{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:32:52Z","timestamp":1793338372441,"version":"4.5.0"},"reference-count":113,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22027810"],"award-info":[{"award-number":["22027810"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971318"],"award-info":[{"award-number":["31971318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273590"],"award-info":[{"award-number":["82273590"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2020B0101020001"],"award-info":[{"award-number":["2020B0101020001"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.mtbio.2023.100588","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T13:29:22Z","timestamp":1676899762000},"page":"100588","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Advanced hydrogels: New expectation for the repair of organic erectile dysfunction"],"prefix":"10.1016","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2507-3009","authenticated-orcid":false,"given":"Yan","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueguang","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6540-0473","authenticated-orcid":false,"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.mtbio.2023.100588_bib1","first-page":"633","article-title":"Erectile dysfunction: AUA guideline","volume":"200","author":"Burnett","year":"2018","journal-title":"J.\u00a0Urol."},{"issue":"3","key":"10.1016\/j.mtbio.2023.100588_bib2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.7326\/0003-4819-139-3-200308050-00005","article-title":"Sexual function in men older than 50 years of age: results from the health professionals follow-up study","volume":"139","author":"Bacon","year":"2003","journal-title":"Ann. Intern. Med."},{"issue":"9861","key":"10.1016\/j.mtbio.2023.100588_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0140-6736(12)60520-0","article-title":"Erectile dysfunction","volume":"381","author":"Shamloul","year":"2013","journal-title":"Lancet."},{"issue":"5","key":"10.1016\/j.mtbio.2023.100588_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrurol.2018.20","article-title":"Sexual dysfunction and male infertility","volume":"15","author":"Lotti","year":"2018","journal-title":"Nat. Rev. Urol."},{"issue":"3","key":"10.1016\/j.mtbio.2023.100588_bib5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.eururo.2021.06.007","article-title":"European association of Urology guidelines on sexual and reproductive health-2021 update: male sexual dysfunction","volume":"80","author":"Salonia","year":"2021","journal-title":"Eur. Urol."},{"issue":"5","key":"10.1016\/j.mtbio.2023.100588_bib6","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.eururo.2013.08.023","article-title":"A\u00a0systematic review of the association between erectile dysfunction and cardiovascular disease","volume":"65","author":"Gandaglia","year":"2014","journal-title":"Eur. Urol."},{"issue":"1","key":"10.1016\/j.mtbio.2023.100588_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41569-021-00593-6","article-title":"Interactions between erectile dysfunction, cardiovascular disease and cardiovascular drugs","volume":"19","author":"Terentes-Printzios","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"issue":"27","key":"10.1016\/j.mtbio.2023.100588_bib8","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1093\/eurheartj\/eht112","article-title":"Erectile dysfunction in the cardiovascular patient","volume":"34","author":"Vlachopoulos","year":"2013","journal-title":"Eur. Heart J."},{"issue":"11","key":"10.1016\/j.mtbio.2023.100588_bib9","first-page":"e596","article-title":"ACC\/AHA guideline on the primary prevention of cardiovascular disease: a report of the American college of cardiology\/American heart association task force on clinical practice guidelines","volume":"140","author":"Arnett","year":"2019","journal-title":"Circulation."},{"issue":"4","key":"10.1016\/j.mtbio.2023.100588_bib10","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/andr.13003","article-title":"Mask up to keep it up\": preliminary evidence of the association between erectile dysfunction and COVID-19","volume":"9","author":"Sansone","year":"2021","journal-title":"Andrology."},{"key":"10.1016\/j.mtbio.2023.100588_bib11","series-title":"EAU Guidelines on Sexual and Reproductive Health","year":"2021"},{"issue":"6","key":"10.1016\/j.mtbio.2023.100588_bib12","first-page":"1309","article-title":"The relationship between metabolic syndrome, its components, and erectile dysfunction: a systematic review and a meta-analysis of observational studies","volume":"12","author":"Besiroglu","year":"2015","journal-title":"J.