{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:16:49Z","timestamp":1790389009496,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001849","name":"Defence Research and Development Organisation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001849","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.msec.2020.111604","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T18:57:14Z","timestamp":1602269834000},"page":"111604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Decellularized bone matrix\/oleoyl chitosan derived supramolecular injectable hydrogel promotes efficient bone integration"],"prefix":"10.1016","volume":"119","author":[{"given":"Sayanti","family":"Datta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Prabhu","family":"Rameshbabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamakshi","family":"Bankoti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhurima","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrika","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhodeep","family":"Jana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Kumar","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramkrishna","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santanu","family":"Dhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2020.111604_bb0005","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.2215\/CJN.04151206","article-title":"Normal bone anatomy and physiology","volume":"3","author":"Clarke","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.msec.2020.111604_bb0010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0169-6009(89)90044-5","article-title":"Noncollagenous matrix proteins and their role in mineralization","volume":"6","author":"Boskey","year":"1989","journal-title":"Bone Miner."},{"key":"10.1016\/j.msec.2020.111604_bb0015","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2106\/00004623-200703000-00026","article-title":"Bone grafts and bone graft substitutes in orthopaedic trauma surgery. A critical analysis","volume":"89","author":"De Long","year":"2007","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.msec.2020.111604_bb0020","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/S0142-9612(00)00102-2","article-title":"Biomaterial developments for bone tissue engineering","volume":"21","author":"Burg","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2020.111604_bb0025","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1096\/fasebj.3.9.2501132","article-title":"Essential fatty acids and immune response","volume":"3","author":"Hwang","year":"1989","journal-title":"FASEB J."},{"key":"10.1016\/j.msec.2020.111604_bb0030","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1002\/jcp.24013","article-title":"Unsaturated fatty acids induce mesenchymal stem cells to increase secretion of angiogenic mediators","volume":"227","author":"Smith","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.msec.2020.111604_bb0035","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11914-013-0149-0","article-title":"Polyunsaturated fatty acids and their relation with bone and muscle health in adults","volume":"11","author":"Mangano","year":"2013","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.msec.2020.111604_bb0040","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1177\/1535370217731104","article-title":"Fatty acid is a potential agent for bone tissue induction: in vitro and in vivo approach","volume":"242","author":"Cardoso","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.msec.2020.111604_bb0045","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1021\/acsbiomaterials.7b00189","article-title":"Oleoyl-chitosan-based nanofiber mats impregnated with amniotic membrane derived stem cells for accelerated full-thickness excisional wound healing","volume":"3","author":"Datta","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.msec.2020.111604_bb0050","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nmat2441","article-title":"Complexity in biomaterials for tissue engineering","volume":"8","author":"Place","year":"2009","journal-title":"Nat. Mat."},{"key":"10.1016\/j.msec.2020.111604_bb0055","first-page":"3675","volume":"27","author":"Gilbert","year":"2006","journal-title":"Decellularization of tissues and organs. Biomaterials"},{"key":"10.1016\/j.msec.2020.111604_bb0060","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/S0002-9440(10)65020-1","article-title":"Regulation of tissue injury responses by the exposure of matricryptic sites within extracellular matrix molecules","volume":"156","author":"Davis","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.msec.2020.111604_bb0065","doi-asserted-by":"crossref","first-page":"7865","DOI":"10.1016\/j.actbio.2013.04.029","article-title":"Hydrogels derived from demineralized and decellularized bone extracellular matrix","volume":"9","author":"Sawkins","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2020.111604_bb0070","doi-asserted-by":"crossref","first-page":"7028","DOI":"10.1016\/j.biomaterials.2012.06.051","article-title":"A hydrogel derived from decellularized dermal extracellular matrix","volume":"33","author":"Wolf","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2020.111604_bb0075","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.actbio.2015.10.013","article-title":"Preparation and characterization of pro-angiogenic gel derived from small intestinal submucosa","volume":"29","author":"Wang","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2020.111604_bb0080","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1021\/bm4015039","article-title":"Liver extracellular matrix providing dual functions of two-dimensional substrate coating and three-dimensional injectable hydrogel platform for liver tissue engineering","volume":"15","author":"Lee","year":"2014","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.msec.2020.111604_bb0085","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.biomaterials.2007.12.014","article-title":"Preparation and rheological characterization of a gel form of the porcine urinary bladder matrix","volume":"29","author":"Freytes","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2020.111604_bb0090","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.trsl.2013.11.003","article-title":"Extracellular matrix as an inductive scaffold for functional tissue reconstruction","volume":"163","author":"Brown","year":"2014","journal-title":"Transl. Res."