{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:48:47Z","timestamp":1790938127629,"version":"4.1.0"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:00:00Z","timestamp":1644624000000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/20206\\u20138"],"award-info":[{"award-number":["2015\/20206\\u20138"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/02313\\u20130"],"award-info":[{"award-number":["2020\/02313\\u20130"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2018\/19537\\u20138"],"award-info":[{"award-number":["2018\/19537\\u20138"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303646\/2019\\u20135"],"award-info":[{"award-number":["303646\/2019\\u20135"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2018\/06635\\u20131"],"award-info":[{"award-number":["2018\/06635\\u20131"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302212\/2019\\u20131"],"award-info":[{"award-number":["302212\/2019\\u20131"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.mtbio.2022.100221","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T12:10:32Z","timestamp":1645013432000},"page":"100221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Trends in hydrogel-based encapsulation technologies for advanced cell therapies applied to limb ischemia"],"prefix":"10.1016","volume":"13","author":[{"given":"Ana Let\u00edcia Rodrigues","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Willerth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucimara Gaziola","family":"de la Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4953-7680","authenticated-orcid":false,"given":"Sang Won","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2022.100221_bib1","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.jvs.2006.12.037","article-title":"Inter-society consensus for the management of peripheral arterial disease (TASC II)","volume":"45","author":"Norgren","year":"2007","journal-title":"J.\u00a0Vasc. Surg."},{"key":"10.1016\/j.mtbio.2022.100221_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.mtbio.2022.100221_bib3","article-title":"Terapia g\u00eanica de isquemia de membro \u00e9 uma realidade?","volume":"19","author":"Han","year":"2020","journal-title":"J.\u00a0Vasc. Bras."},{"key":"10.1016\/j.mtbio.2022.100221_bib4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/74651","article-title":"Mechanisms of angiogenesis and arteriogenesis","volume":"6","author":"Carmeliet","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.mtbio.2022.100221_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092233","article-title":"The role of the stem cells therapy in the peripheral artery disease","volume":"20","author":"Biscetti","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2022.100221_bib6","series-title":"Non-viral Vector for Muscle-Mediated Gene Therapy BT - Muscle Gene Therapy","first-page":"157","author":"Braun","year":"2019"},{"key":"10.1016\/j.mtbio.2022.100221_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0012-1606(03)00357-9","article-title":"Significant differences among skeletal muscles in the incorporation of bone marrow-derived cells","volume":"262","author":"Brazelton","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mtbio.2022.100221_bib8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jconrel.2016.06.047","article-title":"Injectable alginate hydrogel for enhanced spatiotemporal control of lentivector delivery in murine skeletal muscle","volume":"237","author":"Stilhano","year":"2016","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.mtbio.2022.100221_bib9","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.1214804","article-title":"Designing cell-compatible hydrogels for biomedical applications","volume":"336","author":"Seliktar","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2022.100221_bib10","first-page":"18","article-title":"Cell therapy","volume":"392","author":"Gage","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2022.100221_bib11","series-title":"Microfluidic-based Synthesis of Hydrogel Particles for Cell Microencapsulation and Cell-Based Drug Delivery","author":"Wan","year":"2012"},{"key":"10.1016\/j.mtbio.2022.100221_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115430","article-title":"Gellan gum-based delivery systems of therapeutic agents and cells","author":"Palumbo","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2022.100221_bib13","series-title":"3D Cell Culture