{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:40:25Z","timestamp":1791178825619,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.msec.2021.111941","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T19:53:10Z","timestamp":1612554790000},"page":"111941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Double layer composite membrane for preventing tendon adhesion and promoting tendon healing"],"prefix":"10.1016","volume":"123","author":[{"given":"Zuofa","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjun","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2021.111941_bb0005","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1053\/j.oto.2016.06.011","article-title":"Cell and biologic-based treatment of flexor tendon injuries","volume":"26","author":"Linderman","year":"2016","journal-title":"Oper. Tech. Orthop."},{"key":"10.1016\/j.msec.2021.111941_bb0010","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1089\/ten.tea.2012.0208","article-title":"Prevention of peritendinous adhesions with electrospun ibuprofen-loaded poly (l-lactic acid)-polyethylene glycol fibrous membranes","volume":"19","author":"Liu","year":"2013","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.msec.2021.111941_bb0015","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1152\/japplphysiol.00281.2017","article-title":"Effects of anti-inflammatory (NSAID) treatment on human tendinopathic tissue","volume":"123","author":"Heinemeier","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.msec.2021.111941_bb0020","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1007\/s10439-017-1876-7","article-title":"Electrospun PLGA nanofiber scaffolds release ibuprofen faster and degrade slower after in vivo implantation","volume":"45","author":"Riggin","year":"2017","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.msec.2021.111941_bb0025","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.actbio.2017.09.010","article-title":"Thermo-responsive in-situ forming hydrogels as barriers to prevent post-operative peritendinous adhesion","volume":"63","author":"Chou","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2021.111941_bb0030","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.actbio.2017.08.002","article-title":"Polymer materials for prevention of postoperative adhesion","volume":"61","author":"Li","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2021.111941_bb0035","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s10118-015-1611-5","article-title":"Prevention of postoperative tendon adhesion by biodegradable electrospun membrane of poly(lactide-co-glycolide)","volume":"33","author":"Song","year":"2015","journal-title":"Chin. J. Polym. Sci."},{"key":"10.1016\/j.msec.2021.111941_bb0040","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1039\/C6BM00958A","article-title":"Macrophage infiltration of electrospun polyester fibers","volume":"5","author":"Liu","year":"2017","journal-title":"Biomater Sci"},{"key":"10.1016\/j.msec.2021.111941_bb0045","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.actbio.2018.03.044","article-title":"Multi-functional electrospun antibacterial core-shell nanofibrous membranes for prolonged prevention of post-surgical tendon adhesion and inflammation","volume":"72","author":"Shalumon","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2021.111941_bb0050","doi-asserted-by":"crossref","first-page":"7381","DOI":"10.1016\/j.actbio.2013.03.040","article-title":"Long-term drug release from electrospun fibers for in vivo inflammation prevention in the prevention of peritendinous adhesions","volume":"9","author":"Hu","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2021.111941_bb0055","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3390\/ijms19030820","article-title":"Exploring the in vivo anti-inflammatory actions of simvastatin-loaded porous microspheres on inflamed tenocytes in a collagenase-induced animal model of Achilles tendinitis","volume":"19","author":"Jeong","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.msec.2021.111941_bb0060","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1089\/humc.2018.121","article-title":"Ultrasound-targeted microbubble destruction delivery of insulin-like growth factor 1 cDNA and transforming growth factor Beta short hairpin RNA enhances tendon regeneration and inhibits scar formation in vivo","volume":"29","author":"Xiang","year":"2018","journal-title":"Hum Gene Ther Clin Dev"},{"key":"10.1016\/j.msec.2021.111941_bb0065","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12891-016-0999-6","article-title":"Stem cells and bFGF in tendon healing: effects of lentiviral gene transfer and long-term follow-up in a rat Achilles tendon defect model","volume":"17","author":"Kraus","year":"2016","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.msec.2021.111941_bb0070","first-page":"26","article-title":"Effect of basic fibroblast growth factor on Achilles tendon healing in rabbit","volume":"6","author":"Najafbeygi","year":"2017","journal-title":"World J Plast Surg"},{"key":"10.1016\/j.msec.2021.111941_bb0075","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1016\/j.biomaterials.2013.03.026","article-title":"Tendon healing and anti-adhesion properties of electrospun fibrous membranes containing bFGF loaded nanoparticles","volume":"34","author":"Liu","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2021.111941_bb0080","doi-asserted-by":"crossref","DOI":"10.1038\/natrevmats.2016.71","article-title":"Designing hydrogels for controlled drug delivery","volume":"1","author":"Li","year":"2016","journal-title":"Nature Reviews Materials"},{"key":"10.1016\/j.msec.2021.111941_bb0085","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1021\/acsami.7b17020","article-title":"Injectable and thermosensitive hydrogel and PDLLA electrospun nanofiber membrane composites for guided spinal fusion","volume":"10","author":"Qu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.msec.2021.111941_bb0090","doi-asserted-by":"crossref","first-page":"11568","DOI":"10.1021\/acsami.7b02488","article-title":"Injectable polypeptide Thermogel as a tissue engineering system for hepatogenic differentiation of tonsil-derived mesenchymal stem cells","volume":"9","author":"Hong","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.msec.2021.111941_bb0095","doi-asserted-by":"crossref","first-page":"5951","DOI":"10.1039\/c3sm50582k","article-title":"Responsive organogels formed by supramolecular self assembly of PEG-block-allyl-functionalized racemic polypeptides into \u03b2-sheet-driven polymeric ribbons","volume":"9","author":"Zou","year":"2013","journal-title":"Soft