{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:07:23Z","timestamp":1790892443091,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.msec.2020.111582","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T03:30:27Z","timestamp":1601955027000},"page":"111582","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"special_numbering":"C","title":["Enteric-coated gelatin nanoparticles mediated oral delivery of 5-aminosalicylic acid alleviates severity of DSS-induced ulcerative colitis"],"prefix":"10.1016","volume":"119","author":[{"given":"Anas","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Meraj","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Vyawahare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul Kumar","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Shadab","family":"Raza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehan","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2020.111582_bb0005","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.7150\/thno.15710","article-title":"Combination therapy for ulcerative colitis: orally targeted nanoparticles prevent mucosal damage and relieve inflammation","volume":"6","author":"Xiao","year":"2016","journal-title":"Theranostics."},{"key":"10.1016\/j.msec.2020.111582_bb0010","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.msec.2020.111582_bb0015","first-page":"357","article-title":"Definition and epidemiology of inflammatory bowel disease","volume":"75","author":"Fujii","year":"2017","journal-title":"Nippon Rinsho"},{"key":"10.1016\/j.msec.2020.111582_bb0020","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nrgastro.2011.96","article-title":"Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis","volume":"8","author":"Thorsteinsdottir","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.msec.2020.111582_bb0025","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.aat0835","article-title":"Intestinal barriers protect against disease","volume":"359","author":"Citi","year":"2018","journal-title":"Science."},{"key":"10.1016\/j.msec.2020.111582_bb0030","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.msec.2020.111582_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nmicrobiol.2017.4","article-title":"Dynamics of the human gut microbiome in inflammatory bowel disease","volume":"2","author":"Halfvarson","year":"2017","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.msec.2020.111582_bb0040","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.msec.2020.111582_bb0045","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/ni.3690","article-title":"NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth","volume":"18","author":"Chen","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.msec.2020.111582_bb0050","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ni.2920","article-title":"TH9 cells that express the transcription factor PU.1 drive T cell\u2013mediated colitis via IL-9 receptor signaling in intestinal epithelial cells","volume":"15","author":"Gerlach","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.msec.2020.111582_bb0055","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41575-018-0079-5","article-title":"Control and dysregulation of redox signalling in the gastrointestinal tract","volume":"16","author":"Campbell","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.msec.2020.111582_bb0060","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrgastro.2017.136","article-title":"Environmental triggers in IBD: a review of progress and evidence","volume":"15","author":"Ananthakrishnan","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.msec.2020.111582_bb0065","doi-asserted-by":"crossref","DOI":"10.1021\/acsnano.9b09125","article-title":"Amyloid\u2013polyphenol hybrid nanofilaments mitigate colitis and regulate gut microbial dysbiosis","author":"Hu","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.msec.2020.111582_bb0070","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41563-019-0462-9","article-title":"Hyaluronic acid\u2013bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis","volume":"19","author":"Lee","year":"2020","journal-title":"Nat. Mater."},{"key":"10.1016\/j.msec.2020.111582_bb0075","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.apsb.2016.07.012","article-title":"An update on the role of intestinal cytochrome P450 enzymes in drug disposition","volume":"6","author":"Xie","year":"2016","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.msec.2020.111582_bb0080","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jsps.2012.03.005","article-title":"Loss of orally administered drugs in GI tract","volume":"20","author":"Gavhane","year":"2012","journal-title":"Saudi Pharm J."},{"key":"10.1016\/j.msec.2020.111582_bb0085","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1136\/gut.51.4.536","article-title":"Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines","volume":"51","author":"Ransford","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.msec.2020.111582_bb0090","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/14712598.2019.1666101","article-title":"Modern use of 5-aminosalicylic acid compounds for ulcerative colitis","volume":"20","author":"Berre","year":"2020","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.msec.2020.111582_bb0095","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5217\/ir.2019.00084","article-title":"5-Aminosalicylic acid intolerance is associated with a risk of adverse clinical outcomes and dysbiosis in patients with ulcerative colitis","volume":"18","author":"Mizuno","year":"2020","journal-title":"Intest. Res."