{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:05:31Z","timestamp":1787313931062,"version":"build-2736575974"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["I 4409-B"],"award-info":[{"award-number":["I 4409-B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.mtbio.2022.100315","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T17:54:33Z","timestamp":1654797273000},"page":"100315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Immunological reaction to magnesium-based implants for orthopedic applications. What do we know so far? A systematic review on in vivo studies"],"prefix":"10.1016","volume":"15","author":[{"given":"Omer","family":"Suljevic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan F.","family":"Fischerauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelie M.","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole G.","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2022.100315_bib1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3390\/jfb8040044","article-title":"Biodegradable materials and metallic implants\u2014a review","volume":"8","author":"Prakasam","year":"2017","journal-title":"J.\u00a0Funct. Biomater."},{"key":"10.1016\/j.mtbio.2022.100315_bib2","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.biomaterials.2005.10.003","article-title":"Magnesium and its alloys as orthopedic biomaterials: a review","volume":"27","author":"Staiger","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2022.100315_bib3","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1016\/j.biomaterials.2008.02.003","article-title":"In vitro degradation and mechanical integrity of calcium-containing magnesium alloys in modified-simulated body fluid","volume":"29","author":"Kannan","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2022.100315_bib4","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.actbio.2009.06.028","article-title":"Research on an Mg\u2013Zn alloy as a degradable biomaterial","volume":"6","author":"Zhang","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2022.100315_bib5","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1016\/j.biomaterials.2004.09.049","article-title":"In vivo corrosion of four magnesium alloys and the associated bone response","volume":"26","author":"Witte","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2022.100315_bib6","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/jbm.a.31293","article-title":"Biodegradable magnesium scaffolds: Part II: peri-implant bone remodeling","volume":"81A","author":"Witte","year":"2007","journal-title":"J.\u00a0Biomed. Mater. Res."},{"key":"10.1016\/j.mtbio.2022.100315_bib7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1475-925X-12-62","article-title":"Biodegradable magnesium-based screw clinically equivalent to titanium screw in hallux valgus surgery: short term results of the first prospective, randomized, controlled clinical pilot study","volume":"12","author":"Windhagen","year":"2013","journal-title":"Biomed. Eng. Online"},{"key":"10.1016\/j.mtbio.2022.100315_bib8","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1302\/2046-3758.98.BJR-2020-0017.R2","article-title":"A\u00a0lean bioabsorbable magnesium-zinc-calcium alloy ZX00 used for operative treatment of medial malleolus fractures","volume":"9","author":"Holweg","year":"2020","journal-title":"Bone Joint Res."},{"key":"10.1016\/j.mtbio.2022.100315_bib9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jos.2017.11.005","article-title":"Bioabsorbable magnesium versus standard titanium compression screws for fixation of distal metatarsal osteotomies \u2013 3 year results of a randomized clinical trial","volume":"23","author":"Plaass","year":"2018","journal-title":"J.\u00a0Orthop. Sci."},{"key":"10.1016\/j.mtbio.2022.100315_bib10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.biomaterials.2015.11.038","article-title":"Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head","volume":"81","author":"Zhao","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2022.100315_bib11","first-page":"191","article-title":"Complications of implant removal in ankle fractures","volume":"16","author":"Kasai","year":"2019","journal-title":"J.\u00a0Orthop."},{"key":"10.1016\/j.mtbio.2022.100315_bib12","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s10266-018-0345-6","article-title":"Complications of a poly-l-lactic acid and polyglycolic acid osteosynthesis device for internal fixation in maxillofacial surgery","volume":"106","author":"Sukegawa","year":"2018","journal-title":"Odontology"},{"key":"10.1016\/j.mtbio.2022.100315_bib13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/cod.12565","article-title":"Titanium: a review on exposure, release, penetration, allergy, epidemiology, and clinical reactivity","volume":"74","author":"Fage","year":"2016","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.mtbio.2022.100315_bib14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3171\/2018.1.JNS171804","article-title":"Association between metal hypersensitivity and implant failure in patients who underwent titanium cranioplasty","volume":"131","author":"Sun","year":"2019","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.mtbio.2022.100315_bib15","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.3390\/ma13183914","article-title":"Is there a role for absorbable metals in surgery? A systematic review and meta-analysis of Mg\/Mg alloy based implants","volume":"13","author":"Sukotjo","year":"2020","journal-title":"Materials"},{"key":"10.1016\/j.mtbio.2022.100315_bib16","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0142-9612(99)00235-5","article-title":"Hypersensitivity to metallic biomaterials: a review of leukocyte migration inhibition assays","volume":"21","author":"Hallab","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2022.100315_bib17","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.actbio.2019.10.014","article-title":"Inflammatory response to magnesium-based biodegradable implant materials","volume":"101","author":"Costantino","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2022.100315_bib18","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1002\/jbm.a.35758","article-title":"Evaluation of the inflammatory potential of implant materials in a mouse model by bioluminescent imaging of intravenously injected bone marrow cells","volume":"104","author":"Rais","year":"2016","journal-title":"J.