Matter"},{"key":"10.1016\/j.msec.2021.111941_bb0100","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1021\/bm3004308","article-title":"Decisive role of hydrophobic side groups of polypeptides in thermosensitive gelation","volume":"13","author":"Cheng","year":"2012","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.msec.2021.111941_bb0105","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/btpr.2270","article-title":"Prevention of adhesion bands by ibuprofen-loaded PLGA nanofibers","volume":"32","author":"Jamshidiadegani","year":"2016","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.msec.2021.111941_bb0110","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.mattod.2013.06.005","article-title":"Biomimetic electrospun nanofibrous structures for tissue engineering","volume":"16","author":"Wang","year":"2013","journal-title":"Mater. Today"},{"key":"10.1016\/j.msec.2021.111941_bb0115","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1016\/j.nano.2016.12.024","article-title":"Biology and medicine, design of electrospun nanofibrous mats for osteogenic differentiation of mesenchymal stem cells","volume":"14","author":"Wang","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.msec.2021.111941_bb0120","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s11095-006-9036-z","article-title":"Electrospun micro-and nanofibers for sustained delivery of paclitaxel to treat C6 glioma in vitro","volume":"23","author":"Xie","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.msec.2021.111941_bb0125","doi-asserted-by":"crossref","unstructured":"J.D. Han, X.Y. Zhao, W.G. Xu, W. Wang, Y.P. Han, X.R. Feng, Effect of hydrophobic polypeptide length on performances of thermo-sensitive hydrogels, Molecules, 23 (2018) 1017.","DOI":"10.3390\/molecules23051017"},{"key":"10.1016\/j.msec.2021.111941_bb0130","doi-asserted-by":"crossref","first-page":"034107","DOI":"10.1088\/1748-605X\/aaadd1","article-title":"Functionalized thermosensitive hydrogel combined with tendon stem\/progenitor cells as injectable cell delivery carrier for tendon tissue engineering","volume":"13","author":"Yin","year":"2018","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.msec.2021.111941_bb0135","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jhsa.2017.06.013","article-title":"Molecular biology of flexor tendon healing in relation to reduction of tendon adhesions","volume":"42","author":"Legrand","year":"2017","journal-title":"J Hand Surg Am"},{"key":"10.1016\/j.msec.2021.111941_bb0140","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.actbio.2018.01.047","article-title":"Localized delivery of miRNAs targets cyclooxygenases and reduces flexor tendon adhesions","volume":"70","author":"Zhou","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2021.111941_bb0145","doi-asserted-by":"crossref","unstructured":"J. B. Tang, Y. F. Wu, Y. Cao, C. H. Chen, Y. L. Zhou, B. Avanessian, M. Shimada, X. T. Wang, P. Y. Liu, Basic FGF or VEGF gene therapy corrects insufficiency in the intrinsic healing capacity of tendons, Sci. Rep., 6 (2016) 20643.","DOI":"10.1038\/srep20643"},{"key":"10.1016\/j.msec.2021.111941_bb0150","doi-asserted-by":"crossref","unstructured":"A. Vinhas, M. T. Rodrigues, M. E. Gomes, Exploring stem cells and inflammation in tendon repair and regeneration, Adv. Exp. Med. Biol., 1089 (2018) 37\u201346.","DOI":"10.1007\/5584_2018_258"},{"key":"10.1016\/j.msec.2021.111941_bb0155","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1302\/2058-5241.2.160075","article-title":"Tendon injuries: basic science and new repair proposals","volume":"2","author":"Wu","year":"2017","journal-title":"EFORT Open Rev"},{"key":"10.1016\/j.msec.2021.111941_bb0160","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.trsl.2019.02.002","article-title":"The cellular basis of fibrotic tendon healing: challenges and opportunities","volume":"209","author":"Nichols","year":"2019","journal-title":"Transl. Res."},{"key":"10.1016\/j.msec.2021.111941_bb0165","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.addr.2014.11.015","article-title":"Biologics for tendon repair","volume":"84","author":"Docheva","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.msec.2021.111941_bb0170","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/000164700317381234","article-title":"Effects of basic fibroblast growth factor (bFGF) on early stages of tendon healing: a rat patellar tendon model","volume":"71","author":"Chan","year":"2000","journal-title":"Acta Orthop. Scand."},{"key":"10.1016\/j.msec.2021.111941_bb0175","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40634-017-0082-8","article-title":"Different culture conditions affect the growth of human tendon stem\/progenitor cells (TSPCs) within a mixed tendon cells (TCs) population","volume":"4","author":"Vigan\u00f2","year":"2017","journal-title":"J Exp Orthop"},{"key":"10.1016\/j.msec.2021.111941_bb0180","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1177\/0363546518814534","article-title":"Response of the injured tendon to growth factors in the presence or absence of the paratenon","volume":"47","author":"M\u00fcller","year":"2019","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.msec.2021.111941_bb0185","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1152\/japplphysiol.00053.2013","article-title":"NSAID therapy effects on healing of bone, tendon, and the enthesis","volume":"115","author":"Su","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.msec.2021.111941_bb0190","first-page":"3002","article-title":"Mesenchymal stem cells empowering tendon regenerative therapies","volume":"Mol,12","author":"Costa-Almeida","year":"2019","journal-title":"Int. J."},{"key":"10.1016\/j.msec.2021.111941_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40634-017-0117-1","article-title":"Boosting tendon repair: interplay of cells, growth factors and scaffold-free and gel- based carriers","volume":"5","author":"Yan","year":"2018","journal-title":"J Exp Orthop"}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493121000795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928493121000795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:11:54Z","timestamp":1760533914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928493121000795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":39,"alternative-id":["S0928493121000795"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2021.111941","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Double layer composite membrane for preventing tendon adhesion and promoting tendon healing","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2021.111941","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111941"}}