},{"key":"10.1016\/j.msec.2020.111582_bb0100","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/cpt1972134539","article-title":"Absorption, metabolism, and excretion of salicylazosulfapyridine in man","volume":"13","author":"Schr\u00f6der","year":"1972","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.msec.2020.111582_bb0105","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1002\/jps.24103","article-title":"On the colonic bacterial metabolism of azo-bonded prodrugsof 5-aminosalicylic acid","volume":"103","author":"Sousa","year":"2014","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.msec.2020.111582_bb0110","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jconrel.2007.08.008","article-title":"5-Amino salicylic acid bound nanoparticles for the therapy of inflammatory bowel disease","volume":"123","author":"Pertuit","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.msec.2020.111582_bb0115","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1177\/1756283X11405250","article-title":"Optimizing clinical use of mesalazine (5-aminosalicylic acid) in inflammatory bowel disease","volume":"4","author":"Williams","year":"2011","journal-title":"Ther. Adv. Gastroenterol."},{"key":"10.1016\/j.msec.2020.111582_bb0120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.msec.2018.12.127","article-title":"Fabrication of alginate-based stimuli-responsive, non-cytotoxic, terpolymric semi-IPN hydrogel as a carrier for controlled release of bovine albumin serum and 5-amino salicylic acid","volume":"98","author":"Das","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2020.111582_bb0125","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa5657","article-title":"An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease","volume":"7","author":"Zhang","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.msec.2020.111582_bb0130","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.addr.2013.10.001","article-title":"Drug delivery strategies in the therapy of inflammatory bowel disease","volume":"71","author":"Lautenschl\u00e4ger","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.msec.2020.111582_bb0135","first-page":"309","author":"Fassihi","year":"2019","journal-title":"Am. Chem. Soc."},{"key":"10.1016\/j.msec.2020.111582_bb0140","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41578-019-0156-6","article-title":"Materials for oral delivery of proteins and peptides","volume":"5","author":"Brown","year":"2020","journal-title":"Nature Reviews Materials."},{"key":"10.1016\/j.msec.2020.111582_bb0145","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.fct.2017.03.064","article-title":"Magurany, GRAS from the ground up: review of the interim pilot program for GRAS notification","volume":"105","author":"Hanlon","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.msec.2020.111582_bb0150","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1021\/nn501040h","article-title":"Core\u2013shell supramolecular gelatin nanoparticles for adaptive and \u201con-demand\u201d antibiotic delivery","volume":"8","author":"Li","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.msec.2020.111582_bb0155","doi-asserted-by":"crossref","first-page":"10636","DOI":"10.1021\/acsnano.8b06104","article-title":"Stimuli-responsive nano-architecture drug-delivery systems to solid tumor micromilieu: past, present, and future perspectives","volume":"12","author":"El-Sawy","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.msec.2020.111582_bb0160","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1021\/acs.molpharmaceut.8b01068","article-title":"Fixed dose combination formulations: multilayered platforms designed for the management of cardiovascular disease","volume":"16","author":"Andrews","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.msec.2020.111582_bb0165","doi-asserted-by":"crossref","first-page":"1701955","DOI":"10.1002\/adfm.201701955","article-title":"Black phosphorus nanoparticles potentiate the anticancer effect of oxaliplatin in ovarian cancer cell line","volume":"27","author":"Fojt\u016f","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.msec.2020.111582_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032084","article-title":"Dextran sodium sulfate (DSS) induces colitis in mice by forming nano-lipocomplexes with medium-chain-length fatty acids in the colon","volume":"7","author":"Laroui","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.msec.2020.111582_bb0175","article-title":"Glycyrrhizic acid suppresses the development of precancerous lesions via regulating the hyperproliferation, inflammation, angiogenesis and apoptosis in the colon of Wistar rats","volume":"8","author":"Khan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.msec.2020.111582_bb0180","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1021\/acsbiomaterials.9b00427","article-title":"Zinc gluconate-loaded chitosan nanoparticles reduce severity of collagen-induced arthritis in Wistar rats","volume":"5","author":"Ansari","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.msec.2020.111582_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10020057","article-title":"Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems","volume":"10","author":"Danaei","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.msec.2020.111582_bb0190","unstructured":"Polydispersity index - an overview|ScienceDirect Topics, (n.d.). https:\/\/www.sciencedirect.com\/topics\/engineering\/polydispersity-index (accessed May 4, 2020)."