in Alginate Hydrogels","author":"Andersen","year":"2015"},{"key":"10.1016\/j.mtbio.2022.100221_bib14","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1021\/bm070194b","article-title":"In vitro characterization and in vivo functionality of erythropoietin-secreting cells immobilized in Alginate\u2212Poly-l-Lysine\u2212Alginate microcapsules","volume":"8","author":"Murua","year":"2007","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.mtbio.2022.100221_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2009.05.027","article-title":"Prediction models for shape and size of ca-alginate macrobeads produced through extrusion-dripping method","author":"Chan","year":"2009","journal-title":"J.\u00a0Colloid Interface Sci."},{"key":"10.1016\/j.mtbio.2022.100221_bib16","doi-asserted-by":"crossref","DOI":"10.1177\/0883911509103329","article-title":"Design and evaluation of a cell microencapsulating device for cell assembly technology","author":"Yao","year":"2009","journal-title":"J.\u00a0Bioact. Compat Polym."},{"key":"10.1016\/j.mtbio.2022.100221_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-018-1130-8","article-title":"Mesenchymal stem cell 3D encapsulation technologies for biomimetic microenvironment in tissue regeneration","author":"Kim","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.mtbio.2022.100221_bib18","doi-asserted-by":"crossref","DOI":"10.2147\/nano.2006.1.2.163","article-title":"Immobilization of cells by electrostatic droplet generation: a model system for potential application in medicine","author":"Manojlovic","year":"2006","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2022.100221_bib19","doi-asserted-by":"crossref","DOI":"10.1115\/1.3153326","article-title":"Encapsulation of living cells in small (\u223c100 \u03bcm) alginate microcapsules by electrostatic spraying: a parametric study","author":"Zhang","year":"2009","journal-title":"J.\u00a0Biomech. Eng."},{"key":"10.1016\/j.mtbio.2022.100221_bib20","doi-asserted-by":"crossref","DOI":"10.1097\/SAP.0b013e3181d37713","article-title":"Alginate microencapsulation technology for the percutaneous delivery of adipose-derived stem cells","author":"Moyer","year":"2010","journal-title":"Ann. Plast. Surg."},{"key":"10.1016\/j.mtbio.2022.100221_bib21","series-title":"Controlled Release of Rat Adipose-Derived Stem Cells from Alginate Microbeads","author":"Leslie","year":"2013"},{"key":"10.1016\/j.mtbio.2022.100221_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/term.1680","article-title":"Alginate microencapsulation of human mesenchymal stem cells as a strategy to enhance paracrine-mediated vascular recovery after hindlimb ischaemia","author":"Land\u00e1zuri","year":"2016","journal-title":"J.\u00a0Tissue Eng. Regen. Med."},{"key":"10.1016\/j.mtbio.2022.100221_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/stem.1096","article-title":"X-ray-visible microcapsules containing mesenchymal stem cells improve hind limb perfusion in a rabbit model of peripheral arterial disease","author":"Kedziorek","year":"2012","journal-title":"Stem Cell."},{"key":"10.1016\/j.mtbio.2022.100221_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41536-019-0068-5","article-title":"Encapsulation of macrophages enhances their retention and angiogenic potential","author":"Ludwinski","year":"2019","journal-title":"Npj Regen. Med."},{"key":"10.1016\/j.mtbio.2022.100221_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2014.05.010","article-title":"Injectable multifunctional microgel encapsulating outgrowth endothelial cells and growth factors for enhanced neovascularization","author":"Kim","year":"2014","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.mtbio.2022.100221_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9732319","article-title":"Noninvasive monitoring of allogeneic stem cell delivery with dual-modality imaging-visible microcapsules in a rabbit model of peripheral arterial disease","author":"Fu","year":"2019","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.mtbio.2022.100221_bib27","doi-asserted-by":"crossref","DOI":"10.3109\/02652048.2014.898706","article-title":"Behaviour and ultrastructure of human bone marrow-derived mesenchymal stem cells immobilised in alginate-poly-l-lysine-alginate microcapsules","author":"Attia","year":"2014","journal-title":"J.\u00a0Microencapsul."