{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:18:09Z","timestamp":1787977089684,"version":"build-2784847793"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Science and Engineering: C"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.msec.2021.112101","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T04:18:18Z","timestamp":1618546698000},"page":"112101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Probiotic bacteria cell surface-associated protein mineralized hydroxyapatite incorporated in porous scaffold: In vitro evaluation for bone cell growth and differentiation"],"prefix":"10.1016","volume":"126","author":[{"given":"Priya","family":"Mullick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Aiyagari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msec.2021.112101_bb0005","first-page":"7442","article-title":"Recent advances in the synthesis, functionalization and biomedical applications of hydroxyapatite: a review","volume":"7","author":"Haider","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.msec.2021.112101_bb0010","first-page":"5319","article-title":"Inorganic biomaterials for regenerative medicine","volume":"12","author":"Brokesh","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.msec.2021.112101_bb0015","first-page":"S20","article-title":"Bone substitutes: an update","volume":"36","author":"Giannoudis","year":"2005","journal-title":"Injury"},{"key":"10.1016\/j.msec.2021.112101_bb0020","first-page":"2769","article-title":"Nanoscale hydroxyapatite particles for bone tissue engineering","volume":"7","author":"Zhou","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2021.112101_bb0025","first-page":"320","article-title":"Controllable synthesis of biomimetic hydroxyapatite nanorods with high osteogenic bioactivity","volume":"6","author":"Li","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.msec.2021.112101_bb0030","first-page":"26707","article-title":"Bioinspired composite matrix containing hydroxyapatite-silica core-shell nanorods for bone tissue engineering","volume":"9","author":"Anitha","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.msec.2021.112101_bb0035","first-page":"3813","article-title":"Various preparation methods of highly porous hydroxyapatite\/polymer nanoscale biocomposites for bone regeneration","volume":"7","author":"Sun","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2021.112101_bb0040","first-page":"575","article-title":"Three-dimensional high-porosity chitosan\/honeycomb porous carbon\/hydroxyapatite scaffold with enhanced osteoinductivity for bone regeneration","volume":"6","author":"Dai","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.msec.2021.112101_bb0045","first-page":"1399","article-title":"Poly (lactide-co-glycolide)\/hydroxyapatite composite scaffolds for bone tissue engineering","volume":"27","author":"Kim","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2021.112101_bb0050","first-page":"18235","article-title":"Intrafibrillar mineralized collagen\u2013hydroxyapatite- based scaffolds for bone regeneration","volume":"12","author":"Yu","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.msec.2021.112101_bb0055","first-page":"68","article-title":"Silk fibroin\/hydroxyapatite composites for bone tissue engineering, Biotechnol","volume":"36","author":"Farokhi","year":"2018","journal-title":"Adv."},{"key":"10.1016\/j.msec.2021.112101_bb0060","first-page":"3441","article-title":"Protein-based hydroxyapatite materials: tuning composition toward biomedical applications","volume":"3","author":"Veiga","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.msec.2021.112101_bb0065","first-page":"7591","article-title":"Synthesis methods for nanosized hydroxyapatite with diverse structures","volume":"9","author":"Shojai","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.msec.2021.112101_bb0070","first-page":"401","article-title":"Protein\/peptide-templated biomimetic synthesis of inorganic nanoparticles for biomedical applications","volume":"5","author":"Yang","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.msec.2021.112101_bb0075","first-page":"729","article-title":"A facile method to synthesize mussel-inspired polydopamine nanospheres as an active template for in situ formation of biomimetic hydroxyapatite","volume":"94","author":"Ghorbani","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2021.112101_bb0080","first-page":"16338","article-title":"Flagellar display of bone-protein-derived peptides for studying peptide-mediated biomineralization","volume":"28","author":"Li","year":"2012","journal-title":"Langmuir"},{"key":"10.1016\/j.msec.2021.112101_bb0085","first-page":"8745","article-title":"A novel protein tightly bound to bacterial magnetic particles in Magnetospirillum magneticum strain AMB-1","volume":"278","author":"Arakaki","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.msec.2021.112101_bb0090","first-page":"1387","article-title":"Osteoconductive composite graft based on bacterial synthesized hydroxyapatite nanoparticles doped with different ions: from synthesis to in vivo studies, Nanomed","volume":"12","author":"Ahmadzadeh","year":"2016","journal-title":"Nanotech. Biol. Med."