},{"key":"10.1016\/j.msec.2020.111582_bb0195","doi-asserted-by":"crossref","first-page":"1900260","DOI":"10.1002\/macp.201900260","article-title":"Design and characterization of surface-crosslinked gelatin nanoparticles for the delivery of hydrophilic macromolecular drugs","volume":"220","author":"Baseer","year":"2019","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.msec.2020.111582_bb0200","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/238351","article-title":"Cationic gelatin nanoparticles for drug delivery to the ocular surface: in vitro and in vivo evaluation","volume":"2013","author":"Tseng","year":"2013","journal-title":"J. Nanomater."},{"key":"10.1016\/j.msec.2020.111582_bb0205","article-title":"Lipid-based nanocarrier-mediated targeted delivery of celecoxib attenuate severity of ulcerative colitis","volume":"111103","author":"Mishra","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2020.111582_bb0210","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijpharm.2007.05.028","article-title":"Colon-specific delivery of 5-aminosalicylic acid from chitosan-Ca-alginate microparticles","volume":"342","author":"Mladenovska","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.msec.2020.111582_bb0215","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00289-010-0370-2","article-title":"New bilayer-coated microbead system for controlled release of 5-aminosalicylic acid","volume":"66","author":"Karewicz","year":"2011","journal-title":"Polym. Bull."},{"key":"10.1016\/j.msec.2020.111582_bb0220","first-page":"100024","article-title":"Using zeta potential to study the ionisation behaviour of polymers employed in modified-release dosage forms and estimating their pKa","volume":"1","author":"Barbosa","year":"2019","journal-title":"International Journal of Pharmaceutics: X."},{"key":"10.1016\/j.msec.2020.111582_bb0225","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3109\/02652048.2015.1046516","article-title":"Mucoadhesive drug carrier based on functional-modified cellulose as poorly water-soluble drug delivery system","volume":"32","author":"Songsurang","year":"2015","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.msec.2020.111582_bb0230","first-page":"1357","article-title":"In vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis","volume":"16","author":"Araki","year":"2006","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.msec.2020.111582_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220156","article-title":"Pharmacological inhibition of NPY receptors illustrates dissociable features of experimental colitis in the mouse DSS model: implications for preclinical evaluation of efficacy in an inflammatory bowel disease model","volume":"14","author":"Ruiz","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.msec.2020.111582_bb0240","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bcp.2019.01.001","article-title":"Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system","volume":"161","author":"Salaga","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.msec.2020.111582_bb0245","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41586-019-1856-1","article-title":"Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis","volume":"577","author":"Kakiuchi","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.msec.2020.111582_bb0250","first-page":"28","article-title":"L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer","volume":"1","author":"Ganesh","year":"2020","journal-title":"Nat. Can."},{"key":"10.1016\/j.msec.2020.111582_bb0255","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41590-020-0621-9","article-title":"Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities","volume":"21","author":"Martens","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.msec.2020.111582_bb0260","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.3748\/wjg.v23.i33.6016","article-title":"Dextran sodium sulfate colitis murine model: an indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis","volume":"23","author":"Eichele","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.msec.2020.111582_bb0265","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.4049\/jimmunol.1402300","article-title":"Porcine \u03b2-defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate\u2013induced colitis","volume":"194","author":"Han","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.msec.2020.111582_bb0270","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1590\/s0102-865020170030000002","article-title":"Tissue sulfomucin and sialomucin content in colon mucosa without intestinal transit subjected to intervention with Curcuma longa (curcumin)","volume":"32","author":"Alves J\u00fanior","year":"2017","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.msec.2020.111582_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024447","article-title":"On the relationship between sialomucin and sulfomucin expression and hydrogenotrophic microbes in the human colonic mucosa","volume":"6","author":"Croix","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.msec.2020.111582_bb0280","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/s41590-019-0493-z","article-title":"House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation","volume":"20","author":"Serhan","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.msec.2020.111582_bb0285","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri3690","article-title":"Mast