},{"key":"10.1016\/j.mtbio.2022.100221_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2019.01.057","article-title":"Gelatin-based micro-hydrogel carrying genetically engineered human endothelial cells for neovascularization","author":"Choi","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2022.100221_bib29","doi-asserted-by":"crossref","first-page":"110896","DOI":"10.1016\/j.msec.2020.110896","article-title":"Cell-modified bioprinted microspheres for vascular regeneration","volume":"112","author":"Shen","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.mtbio.2022.100221_bib30","unstructured":"Business Communication LCC, BUCHI B-395 Pro encapsulator, URL: https:\/\/www.bcluae.com\/encapsulator, 12 October 2021, (n.d.). https:\/\/www.bcluae.com\/encapsulator (accessed October 12, 2021)."},{"key":"10.1016\/j.mtbio.2022.100221_bib31","series-title":"Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues","author":"Xie","year":"2020"},{"key":"10.1016\/j.mtbio.2022.100221_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2006.02.005","article-title":"Formation of perfused, functional microvascular tubes in vitro","author":"Chrobak","year":"2006","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mtbio.2022.100221_bib33","series-title":"Versatile Fabrication of Vascularizable Scaffolds for Large Tissue Engineering in Bioreactor","author":"Tocchio","year":"2015"},{"key":"10.1016\/j.mtbio.2022.100221_bib34","doi-asserted-by":"crossref","DOI":"10.1039\/b618409j","article-title":"Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element","author":"Golden","year":"2007","journal-title":"Lab Chip"},{"key":"10.1016\/j.mtbio.2022.100221_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/term.231","article-title":"Micropatterned three-dimensional hydrogel system to study human endothelial-mesenchymal stem cell interactions","author":"Trkov","year":"2010","journal-title":"J.\u00a0Tissue Eng. Regen. Med."},{"key":"10.1016\/j.mtbio.2022.100221_bib36","doi-asserted-by":"crossref","DOI":"10.1039\/c3lc50493j","article-title":"Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients","author":"Baker","year":"2013","journal-title":"Lab Chip"},{"key":"10.1016\/j.mtbio.2022.100221_bib37","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1221526110","article-title":"Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro","author":"Nguyen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mtbio.2022.100221_bib38","doi-asserted-by":"crossref","DOI":"10.1039\/C4LC00069B","article-title":"Engineering interconnected 3D vascular networks in hydrogels using molded sodium alginate lattice as the sacrificial template","author":"Wang","year":"2014","journal-title":"Lab Chip"},{"key":"10.1016\/j.mtbio.2022.100221_bib39","series-title":"In Vitro Microvessels for the Study of Angiogenesis and Thrombosis","author":"Zheng","year":"2012"},{"key":"10.1016\/j.mtbio.2022.100221_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/0a0b70a9-a6e0-4e60-b6bd-8ef894ed22cd","article-title":"Cell encapsulation in sub-mm sized gel modules using replica molding","author":"McGuigan","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.mtbio.2022.100221_bib41","article-title":"Engineering of a biomimetic pericyte-covered 3D microvascular network","author":"Kim","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mtbio.2022.100221_bib42","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41467-020-14480-0","article-title":"Microchannel network hydrogel induced ischemic blood perfusion connection","volume":"11","author":"Lee","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2022.100221_bib43","series-title":"Cell-laden Microengineered Gelatin Methacrylate Hydrogels","author":"Nichol","year":"2010"},{"key":"10.1016\/j.mtbio.2022.100221_bib44","doi-asserted-by":"crossref","first-page":"e00069","DOI":"10.1016\/j.bprint.2019.e00069","article-title":"Multilayered microcasting of agarose\u2013collagen composites for neurovascular modeling","volume":"17","author":"Heidari","year":"2020","journal-title":"Bioprinting"},{"key":"10.1016\/j.mtbio.2022.100221_bib45","doi-asserted-by":"crossref","DOI":"10.1007\/s12257-014-0021-9","article-title":"Implantable microfluidic device for the formation of three-dimensional vasculature by human endothelial progenitor cells","author":"Kim","year":"2014","journal-title":"Biotechnol. Bioproc. Eng."