\u00a0Sex. Med."},{"issue":"4","key":"10.1016\/j.mtbio.2023.100588_bib13","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s11154-020-09541-0","article-title":"Associations between body mass index, waist circumference and erectile dysfunction: a systematic review and META-analysis","volume":"21","author":"Pizzol","year":"2020","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"4","key":"10.1016\/j.mtbio.2023.100588_bib14","first-page":"465","article-title":"Pharmacotherapy for erectile dysfunction: recommendations from the fourth international consultation for sexual medicine (ICSM 2015)","volume":"13","author":"Hatzimouratidis","year":"2016","journal-title":"J.\u00a0Sex. Med."},{"issue":"11","key":"10.1016\/j.mtbio.2023.100588_bib15","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3390\/pharmaceutics12111055","article-title":"Development of a sildenafil citrate microemulsion-loaded hydrogel as a potential system for drug delivery to the penis and its cellular metabolic mechanism","volume":"12","author":"Atipairin","year":"2020","journal-title":"Pharmaceutics."},{"issue":"2","key":"10.1016\/j.mtbio.2023.100588_bib16","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.matt.2022.11.032","article-title":"Bionic artificial penile Tunica albuginea","volume":"6","author":"Chai","year":"2023","journal-title":"Matter."},{"key":"10.1016\/j.mtbio.2023.100588_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.120226","article-title":"Injectable thermo-sensitive hydrogel containing ADSC-derived exosomes for the treatment of cavernous nerve injury","volume":"300","author":"Liu","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2023.100588_bib18","doi-asserted-by":"crossref","first-page":"5988","DOI":"10.1038\/ncomms6988","article-title":"Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor","volume":"6","author":"Liu","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.mtbio.2023.100588_bib19","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1038\/s41467-020-16192-x","article-title":"Functional reconstruction of injured corpus cavernosa using 3D-printed hydrogel scaffolds seeded with HIF-1\u03b1-expressing stem cells","volume":"11","author":"An","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2023.100588_bib20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jconrel.2020.01.020","article-title":"Mechanism of a long-term controlled drug release system based on simple blended electrospun fibers","volume":"320","author":"Wu","year":"2020","journal-title":"J.\u00a0Contr. Release."},{"key":"10.1016\/j.mtbio.2023.100588_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202104165","article-title":"Self-assembling peptide-based hydrogels for wound tissue repair","author":"Guan","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mtbio.2023.100588_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101467","article-title":"An enzyme cross-linked hydrogel as a minimally invasive arterial tissue sealing and anti-adhesion barrier","volume":"44","author":"Sun","year":"2022","journal-title":"Nano Today."},{"issue":"24","key":"10.1016\/j.mtbio.2023.100588_bib23","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJM200006153422407","article-title":"Erectile dysfunction","volume":"342","author":"Lue","year":"2000","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"4","key":"10.1016\/j.mtbio.2023.100588_bib24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ucl.2005.08.007","article-title":"Physiology of penile erection and pathophysiology of erectile dysfunction","volume":"32","author":"Dean","year":"2005","journal-title":"Urol. Clin."},{"key":"10.1016\/j.mtbio.2023.100588_bib25","article-title":"Erectile dysfunction","volume":"2","author":"Yafi","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"12","key":"10.1016\/j.mtbio.2023.100588_bib26","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41585-019-0246-7","article-title":"Towards clinical application of tissue engineering for erectile penile regeneration","volume":"16","author":"Andrew","year":"2019","journal-title":"Nat. Rev. Urol."},{"issue":"10","key":"10.1016\/j.mtbio.2023.100588_bib27","doi-asserted-by":"crossref","first-page":"469","DOI":"10.5694\/mja2.50167","article-title":"Current diagnosis and management of erectile dysfunction","volume":"210","author":"McMahon","year":"2019","journal-title":"Med. J. Aust."