{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:30:22Z","timestamp":1783402222297,"version":"3.54.6"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:00:00Z","timestamp":1652486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172391"],"award-info":[{"award-number":["82172391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51973090"],"award-info":[{"award-number":["51973090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902198"],"award-info":[{"award-number":["81902198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900952"],"award-info":[{"award-number":["31900952"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["yzjj2018rc09"],"award-info":[{"award-number":["yzjj2018rc09"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012152","name":"National Postdoctoral Program for Innovative Talents","doi-asserted-by":"publisher","award":["BX20190150"],"award-info":[{"award-number":["BX20190150"]}],"id":[{"id":"10.13039\/501100012152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2019A1515011706"],"award-info":[{"award-number":["2019A1515011706"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2020A1515010398"],"award-info":[{"award-number":["2020A1515010398"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M662980"],"award-info":[{"award-number":["2019M662980"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.mtbio.2022.100296","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T02:27:25Z","timestamp":1652927245000},"page":"100296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Robust drug bioavailability and safety for rheumatoid arthritis therapy using D-amino acids-based supramolecular hydrogels"],"prefix":"10.1016","volume":"15","author":[{"given":"Shaodan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weicheng","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7650-4828","authenticated-orcid":false,"given":"Yao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2022.100296_bib1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.mtbio.2022.100296_bib2","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(10)60826-4","article-title":"Rheumatoid arthritis","volume":"376","author":"Scott","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.mtbio.2022.100296_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/acr.22783","article-title":"american college of rheumatology guideline for the treatment of rheumatoid arthritis","volume":"68","author":"Singh","year":"2015","journal-title":"Arthritis Care Res."},{"key":"10.1016\/j.mtbio.2022.100296_bib4","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/bjd.15377","article-title":"Relative risk of and determinants for adverse events of methotrexate prescribed at a low dose: a systematic review and meta-analysis of randomized placebo-controlled trials","volume":"177","author":"Mazaud","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.mtbio.2022.100296_bib5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/jama.2009.146","article-title":"Risk of herpes zoster in patients with rheumatoid arthritis treated with anti-TNF-alpha agents","volume":"301","author":"Strangfeld","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.mtbio.2022.100296_bib6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.2217\/nnm-2017-0377","article-title":"Hyaluronic acid-conjugated pH-sensitive liposomes for targeted delivery of prednisolone on rheumatoid arthritis therapy","volume":"13","author":"Gouveia","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.mtbio.2022.100296_bib7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11095-019-2653-0","article-title":"Folate conjugated double liposomes bearing prednisolone and methotrexate for targeting rheumatoid arthritis","volume":"36","author":"Verma","year":"2019","journal-title":"Pharm. Res. (N. Y.)"},{"key":"10.1016\/j.mtbio.2022.100296_bib8","doi-asserted-by":"crossref","first-page":"12280","DOI":"10.1021\/nn504537b","article-title":"Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes","volume":"8","author":"Sacchetti","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2022.100296_bib9","doi-asserted-by":"crossref","first-page":"465102","DOI":"10.1088\/0957-4484\/22\/46\/465102","article-title":"Single-walled carbon nanohorns as drug carriers: adsorption of prednisolone and anti-inflammatory effects on arthritis","volume":"22","author":"Nakamura","year":"2011","journal-title":"Nanotechnology"},{"key":"10.1016\/j.mtbio.2022.100296_bib10","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1166\/jbn.2019.2848","article-title":"Comparison of the therapeutic effects of gold nanoclusters and gold nanoparticles on rheumatoid arthritis","volume":"15","author":"Zhao","year":"2019","journal-title":"J.\u00a0Biomed. Nanotechnol."},{"key":"10.1016\/j.mtbio.2022.100296_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biomaterials.2015.05.018","article-title":"Drug-loaded gold\/iron\/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis","volume":"61","author":"Kim","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2022.100296_bib12","doi-asserted-by":"crossref","first-page":"8546","DOI":"10.1039\/D0NR00454E","article-title":"A\u00a0novel indomethacin\/methotrexate\/MMP-9 siRNA in situ hydrogel with dual effects of anti-inflammatory activity and reversal of cartilage disruption for the synergistic treatment of rheumatoid arthritis","volume":"12","author":"Yin","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.mtbio.2022.100296_bib13","doi-asserted-by":"crossref","first-page":"24984","DOI":"10.1021\/acsami.9b04979","article-title":"Injectable Click-Crosslinked hyaluronic acid depot to prolong therapeutic activity in articular joints affected by rheumatoid arthritis","volume":"11","author":"Seo","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2022.100296_bib14","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1039\/c2nr31149f","article-title":"Short-peptide-based molecular hydrogels: novel gelation strategies and applications for tissue engineering and drug delivery","volume":"4","author":"Wang","year":"2012","journal-title":"Nanoscale"},{"key":"10.1016\/j.mtbio.2022.100296_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201901100","article-title":"A\u00a0cell Membrane-Targeting Self-Delivery chimeric peptide for enhanced photodynamic therapy and in situ therapeutic feedback","volume":"9","author":"Ma","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.mtbio.2022.100296_bib16","doi-asserted-by":"crossref","first-page":"8121","DOI":"10.1002\/anie.202014278","article-title":"Enzyme-Instructed Self-Assembly enabled Monomer-Excimer transition to construct higher ordered luminescent supramolecular assembly for activity-based bioimaging","volume":"60","author":"Zhong","year":"2021","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.mtbio.2022.100296_bib17","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1021\/jacs.6b12322","article-title":"Supramolecular \"trojan horse\" for nuclear delivery of dual anticancer drugs","volume":"139","author":"Cai","year":"2017","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.mtbio.2022.100296_bib18","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1021\/acsnano.9b07396","article-title":"Supramolecular peptide Hydrogel-Based soft neural interface augments brain signals through a Three-Dimensional electrical network","volume":"14","author":"Nam","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2022.100296_bib19","doi-asserted-by":"crossref","first-page":"13438","DOI":"10.1073\/pnas.1016546108","article-title":"Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair","volume":"108","author":"Webber","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mtbio.2022.100296_bib20","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1039\/C7BM00251C","article-title":"Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db\/db