},{"key":"10.1016\/j.mtbio.2022.100221_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/nature05058","article-title":"The origins and the future of microfluidics","author":"Whitesides","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2022.100221_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/nrd744","article-title":"Building drug delivery into tissue engineering","author":"Saltzman","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mtbio.2022.100221_bib48","doi-asserted-by":"crossref","DOI":"10.1039\/b904769g","article-title":"Laminar flow used as \u201cliquid etch mask\u201d in wet chemical etching to generate glass microstructures with an improved aspect ratio","author":"Mu","year":"2009","journal-title":"Lab Chip"},{"key":"10.1016\/j.mtbio.2022.100221_bib49","doi-asserted-by":"crossref","DOI":"10.1039\/C3LC51414E","article-title":"Microfluidic spinning of micro- and nano-scale fibers for tissue engineering","author":"Jun","year":"2014","journal-title":"Lab Chip"},{"key":"10.1016\/j.mtbio.2022.100221_bib50","doi-asserted-by":"crossref","DOI":"10.1021\/la700818q","article-title":"On the fly\u201d continuous generation of alginate fibers using a microfluidic device","author":"Shin","year":"2007","journal-title":"Langmuir"},{"key":"10.1016\/j.mtbio.2022.100221_bib51","doi-asserted-by":"crossref","first-page":"6989","DOI":"10.1039\/C6TB02150F","article-title":"Microfluidic generation of alginate microgels for the controlled delivery of lentivectors","volume":"4","author":"Madrigal","year":"2016","journal-title":"J.\u00a0Mater. Chem. B."},{"key":"10.1016\/j.mtbio.2022.100221_bib52","doi-asserted-by":"crossref","DOI":"10.1002\/bip.23432","article-title":"Microfluidic encapsulation of nanoparticles in alginate microgels gelled via competitive ligand exchange crosslinking","volume":"112","author":"Cinel","year":"2021","journal-title":"Biopolymers"},{"key":"10.1016\/j.mtbio.2022.100221_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/(SICI)1522-2683(20000101)21:1<12::AID-ELPS12>3.0.CO;2-7","article-title":"Polymer microfabrication methods for microfluidic analytical applications","author":"Becker","year":"2000","journal-title":"Electrophoresis"},{"key":"10.1016\/j.mtbio.2022.100221_bib54","doi-asserted-by":"crossref","DOI":"10.1039\/c2lc21164e","article-title":"Microfluidic synthesis of advanced microparticles for encapsulation and controlled release","author":"Duncanson","year":"2012","journal-title":"Lab Chip"},{"key":"10.1016\/j.mtbio.2022.100221_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.expthermflusci.2017.03.003","article-title":"Studies of droplets formation regime and actual flow rate of liquid-liquid flows in flow-focusing microfluidic devices","volume":"85","author":"Costa","year":"2017","journal-title":"Exp. Therm. Fluid Sci."},{"key":"10.1016\/j.mtbio.2022.100221_bib56","series-title":"Synthesis of Cell Composite Alginate Microfibers by Microfluidics with the Application Potential of Small Diameter Vascular Grafts","author":"Liu","year":"2017"},{"key":"10.1016\/j.mtbio.2022.100221_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2016.04.036","article-title":"Microfluidic-based generation of functional microfibers for biomimetic complex tissue construction","author":"Zuo","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2022.100221_bib58","article-title":"Controlled fabrication of bioactive microfibers for creating tissue constructs using microfluidic techniques","author":"Cheng","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2022.100221_bib59","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-03749-3","article-title":"Bioinspired multicompartmental microfibers from microfluidics","author":"Cheng","year":"2014","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2022.100221_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfoodeng.2019.109884","article-title":"Development of a microfluidic route for the formation of gellan-based microgels incorporating jabuticaba (Myrciaria cauliflora) extract","author":"Santos","year":"2020","journal-title":"J.\u00a0Food Eng."