},{"issue":"3","key":"10.1016\/j.mtbio.2023.100588_bib28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nrurol.2010.7","article-title":"Treatment of infertility in men with spinal cord injury","volume":"7","author":"Brackett","year":"2010","journal-title":"Nat. Rev. Urol."},{"issue":"6","key":"10.1016\/j.mtbio.2023.100588_bib29","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S1474-4422(22)00036-9","article-title":"Approach and management to patients with neurological disorders reporting sexual dysfunction","volume":"21","author":"Hentzen","year":"2022","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.mtbio.2023.100588_bib30","first-page":"415","article-title":"Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat","volume":"6","author":"Ferrini","year":"2009","journal-title":"J.\u00a0Sex. Med."},{"issue":"2","key":"10.1016\/j.mtbio.2023.100588_bib31","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.eururo.2016.01.026","article-title":"A\u00a0critical analysis of the current knowledge of surgical anatomy of the prostate related to optimisation of cancer control and preservation of continence and erection in candidates for radical prostatectomy: an update","volume":"70","author":"Walz","year":"2016","journal-title":"Eur. Urol."},{"issue":"12","key":"10.1016\/j.mtbio.2023.100588_bib32","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1056\/NEJMoa074311","article-title":"Quality of life and satisfaction with outcome among prostate-cancer survivors","volume":"358","author":"Sanda","year":"2008","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.mtbio.2023.100588_bib33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.expneurol.2018.11.001","article-title":"Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus","volume":"312","author":"Dobbs","year":"2019","journal-title":"Exp. Neurol."},{"issue":"1105","key":"10.1016\/j.mtbio.2023.100588_bib34","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1136\/postgradmedj-2016-134073","article-title":"Recent advances in the treatment of erectile dysfunction","volume":"93","author":"Mobley","year":"2017","journal-title":"Postgrad. Med."},{"issue":"12","key":"10.1016\/j.mtbio.2023.100588_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.amjcard.2005.07.006","article-title":"The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease","volume":"96","author":"Montorsi","year":"2005","journal-title":"Am. J. Cardiol."},{"issue":"1","key":"10.1016\/j.mtbio.2023.100588_bib36","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3390\/ijms22010418","article-title":"Hyperhomocysteinemia: focus on endothelial damage as a cause of erectile dysfunction","volume":"22","author":"Salvio","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.mtbio.2023.100588_bib37","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nrurol.2016.23","article-title":"Molecular mechanisms associated with diabetic endothelial-erectile dysfunction","volume":"13","author":"Castela","year":"2016","journal-title":"Nat. Rev. Urol."},{"issue":"2","key":"10.1016\/j.mtbio.2023.100588_bib38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11255-018-2055-y","article-title":"Low serum folic acid can be a potential independent risk factor for erectile dysfunction: a prospective case-control study","volume":"51","author":"Attia","year":"2019","journal-title":"Int. Urol. Nephrol."},{"issue":"5","key":"10.1016\/j.mtbio.2023.100588_bib39","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jacc.2015.12.005","article-title":"Testosterone and cardiovascular disease","volume":"67","author":"Kloner","year":"2016","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.mtbio.2023.100588_bib40","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/j.1939-4640.2003.tb02728.x","article-title":"A\u00a0simple self-report diary for assessing psychosexual function in hypogonadal men","volume":"24","author":"Lee","year":"2003","journal-title":"J.\u00a0Androl."},{"issue":"6","key":"10.1016\/j.mtbio.2023.100588_bib41","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/ijir.2008.43","article-title":"Early endothelial dysfunction as a marker of vasculogenic erectile dysfunction in young habitual cannabis users","volume":"20","author":"Aversa","year":"2008","journal-title":"Int. J. Impot. Res."},{"issue":"5","key":"10.1016\/j.mtbio.2023.100588_bib42","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.eururo.2010.02.020","article-title":"Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation","volume":"57","author":"Hatzimouratidis","year":"2010","journal-title":"Eur. Urol."