{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:07:37Z","timestamp":1790712457814,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["96-03-87-36280"],"award-info":[{"award-number":["96-03-87-36280"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.msec.2020.111427","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T04:45:18Z","timestamp":1598417118000},"page":"111427","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Use of mPEG-PLGA nanoparticles to improve bioactivity and hemocompatibility of streptokinase: In-vitro and in-vivo studies"],"prefix":"10.1016","volume":"118","author":[{"given":"Akram","family":"Hasanpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Esmaeili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Amani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.msec.2020.111427_bb0005","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.amjsurg.2016.04.005","article-title":"In vivo biocompatibility and hemocompatibility of a polytetrafluoroethylene small diameter vascular graft modified with sulfonated silk fibroin","volume":"213","author":"Zhang","year":"2017","journal-title":"Am. J. Surg."},{"issue":"1","key":"10.1016\/j.msec.2020.111427_bb0010","first-page":"520","article-title":"Thrombotic disorders: diagnosis and treatment","volume":"2003","author":"Schafer","year":"2003","journal-title":"ASH Educ. Progr. B."},{"issue":"4","key":"10.1016\/j.msec.2020.111427_bb0015","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1515\/cclm.2011.831","article-title":"The role of red blood cell distribution width in cardiovascular and thrombotic disorders","volume":"50","author":"Montagnana","year":"2012","journal-title":"Clin. Chem. Lab. Med."},{"issue":"3","key":"10.1016\/j.msec.2020.111427_bb0020","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1128\/AEM.64.3.824-829.1998","article-title":"Engineering of plasmin-resistant forms of streptokinase and their production in Bacillus subtilis: streptokinase with longer functional half- life","volume":"64","author":"Wu","year":"1998","journal-title":"Appl. Environ. Microbiol."},{"issue":"35","key":"10.1016\/j.msec.2020.111427_bb0025","doi-asserted-by":"crossref","first-page":"5921","DOI":"10.1039\/C6TB01349J","article-title":"Streptokinase@alumina nanoparticles as a promising thrombolytic colloid with prolonged action","volume":"4","author":"Chapurina","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.msec.2020.111427_bb0030","doi-asserted-by":"crossref","unstructured":"G. Liu, X. Miao, W. Fan, R. Crawford, and Y. Xiao, \u201cPorous PLGA microspheres effectively loaded with BSA protein by electrospraying combined with phase separation in liquid nitrogen,\u201d in Journal of Biomimetics, Biomaterials, and Tissue Engineering, 2010, vol. 6, no. 1, pp. 1\u201318.","DOI":"10.4028\/www.scientific.net\/JBBTE.6.1"},{"issue":"5","key":"10.1016\/j.msec.2020.111427_bb0035","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3109\/02652048.2012.752537","article-title":"Controlled release behaviour of protein-loaded microparticles prepared via coaxial or emulsion electrospray","volume":"30","author":"Wang","year":"2013","journal-title":"J. Microencapsul."},{"issue":"3","key":"10.1016\/j.msec.2020.111427_bb0040","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1021\/bc060322d","article-title":"Synthesis, characterization, and in vitro activity of dendrimer- streptokinase conjugates","volume":"18","author":"Wang","year":"2007","journal-title":"Bioconjug. Chem."},{"issue":"12","key":"10.1016\/j.msec.2020.111427_bb0045","doi-asserted-by":"crossref","first-page":"10127","DOI":"10.1166\/jnn.2015.11696","article-title":"Optimization of self-assembled chitosan\/streptokinase nanoparticles and evaluation of their cytotoxicity and thrombolytic activity","volume":"15","author":"Baharifar","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"issue":"5","key":"10.1016\/j.msec.2020.111427_bb0050","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3109\/10837450.2013.813542","article-title":"Preparation and characterization of self-assembled chitosan nanoparticles for the sustained delivery of streptokinase: an in vivo study","volume":"19","author":"Modaresi","year":"2014","journal-title":"Pharm. Dev. Technol."