},{"key":"10.1016\/j.msec.2021.112101_bb0095","first-page":"2664","article-title":"Lactic acid bacterial extract as a biogenic mineral growth modifier","volume":"311","author":"Borah","year":"2009","journal-title":"J. Cryst. Growth"},{"key":"10.1016\/j.msec.2021.112101_bb0100","first-page":"2927","article-title":"Generation of a hydroxyapatite nanocarrier through biomineralization using cell-free extract of lactic acid bacteria for antibiofilm application","volume":"2","author":"Mullick","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.msec.2021.112101_bb0105","article-title":"Lactobacillus rhamnosus GG genomic and phenotypic stability in an industrial production process","volume":"86","author":"Stage","year":"2020","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.msec.2021.112101_bb0110","first-page":"121","article-title":"Survival of Lactobacillus species (strain GG) in human gastrointestinal tract, Dig","volume":"37","author":"Goldin","year":"1992","journal-title":"Dis. Sci."},{"key":"10.1016\/j.msec.2021.112101_bb0115","first-page":"18","article-title":"Probiotics as prevention and treatment for diarrhea, Curr","volume":"25","author":"Guarino","year":"2009","journal-title":"Opin. Gastroenterol."},{"key":"10.1016\/j.msec.2021.112101_bb0120","first-page":"1230","article-title":"Effect of growth time on the surface and adhesion properties of Lactobacillus rhamnosus GG","volume":"107","author":"Deepika","year":"2009","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.msec.2021.112101_bb0125","first-page":"5225","article-title":"Lactobacillus surface layer proteins: structure, function and applications","volume":"97","author":"Hyn\u00f6nen","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.msec.2021.112101_bb0130","first-page":"196","article-title":"The dynamic nature of bacterial surfaces: implications for metal\u2013membrane interaction","volume":"39","author":"French","year":"2013","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.msec.2021.112101_bb0135","first-page":"10911","article-title":"Dynamics characterization of fully hydrated bacterial cell walls by solid- state NMR: evidence for cooperative binding of metal ions","volume":"132","author":"Kern","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.msec.2021.112101_bb0140","first-page":"276","article-title":"Teichoic acids and related cell-wall glycopolymers in gram-positive physiology and host interactions","volume":"6","author":"Weidenmaier","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.msec.2021.112101_bb0145","first-page":"5943","article-title":"Surface display of foreign epitopes on the Lactobacillus brevis S-layer, Appl","volume":"68","author":"AvallJaaskelainen","year":"2002","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.msec.2021.112101_bb0150","first-page":"4958","article-title":"Zn-and Mg-doped hydroxyapatite nanoparticles for controlled release of protein","volume":"26","author":"Dasgupta","year":"2010","journal-title":"Langmuir"},{"key":"10.1016\/j.msec.2021.112101_bb0155","first-page":"115","article-title":"Development of gelatin\/carboxymethyl chitosan\/nano-hydroxyapatite composite 3D macroporous scaffold for bone tissue engineering applications, Carbohydr","volume":"189","author":"Maji","year":"2018","journal-title":"Polym."},{"key":"10.1016\/j.msec.2021.112101_bb0160","first-page":"5305","article-title":"Chitosan-gelatin scaffolds incorporating decellularized platelet-rich fibrin promote bone regeneration","volume":"5","author":"Chi","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.msec.2021.112101_bb0165","first-page":"4115","article-title":"Nanocomposites of bio-based hyperbranched polyurethane\/funtionalized MWCNT as non-immunogenic, osteoconductive, biodegradable and biocompatible scaffolds in bone tissue engineering","volume":"B.1","author":"Das","year":"2013","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.msec.2021.112101_bb0170","first-page":"512417","article-title":"Chemical synthesis, characterization, and biocompatibility study of hydroxyapatite\/chitosan phosphate nanocomposite for bone tissue engineering applications","author":"Pramanik","year":"2009","journal-title":"Int. J. Biomater."},{"key":"10.1016\/j.msec.2021.112101_bb0175","first-page":"402","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"key":"10.1016\/j.msec.2021.112101_bb0180","first-page":"4573","article-title":"S-layer production by Lactobacillus acidophilus IBB 801 under environmental stress conditions","volume":"100","author":"Grosu-Tudor","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.msec.2021.112101_bb0185","first-page":"3499","article-title":"Polydopamine-templated hydroxyapatite reinforced polycaprolactone composite nanofibers with enhanced cytocompatibility and osteogenesis for bone tissue engineering","volume":"8","author":"Gao","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.msec.2021.112101_bb0190","first-page":"3158","article-title":"Synthesis and characterization of mesoporous hydroxyapatite powder by microemulsion technique","volume":"8","author":"Huang","year":"2019","journal-title":"J. Mater. Res. Technol."