},{"key":"10.1016\/j.mtbio.2023.100588_bib43","article-title":"Phosphodiesterase 5 (PDE5): structure-function regulation and therapeutic applications of inhibitors, Biomed","volume":"134","author":"Ahmed","year":"2021","journal-title":"Pharma."},{"issue":"14","key":"10.1016\/j.mtbio.2023.100588_bib44","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3109\/09638280903511594","article-title":"Penile rehabilitation therapy following radical prostatectomy","volume":"32","author":"Pace","year":"2010","journal-title":"Disabil. Rehabil."},{"issue":"9","key":"10.1016\/j.mtbio.2023.100588_bib45","first-page":"2361","article-title":"Dropout in the treatment of erectile dysfunction with PDE5: a study on predictors and a qualitative analysis of reasons for discontinuation","volume":"9","author":"Carvalheira","year":"2012","journal-title":"J.\u00a0Sex. Med."},{"issue":"8","key":"10.1016\/j.mtbio.2023.100588_bib46","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJMp1506632","article-title":"Testosterone and \"Age-Related hypogonadism\"--FDA concerns","volume":"373","author":"Nguyen","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"2","key":"10.1016\/j.mtbio.2023.100588_bib47","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41591-020-0751-5","article-title":"Using human genetics to understand the disease impacts of testosterone in men and women","volume":"26","author":"Ruth","year":"2020","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.mtbio.2023.100588_bib48","doi-asserted-by":"crossref","DOI":"10.1172\/JCI146607","article-title":"Testosterone replacement in aging men: an evidence-based patient-centric perspective","volume":"131","author":"Bhasin","year":"2021","journal-title":"J.\u00a0Clin. Invest."},{"issue":"6","key":"10.1016\/j.mtbio.2023.100588_bib49","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/MOU.0000000000000442","article-title":"Testosterone therapy improves erectile function and libido in hypogonadal men","volume":"27","author":"Rizk","year":"2017","journal-title":"Curr. Opin. Urol."},{"issue":"1","key":"10.1016\/j.mtbio.2023.100588_bib50","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.nano.2016.08.032","article-title":"Peptide amphiphile nanofiber hydrogel delivery of sonic hedgehog protein to the cavernous nerve to promote regeneration and prevent erectile dysfunction","volume":"13","author":"Choe","year":"2017","journal-title":"Nanomedicine."},{"key":"10.1016\/j.mtbio.2023.100588_bib51","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.copbio.2016.04.021","article-title":"Hydrogels for brain repair after stroke: an emerging treatment option","volume":"40","author":"Nih","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.mtbio.2023.100588_bib52","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jconrel.2020.11.049","article-title":"Injectable thermoresponsive hydrogels as drug delivery system for the treatment of central nervous system disorders: a review","volume":"329","author":"Bellotti","year":"2021","journal-title":"J.\u00a0Contr. Release."},{"key":"10.1016\/j.mtbio.2023.100588_bib53","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.neulet.2013.01.057","article-title":"Prostate carcinoma cell growth-inhibiting hydrogel supports axonal regeneration in vitro","volume":"541","author":"Franke","year":"2013","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.mtbio.2023.100588_bib54","first-page":"130","article-title":"SOP conservative (medical and mechanical) treatment of erectile dysfunction","volume":"10","author":"Porst","year":"2013","journal-title":"J.\u00a0Sex. Med."},{"issue":"1","key":"10.1016\/j.mtbio.2023.100588_bib55","first-page":"524","article-title":"Pharmacotherapy for erectile dysfunction","volume":"7","author":"Eardley","year":"2010","journal-title":"J.\u00a0Sex. Med."},{"issue":"6","key":"10.1016\/j.mtbio.2023.100588_bib56","first-page":"1007","article-title":"Erectile dysfunction: a global review of intracavernosal injectables, World","volume":"37","author":"Duncan","year":"2019","journal-title":"J.\u00a0Urol."},{"issue":"10","key":"10.1016\/j.mtbio.2023.100588_bib57","first-page":"1490","article-title":"Low-intensity shock wave therapy in sexual medicine-clinical recommendations from the European society of sexual medicine (ESSM)","volume":"16","author":"Capogrosso","year":"2019","journal-title":"J.\u00a0Sex. Med."},{"issue":"5","key":"10.1016\/j.mtbio.2023.100588_bib58","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.eururo.2011.02.033","article-title":"Shock wave technology and application: an update","volume":"59","author":"Rassweiler","year":"2011","journal-title":"Eur. Urol."