},{"key":"10.1016\/j.msec.2020.111604_bb0095","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s002640050290","volume":"22","author":"Solheim","year":"1998","journal-title":"Growth factors in bone. Int. Orthop."},{"key":"10.1016\/j.msec.2020.111604_bb0100","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/jbm.b.33894","article-title":"Bone extracellular matrix hydrogel enhances osteogenic differentiation of C2C12 myoblasts and mouse primary calvarial cells","volume":"106","author":"Alom","year":"2018","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.msec.2020.111604_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145080","article-title":"In vivo assessment of bone regeneration in alginate\/bone ECM hydrogels with incorporated skeletal stem cells and single growth factors","volume":"10","author":"Gothard","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.msec.2020.111604_bb0110","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1634\/stemcells.2007-0637","article-title":"Concise review: mesenchymal stem\/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair\u2014current views","volume":"25","author":"Phinney","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.msec.2020.111604_bb0115","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.1214804","article-title":"Designing cell-compatible hydrogels for biomedical applications","volume":"336","author":"Seliktar","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.msec.2020.111604_bb0120","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.actbio.2016.04.019","article-title":"Approaching the compressive modulus of articular cartilage with a decellularized cartilage-based hydrogel","volume":"38","author":"Beck","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2020.111604_bb0125","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1089\/ten.tea.2014.0490","article-title":"Optimization of an injectable tendon hydrogel: the effects of platelet-rich plasma and adipose-derived stem cells on tendon healing in vivo","volume":"21","author":"Chiou","year":"2015","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.msec.2020.111604_bb0130","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1016\/j.actbio.2014.05.025","article-title":"Evaluation of skeletal tissue repair, part 2: enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model","volume":"10","author":"Smith","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2020.111604_bb0135","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.biomaterials.2017.04.004","article-title":"Stem cell delivery in tissue-specific hydrogel enabled meniscal repair in an orthotopic rat model","volume":"132","author":"Yuan","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2020.111604_bb0140","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1016\/j.biomaterials.2011.12.033","article-title":"Non-invasive imaging of transplanted human neural stem cells and ECM scaffold remodeling in the stroke-damaged rat brain by (19)F- and diffusion-MRI","volume":"33","author":"Bible","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2020.111604_bb0145","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1089\/ten.tea.2015.0422","article-title":"Injectable extracellular matrix hydrogels as scaffolds for spinal cord injury repair","volume":"22","author":"Tukmachev","year":"2016","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.msec.2020.111604_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148225","article-title":"Odontogenic differentiation of human dental pulp stem cells on hydrogel scaffolds derived from decellularized bone extracellular matrix and collagen type I","volume":"11","author":"Paduano","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.msec.2020.111604_bb0155","doi-asserted-by":"crossref","first-page":"24779","DOI":"10.1038\/srep24779","article-title":"Genipin crosslinking reduced the immunogenicity of xenogeneic decellularized porcine whole-liver matrices through regulation of immune cell proliferation and polarization","volume":"21","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.msec.2020.111604_bb0160","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10561-009-9168-6","article-title":"BMP depletion occurs during prolonged acid demineralization of bone: characterization and implications for graft preparation","volume":"12","author":"Pietrzak","year":"2011","journal-title":"Cell Tissue Bank."},{"key":"10.1016\/j.msec.2020.111604_bb0165","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1016\/j.biortech.2009.12.133","article-title":"Isolation and characterization of fish scale collagen of higher thermal stability","volume":"101","author":"Pati","year":"2010","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.msec.2020.111604_bb0170","doi-asserted-by":"crossref","first-page":"4618","DOI":"10.1016\/j.actbio.2014.07.031","article-title":"Electrospun biodegradable elastic polyurethane scaffolds with dipyridamole release for small diameter vascular grafts","volume":"10","author":"Punnakitikashem","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2020.111604_bb0175","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nmat2915","article-title":"A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability","volume":"10","author":"Li","year":"2011","journal-title":"Nat. Mat."