{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:57:57Z","timestamp":1791917877846,"version":"4.3.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005182","name":"Institute of Nuclear Energy Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["108-2221-E-008-055"],"award-info":[{"award-number":["108-2221-E-008-055"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.msec.2020.111385","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T12:30:54Z","timestamp":1597321854000},"page":"111385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"special_numbering":"C","title":["Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing"],"prefix":"10.1016","volume":"118","author":[{"given":"Yu-Hsiang","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ling","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai-Li","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2020.111385_bb0005","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1002\/jps.21210","article-title":"Wound healing dressings and drug delivery systems: a review","volume":"97","author":"Boateng","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.msec.2020.111385_bb0010","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/dmrr.2400","article-title":"Diabetic foot disease: impact of ulcer location on ulcer healing","volume":"29","author":"Pickwell","year":"2013","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.msec.2020.111385_bb0015","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.2337\/dc12-0200","article-title":"Long-termprognosis of diabetic foot patients and their limbs: amputation and death over the course of a decade","volume":"35","author":"Morbach","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.msec.2020.111385_bb0020","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jdiacomp.2016.11.020","article-title":"Diabetic foot ulcer severity predicts mortality among veterans with type 2 diabetes","volume":"31","author":"Brennan","year":"2017","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.msec.2020.111385_bb0025","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.2337\/dc09-0651","article-title":"History of foot ulcer increases mortality among individuals with diabetes: ten-year follow-up of the Nord-Tr\u00f8ndelag Health Study, Norway","volume":"2","author":"Iversen","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.msec.2020.111385_bb0030","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1742-481X.2007.00392.x","article-title":"Guest editorial: are diabetes-related wounds and amputations worse than cancer?","volume":"4","author":"Armstrong","year":"2007","journal-title":"Int. Wound J."},{"key":"10.1016\/j.msec.2020.111385_bb0035","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/j.1468-3083.2011.04415.x","article-title":"Cytokines, chemokines and growth factors in wound healing","volume":"26","author":"Behm","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.msec.2020.111385_bb0040","first-page":"269","article-title":"Wound care in the geriatric client","volume":"4","author":"Gist","year":"2009","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.msec.2020.111385_bb0045","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/1523-1747.ep12614460","article-title":"Comparison of the effects of moist and dry conditions on the process of angiogenesis during dermal repair","volume":"99","author":"Dyson","year":"1992","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.msec.2020.111385_bb0050","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.radphyschem.2009.12.017","article-title":"Cytotoxicity and wound healing properties of PVA\/ws-chitosan\/glycerol hydrogels made by irradiation followed by freeze\u2013thawing","volume":"79","author":"Yang","year":"2010","journal-title":"Radiat. Phys. Chem."},{"key":"10.1016\/j.msec.2020.111385_bb0055","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.ijbiomac.2017.03.142","article-title":"Chitosan-hyaluronic acid hydrogel for cartilage repair","volume":"104","author":"Mohan","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.msec.2020.111385_bb0060","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.biomaterials.2012.10.077","article-title":"Docetaxel-loaded thermoresponsive conjugated linoleic acid-incorporated poloxamer hydrogel for the suppression of peritoneal metastasis of gastric cancer","volume":"37","author":"Bae","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2020.111385_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemphyslip.2019.104783","article-title":"A liposomal hydrogel with enzyme triggered release for infected wound","volume":"223","author":"Li","year":"2019","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.msec.2020.111385_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/polym11050927","article-title":"Compositional and temperature effects on the rheological properties of polyelectrolyte-surfactant hydrogels","volume":"11","author":"Smilek","year":"2019","journal-title":"Polymers"},{"key":"10.1016\/j.msec.2020.111385_bb0075","doi-asserted-by":"crossref","first-page":"536","DOI":"10.18433\/J3JC7C","article-title":"Chitosan mediated targeted drug delivery system: a review","volume":"13","author":"Patel","year":"2010","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.msec.2020.111385_bb0080","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.msec.2020.111385_bb0085","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1479-666X(08)80114-X","article-title":"Epidermal growth factor therapy and wound healing\u2014past, present and future perspectives","volume":"6","author":"Hardwicke","year":"2008","journal-title":"Surgeon"},{"key":"10.1016\/j.msec.2020.111385_bb0090","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jconrel.2009.10.030","article-title":"Hydrogel-based