},{"issue":"5","key":"10.1016\/j.mtbio.2023.100588_bib59","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4111\/kju.2014.55.5.295","article-title":"Penile low-intensity shock wave therapy: a promising novel modality for erectile dysfunction","volume":"55","author":"Abu-Ghanem","year":"2014","journal-title":"Kor. J. Urol."},{"issue":"3","key":"10.1016\/j.mtbio.2023.100588_bib60","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41443-019-0117-z","article-title":"Clinical studies on low intensity extracorporeal shockwave therapy for erectile dysfunction: a systematic review and meta-analysis of randomised controlled trials","volume":"31","author":"Sokolakis","year":"2019","journal-title":"Int. J. Impot. Res."},{"issue":"2","key":"10.1016\/j.mtbio.2023.100588_bib61","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.eururo.2016.05.050","article-title":"Low-intensity extracorporeal shock wave treatment improves erectile function: a systematic review and meta-analysis","volume":"71","author":"Lu","year":"2017","journal-title":"Eur. Urol."},{"issue":"4","key":"10.1016\/j.mtbio.2023.100588_bib62","first-page":"389","article-title":"Therapeutic neovascularization promoted by injectable hydrogels","volume":"3","author":"Pal","year":"2018","journal-title":"Bioact. Mater."},{"issue":"2","key":"10.1016\/j.mtbio.2023.100588_bib63","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41585-021-00532-7","article-title":"Indications and characteristics of penile traction and vacuum erection devices","volume":"19","author":"Sultana","year":"2022","journal-title":"Nat. Rev. Urol."},{"issue":"4","key":"10.1016\/j.mtbio.2023.100588_bib64","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/ijir.2010.4","article-title":"Vacuum therapy in erectile dysfunction\u2014science and clinical evidence","volume":"22","author":"Yuan","year":"2010","journal-title":"Int. J. Impot. Res."},{"issue":"2","key":"10.1016\/j.mtbio.2023.100588_bib65","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.sxmr.2019.05.003","article-title":"Etiology of erectile dysfunction and duration of symptoms in patients undergoing penile prosthesis: a systematic review","volume":"8","author":"Bajic","year":"2020","journal-title":"Sex. Med. Rev."},{"issue":"3","key":"10.1016\/j.mtbio.2023.100588_bib66","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/bju.15219","article-title":"UK practice for penile prosthesis surgery: baseline analysis of the British Association of Urological Surgeons (BAUS) Penile Prosthesis Audit","volume":"127","author":"Muneer","year":"2021","journal-title":"BJU Int."},{"issue":"10","key":"10.1016\/j.mtbio.2023.100588_bib67","first-page":"2589","article-title":"Penile prostheses and the litigious patient: a legal database review","volume":"11","author":"Sunaryo","year":"2014","journal-title":"J.\u00a0Sex. Med."},{"issue":"9","key":"10.1016\/j.mtbio.2023.100588_bib68","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41585-022-00607-z","article-title":"The International Penile Prosthesis Implant Consensus Forum: clinical recommendations and surgical principles on the inflatable 3-piece penile prosthesis implant","volume":"19","author":"Chung","year":"2022","journal-title":"Nat. Rev. Urol."},{"issue":"1","key":"10.1016\/j.mtbio.2023.100588_bib69","first-page":"39","article-title":"Penile prosthesis implant in the special populations: diabetics, neurogenic conditions, fibrotic cases, concurrent urinary continence surgery, and salvage implants","volume":"22","author":"Chung","year":"2020","journal-title":"J.\u00a0Androl."},{"issue":"4","key":"10.1016\/j.mtbio.2023.100588_bib70","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3109\/08982104.2015.1117490","article-title":"Solid lipid nanoparticles for transdermal delivery of avanafil: optimization, formulation, in-vitro and ex-vivo studies","volume":"26","author":"Kurakula","year":"2016","journal-title":"J.\u00a0Liposome Res."},{"key":"10.1016\/j.mtbio.2023.100588_bib71","article-title":"Hydrogel forming microneedle-mediated transdermal delivery of sildenafil citrate from polyethylene glycol reservoir: an ex vivo proof of concept study","volume":"222","author":"Elim","year":"2022","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"3","key":"10.1016\/j.mtbio.2023.100588_bib72","first-page":"1175","article-title":"Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction","volume":"169","author":"User","year":"2003","journal-title":"J.\u00a0Urol."