cell secretory granules: armed for battle","volume":"14","author":"Wernersson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.msec.2020.111582_bb0290","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1097\/MIB.0000000000000142","article-title":"The multifaceted mast cell in inflammatory bowel disease","volume":"20","author":"Hamilton","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.msec.2020.111582_bb0295","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3748\/wjg.v10.i3.309","article-title":"Key role of mast cells and their major secretory products in inflammatory bowel disease","volume":"10","author":"He","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.msec.2020.111582_bb0300","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.7150\/thno.36120","article-title":"Copper-incorporated bioactive glass-ceramics inducing anti-inflammatory phenotype and regeneration of cartilage\/bone interface","volume":"9","author":"Lin","year":"2019","journal-title":"Theranostics."},{"key":"10.1016\/j.msec.2020.111582_bb0305","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1021\/am4060035","article-title":"Multidirectional effects of Sr-, Mg-, and Si-containing bioceramic coatings with high bonding strength on inflammation, osteoclastogenesis, and osteogenesis","volume":"6","author":"Wu","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.msec.2020.111582_bb0310","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.bone.2012.06.029","article-title":"Synthesis and inflammatory response of a novel silk fibroin scaffold containing BMP7 adenovirus for bone regeneration","volume":"51","author":"Zhang","year":"2012","journal-title":"Bone."},{"key":"10.1016\/j.msec.2020.111582_bb0315","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3021863","article-title":"Anti-TNF-\u03b1 therapy suppresses proinflammatory activities of mucosal neutrophils in inflammatory bowel disease","volume":"2018","author":"Zhang","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.msec.2020.111582_bb0320","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1365-2249.1993.tb05997.x","article-title":"Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn\u2019s disease","volume":"94","author":"Reinecker","year":"1993","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.msec.2020.111582_bb0325","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.4049\/jimmunol.1701643","article-title":"REDD1\/autophagy pathway is associated with neutrophil-driven IL-1\u03b2 inflammatory response in active ulcerative colitis","volume":"200","author":"Angelidou","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.msec.2020.111582_bb0330","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/ijms20010057","article-title":"NLRP3-dependent and -independent processing of interleukin (IL)-1\u03b2 in active ulcerative colitis","volume":"20","author":"Ranson","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.msec.2020.111582_bb0335","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.3390\/ijms19103257","article-title":"C-C motif ligand 20 (CCL20) and C-C motif chemokine receptor 6 (CCR6) in human peripheral blood mononuclear cells: dysregulated in ulcerative colitis and a potential role for CCL20 in IL-1\u03b2 release","volume":"19","author":"Skovdahl","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.msec.2020.111582_bb0340","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/mnfr.201500947","article-title":"Inflammation related responses of intestinal cells to plum and cabbage digesta with differential carotenoid and polyphenol profiles following simulated gastrointestinal digestion","volume":"60","author":"Kaulmann","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.msec.2020.111582_bb0345","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1039\/c2fo30097d","article-title":"Curcumin, an active component of turmeric in the prevention and treatment of ulcerative colitis: preclinical and clinical observations","volume":"3","author":"Baliga","year":"2012","journal-title":"Food Funct."},{"key":"10.1016\/j.msec.2020.111582_bb0350","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.3748\/wjg.v17.i36.4076","article-title":"Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis","volume":"17","author":"Zwolinska-Wcislo","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.msec.2020.111582_bb0355","first-page":"482","article-title":"Ferulic acid ameliorates TNBS-induced ulcerative colitis through modulation of cytokines, oxidative stress, iNOs, COX-2, and apoptosis in laboratory rats","volume":"15","author":"Sadar","year":"2016","journal-title":"EXCLI J."},{"key":"10.1016\/j.msec.2020.111582_bb0360","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.intimp.2013.09.022","article-title":"Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-\u03baB signal transduction pathways in rats with ulcerative colitis","volume":"17","author":"Sakthivel","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.msec.2020.111582_bb0365","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.intimp.2006.11.006","article-title":"Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis","volume":"7","author":"Camacho-Barquero","year":"2007","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.msec.2020.111582_bb0370","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3390\/nu9040391","article-title":"Oleuropein decreases cyclooxygenase-2 and interleukin-17 expression and attenuates inflammatory damage in colonic samples from ulcerative colitis patients","volume":"9","author":"Larussa","year":"2017","journal-title":"Nutrients."