},{"key":"10.1016\/j.msec.2020.111604_bb0180","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1039\/C5TB02321A","article-title":"Investigating the potential of human placenta-derived extracellular matrix sponges coupled with amniotic membrane-derived stem cells for osteochondral tissue engineering","volume":"4","author":"Rameshbabu","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.msec.2020.111604_bb0185","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nprot.2006.13","article-title":"The gelatin sponge-chorioallantoic membrane assay","volume":"1","author":"Ribatti","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.msec.2020.111604_bb0190","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.biomaterials.2009.09.061","article-title":"Surface characterization of extracellular matrix scaffolds","volume":"31","author":"Brown","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2020.111604_bb0195","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1021\/acsbiomaterials.7b00619","article-title":"Decellularized matrices as cell-instructive scaffolds to guide tissue-specific regeneration","volume":"4","author":"Robb","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.msec.2020.111604_bb0200","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.actbio.2014.01.028","article-title":"Immunogenicity in xenogeneic scaffold generation: antigen removal vs","volume":"10","author":"Wong","year":"2014","journal-title":"Decellularization. Acta Biomater."},{"key":"10.1016\/j.msec.2020.111604_bb0205","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1016\/j.biomaterials.2011.01.057","article-title":"An overview of tissue and whole organ decellularization processes","volume":"32","author":"Crapo","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2020.111604_bb0210","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1073\/pnas.152324099","volume":"99","author":"Street","year":"2002","journal-title":"U S A"},{"key":"10.1016\/j.msec.2020.111604_bb0215","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/ng1916","article-title":"BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing","volume":"38","author":"Tsuji","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.msec.2020.111604_bb0220","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3109\/17453679308993691","article-title":"Transforming growth factor-beta enhances fracture healing in rabbit tibiae","volume":"64","author":"Lind","year":"1993","journal-title":"Acta Orthop. Scand."},{"key":"10.1016\/j.msec.2020.111604_bb0225","article-title":"TGF-\u03b2 and BMP signaling in osteoblast, skeletal development, and bone formation","volume":"4","author":"Wu","year":"2016","journal-title":"homeostasis and disease. Bone Res."},{"key":"10.1016\/j.msec.2020.111604_bb0230","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1369-7021(08)70086-5","article-title":"Biomaterials for bone tissue engineering","volume":"11","author":"Stevens","year":"2008","journal-title":"Mater. Today"},{"key":"10.1016\/j.msec.2020.111604_bb0235","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1016\/S0142-9612(00)00108-3","article-title":"Injectable biodegradable materials for orthopedic tissue engineering","volume":"21","author":"Tememoff","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2020.111604_bb0240","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nbt874","article-title":"Fabrication of novel biomaterials through molecular self-assembly","volume":"21","author":"Zhang","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.msec.2020.111604_bb0245","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1021\/la010223i","article-title":"Self-assembly of model collagen peptide amphiphiles","volume":"17","author":"Gore","year":"2001","journal-title":"Langmuir"},{"key":"10.1016\/j.msec.2020.111604_bb0250","doi-asserted-by":"crossref","first-page":"6295","DOI":"10.1038\/ncomms7295","article-title":"Self-assembled hydrogels utilizing polymer-nanoparticle interactions","volume":"6","author":"Appel","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.msec.2020.111604_bb0255","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00216-009-3019-y","article-title":"Collagen types analysis and differentiation by FTIR spectroscopy","volume":"395","author":"Belbachir","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.msec.2020.111604_bb0260","doi-asserted-by":"crossref","unstructured":"Ahn, G.; Min, K. H.; Kim, C.; Lee, J. S.; Kang, D.; Won, J. Y.; Cho, D. W.; Kim, J. Y.; Jin, S.; Yun, W. S.; Shim, J. H. Precise stacking of decellularized extracellular matrix based 3D cell-laden constructs by A 3D cell printing system equipped with heating modules. Sci. Rep. 7: 8624 | DOI: https:\/\/doi.org\/10.1038\/s41598-017-09201-5.","DOI":"10.1038\/s41598-017-09201-5"},{"key":"10.1016\/j.msec.2020.111604_bb0265","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.carbpol.2008.01.024","article-title":"Antibacterial activity of oleoyl-chitosan nanoparticles: a novel antibacterial dispersion system","volume":"74","author":"Xing","year":"2008","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.msec.2020.111604_bb0270","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S1359-6446(03)02866-6","article-title":"Angiogenesis and bone repair","volume":"8","author":"Carano","year":"2003","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.msec.2020.111604_bb0275","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1124\/pr.56.4.3","article-title":"Vascular endothelial growth factor and angiogenesis","volume":"56","author":"Hoeben","year":"2004","journal-title":"Pharmacol. Rev."}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493120335220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493120335220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:17:13Z","timestamp":1760534233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493120335220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":55,"alternative-id":["S0928493120335220"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2020.111604","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decellularized bone matrix\/oleoyl chitosan derived supramolecular injectable hydrogel promotes efficient bone integration","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2020.111604","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111604"}}