},{"issue":"3","key":"10.1016\/j.msec.2020.111427_bb0055","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/polym3031377","article-title":"Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier","volume":"3","author":"Makadia","year":"2011","journal-title":"Polymers (Basel)."},{"key":"10.1016\/j.msec.2020.111427_bb0060","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.ijbiomac.2014.09.004","article-title":"Development and optimization of N-acetylcysteine-loaded poly (lactic-co-glycolic acid) nanoparticles by electrospray","volume":"72","author":"Zarchi","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.msec.2020.111427_bb0065","doi-asserted-by":"crossref","first-page":"131","DOI":"10.15171\/apb.2017.017","article-title":"Preparation, optimization and activity evaluation of PLGA\/streptokinase nanoparticles using electrospray","volume":"7","author":"Yaghoobi","year":"2017","journal-title":"Adv. Pharm. Bull."},{"issue":"4","key":"10.1016\/j.msec.2020.111427_bb0070","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s40089-017-0224-0","article-title":"Electrosprayed chitosan nanoparticles: facile and efficient approach for bacterial transformation","volume":"7","author":"Abyadeh","year":"2017","journal-title":"Int. Nano Lett."},{"key":"10.1016\/j.msec.2020.111427_bb0075","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.addr.2015.09.007","article-title":"Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering","volume":"94","author":"Jayaraman","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.msec.2020.111427_bb0080","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.ijbiomac.2014.09.004","article-title":"Development and optimization of N-acetylcysteine-loaded poly (lactic-co-glycolic acid) nanoparticles by electrospray","volume":"72","author":"Karimi Zarchi","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"issue":"31","key":"10.1016\/j.msec.2020.111427_bb0085","doi-asserted-by":"crossref","first-page":"6122","DOI":"10.1016\/j.biomaterials.2005.03.033","article-title":"AC electrospray biomaterials synthesis","volume":"26","author":"Yeo","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2020.111427_bb0090","unstructured":"N. J. Kruger, \u201cThe Bradford method for protein quantitation.,\u201d in Methods in molecular biology (Clifton, N.J.), vol. 32, Springer, 1994, pp. 9\u201315."},{"issue":"3","key":"10.1016\/j.msec.2020.111427_bb0095","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/pro.5560070313","article-title":"Role of the amino-terminal region of streptokinase in the generation of a fully functional plasminogen activator complex probed with synthetic peptides","volume":"7","author":"Nihalani","year":"1998","journal-title":"Protein Sci."},{"key":"10.1016\/j.msec.2020.111427_bb0100","doi-asserted-by":"crossref","unstructured":"J. Van Meerloo, G. J. L. Kaspers, and J. Cloos, \u201cCell sensitivity assays: The MTT assay,\u201d in Methods in Molecular Biology, vol. 731, Springer, 2011, pp. 237\u2013245.","DOI":"10.1007\/978-1-61779-080-5_20"},{"key":"10.1016\/j.msec.2020.111427_bb0105","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.actbio.2018.05.024","article-title":"Self-stabilized silk sericin-based nanoparticles: in vivo biocompatibility and reduced doxorubicin-induced toxicity","volume":"74","author":"Hu","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2020.111427_bb0110","doi-asserted-by":"crossref","unstructured":"G. Hajje, Y. Saliba, T. Itani, M. Moubarak, G. Aftimos, and N. Far\u00e8s, \u201cHypothyroidism and its rapid correction alter cardiac remodeling,\u201d PLoS One, vol. 9, no. 10, 2014.","DOI":"10.1371\/journal.pone.0109753"},{"issue":"1","key":"10.1016\/j.msec.2020.111427_bb0115","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0009-8981(96)06447-9","article-title":"Albumin standards and the measurement of serum albumin with bromcresol green","volume":"258","author":"Doumas","year":"1997","journal-title":"Clin. Chim. Acta"},{"issue":"2","key":"10.1016\/j.msec.2020.111427_bb0120","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0003-2697(79)90736-X","article-title":"Extending the range of application of the biuret reaction: quantitative determination of insoluble proteins","volume":"95","author":"Goshev","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.msec.2020.111427_bb0125","doi-asserted-by":"crossref","unstructured":"A. Mazur