},{"issue":"5","key":"10.1016\/j.mtbio.2023.100588_bib73","first-page":"1240","article-title":"Sonic hedgehog is neuroprotective in the cavernous nerve with crush injury","volume":"10","author":"Angeloni","year":"2013","journal-title":"J.\u00a0Sex. Med."},{"issue":"3","key":"10.1016\/j.mtbio.2023.100588_bib74","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10319","article-title":"An EPO-loaded multifunctional hydrogel synergizing with adipose-derived stem cells restores neurogenic erectile function via enhancing nerve regeneration and penile rehabilitation","volume":"7","author":"Shao","year":"2022","journal-title":"Bioeng. Transl. Med."},{"issue":"1","key":"10.1016\/j.mtbio.2023.100588_bib75","first-page":"78","article-title":"Peptide amphiphile nanofiber delivery of sonic hedgehog protein to reduce smooth muscle apoptosis in the penis after cavernous nerve resection","volume":"8","author":"Bond","year":"2011","journal-title":"J.\u00a0Sex. Med."},{"issue":"1","key":"10.1016\/j.mtbio.2023.100588_bib76","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1095\/biolreprod.106.053926","article-title":"Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehog","volume":"76","author":"Podlasek","year":"2007","journal-title":"Biol. Reprod."},{"issue":"7","key":"10.1016\/j.mtbio.2023.100588_bib77","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nmat2778","article-title":"A\u00a0self-assembly pathway to aligned monodomain gels","volume":"9","author":"Zhang","year":"2010","journal-title":"Nat. Mater."},{"issue":"4","key":"10.1016\/j.mtbio.2023.100588_bib78","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.biomaterials.2010.10.003","article-title":"Regeneration of the cavernous nerve by Sonic hedgehog using aligned peptide amphiphile nanofibers","volume":"32","author":"Angeloni","year":"2011","journal-title":"Biomaterials."},{"key":"10.1016\/j.mtbio.2023.100588_bib79","article-title":"Optimization of sonic hedgehog delivery to the penis from self-assembling nanofiber hydrogels to preserve penile morphology after cavernous nerve injury","volume":"20","author":"Choe","year":"2019","journal-title":"Nanomedicine."},{"key":"10.1016\/j.mtbio.2023.100588_bib80","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.actbio.2016.01.014","article-title":"Sonic hedgehog delivery from self-assembled nanofiber hydrogels reduces the fibrotic response in models of erectile dysfunction","volume":"32","author":"Choe","year":"2016","journal-title":"Acta Biomater."},{"issue":"7","key":"10.1016\/j.mtbio.2023.100588_bib81","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.nano.2018.06.006","article-title":"Peptide amphiphile delivery of sonic hedgehog protein promotes neurite formation in penile projecting neurons","volume":"14","author":"Dobbs","year":"2018","journal-title":"Nanomedicine."},{"issue":"4","key":"10.1016\/j.mtbio.2023.100588_bib82","first-page":"711","article-title":"Caspase signaling in ED patients and animal models","volume":"18","author":"Martin","year":"2021","journal-title":"J.\u00a0Sex. Med."},{"key":"10.1016\/j.mtbio.2023.100588_bib83","article-title":"Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog protein to the penis and cavernous nerve suppresses intrinsic and extrinsic apoptotic signaling mechanisms, which are an underlying cause of erectile dysfunction","volume":"37","author":"Martin","year":"2021","journal-title":"Nanomedicine."},{"issue":"12","key":"10.1016\/j.mtbio.2023.100588_bib84","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.2174\/1381612821666150115154602","article-title":"Controlled release of growth factors for regenerative medicine","volume":"21","author":"Liu","year":"2015","journal-title":"Curr. Pharmaceut. Des."},{"issue":"23\u201324","key":"10.1016\/j.mtbio.2023.100588_bib85","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1089\/ten.tea.2017.0469","article-title":"Therapeutic effect of controlled release of dual growth factor using heparin-pluronic hydrogel\/gelatin-poly (ethylene glycol)-tyramine hydrogel system in a rat model of cavernous nerve injury, tissue","volume":"24","author":"Jung","year":"2018","journal-title":"Eng. Part. A."},{"issue":"5","key":"10.1016\/j.mtbio.2023.100588_bib86","doi-asserted-by":"crossref","first-page":"1248.e1","DOI":"10.1016\/j.urology.2014.07.028","article-title":"Comparison between subcutaneous injection of basic fibroblast growth factor-hydrogel and intracavernous injection of adipose-derived stem cells in a rat model of cavernous nerve injury","volume":"84","author":"Bae","year":"2014","journal-title":"Urology."