\u00a0Biomed. Mater. Res."},{"key":"10.1016\/j.mtbio.2022.100315_bib19","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s11837-014-0874-6","article-title":"Immunological response to biodegradable magnesium implants","volume":"66","author":"Pichler","year":"2014","journal-title":"JOM"},{"key":"10.1016\/j.mtbio.2022.100315_bib20","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3390\/jcm7120526","article-title":"Bone immune response to materials, Part I: titanium, PEEK and copper in comparison to sham at 10 Days in rabbit tibia","volume":"7","author":"Trindade","year":"2018","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.mtbio.2022.100315_bib21","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3390\/jcm8060814","article-title":"Bone immune response to materials, Part II: copper and polyetheretherketone (PEEK) compared to titanium at 10 and 28 Days in rabbit tibia","volume":"8","author":"Trindade","year":"2019","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.mtbio.2022.100315_bib22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.matsci.31.1.81","article-title":"Biological responses to materials","volume":"31","author":"Anderson","year":"2001","journal-title":"Annu. Rev. Mater. Res."},{"key":"10.1016\/j.mtbio.2022.100315_bib23","doi-asserted-by":"crossref","DOI":"10.1089\/ten.2006.12.1955","article-title":"Cellular and molecular dynamics in the foreign body reaction","volume":"12","author":"Luttikhuizen","year":"2006","journal-title":"Tissue Eng."},{"key":"10.1016\/j.mtbio.2022.100315_bib24","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1163\/156856206777346340","article-title":"The inflammatory cell influx and cytokines changes during transition from acute inflammation to fibrous repair around implanted materials","volume":"17","author":"Gretzer","year":"2006","journal-title":"J.\u00a0Biomater. Sci."},{"key":"10.1016\/j.mtbio.2022.100315_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00062752-200001000-00008","article-title":"Multinucleated giant cells","volume":"7","author":"Anderson","year":"2000","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.mtbio.2022.100315_bib26","series-title":"Biosurfaces","first-page":"106","article-title":"Host response of implanted biomaterials","author":"Rajesh","year":"2015"},{"key":"10.1016\/j.mtbio.2022.100315_bib27","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.3390\/ma8095269","article-title":"Macrophages, foreign body giant cells and their response to implantable biomaterials","volume":"8","author":"Sheikh","year":"2015","journal-title":"Materials"},{"key":"10.1016\/j.mtbio.2022.100315_bib28","series-title":"Engineering Biomaterials for Regenerative Medicine","first-page":"143","article-title":"Host response to biomaterials","author":"Gonzalez-Simon","year":"2012"},{"key":"10.1016\/j.mtbio.2022.100315_bib29","first-page":"5","article-title":"From monocytes to M1\/M2 macrophages: phenotypical vs. Functional differentiation","author":"Italiani","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2022.100315_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.609297","article-title":"Biomaterials-Mediated regulation of macrophage cell fate","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2022.100315_bib31","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/jbm.a.30313","article-title":"Lymphocytes and the foreign body response: lymphocyte enhancement of macrophage adhesion and fusion","volume":"74A","author":"Brodbeck","year":"2005","journal-title":"J.\u00a0Biomed. Mater. Res."},{"key":"10.1016\/j.mtbio.2022.100315_bib32","series-title":"Center for Devices and Radiological Health, Biological Response to Metal Implants","author":"Food","year":"2019"},{"key":"10.1016\/j.mtbio.2022.100315_bib33","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.4049\/jimmunol.165.6.3058","article-title":"Disparate cytotoxic activity of nickel-specific CD8 + and CD4 + T cell subsets against keratinocytes","volume":"165","author":"Traidl","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.mtbio.2022.100315_bib34","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/cod.12242","article-title":"Implants and contact allergy: are sensitizing metals released as haptens from coronary stents?","volume":"71","author":"Svedman","year":"2014","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.mtbio.2022.100315_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063470","article-title":"Lymphoid aggregates that resemble tertiary lymphoid organs define a specific pathological subset in metal-on-metal hip replacements","volume":"8","author":"Mittal","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mtbio.2022.100315_bib36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/cod.12486","article-title":"Anti-hapten antibodies in response to skin sensitization","volume":"74","author":"Singleton","year":"2016","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.mtbio.2022.100315_bib37","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1186\/s12891-016-1342-y","article-title":"Hypersensitivity reactions to metal implants: laboratory options","volume":"17","author":"Carossino","year":"2016","journal-title":"BMC Muscoskel. Disord."