},{"key":"10.1016\/j.msec.2021.112101_bb0195","first-page":"62556","article-title":"Biomimetic matrix mediated room temperature synthesis and characterization of nano-hydroxyapatite towards targeted drug delivery","volume":"6","author":"Sheikh","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.msec.2021.112101_bb0200","first-page":"6720","article-title":"Cosynthesis of cargo-loaded hydroxyapatite\/alginate core\u2013shell nanoparticles (HAP@ Alg) as pH-responsive nanovehicles by a pre-gel method","volume":"4","author":"Liang","year":"2012","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.msec.2021.112101_bb0205","first-page":"340","article-title":"Crystal structure of calcium-deficient carbonated hydroxyapatite","volume":"160","author":"Ivanova","year":"2001","journal-title":"Thermal decomposition, J. Solid State Chem."},{"key":"10.1016\/j.msec.2021.112101_bb0210","first-page":"3338","article-title":"Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite\/polyamide composite scaffolds for bone tissue engineering","volume":"28","author":"Wang","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2021.112101_bb0215","first-page":"16","article-title":"Non-mulberry silk fibroin grafted poly (\u0404-caprolactone)\/nano hydroxyapatite nanofibrous scaffold for dual growth factor delivery to promote bone regeneration","volume":"472","author":"Bhattacharjee","year":"2016","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.msec.2021.112101_bb0220","first-page":"45","article-title":"Interconnected porosity analysis by 3D X-ray microtomography and mechanical behavior of biomimetic organic-inorganic composite materials","volume":"C. 80","author":"Alonso-Sierra","year":"2017","journal-title":"Mat. Sci. Eng."},{"key":"10.1016\/j.msec.2021.112101_bb0225","first-page":"1","article-title":"Fabrication aspects of porous biomaterials in orthopedic applications: a review, ACS Biomater","volume":"4","author":"Babaie","year":"2018","journal-title":"Sci. Eng."},{"key":"10.1016\/j.msec.2021.112101_bb0230","first-page":"325","article-title":"Biomimetic composite scaffold of hydroxyapatite\/gelatin-chitosan core-shell nanofibers for bone tissue engineering","volume":"97","author":"Chen","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.msec.2021.112101_bb0235","first-page":"3991","article-title":"Microcellular polyHIPE polymer supports osteoblast growth and bone formation in vitro","volume":"25","author":"Akay","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2021.112101_bb0240","first-page":"1100","article-title":"Biomineralization of recombinant peptide scaffolds: interplay among chemistry, architecture, and mechanics","volume":"3","author":"Pawelec","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.msec.2021.112101_bb0245","first-page":"487","article-title":"Development of novel biocomposite scaffold of chitosan-gelatin\/nanohydroxyapatite for potential bone tissue engineering applications, Nanoscale Res","volume":"11","author":"Dan","year":"2016","journal-title":"Lett."},{"key":"10.1016\/j.msec.2021.112101_bb0250","first-page":"255","article-title":"A simple method to measure cell viability in proliferation and cytotoxicity assays, Braz","volume":"23","author":"Borra","year":"2009","journal-title":"Oral Res."},{"key":"10.1016\/j.msec.2021.112101_bb0255","first-page":"9167","article-title":"Electrospun hydroxyapatite-containing chitosan nanofibers crosslinked with genipin for bone tissue engineering","volume":"33","author":"Frohbergh","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.msec.2021.112101_bb0260","first-page":"444","article-title":"The role of alkaline phosphatase in mineralization, Curr","volume":"18","author":"Golub","year":"2007","journal-title":"Opin. Orthop."},{"key":"10.1016\/j.msec.2021.112101_bb0265","first-page":"317","article-title":"Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics","volume":"1","author":"Barr\u00e8re","year":"2006","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.msec.2021.112101_bb0270","first-page":"446","article-title":"Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways","volume":"88","author":"Franceschi","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.msec.2021.112101_bb0275","first-page":"696","article-title":"Mechanisms of bone development and repair","volume":"21","author":"Salhotra","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.msec.2021.112101_bb0280","first-page":"1","article-title":"Calcite incorporated in silica\/collagen xerogels mediates calcium release and enhances osteoblast proliferation and differentiation, Sci","volume":"10","author":"Robler","year":"2020","journal-title":"Rep."}],"container-title":["Materials Science and Engineering: C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092849312100240X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092849312100240X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:15:19Z","timestamp":1760534119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092849312100240X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":56,"alternative-id":["S092849312100240X"],"URL":"https:\/\/doi.org\/10.1016\/j.msec.2021.112101","relation":{},"ISSN":["0928-4931"],"issn-type":[{"value":"0928-4931","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Probiotic bacteria cell surface-associated protein mineralized hydroxyapatite incorporated in porous scaffold: In vitro evaluation for bone cell growth and differentiation","name":"articletitle","label":"Article Title"},{"value":"Materials Science and Engineering: C","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msec.2021.112101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112101"}}