et al., \u201cAngiotensin converting enzyme inhibitor has a protective effect on decompression sickness in rats,\u201d Front. Physiol., vol. 9, no. MAR, p. 64, 2018.","DOI":"10.3389\/fphys.2018.00064"},{"issue":"2","key":"10.1016\/j.msec.2020.111427_bb0130","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s12035-013-8581-9","article-title":"Il1-\u03b2 involvement in cognitive impairment after sepsis","volume":"49","author":"Mina","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.msec.2020.111427_bb0135","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijbiomac.2019.11.157","article-title":"Preparation of PEG-grafted chitosan\/streptokinase nanoparticles to improve biological half-life and reduce immunogenicity of the enzyme","volume":"143","author":"Baharifar","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.msec.2020.111427_bb0140","doi-asserted-by":"crossref","unstructured":"S. Chopra, J.-M. Lim, R. Karnik, and O. Farokhzad, \u201cRole of electrostatic interactions in protein loading in PLGA-PEG nanoparticles,\u201d in 2014 40th Annual Northeast Bioengineering Conference (Nebec), 2014, pp. 1\u20132.","DOI":"10.1109\/NEBEC.2014.6972756"},{"key":"10.1016\/j.msec.2020.111427_bb0145","doi-asserted-by":"crossref","unstructured":"M. M. Pakulska et al., \u201cEncapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles,\u201d Sci. Adv., vol. 2, no. 5, p. e1600519, 2016.","DOI":"10.1126\/sciadv.1600519"},{"issue":"1\u20132","key":"10.1016\/j.msec.2020.111427_bb0150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ijpharm.2016.01.021","article-title":"Impact of PEG and PEG-b-PAGE modified PLGA on nanoparticle formation, protein loading and release","volume":"500","author":"Rietscher","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.msec.2020.111427_bb0155","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1021\/mp800051m","article-title":"Factors affecting the clearance and biodistribution of polymeric nanoparticles","volume":"5","author":"Alexis","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.msec.2020.111427_bb0160","doi-asserted-by":"crossref","unstructured":"A. B. de Barros, A. Tsourkas, B. Saboury, V. N. Cardoso, and A. Alavi, \u201cEmerging role of radiolabeled nanoparticles as an effective diagnostic technique,\u201d EJNMMI Res., vol. 2, no. 1, p. 39, 2012.","DOI":"10.1186\/2191-219X-2-39"},{"issue":"8","key":"10.1016\/j.msec.2020.111427_bb0165","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1073\/pnas.1200718109","article-title":"Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane","volume":"109","author":"Zuckerman","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8","key":"10.1016\/j.msec.2020.111427_bb0170","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1016\/j.bmc.2009.02.043","article-title":"Nanoparticles in cellular drug delivery","volume":"17","author":"Faraji","year":"2009","journal-title":"Bioorg. Med. Chem."},{"issue":"10","key":"10.1016\/j.msec.2020.111427_bb0175","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1007\/s11095-012-0958-3","article-title":"Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery","volume":"30","author":"Kulkarni","year":"2013","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.msec.2020.111427_bb0180","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1161\/01.CIR.89.1.76","article-title":"Abrupt complement activation and transient neutropenia in patients with acute myocardial infarction treated with streptokinase","volume":"89","author":"Frangi","year":"1994","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.msec.2020.111427_bb0185","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0021-9258(17)32743-6","article-title":"Activation of human plasminogen by equimolar levels of streptokinase","volume":"252","author":"Bajaj","year":"1977","journal-title":"J. Biol. Chem."