255","first-page":"3733","article-title":"Development and validation of RP-HPLC method for estimation of bimatoprost in pharmaceutical dosage forms","volume":"4","author":"Kumar","year":"2011","journal-title":"J. Pharm. Res."},{"issue":"3","key":"10.1016\/j.msec.2020.110885_bb0260","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.clae.2009.02.006","article-title":"Hyaluronic acid in hydrophilic contact lenses: spectroscopic investigation of the content and release in solution","volume":"32","author":"Fagnola","year":"2009","journal-title":"Contact Lens and Anterior Eye"},{"issue":"2","key":"10.1016\/j.msec.2020.110885_bb0265","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1006\/abio.1993.1520","article-title":"Spectrophotometric method for the assay of glycosaminoglycans and glycosaminoglycan-depolymerizing enzymes","volume":"214","author":"Homer","year":"1993","journal-title":"Anal. Biochem."},{"issue":"4","key":"10.1016\/j.msec.2020.110885_bb0270","first-page":"294","article-title":"Ultraviolet radiation for the sterilization of contact lenses","volume":"16","author":"Gritz","year":"1990","journal-title":"The CLAO journal: official publication of the Contact Lens Association of Ophthalmologists, Inc"},{"issue":"2","key":"10.1016\/j.msec.2020.110885_bb0275","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0168-3659(02)00213-4","article-title":"Timolol uptake and release by imprinted soft contact lenses made of N, N-diethylacrylamide and methacrylic acid","volume":"83","author":"Hiratani","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.msec.2020.110885_bb0280","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.actbio.2019.01.004","article-title":"Effect of gold nanoparticles on timolol uptake and its release kinetics from contact lenses: in vitro and in vivo evaluation","volume":"86","author":"Maulvi","year":"2019","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.msec.2020.110885_bb0285","first-page":"17","article-title":"Effect of timolol maleate concentration on uptake and release from hydrogel contact lenses using soaking method","volume":"1","author":"Maulvi","year":"2014","journal-title":"J Pharm Appl Sci"},{"issue":"4","key":"10.1016\/j.msec.2020.110885_bb0290","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.clae.2007.02.010","article-title":"Surface morphology of contact lenses probed with microscopy techniques","volume":"30","author":"Guryca","year":"2007","journal-title":"Contact Lens and Anterior Eye"},{"issue":"2","key":"10.1016\/j.msec.2020.110885_bb0295","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jbm.b.30954","article-title":"Comparative study of silicone-hydrogel contact lenses surfaces before and after wear using atomic force microscopy","volume":"85","author":"Lira","year":"2008","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"issue":"7","key":"10.1016\/j.msec.2020.110885_bb0300","doi-asserted-by":"crossref","first-page":"E475","DOI":"10.1097\/OPX.0b013e3181e170c5","article-title":"Soft contact lens surface profile by atomic force microscopy","volume":"87","author":"Giraldez","year":"2010","journal-title":"Optometry & Vision Science"},{"issue":"1\u20132","key":"10.1016\/j.msec.2020.110885_bb0305","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijpharm.2017.03.083","article-title":"Effect of surfactant chain length on drug release kinetics from microemulsion-laden contact lenses","volume":"524","author":"Maulvi","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.msec.2020.110885_bb0310","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10856-016-5724-3","article-title":"Extended release of ketotifen from silica shell nanoparticle-laden hydrogel contact lenses: in vitro and in vivo evaluation","volume":"27","author":"Maulvi","year":"2016","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"7","key":"10.1016\/j.msec.2020.110885_bb0315","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1167\/iovs.08-2826","article-title":"A drug-eluting contact lens","volume":"50","author":"Ciolino","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.msec.2020.110885_bb0320","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.ijbiomac.2014.10.014","article-title":"Amphotericin-B entrapped lecithin\/chitosan nanoparticles for prolonged ocular application","volume":"72","author":"Chhonker","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.msec.2020.110885_bb0325","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1097\/ICO.0b013e318254688a","article-title":"Changes in corneal biometry and the associated histology in rhesus monkeys wearing orthokeratology contact lenses","volume":"31","author":"Ding","year":"2012","journal-title":"Cornea"},{"issue":"1","key":"10.1016\/j.msec.2020.110885_bb0330","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mpdhp.2010.10.001","article-title":"Histopathology and molecular diagnosis of corneal infections","volume":"17","author":"Vemuganti","year":"2011","journal-title":"Diagnostic Histopathology"},{"key":"10.1016\/j.msec.2020.110885_bb0335","series-title":"Carleton\u2019s Histological Technique","author":"Carleton","year":"1980"},{"issue":"1\u20132","key":"10.1016\/j.msec.2020.110885_bb0340","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0376-7388(00)85117-0","article-title":"Oxygen permeability coefficients of polymers for hard and soft contact lens applications","volume":"9","author":"Yang","year":"1981","journal-title":"J. Membr. Sci."