},{"issue":"1\u20132","key":"10.1016\/j.mtbio.2023.100588_bib87","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1089\/ten.tea.2011.0654","article-title":"Effect of an adipose-derived stem cell and nerve growth factor-incorporated hydrogel on recovery of erectile function in a rat model of cavernous nerve injury, Tissue","volume":"19","author":"Kim","year":"2013","journal-title":"Eng. Part. A."},{"issue":"17\u201318","key":"10.1016\/j.mtbio.2023.100588_bib88","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1089\/ten.tea.2013.0495","article-title":"Combined effects of brain-derived neurotrophic factor immobilized poly-lactic-co-glycolic acid membrane with human adipose-derived stem cells and basic fibroblast growth factor hydrogel on recovery of erectile dysfunction","volume":"20","author":"Lee","year":"2014","journal-title":"Tissue Eng."},{"issue":"5","key":"10.1016\/j.mtbio.2023.100588_bib89","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nn.4541","article-title":"Cell transplantation therapy for spinal cord injury","volume":"20","author":"Assinck","year":"2017","journal-title":"Nat. Neurosci."},{"issue":"12","key":"10.1016\/j.mtbio.2023.100588_bib90","doi-asserted-by":"crossref","first-page":"14283","DOI":"10.1021\/acsnano.9b07598","article-title":"A\u00a0MnO(2) nanoparticle-dotted hydrogel promotes spinal cord repair via regulating reactive oxygen species microenvironment and synergizing with mesenchymal stem cells","volume":"13","author":"Li","year":"2019","journal-title":"ACS Nano."},{"key":"10.1016\/j.mtbio.2023.100588_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120448","article-title":"MSC spheroids-loaded collagen hydrogels simultaneously promote neuronal differentiation and suppress inflammatory reaction through PI3K-Akt signaling pathway","volume":"265","author":"He","year":"2021","journal-title":"Biomaterials."},{"issue":"44","key":"10.1016\/j.mtbio.2023.100588_bib92","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201703404","article-title":"Thiol-ene clickable gelatin: a platform bioink for multiple 3D biofabrication technologies","volume":"29","author":"Bertlein","year":"2017","journal-title":"Adv. Mater."},{"issue":"8","key":"10.1016\/j.mtbio.2023.100588_bib93","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201604983","article-title":"A\u00a0generalizable strategy for the 3D bioprinting of hydrogels from nonviscous photo-crosslinkable inks","volume":"29","author":"Ouyang","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2023.100588_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111214","article-title":"Injectable and self-healing hydrogel as a stem cells carrier for treatment of diabetic erectile dysfunction","volume":"116","author":"Yan","year":"2020","journal-title":"Mater. Sci. Eng. C. Mater. Biol. Appl."},{"issue":"22","key":"10.1016\/j.mtbio.2023.100588_bib95","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.7150\/thno.34008","article-title":"Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics."},{"key":"10.1016\/j.mtbio.2023.100588_bib96","first-page":"147","article-title":"Photoacoustic image-guided corpus cavernosum intratunical injection of adipose stem cell-derived exosomes loaded polydopamine thermosensitive hydrogel for erectile dysfunction treatment","volume":"9","author":"Liang","year":"2022","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.mtbio.2023.100588_bib97","first-page":"224","article-title":"Nanoparticles as a novel delivery vehicle for therapeutics targeting erectile dysfunction","volume":"7","author":"Han","year":"2010","journal-title":"J.\u00a0Sex. Med."},{"issue":"12","key":"10.1016\/j.mtbio.2023.100588_bib98","first-page":"2903","article-title":"Topically applied NO-releasing nanoparticles can increase intracorporal pressure and elicit spontaneous erections in a rat model of radical prostatectomy","volume":"11","author":"Tar","year":"2014","journal-title":"J.\u00a0Sex. Med."},{"key":"10.1016\/j.mtbio.2023.100588_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101169","article-title":"Safety assessment of nanoparticles in food: current status and prospective","volume":"39","author":"Wang","year":"2021","journal-title":"Nano Today."},{"issue":"10","key":"10.1016\/j.mtbio.2023.100588_bib100","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1002\/smll.201102280","article-title":"Efficient delivery of antitumor drug to the nuclei of tumor cells by amphiphilic biodegradable poly(L-aspartic acid-co-lactic acid)\/DPPE co-polymer nanoparticles","volume":"8","author":"Han","year":"2012","journal-title":"Small."