},{"key":"10.1016\/j.mtbio.2022.100221_bib61","doi-asserted-by":"crossref","DOI":"10.1038\/nature04163","article-title":"Controlled microfluidic interfaces","author":"Atencia","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2022.100221_bib62","doi-asserted-by":"crossref","DOI":"10.1039\/c2lc21197a","article-title":"Comparison of monodisperse droplet generation in flow-focusing devices with hydrophilic and hydrophobic surfaces","author":"Roberts","year":"2012","journal-title":"Lab Chip"},{"key":"10.1016\/j.mtbio.2022.100221_bib63","series-title":"Controlled Release of Basic Fibroblast Growth Factor for Angiogenesis Using Acoustically-Responsive Scaffolds","author":"Moncion","year":"2017"},{"key":"10.1016\/j.mtbio.2022.100221_bib64","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3389\/fbioe.2021.715408","article-title":"Probing single-cell macrophage polarization and heterogeneity using thermo-reversible hydrogels in droplet-based microfluidics","volume":"9","author":"Tiemeijer","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2022.100221_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/s41551-017-0083","article-title":"3D-printed vascular networks direct therapeutic angiogenesis in ischaemia","author":"Mirabella","year":"2017","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.mtbio.2022.100221_bib66","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201700798","article-title":"Tissue engineered bio-blood-vessels constructed using a tissue-specific bioink and 3D coaxial cell printing technique: a novel therapy for ischemic disease","author":"Gao","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2022.100221_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering8020027","article-title":"Natural biomaterials and their use as bioinks for printing tissues","volume":"8","author":"Benwood","year":"2021","journal-title":"Bioengineering"},{"key":"10.1016\/j.mtbio.2022.100221_bib68","series-title":"Essentials 3D Biofabrication Transl","article-title":"Bioprinting of blood vessels","author":"Melchiorri","year":"2015"},{"key":"10.1016\/j.mtbio.2022.100221_bib69","doi-asserted-by":"crossref","DOI":"10.1161\/01.CIR.0000061911.47710.8A","article-title":"The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis","author":"Henry","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.mtbio.2022.100221_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/gt.2012.17","article-title":"VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond","author":"Giacca","year":"2012","journal-title":"Gene Ther."},{"key":"10.1016\/j.mtbio.2022.100221_bib71","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2007-10-118273","article-title":"Bone marrow derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature","author":"Au","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.mtbio.2022.100221_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/428138a","article-title":"Tissue engineering: creation of long-lasting blood vessels","author":"Koike","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2022.100221_bib73","article-title":"3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs","author":"Kolesky","year":"2014","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2022.100221_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/nmat3357","article-title":"Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues","author":"Miller","year":"2012","journal-title":"Nat. Mater."},{"key":"10.1016\/j.mtbio.2022.100221_bib75","series-title":"Direct 3D Bioprinting of Prevascularized Tissue Constructs with Complex Microarchitecture","author":"Zhu","year":"2017"},{"key":"10.1016\/j.mtbio.2022.100221_bib76","doi-asserted-by":"crossref","DOI":"10.1109\/TBME.2013.2243912","article-title":"Bioprinting toward organ fabrication: challenges and future trends","author":"Ozbolat","year":"2013","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.mtbio.2022.100221_bib77","doi-asserted-by":"crossref","DOI":"10.1007\/s10439-014-1207-1","article-title":"Biomaterials for integration with 3-D bioprinting","author":"Skardal","year":"2015","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.mtbio.2022.100221_bib78","doi-asserted-by":"crossref","DOI":"10.1007\/s12195-014-0340-0","article-title":"Generation of multi-scale vascular network system within 3D hydrogel using 3D bio-printing technology","author":"Lee","year":"2014","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.mtbio.2022.100221_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbiomech.2004.09.030","article-title":"Molecular basis of the effects of shear stress on vascular endothelial cells","author":"Li","year":"2005","journal-title":"J.\u00a0Biomech."