{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:31:53Z","timestamp":1784295113691,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21873039"],"award-info":[{"award-number":["21873039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21573087"],"award-info":[{"award-number":["21573087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21573092"],"award-info":[{"award-number":["21573092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.msec.2020.111127","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T22:13:15Z","timestamp":1590617595000},"page":"111127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Multi-functionalized Nano-conjugate for combating multidrug resistant breast Cancer via starvation-assisted chemotherapy"],"prefix":"10.1016","volume":"116","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongyang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2020.111127_bb0005","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1021\/nn200007z","article-title":"Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells","volume":"5","author":"Wang","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.msec.2020.111127_bb0010","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1021\/acs.nanolett.7b01382","article-title":"Enhanced phototherapy by nanoparticle-enzyme via generation and photolysis of hydrogen peroxide","volume":"17","author":"Chang","year":"2017","journal-title":"Nano Lett."},{"key":"10.1016\/j.msec.2020.111127_bb0015","doi-asserted-by":"crossref","first-page":"7006","DOI":"10.1021\/acsnano.7b02533","article-title":"Cancer cell membrane camouflaged cascade bioreactor for cancer targeted starvation and photodynamic therapy","volume":"11","author":"Li","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.msec.2020.111127_bb0020","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nnano.2016.280","article-title":"Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy","volume":"12","author":"Zhang","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.msec.2020.111127_bb0025","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1021\/jacs.5b10997","article-title":"A real-time surface enhanced Raman spectroscopy study of plasmonic photothermal cell death using targeted gold nanoparticles","volume":"138","author":"Aioub","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.msec.2020.111127_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2016.06.017","article-title":"Targeting heat shock protein 70 using gold nanorods enhances cancer cell apoptosis in low dose plasmonic photothermal therapy","volume":"102","author":"Ali","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2020.111127_bb0035","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1021\/nl400448n","article-title":"Intracellular SERS nanoprobes for distinction of different neuronal cell types","volume":"13","author":"Huefner","year":"2013","journal-title":"Nano Lett."},{"key":"10.1016\/j.msec.2020.111127_bb0040","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1021\/ja9102698","article-title":"Nuclear targeting of gold nanoparticles in cancer cells induces DNA damage, causing cytokinesis arrest and apoptosis","volume":"132","author":"Kang","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.msec.2020.111127_bb0045","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1021\/ja5112628","article-title":"Single gold@silver nanoprobes for real-time tracing the entire autophagy process at single-cell level","volume":"137","author":"Chen","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.msec.2020.111127_bb0050","doi-asserted-by":"crossref","first-page":"9721","DOI":"10.1021\/ac4021227","article-title":"FRET-based biofriendly Apo-GO(x)-modified gold nanoprobe for specific and sensitive glucose sensing and cellular imaging","volume":"85","author":"Li","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.msec.2020.111127_bb0055","doi-asserted-by":"crossref","first-page":"15395","DOI":"10.1021\/acsami.5b03423","article-title":"Multifunctional Janus hematite silica nanoparticles: mimicking peroxidase-like activity and sensitive colorimetric detection of glucose","volume":"7","author":"Lu","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.msec.2020.111127_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.303","article-title":"Ultraviolet irradiation increases green fluorescence of dihydrorhodamine (DHR) 123: false-positive results for reactive oxygen species generation","volume":"5","author":"Djiadeu","year":"2017","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.msec.2020.111127_bb0065","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1073\/pnas.1414055112","article-title":"SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx","volume":"112","author":"Douda","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.msec.2020.111127_bb0070","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1432-1033.1993.tb18328.x","article-title":"Dihydrorhodamine 123: a fluorescent probe for superoxide generation?","volume":"217","author":"Henderson","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.msec.2020.111127_bb0075","doi-asserted-by":"crossref","DOI":"10.1063\/1.4878715","article-title":"Note: Raman microspectroscopy integrated with fluorescence and dark field imaging","volume":"85","author":"Li","year":"2014","journal-title":"Rev. Sci. Instrum."},{"key":"10.1016\/j.msec.2020.111127_bb0080","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1021\/ac504550w","article-title":"In situ surface-enhanced Raman scattering spectroscopy exploring molecular changes of drug-treated cancer cell nucleus","volume":"87","author":"Liang","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.msec.2020.111127_bb0085","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.msec.2020.111127_bb0090","doi-asserted-by":"crossref","first-page":"7994","DOI":"10.1158\/1078-0432.CCR-04-1087","article-title":"Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses","volume":"10","author":"Zhao","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.msec.2020.111127_bb0095","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1021\/nl052396o","article-title":"Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells","volume":"6","author":"Chithrani","year":"2006","journal-title":"Nano Lett."},{"key":"10.1016\/j.msec.2020.111127_bb0100","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1021\/acs.analchem.6b03971","article-title":"Tracing the therapeutic process of targeted Aptamer\/drug conjugate on cancer cells by surface-enhanced Raman scattering spectroscopy","volume":"89","author":"Deng","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.msec.2020.111127_bb0105","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1002\/anie.201610682","article-title":"Glucose-responsive sequential generation of hydrogen peroxide and nitric oxide for synergistic cancer starving-like\/gas therapy","volume":"56","author":"Fan","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.msec.2020.111127_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2006.10.029","article-title":"Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy","volume":"252","author":"Lopez-Lazaro","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1016\/j.msec.2020.111127_bb0115","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201600124","article-title":"Reactive-oxygen-species-responsive drug delivery systems: promises and challenges","volume":"4","author":"Saravanakumar","year":"2017","journal-title":"Adv. Sci."},{"key":"10.1016\/j.msec.2020.111127_bb0120","doi-asserted-by":"crossref","first-page":"7524","DOI":"10.1021\/nn403722x","article-title":"Surface-enhanced Raman spectroscopy for real-time monitoring of reactive oxygen species-induced DNA damage and its prevention by platinum nanoparticles","volume":"7","author":"Panikkanvalappil","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.msec.2020.111127_bb0125","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/adma.201403848","article-title":"Highly fluorescent, photostable, and ultrasmall silicon drug Nanocarriers for long-term tumor cell tracking and in-vivo Cancer therapy","volume":"27","author":"Ji","year":"2015","journal-title":"Adv. Mater."},{"key":"10.1016\/j.msec.2020.111127_bb0130","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/oxfordjournals.annonc.a058203","article-title":"The impact of pharmacokinetically guided dose escalation strategies in phase I clinical trials: critical evaluation and recommendations for future studies","volume":"3","author":"Graham","year":"1992","journal-title":"Ann. Concol."}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493119316637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493119316637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:01:56Z","timestamp":1760533316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493119316637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":26,"alternative-id":["S0928493119316637"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2020.111127","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-functionalized Nano-conjugate for combating multidrug resistant breast Cancer via starvation-assisted chemotherapy","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2020.111127","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111127"}}