},{"issue":"1","key":"10.1016\/j.mtbio.2023.100588_bib101","first-page":"36","article-title":"Role of nanotechnology in erectile dysfunction treatment","volume":"14","author":"Wang","year":"2017","journal-title":"J.\u00a0Sex. Med."},{"key":"10.1016\/j.mtbio.2023.100588_bib102","first-page":"2431","article-title":"Preparation and clinical evaluation of nano-transferosomes for treatment of erectile dysfunction","volume":"9","author":"Ali","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"issue":"6","key":"10.1016\/j.mtbio.2023.100588_bib103","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3923\/ijp.2019.738.744","article-title":"Novel combination of alprostadil-D-tocopheryl polyethylene glycol succinate for treatment of erectile dysfunction","volume":"15","author":"Radwan","year":"2019","journal-title":"Int. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.mtbio.2023.100588_bib104","first-page":"933","article-title":"In vitro skin penetration and pharmacodynamic evaluation of prostaglandin E1 ethyl ester, a vasoactive prodrug of prostaglandin E1, formulated into alcoholic hydrogels","volume":"61","author":"Park","year":"2006","journal-title":"Pharmazie."},{"issue":"2","key":"10.1016\/j.mtbio.2023.100588_bib105","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202000307","article-title":"Hydrogel-forming microneedles: current advancements and future trends","volume":"21","author":"Turner","year":"2021","journal-title":"Macromol. Biosci."},{"issue":"15","key":"10.1016\/j.mtbio.2023.100588_bib106","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJMoa1606221","article-title":"Patient-reported outcomes after monitoring, surgery, or radiotherapy for prostate cancer","volume":"375","author":"Donovan","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"1119","key":"10.1016\/j.mtbio.2023.100588_bib107","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20200433","article-title":"Dosimetric feasibility of neurovascular bundle-sparing stereotactic body radiotherapy with periprostatic hydrogel spacer for localized prostate cancer to preserve erectile function","volume":"94","author":"Hwang","year":"2021","journal-title":"Br. J. Radiol."},{"issue":"10","key":"10.1016\/j.mtbio.2023.100588_bib108","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1166\/jbn.2019.2838","article-title":"Dual-functional esophageal stent coating composed of paclitaxel-loaded electrospun membrane and protective film","volume":"15","author":"Xia","year":"2019","journal-title":"J.\u00a0Biomed. Nanotechnol."},{"issue":"38","key":"10.1016\/j.mtbio.2023.100588_bib109","doi-asserted-by":"crossref","first-page":"17782","DOI":"10.1039\/C9NR05795A","article-title":"MOF-based fibrous membranes adsorb PM efficiently and capture toxic gases selectively","volume":"11","author":"Wang","year":"2019","journal-title":"Nanoscale."},{"issue":"2","key":"10.1016\/j.mtbio.2023.100588_bib110","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.scib.2017.11.018","article-title":"Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes","volume":"63","author":"Guo","year":"2018","journal-title":"Sci. Bull."},{"key":"10.1016\/j.mtbio.2023.100588_bib111","first-page":"16","article-title":"Surface structure change properties: auto-soft bionic fibrous membrane in reducing postoperative adhesion","volume":"12","author":"Xu","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2023.100588_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2021.110019","article-title":"Three dimensional fibrous scaffolds as tissue repairing templates during post-operative healing","volume":"210","author":"Wang","year":"2021","journal-title":"Mater. Des."},{"issue":"4","key":"10.1016\/j.mtbio.2023.100588_bib113","first-page":"998","article-title":"Advanced hydrogels for the repair of cartilage defects and regeneration","volume":"6","author":"Wei","year":"2021","journal-title":"Bioact. Mater."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006423000480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006423000480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:27:17Z","timestamp":1762907237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006423000480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":113,"alternative-id":["S2590006423000480"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2023.100588","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advanced hydrogels: New expectation for the repair of organic erectile dysfunction","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2023.100588","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100588"}}