},{"issue":"2","key":"10.1016\/j.msec.2020.110885_bb0345","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijpharm.2008.09.002","article-title":"Molecular imprinting within hydrogels II: progress and analysis of the field","volume":"364","author":"Byrne","year":"2008","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.msec.2020.110885_bb0350","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/01.ICL.0000062463.64717.86","article-title":"Calibrated oxygen permeability of 35 conventional hydrogel materials and correlation with water content","volume":"29","author":"Young","year":"2003","journal-title":"Eye contact lens"},{"issue":"5","key":"10.1016\/j.msec.2020.110885_bb0355","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3109\/03639045.2014.948451","article-title":"Development of ocular drug delivery systems using molecularly imprinted soft contact lenses","volume":"41","author":"Tashakori-Sabzevar","year":"2015","journal-title":"Drug development industrial pharmacy"},{"issue":"3","key":"10.1016\/j.msec.2020.110885_bb0360","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jconrel.2006.05.003","article-title":"Imprinted soft contact lenses as norfloxacin delivery systems","volume":"113","author":"Alvarez-Lorenzo","year":"2006","journal-title":"J. Control. Release"},{"issue":"1\u20132","key":"10.1016\/j.msec.2020.110885_bb0365","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijpharm.2004.11.033","article-title":"Dispersion of microemulsion drops in HEMA hydrogel: a potential ophthalmic drug delivery vehicle","volume":"292","author":"Gulsen","year":"2005","journal-title":"Int. J. Pharm."},{"issue":"8","key":"10.1016\/j.msec.2020.110885_bb0370","doi-asserted-by":"crossref","first-page":"397","DOI":"10.17221\/1930-VETMED","article-title":"Hyaluronic acid (hyaluronan): a review","volume":"53","author":"Necas","year":"2008","journal-title":"Veterinarni medicina"},{"key":"10.1016\/j.msec.2020.110885_bb0375","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.colsurfb.2017.05.064","article-title":"pH triggered controlled drug delivery from contact lenses: addressing the challenges of drug leaching during sterilization and storage","volume":"157","author":"Maulvi","year":"2017","journal-title":"Colloids Surf. B: Biointerfaces"},{"issue":"1","key":"10.1016\/j.msec.2020.110885_bb0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02850114","article-title":"Multicenter, open-label evaluation of hyperemia associated with use of bimatoprost in adults with open-angle glaucoma or ocular hypertension","volume":"20","author":"Abelson","year":"2003","journal-title":"Adv. Ther."},{"key":"10.1016\/j.msec.2020.110885_bb0385","series-title":"Multicenter, Open-Label Evaluation of Hyperemia Associated with Use of Bimatoprost in Adults with Open-Angle Glaucoma or Ocular Hypertension","first-page":"1","volume":"20(1)","author":"Abelson","year":"2003"},{"key":"10.1016\/j.msec.2020.110885_bb0390","series-title":"Comparison of the Ocular Hypotensive Lipid AGN 192024 with Timolol: Dosing, Efficacy, and Safety Evaluation of a Novel Compound for Glaucoma Management","first-page":"994","volume":"119(7)","author":"Laibovitz","year":"2001"},{"key":"10.1016\/j.msec.2020.110885_bb0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/714919","article-title":"From eye drops to ICU, a case report of three side effects of ophthalmic timolol maleate in the same patient","volume":"2015","author":"Rana","year":"2015","journal-title":"Case Reports in Critical Care"},{"issue":"5","key":"10.1016\/j.msec.2020.110885_bb0400","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/j.1755-3768.1993.tb04661.x","article-title":"Beta 1 and beta 2 antagonist activity of topically applied betaxolol and timolol in the systemic circulation","volume":"71","author":"Vuori","year":"1993","journal-title":"Acta Ophthalmol."},{"issue":"9","key":"10.1016\/j.msec.2020.110885_bb0405","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/clc.4960190904","article-title":"Systemic side effects of topical beta-adrenergic blockers","volume":"19","author":"Stewart","year":"1996","journal-title":"Clin. Cardiol."},{"issue":"11","key":"10.1016\/j.msec.2020.110885_bb0410","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1080\/14740338.2016.1225718","article-title":"Cardiac safety of ophthalmic timolol","volume":"15","author":"M\u00e4enp\u00e4\u00e4","year":"2016","journal-title":"Expert Opin. Drug Saf."},{"issue":"3","key":"10.1016\/j.msec.2020.110885_bb0415","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1532-5415.1989.tb06818.x","article-title":"Timolol side effects and inadvertent overdosing","volume":"37","author":"Hayes","year":"1989","journal-title":"J. Am. Geriatr. Soc."},{"issue":"5","key":"10.1016\/j.msec.2020.110885_bb0420","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0161-6420(80)35215-9","article-title":"Adverse reactions from timolol administration","volume":"87","author":"Van","year":"1980","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.msec.2020.110885_bb0425","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ijpharm.2018.06.059","article-title":"Contact lenses with dual drug delivery for the treatment of bacterial conjunctivitis","volume":"548","author":"Maulvi","year":"2018","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.msec.2020.110885_bb0430","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0002-9394(02)01980-3","article-title":"Conjunctival hyperemia in healthy subjects after short-term dosing with latanoprost, bimatoprost, and travoprost","volume":"135","author":"Stewart","year":"2003","journal-title":"Am J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.msec.2020.110885_bb0435","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1527-3466.2005.tb00168.x","article-title":"Bimatoprost: mechanism of ocular surface hyperemia associated with topical therapy","volume":"23","author":"Chen","year":"2005","journal-title":"Cardiovascular drug reviews"},{"issue":"6","key":"10.1016\/j.msec.2020.110885_bb0440","first-page":"1134","article-title":"From PGF2\u03b1-isopropyl ester to latanoprost: a review of the development of xalatan the proctor lecture","volume":"42","author":"Stjernschantz","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493119321770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493119321770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:58:56Z","timestamp":1760533136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493119321770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":88,"alternative-id":["S0928493119321770"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2020.110885","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple drug delivery from the drug-implants-laden silicone contact lens: Addressing the issue of burst drug release","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2020.110885","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110885"}}