},{"issue":"26","key":"10.1016\/j.msec.2020.111427_bb0190","doi-asserted-by":"crossref","first-page":"6620","DOI":"10.1021\/bi00269a001","article-title":"Complete amino acid sequence of streptokinase and its homology with serine proteases","volume":"21","author":"Jackson","year":"1982","journal-title":"Biochemistry"},{"issue":"7","key":"10.1016\/j.msec.2020.111427_bb0195","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.7150\/thno.14471","article-title":"Safe and immunocompatible nanocarriers cloaked in RBC membranes for drug delivery to treat solid tumors","volume":"6","author":"Luk","year":"2016","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.msec.2020.111427_bb0200","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0167-5273(89)90156-3","article-title":"Streptokinase in the management of arterial thrombosis in infancy","volume":"25","author":"Kirk","year":"1989","journal-title":"Int. J. Cardiol."},{"issue":"3","key":"10.1016\/j.msec.2020.111427_bb0205","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/smll.201201528","article-title":"Gold nanoparticles downregulate interleukin-1\u03b2-induced pro-inflammatory responses","volume":"9","author":"Sumbayev","year":"2013","journal-title":"Small"},{"issue":"5","key":"10.1016\/j.msec.2020.111427_bb0210","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0002-9378(89)90172-5","article-title":"Infection and labor: III. Interleukin-1: a signal for the onset of parturition","volume":"160","author":"Romero","year":"1989","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.msec.2020.111427_bb0215","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ymthe.2004.09.015","article-title":"Evaluation of polyethylene glycol modification of first-generation and helper-dependent adenoviral vectors to reduce innate immune responses","volume":"11","author":"Mok","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.msec.2020.111427_bb0220","doi-asserted-by":"crossref","unstructured":"M. Narazaki and T. Kishimoto, \u201cThe two-faced cytokine IL-6 in host defense and diseases,\u201d Int. J. Mol. Sci., vol. 19, no. 11, p. 3528, 2018.","DOI":"10.3390\/ijms19113528"},{"key":"10.1016\/j.msec.2020.111427_bb0225","series-title":"Interaction of Nanoparticles with Blood Components and Associated Pathophysiological Effects","author":"De La Cruz","year":"2018"},{"issue":"4","key":"10.1016\/j.msec.2020.111427_bb0230","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/jbm.a.33220","article-title":"Effect of thiol functionalization on the hemo-compatibility of PLGA nanoparticles","volume":"99","author":"Thasneem","year":"2011","journal-title":"J. Biomed. Mater. Res. Part A"},{"issue":"4","key":"10.1016\/j.msec.2020.111427_bb0235","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0024-3205(99)00257-X","article-title":"Reducing the immunogenicity and improving the in vivo activity of trichosanthin by site-directed pegylation","volume":"65","author":"He","year":"1999","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.msec.2020.111427_bb0240","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0169-409X(94)90016-7","article-title":"The use of glycolipids and hydrophilic polymers in avoiding rapid uptake of liposomes by the mononuclear phagocyte system","volume":"13","author":"Allen","year":"1994","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.msec.2020.111427_bb0245","first-page":"437","article-title":"Properties of streptokinase included in polyetylenglycol microcapsules","volume":"39","author":"Mukhametova","year":"2013","journal-title":"Bioorg. Khim."},{"issue":"1","key":"10.1016\/j.msec.2020.111427_bb0250","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1182\/blood.V76.1.73.73","article-title":"Catabolism of streptokinase and polyethylene glycol-streptokinase: evidence for transport of intact forms through the biliary system in the mouse","volume":"76","author":"Brucato","year":"1990","journal-title":"Blood"}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493120333452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493120333452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:59:57Z","timestamp":1778558397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493120333452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":50,"alternative-id":["S0928493120333452"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2020.111427","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of mPEG-PLGA nanoparticles to improve bioactivity and hemocompatibility of streptokinase: In-vitro and in-vivo studies","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2020.111427","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111427"}}