drug delivery systems: comparison of drug diffusivity and release kinetics","volume":"142","author":"Brandl","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.msec.2020.111385_bb0095","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jhep.2014.03.033","article-title":"EGF\/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition","volume":"61","author":"Clap\u00e9ron","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.msec.2020.111385_bb0100","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.biopha.2016.05.002","article-title":"Epidermal growth factor (EGF) triggers the malignancy of hemangioma cells via activation of NF-\u03baB signals","volume":"82","author":"Zhang","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.msec.2020.111385_bb0105","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2133.2004.05845.x","article-title":"Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?","volume":"150","author":"Moseley","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.msec.2020.111385_bb0110","first-page":"36","article-title":"Diagnosing and managing infection in acute and chronic wounds","volume":"114","author":"Brown","year":"2018","journal-title":"Nurs. Times"},{"key":"10.1016\/j.msec.2020.111385_bb0115","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1155\/MBD.1994.467","article-title":"Antibacterial silver","volume":"1","author":"Clement","year":"1994","journal-title":"Metal-Based Drugs"},{"key":"10.1016\/j.msec.2020.111385_bb0120","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.apmt.2019.04.009","article-title":"Novel niobium and silver toughened hydroxyapatite nanocomposites with enhanced mechanical and biological properties for load-bearing bone implants","volume":"15","author":"Wei","year":"2019","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.msec.2020.111385_bb0125","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1016\/j.carbpol.2016.11.087","article-title":"Construction of silver sulfadiazine loaded chitosan composite sponges as potential wound dressings","volume":"157","author":"Shao","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.msec.2020.111385_bb0130","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/01.ASW.0000582620.68148.cf","article-title":"Nanocrystalline-coated silver dressings for patients with type 2 diabetes after surgical coronary revascularization","volume":"32","author":"Parys","year":"2019","journal-title":"Adv. Skin Wound Care"},{"key":"10.1016\/j.msec.2020.111385_bb0135","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1021\/cm100023p","article-title":"Toxicity of silver nanoparticles increases during storage because of slow dissolution under release of silver ions","volume":"22","author":"Kittler","year":"2010","journal-title":"Chem. Mater."},{"key":"10.1016\/j.msec.2020.111385_bb0140","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1128\/AEM.02001-07","article-title":"Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli","volume":"74","author":"Jung","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.msec.2020.111385_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jhin.2004.11.014","article-title":"Bacterial resistance to silver in wound care","volume":"60","author":"Percival","year":"2005","journal-title":"J. Hosp. Infect."},{"key":"10.1016\/j.msec.2020.111385_bb0150","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ibiod.2017.07.015","article-title":"A comparative analysis of antibacterial activity, dynamics and effects of silver ions and silver nanoparticles against four bacterial strains","volume":"123","author":"Li","year":"2017","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"10.1016\/j.msec.2020.111385_bb0155","doi-asserted-by":"crossref","DOI":"10.1007\/s12274-013-0395-6","article-title":"Ultrasmall Ag+-rich nanoclusters as highly efficient nanoreservoirs for bacterial killing","volume":"7","author":"Yuan","year":"2014","journal-title":"Nano Res."},{"key":"10.1016\/j.msec.2020.111385_bb0160","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1128\/AEM.02433-09","article-title":"Biogenic silver for disinfection of water contaminated with viruses","volume":"79","author":"De Gusseme","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.msec.2020.111385_bb0165","article-title":"Enhanced photocatalytic and antifungal properties of PbS nanopowder doped with Ag+ ions","volume":"29","author":"Suganya","year":"2018","journal-title":"J. Mater. Sci. Mater. Electron."},{"key":"10.1016\/j.msec.2020.111385_bb0170","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0378-4274(98)00114-3","article-title":"Study of cytotoxicity mechanisms of silver nitrate in human dermal fibroblasts","volume":"98","author":"Hidalgo","year":"1998","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.msec.2020.111385_bb0175","doi-asserted-by":"crossref","first-page":"7190","DOI":"10.1039\/c2ra20546g","article-title":"Serum albumin reduces the antibacterial and cytotoxic effects of hydrogel-embedded colloidal silver nanoparticles","volume":"2","author":"Grade","year":"2012","journal-title":"RSC Adv."},{"key":"10.1016\/j.msec.2020.111385_bb0180","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000112961","article-title":"Nanomedicine: application of nanobiotechnology in medical practice","volume":"17","author":"Jain","year":"2008","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.msec.2020.111385_bb0185","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/masy.200850913","article-title":"Characterization of poly(vinyl alcohol)\/chitosan hydrogels as vascular tissue engineering scaffolds","volume":"269","author":"Vrana","year":"2008","journal-title":"Macromol. Symp."