{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:53:19Z","timestamp":1783648399126,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21877001"],"award-info":[{"award-number":["21877001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22077005"],"award-info":[{"award-number":["22077005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22207006"],"award-info":[{"award-number":["22207006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81821004"],"award-info":[{"award-number":["81821004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.mtbio.2023.100575","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T15:08:12Z","timestamp":1675350492000},"page":"100575","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Triton modified polyethyleneimine conjugates assembled with growth arrest-specific protein 6 for androgenetic alopecia transdermal gene therapy"],"prefix":"10.1016","volume":"19","author":[{"given":"Xinli","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9959-1167","authenticated-orcid":false,"given":"Xinjing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mtbio.2023.100575_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12020-017-1280-y","article-title":"Androgenetic alopecia: a review","volume":"57","author":"Lolli","year":"2017","journal-title":"Endocrine"},{"issue":"4","key":"10.1016\/j.mtbio.2023.100575_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1159\/000506155","article-title":"Molecular mechanisms of hair growth and regeneration: current understanding and novel paradigms","volume":"236","author":"Houschyar","year":"2020","journal-title":"Dermatology"},{"issue":"14","key":"10.1016\/j.mtbio.2023.100575_bib3","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.devcel.2022.06.005","article-title":"Plikus, Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state","volume":"57","author":"Liu","year":"2022","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.mtbio.2023.100575_bib4","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/exd.14251","article-title":"Stem cell-intrinsic mechanisms regulating adult hair follicle homeostasis","volume":"30","author":"Lee","year":"2021","journal-title":"Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.mtbio.2023.100575_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101019","article-title":"Transcriptional profiling of the adult hair follicle mesenchyme reveals R-spondin as a novel regulator of dermal progenitor function","volume":"23","author":"Hagner","year":"2020","journal-title":"iScience"},{"issue":"3","key":"10.1016\/j.mtbio.2023.100575_bib6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.cell.2020.06.031","article-title":"Cell types promoting goosebumps form a niche to regulate hair follicle stem cells","volume":"182","author":"Shwartz","year":"2020","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.mtbio.2023.100575_bib7","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3390\/ph14111128","article-title":"Alleviation of androgenetic alopecia with aqueous paeonia lactiflora and poria cocos extract intake through suppressing the steroid hormone and inflammatory pathway","volume":"14","author":"Zhang","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"20","key":"10.1016\/j.mtbio.2023.100575_bib8","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.3390\/ijms20205070","article-title":"Gas6\/TAM system: a key modulator of the interplay between inflammation and fibrosis","volume":"20","author":"Bellan","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.mtbio.2023.100575_bib9","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.3390\/cancers12071850","article-title":"Gas6\/Axl signaling pathway in the tumor immune microenvironment","volume":"12","author":"Tanaka","year":"2020","journal-title":"Cancers"},{"issue":"7854","key":"10.1016\/j.mtbio.2023.100575_bib10","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41586-021-03417-2","article-title":"Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence","volume":"592","author":"Choi","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2023.100575_bib11","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.2147\/DDDT.S214907","article-title":"Minoxidil and its use in hair disorders: a review","volume":"13","author":"Suchonwanit","year":"2019","journal-title":"Drug Des. Dev. Ther."},{"issue":"4","key":"10.1016\/j.mtbio.2023.100575_bib12","first-page":"332","article-title":"Advances in the treatment of male androgenetic alopecia - a brief review of finasteride studies","volume":"11","author":"Whiting","year":"2001","journal-title":"Eur. J. Dermatol."},{"issue":"22","key":"10.1016\/j.mtbio.2023.100575_bib13","article-title":"Disproportional signal of sexual dysfunction reports associated with finasteride use in young men with androgenetic alopecia: a pharmacovigilance analysis of VigiBase","volume":"S0190\u20139622","author":"Nguyen","year":"2022","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"issue":"6","key":"10.1016\/j.mtbio.2023.100575_bib14","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41565-021-00898-0","article-title":"The current landscape of nucleic acid therapeutics","volume":"16","author":"Kulkarni","year":"2021","journal-title":"Nat. Nanotechnol."