},{"key":"10.1016\/j.mtbio.2022.100221_bib80","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3389\/fcvm.2020.598890","article-title":"Fabrication of new hybrid scaffolds for in vivo perivascular application to treat limb ischemia","volume":"7","author":"Carrabba","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.mtbio.2022.100221_bib81","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202012778","article-title":"Biofabricating murine and human myo-substitutes for rapid volumetric muscle loss restoration","volume":"13","author":"Costantini","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.mtbio.2022.100221_bib82","article-title":"Projection-based 3D printing of cell patterning scaffolds with multiscale channels","author":"Xue","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2022.100221_bib83","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201601099","article-title":"In situ patterning of microfluidic networks in 3D cell-laden hydrogels","author":"Brandenberg","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2022.100221_bib84","article-title":"Fabrication of 3D biomimetic microfluidic networks in hydrogels","author":"Heintz","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.mtbio.2022.100221_bib85","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201703156","article-title":"Multicellular vascularized engineered tissues through user-programmable biomaterial photodegradation","author":"Arakawa","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2022.100221_bib86","doi-asserted-by":"crossref","DOI":"10.1039\/C7LC00926G","article-title":"Stereolithographic hydrogel printing of 3D culture chips with biofunctionalized complex 3D perfusion networks","author":"Zhang","year":"2017","journal-title":"Lab Chip"},{"key":"10.1016\/j.mtbio.2022.100221_bib87","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201801331","article-title":"Complex 3D-printed microchannels within cell-degradable hydrogels","author":"Song","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2022.100221_bib88","series-title":"Scaffold-free Vascular Tissue Engineering Using Bioprinting","author":"Norotte","year":"2009"},{"key":"10.1016\/j.mtbio.2022.100221_bib89","series-title":"Bioprinting Vessel-like Constructs Using Hyaluronan Hydrogels Crosslinked with Tetrahedral Polyethylene Glycol Tetracrylates","author":"Skardal","year":"2010"},{"key":"10.1016\/j.mtbio.2022.100221_bib90","doi-asserted-by":"crossref","DOI":"10.1002\/bit.24591","article-title":"Scaffold-free inkjet printing of three-dimensional zigzag cellular tubes","author":"Xu","year":"2012","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.mtbio.2022.100221_bib91","series-title":"In Vitro Study of Directly Bioprinted Perfusable Vasculature Conduits","author":"Zhang","year":"2015"},{"key":"10.1016\/j.mtbio.2022.100221_bib92","series-title":"Coaxial Nozzle-Assisted 3D Bioprinting with Built-In Microchannels for Nutrients Delivery","author":"Gao","year":"2015"},{"key":"10.1016\/j.mtbio.2022.100221_bib93","series-title":"Direct 3D Bioprinting of Perfusable Vascular Constructs Using a Blend Bioink","author":"Jia","year":"2016"},{"key":"10.1016\/j.mtbio.2022.100221_bib94","article-title":"Laser-assisted printing of alginate long tubes and annular constructs","author":"Yan","year":"2013","journal-title":"Biofabrication"},{"key":"10.1016\/j.mtbio.2022.100221_bib95","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1509405112","article-title":"Laser-based three-dimensional multiscale micropatterning of biocompatible hydrogels for customized tissue engineering scaffolds","author":"Applegate","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mtbio.2022.100221_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120872","article-title":"Hydrogel-based therapeutic angiogenesis: an alternative treatment strategy for critical limb ischemia","volume":"274","author":"Xing","year":"2021","journal-title":"Biomaterials"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006422000199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006422000199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:24:05Z","timestamp":1778905445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006422000199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":96,"alternative-id":["S2590006422000199"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2022.100221","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trends in hydrogel-based encapsulation technologies for advanced cell therapies applied to limb ischemia","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2022.100221","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100221"}}