mice","volume":"5","author":"Senturk","year":"2017","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.mtbio.2022.100296_bib21","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1021\/am507800e","article-title":"Dynamic biostability, biodistribution, and toxicity of L\/D-peptide-based supramolecular nanofibers","volume":"7","author":"Yang","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2022.100296_bib22","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1021\/am406007g","article-title":"Self-assembling peptide of D-amino acids boosts selectivity and antitumor efficacy of 10-hydroxycamptothecin","volume":"6","author":"Liu","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2022.100296_bib23","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1021\/ja310019x","article-title":"D-amino acids boost the selectivity and confer supramolecular hydrogels of a nonsteroidal anti-inflammatory drug (NSAID)","volume":"135","author":"Li","year":"2013","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.mtbio.2022.100296_bib24","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1021\/jacs.5b13541","article-title":"Enzyme-Instructed Self-Assembly of small D-Peptides as a Multiple-Step process for selectively killing cancer cells","volume":"138","author":"Zhou","year":"2016","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.mtbio.2022.100296_bib25","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: a review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.mtbio.2022.100296_bib26","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.7150\/thno.53644","article-title":"Dual-ligand supramolecular nanofibers inspired by the renin-angiotensin system for the targeting and synergistic therapy of myocardial infarction","volume":"11","author":"Wen","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2022.100296_bib27","doi-asserted-by":"crossref","first-page":"22131","DOI":"10.1021\/acsami.0c23153","article-title":"Supramolecular Self-Assembled nanofibers efficiently activate the precursor of hepatocyte growth factor for angiogenesis in myocardial infarction therapy","volume":"13","author":"Guo","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2022.100296_bib28","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1021\/am507800e","article-title":"Dynamic biostability, biodistribution, and toxicity of L\/D-peptide-based supramolecular nanofibers","volume":"7","author":"Yang","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2022.100296_bib29","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1039\/c2nr30408b","article-title":"Molecular hydrogelators of peptoid-peptide conjugates with superior stability against enzyme digestion","volume":"4","author":"Wu","year":"2012","journal-title":"Nanoscale"},{"key":"10.1016\/j.mtbio.2022.100296_bib30","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1021\/acsami.7b13750","article-title":"Multifunctional Copper-Containing carboxymethyl Chitosan\/Alginate scaffolds for eradicating clinical bacterial infection and promoting bone formation","volume":"10","author":"Lu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2022.100296_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A\u00a0simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J.\u00a0Basic Clin. Pharm."},{"key":"10.1016\/j.mtbio.2022.100296_bib32","article-title":"A\u00a0new treatment modality for rheumatoid arthritis: combined photothermal and photodynamic therapy using Cu(7.2)S(4) nanoparticles","volume":"7","author":"Lu","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.mtbio.2022.100296_bib33","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1166\/jbn.2018.2564","article-title":"Anticancer supramolecular hydrogel of D\/L-Peptide with enhanced stability and bioactivity","volume":"14","author":"Ren","year":"2018","journal-title":"J.\u00a0Biomed. Nanotechnol."},{"key":"10.1016\/j.mtbio.2022.100296_bib34","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.molmed.2010.07.004","article-title":"Rheumatoid arthritis progression mediated by activated synovial fibroblasts","volume":"16","author":"Neumann","year":"2010","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.mtbio.2022.100296_bib35","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/ard.60.8.729","article-title":"Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis","volume":"60","author":"Cutolo","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.mtbio.2022.100296_bib36","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.3390\/ijms20205023","article-title":"Methotrexate an old drug with new tricks","volume":"20","author":"Bedoui","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2022.100296_bib37","doi-asserted-by":"crossref","first-page":"102758","DOI":"10.1016\/j.autrev.2021.102758","article-title":"Novel insights into macrophage diversity in rheumatoid arthritis synovium","volume":"20","author":"Boutet","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.mtbio.2022.100296_bib38","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s11926-012-0272-4","article-title":"Managing macrophages in rheumatoid arthritis by reform or removal","volume":"14","author":"Li","year":"2012","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.mtbio.2022.100296_bib39","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nrrheum.2016.91","article-title":"Macrophage heterogeneity in the context of rheumatoid arthritis","volume":"12","author":"Udalova","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.mtbio.2022.100296_bib40","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.7150\/thno.32268","article-title":"Hybrid micelles containing methotrexate-conjugated polymer and co-loaded with microRNA-124 for rheumatoid arthritis therapy","volume":"9","author":"Hao","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2022.100296_bib41","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.2147\/IJN.S151233","article-title":"Fabrication of a triptolide-loaded and poly-\u03b3-glutamic acid-based amphiphilic nanoparticle for the treatment of rheumatoid arthritis","volume":"13","author":"Zhang","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2022.100296_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cbi.2019.04.002","article-title":"Hesperidin inhibits synovial cell inflammation and macrophage polarization through suppression of the PI3K\/AKT pathway in complete Freund's adjuvant-induced arthritis in mice","volume":"306","author":"Qi","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.mtbio.2022.100296_bib43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","article-title":"Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006422000941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006422000941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:25:57Z","timestamp":1778905557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006422000941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":43,"alternative-id":["S2590006422000941"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2022.100296","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Robust drug bioavailability and safety for rheumatoid arthritis therapy using D-amino acids-based supramolecular hydrogels","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2022.100296","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100296"}}