},{"key":"10.1016\/j.mtbio.2022.100315_bib38","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1302\/0301-620X.91B6.21844","article-title":"Circulating levels of cobalt and chromium from metal-on-metal hip replacement are associated with CD8 + T-cell lymphopenia","volume":"91-B","author":"Hart","year":"2009","journal-title":"J.\u00a0Bone Joint Surg."},{"key":"10.1016\/j.mtbio.2022.100315_bib39","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1302\/0301-620X.85B5.13729","article-title":"Immunological changes in patients with primary osteoarthritis of the hip after total joint replacement","volume":"85","author":"Granchi","year":"2003","journal-title":"J.\u00a0Bone Joint Surg."},{"key":"10.1016\/j.mtbio.2022.100315_bib40","first-page":"1","article-title":"Delayed titanium hypersensitivity and retained foreign body causing late abdominal complications","author":"Jain","year":"2021","journal-title":"Case Rep. Surg."},{"key":"10.1016\/j.mtbio.2022.100315_bib41","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s11914-018-0423-2","article-title":"The role of the immune cells in fracture healing","volume":"16","author":"Baht","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.mtbio.2022.100315_bib42","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1007\/BF01161439","article-title":"Tissue-biomaterial interactions","volume":"22","author":"Williams","year":"1987","journal-title":"J.\u00a0Mater. Sci."},{"key":"10.1016\/j.mtbio.2022.100315_bib43","doi-asserted-by":"crossref","DOI":"10.3928\/01477447-20150504-53","article-title":"A\u00a0sclerotic rim provides mechanical support for the femoral head in osteonecrosis","volume":"38","author":"Yu","year":"2015","journal-title":"Orthopedics"},{"key":"10.1016\/j.mtbio.2022.100315_bib44","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.orthres.2003.10.012","article-title":"Mechanical interface conditions affect morphology and cellular activity of sclerotic bone rims forming around experimental loaded implants","volume":"22","author":"Vestermark","year":"2004","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.mtbio.2022.100315_bib45","doi-asserted-by":"crossref","first-page":"6692","DOI":"10.1016\/j.biomaterials.2011.05.078","article-title":"Immune responses to implants \u2013 a review of the implications for the design of immunomodulatory biomaterials","volume":"32","author":"Franz","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2022.100315_bib46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0169-409X(97)00048-3","article-title":"Biodegradation and biocompatibility of PLA and PLGA microspheres","volume":"28","author":"Anderson","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2022.100315_bib47","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/jbm.a.32888","article-title":"Biomimetic organic-inorganic nanocomposite coatings for titanium implants. In vitro and in vivo biological testing","volume":"95A","author":"Schade","year":"2010","journal-title":"J.\u00a0Biomed. Mater. Res."},{"key":"10.1016\/j.mtbio.2022.100315_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.mtbio.2022.100315_bib49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE's risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.mtbio.2022.100315_bib50","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.actbio.2010.08.020","article-title":"Bone\u2013implant interface strength and osseointegration: biodegradable magnesium alloy versus standard titanium control","volume":"7","author":"Castellani","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2022.100315_bib51","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1475-925X-9-63","article-title":"Evaluation of the soft tissue biocompatibility of MgCa0.8 and surgical steel 316L in vivo: a comparative study in rabbits","volume":"9","author":"Erdmann","year":"2010","journal-title":"Biomed. Eng. Online"},{"key":"10.1016\/j.mtbio.2022.100315_bib52","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1475-925X-10-32","article-title":"Comparison of morphological changes in efferent lymph nodes after implantation of resorbable and non-resorbable implants in rabbits","volume":"10","author":"Bondarenko","year":"2011","journal-title":"Biomed. Eng. Online"},{"key":"10.1016\/j.mtbio.2022.100315_bib53","doi-asserted-by":"crossref","first-page":"8548","DOI":"10.1016\/j.actbio.2012.08.028","article-title":"Long-term in vivo degradation behaviour and biocompatibility of the magnesium alloy ZEK100 for use as a biodegradable bone implant","volume":"9","author":"Dziuba","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2022.100315_bib54","doi-asserted-by":"crossref","first-page":"8509","DOI":"10.1016\/j.actbio.2013.02.015","article-title":"Biocompatibility of rapidly solidified magnesium alloy RS66 as a temporary biodegradable metal","volume":"9","author":"Willbold","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2022.100315_bib55","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/8\/4\/045012","article-title":"Degrading magnesium screws ZEK100: biomechanical testing, degradation analysis and soft-tissue biocompatibility in a rabbit model","volume":"8","author":"Reifenrath","year":"2013","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.mtbio.2022.100315_bib56","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1177\/0885328212472215","article-title":"In vivo study of a biodegradable orthopedic screw (MgYREZr-alloy) in a rabbit model for up to 12 months","volume":"28","author":"Waizy","year":"2014","journal-title":"J.