},{"issue":"5","key":"10.1016\/j.mtbio.2023.100575_bib15","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.tibtech.2020.07.012","article-title":"Gene delivery to the skin - how far have we come?","volume":"39","author":"Ain","year":"2021","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.mtbio.2023.100575_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejpb.2016.05.012","article-title":"RNAi mediated IL-6 in vitro knockdown in psoriasis skin model with topical siRNA delivery system based on liquid crystalline phase","volume":"105","author":"Depieri","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"23","key":"10.1016\/j.mtbio.2023.100575_bib17","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1021\/acs.accounts.1c00493","article-title":"Recent advances in the noninvasive delivery of mRNA","volume":"54","author":"Qin","year":"2021","journal-title":"Acc. Chem. Res."},{"issue":"22","key":"10.1016\/j.mtbio.2023.100575_bib18","doi-asserted-by":"crossref","first-page":"4940","DOI":"10.1039\/D0TB00942C","article-title":"Ornithine-derived oligomers and dendrimers for in vitro delivery of DNA and ex vivo transfection of skin cells via saRNA","volume":"8","author":"Saviano","year":"2020","journal-title":"J.\u00a0Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2023.100575_bib19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.colsurfb.2015.12.007","article-title":"Polyethylenimine-polyacrylic acid nanocomposites: type of bonding does influence the gene transfer efficacy and cytotoxicity","volume":"140","author":"Tripathi","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"15","key":"10.1016\/j.mtbio.2023.100575_bib20","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1039\/C9TB02271F","article-title":"Recent advancements in polyethyleneimine-based materials and their biomedical, biotechnology, and biomaterial applications","volume":"8","author":"Chen","year":"2020","journal-title":"J.\u00a0Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2023.100575_bib21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.actbio.2022.06.030","article-title":"Vitro cytotoxicity and cytokine production by lipid-substituted low molecular weight branched PEIs used for gene delivery","volume":"148","author":"Meenakshi Sundaram","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2023.100575_bib22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.actbio.2016.01.025","article-title":"Small hydrophobe substitution on polyethylenimine for plasmid DNA delivery: optimal substitution is critical for effective delivery","volume":"33","author":"Thapa","year":"2016","journal-title":"Acta Biomater."},{"issue":"36","key":"10.1016\/j.mtbio.2023.100575_bib23","doi-asserted-by":"crossref","first-page":"40094","DOI":"10.1021\/acsami.0c10718","article-title":"[12]aneN3-Based gemini-type amphiphiles with two-photon absorption properties for enhanced nonviral gene delivery and bioimaging","volume":"12","author":"Ma","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"13","key":"10.1016\/j.mtbio.2023.100575_bib24","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1039\/C4TB02106A","article-title":"Diol glycidyl ether-bridged low molecular weight PEI as potential gene delivery vehicles","volume":"3","author":"Guo","year":"2015","journal-title":"J.\u00a0Mater. Chem. B"},{"issue":"10","key":"10.1016\/j.mtbio.2023.100575_bib25","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.molpharmaceut.0c00291","article-title":"Triton X-100-modified adenosine triphosphate-responsive siRNA delivery agent for antitumor therapy","volume":"17","author":"Fan","year":"2020","journal-title":"Mol. Pharm."},{"issue":"9","key":"10.1016\/j.mtbio.2023.100575_bib26","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/j.biomaterials.2009.12.005","article-title":"The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways","volume":"31","author":"Griesenbach","year":"2010","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.mtbio.2023.100575_bib27","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1021\/nn202833n","article-title":"Template-free synthesis and encapsulation technique for layer-by-layer polymer nanocarrier fabrication","volume":"5","author":"Qi","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2023.100575_bib28","series-title":"FDA Inactive Ingredient Databases","year":"2022"},{"issue":"45","key":"10.1016\/j.mtbio.2023.100575_bib29","doi-asserted-by":"crossref","first-page":"42364","DOI":"10.1074\/jbc.M107488200","article-title":"Gas6 induces mesangial cell proliferation via latent transcription factor STAT3","volume":"276","author":"Yanagita","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"issue":"6","key":"10.1016\/j.mtbio.2023.100575_bib30","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.bbamcr.2012.03.015","article-title":"Overexpression of phospholipase D enhances Bcl-2 expression by activating STAT3 through independent activation of ERK and p38MAPK in HeLa cells","volume":"1823","author":"Choi","year":"2012","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006423000352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006423000352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:30:23Z","timestamp":1762907423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006423000352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":30,"alternative-id":["S2590006423000352"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2023.100575","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Triton modified polyethyleneimine conjugates assembled with growth arrest-specific protein 6 for androgenetic alopecia transdermal gene therapy","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2023.100575","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100575"}}