},{"key":"10.1016\/j.msec.2020.111582_bb0375","doi-asserted-by":"crossref","first-page":"68108","DOI":"10.18632\/oncotarget.19202","article-title":"Markers of inflammation and influence of nitric oxide on platelet activation in the course of ulcerative colitis","volume":"8","author":"Gawro\u0144ska","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.msec.2020.111582_bb0380","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4292\/wjgpt.v7.i3.353","article-title":"Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases","volume":"7","author":"Soufli","year":"2016","journal-title":"World J. Gastrointest. Pharmacol. Ther."},{"key":"10.1016\/j.msec.2020.111582_bb0385","doi-asserted-by":"crossref","first-page":"5","DOI":"10.17305\/bjbms.2013.2402","article-title":"Nitric oxide as a potential biomarker in inflammatory bowel disease","volume":"13","author":"Avdagi\u0107","year":"2013","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"10.1016\/j.msec.2020.111582_bb0390","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3109\/00365529509096328","article-title":"Serum nitrate levels in ulcerative colitis and Crohn\u2019s disease","volume":"30","author":"Pool","year":"1995","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.msec.2020.111582_bb0395","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.abb.2018.03.012","article-title":"Myeloperoxidase in the inflamed colon: a novel target for treating inflammatory bowel disease","volume":"645","author":"Chami","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.msec.2020.111582_bb0400","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/ibd.21681","article-title":"Myeloperoxidase immunohistochemistry as a measure of disease activity in ulcerative colitis: association with ulcerative colitis-colorectal cancer, tumor necrosis factor polymorphism and RUNX3 methylation","volume":"18","author":"Garrity-Park","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.msec.2020.111582_bb0405","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-016-1057-5","article-title":"Effect of turmeric on colon histology, body weight, ulcer, IL-23, MPO and glutathione in acetic-acid-induced inflammatory bowel disease in rats","volume":"16","author":"Bastaki","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.msec.2020.111582_bb0410","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ejpb.2018.01.016","article-title":"Inflamed site-specific drug delivery system based on the interaction of human serum albumin nanoparticles with myeloperoxidase in a murine model of experimental colitis","volume":"125","author":"Iwao","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.msec.2020.111582_bb0415","doi-asserted-by":"crossref","unstructured":"D.R. Hansberry, K. Shah, P. Agarwal, N. Agarwal, Fecal myeloperoxidase as a biomarker for inflammatory bowel disease, Cureus. 9 (n.d.). doi:https:\/\/doi.org\/10.7759\/cureus.1004.","DOI":"10.7759\/cureus.1004"},{"key":"10.1016\/j.msec.2020.111582_bb0420","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.apmt.2018.09.010","article-title":"Cytotoxicity of phosphorus allotropes (black, violet, red)","volume":"13","author":"Mohamad Latiff","year":"2018","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.msec.2020.111582_bb0425","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.apmt.2018.02.001","article-title":"In vitro cytotoxicity of covalently protected layered molybdenum disulfide","volume":"11","author":"Rosli","year":"2018","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.msec.2020.111582_bb0430","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.apmt.2017.12.003","article-title":"Immunomodulatory effects of mesoporous silica nanoparticles on osteogenesis: from nanoimmunotoxicity to nanoimmunotherapy","volume":"10","author":"Chen","year":"2018","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.msec.2020.111582_bb0435","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41565-018-0085-3","article-title":"Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes","volume":"13","author":"Hawkins","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.msec.2020.111582_bb0440","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/nmat4718","article-title":"Mechanism of hard-nanomaterial clearance by the liver","volume":"15","author":"Tsoi","year":"2016","journal-title":"Nat. Mater."}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493120335001?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493120335001?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:14:43Z","timestamp":1760534083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493120335001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":88,"alternative-id":["S0928493120335001"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2020.111582","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enteric-coated gelatin nanoparticles mediated oral delivery of 5-aminosalicylic acid alleviates severity of DSS-induced ulcerative colitis","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2020.111582","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111582"}}