\u00a0Biomater. Appl."},{"key":"10.1016\/j.mtbio.2022.100315_bib57","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.actbio.2014.09.041","article-title":"Effect of the addition of low rare earth elements (lanthanum, neodymium, cerium) on the biodegradation and biocompatibility of magnesium","volume":"11","author":"Willbold","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2022.100315_bib58","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.actbio.2015.07.025","article-title":"In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model","volume":"25","author":"R\u00f6ssig","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2022.100315_bib59","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.actbio.2015.11.014","article-title":"An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg\u20131Sr alloy","volume":"29","author":"Tie","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2022.100315_bib60","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.msec.2015.11.037","article-title":"Examination of a biodegradable magnesium screw for the reconstruction of the anterior cruciate ligament: a pilot in vivo study in rabbits","volume":"59","author":"Diekmann","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.mtbio.2022.100315_bib61","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.actbio.2016.08.002","article-title":"Biocompatibility and degradation of LAE442-based magnesium alloys after implantation of up to 3.5years in a rabbit model","volume":"44","author":"Angrisani","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2022.100315_bib62","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.actbio.2017.09.018","article-title":"Magnesium (Mg) based interference screws developed for promoting tendon graft incorporation in bone tunnel in rabbits","volume":"63","author":"Wang","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2022.100315_bib63","doi-asserted-by":"crossref","first-page":"1055.e1","DOI":"10.1016\/j.joms.2018.01.015","article-title":"Biocompatibility and efficiency of biodegradable magnesium-based plates and screws in the facial fracture model of beagles","volume":"76","author":"Kim","year":"2018","journal-title":"J.\u00a0Oral Maxillofac. Surg."},{"key":"10.1016\/j.mtbio.2022.100315_bib64","first-page":"1","article-title":"Early osteoimmunomodulatory effects of magnesium-calcium-zinc alloys","volume":"12","author":"Rahmati","year":"2021","journal-title":"J.\u00a0Tissue Eng."},{"key":"10.1016\/j.mtbio.2022.100315_bib65","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1163\/1568562054798563","article-title":"Polycarbonate-urethane hard segment type influences esterase substrate specificity for human-macrophage-mediated biodegradation","volume":"16","author":"Labow","year":"2005","journal-title":"J.\u00a0Biomater. Sci."},{"key":"10.1016\/j.mtbio.2022.100315_bib66","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.actbio.2016.06.025","article-title":"Long-term in vivo degradation behavior and near-implant distribution of resorbed elements for magnesium alloys WZ21 and ZX50","volume":"42","author":"Amerstorfer","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2022.100315_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-23005-2","article-title":"TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration","volume":"12","author":"Qiao","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2022.100315_bib68","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202102035","article-title":"Biomimicking bone\u2013implant interface facilitates the bioadaption of a new degradable magnesium alloy to the bone tissue microenvironment","volume":"8","author":"Li","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mtbio.2022.100315_bib69","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3390\/met7110514","article-title":"The biological responses to magnesium-based biodegradable medical devices","volume":"7","author":"Liu","year":"2017","journal-title":"Metals"},{"key":"10.1016\/j.mtbio.2022.100315_bib70","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s40204-014-0032-9","article-title":"Magnesium corrosion particles do not interfere with the immune function of primary human and murine macrophages","volume":"4","author":"Roth","year":"2015","journal-title":"Prog Biomater."},{"key":"10.1016\/j.mtbio.2022.100315_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119414","article-title":"In vivo and in vitro evaluation of a biodegradable magnesium vascular stent designed by shape optimization strategy","volume":"221","author":"Chen","year":"2019","journal-title":"Biomaterials"},{"issue":"502","key":"10.1016\/j.mtbio.2022.100315_bib72","article-title":"Discovering macrophage functions using in vivo optical imaging techniques","volume":"9","author":"Li","year":"2018","journal-title":"Front. Immunol."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006422001132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006422001132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:23:42Z","timestamp":1762907022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006422001132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":72,"alternative-id":["S2590006422001132"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2022.100315","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunological reaction to magnesium-based implants for orthopedic applications. What do we know so far? A systematic review on in vivo studies","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2022.100315","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100315"}}