},{"key":"10.1016\/j.msec.2020.111385_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/0471141755.ph0547s70","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.msec.2020.111385_bb0195","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/j.biomaterials.2004.06.046","article-title":"Cyclic loading response of bioprosthetic heart valves: effects of fixation stress state on the collagen fiber architecture","volume":"26","author":"Wells","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2020.111385_bb0200","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.actbio.2017.11.040","article-title":"Pressure-induced microstructural changes in porcine tricuspid valve leaflets","volume":"67","author":"Pant","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2020.111385_bb0205","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/jac\/dks372","article-title":"The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies","volume":"68","author":"Randall","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.msec.2020.111385_bb0210","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tca.2009.04.003","article-title":"Miscibility and thermal stability of poly(vinyl alcohol)\/chitosan mixture","volume":"493","author":"Lewandowska","year":"2009","journal-title":"Thermochim. Acta"},{"key":"10.1016\/j.msec.2020.111385_bb0215","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.carbpol.2009.09.029","article-title":"Preparation and physicochemical evaluation of chitosan\/poly(vinyl alcohol)\/pectin ternary film for foodpackaging applications","volume":"79","author":"Tripathi","year":"2010","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.msec.2020.111385_bb0220","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.memsci.2004.02.005","article-title":"Evaluation of chitosan\/PVA blended hydrogel membrances","volume":"236","author":"Yang","year":"2004","journal-title":"J. Membr. Sci."},{"key":"10.1016\/j.msec.2020.111385_bb0225","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/app.26257","article-title":"Studies of chitosan. I. Preparation and characterization of chitosan\/poly(vinyl alcohol) blend films","volume":"105","author":"Chen","year":"2007","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.msec.2020.111385_bb0230","doi-asserted-by":"crossref","DOI":"10.1098\/rsfs.2013.0049","article-title":"Mechanical properties and in vitro characterization of polyvinyl alcoholnano-silver hydrogel wound dressings","volume":"4","author":"Oliveira","year":"2014","journal-title":"Interf. Focus"},{"key":"10.1016\/j.msec.2020.111385_bb0235","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/(SICI)1097-4636(19991215)47:4<595::AID-JBM17>3.0.CO;2-I","article-title":"A pH- and ionic strength-responsive polypeptide hydrogel: synthesis, characterization, and preliminary protein release studies","volume":"47","author":"Markland","year":"1999","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.msec.2020.111385_bb0240","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/15394450701539008","article-title":"Synthesis and characterization of a pH- and ionic strength-responsive hydrogel","volume":"5","author":"Zhang","year":"2007","journal-title":"Soft Mater."},{"key":"10.1016\/j.msec.2020.111385_bb0245","doi-asserted-by":"crossref","first-page":"12018","DOI":"10.1021\/acsami.6b02264","article-title":"Smart macroporous IPN hydrogels responsive to pH, temperature, and ionic strength: synthesis, characterization, and evaluation of controlled release of drugs","volume":"8","author":"Dragan","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.msec.2020.111385_bb0250","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3144\/expresspolymlett.2009.5","article-title":"Swelling characterization and drug delivery kinetics of polyacrylamide-co-itaconic acid\/chitosan hydrogels","volume":"3","author":"Mart\u00ednez-Ruvalcaba","year":"2009","journal-title":"Express Polym Lett"},{"key":"10.1016\/j.msec.2020.111385_bb0255","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.colsurfb.2014.06.051","article-title":"Biodegradable gelatin-ciprofloxacin-montmorillonite composite hydrogels for controlled drug release and wound dressing application","volume":"122","author":"Kevadiya","year":"2014","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.msec.2020.111385_bb0260","doi-asserted-by":"crossref","first-page":"22160","DOI":"10.1021\/acsami.7b04428","article-title":"A bioinspired alginate-gum arabic hydrogel with micro-\/nanoscale structures for controlled drug release in chronic wound healing","volume":"9","author":"Li","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.msec.2020.111385_bb0265","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1089\/wound.2015.0663","article-title":"Regenerative medicine: charting a new course in wound healing","volume":"5","author":"Gurtner","year":"2016","journal-title":"Adv. Wound Care (New Rochelle)"},{"key":"10.1016\/j.msec.2020.111385_bb0270","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/wound.2011.0311","article-title":"Collagen organization critical role in wound contraction","volume":"1","author":"Ehrlich","year":"2012","journal-title":"Adv. Wound Care"}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493120333038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493120333038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:18:55Z","timestamp":1778775535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493120333038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":54,"alternative-id":["S0928493120333038"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2020.111385","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2020.111385","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111385"}}