{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:46:40Z","timestamp":1790563600394,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021JDRC0041"],"award-info":[{"award-number":["2021JDRC0041"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022ZYD0088"],"award-info":[{"award-number":["2022ZYD0088"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630101"],"award-info":[{"award-number":["81630101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81891012"],"award-info":[{"award-number":["81891012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U19A2010"],"award-info":[{"award-number":["U19A2010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.mtbio.2023.100804","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T12:32:38Z","timestamp":1694867558000},"page":"100804","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Preparation of Phillygenin-Hyaluronic acid composite milk-derived exosomes and its anti-hepatic fibrosis effect"],"prefix":"10.1016","volume":"23","author":[{"given":"Lihong","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9256-5716","authenticated-orcid":false,"given":"Yunxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2023.100804_bib1","first-page":"151","volume":"18","author":"Kisseleva","year":"2021","journal-title":"hepatology, Molecular and cellular mechanisms of liver fibrosis and its regression"},{"key":"10.1016\/j.mtbio.2023.100804_bib2","first-page":"e1499","volume":"13","author":"Berumen","year":"2021","journal-title":"Liver fibrosis: Pathophysiology and clinical implications"},{"key":"10.1016\/j.mtbio.2023.100804_bib3","article-title":"Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from","volume":"176","author":"Kumar","year":"2021","journal-title":"NAFLD to liver fibrosis"},{"key":"10.1016\/j.mtbio.2023.100804_bib4","first-page":"2279","article-title":"Hepatic macrophages","volume":"41","author":"Cheng","year":"2021","journal-title":"Key players in the development and progression of liver fibrosis"},{"key":"10.1016\/j.mtbio.2023.100804_bib5","volume":"vol. 10","author":"Foglia","year":"2021"},{"key":"10.1016\/j.mtbio.2023.100804_bib6","first-page":"381","volume":"42","author":"Virarkar","year":"2021","journal-title":"Liver Fibrosis Assessment"},{"key":"10.1016\/j.mtbio.2023.100804_bib7","volume":"vol. 10","author":"Caligiuri","year":"2021"},{"key":"10.1016\/j.mtbio.2023.100804_bib8","first-page":"48","volume":"16","author":"Altamirano-Barrera","year":"2017","journal-title":"Management strategies for liver fibrosis"},{"key":"10.1016\/j.mtbio.2023.100804_bib9","first-page":"4846","article-title":"Traditional Chinese medicine, liver fibrosis, intestinal flora: is there any connection?","volume":"10","author":"Liu","year":"2021","journal-title":"-a narrative review"},{"key":"10.1016\/j.mtbio.2023.100804_bib10","volume":"248","author":"Hu","year":"2020","journal-title":"Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4\/MyD88\/NF-\u03baB signaling pathway"},{"key":"10.1016\/j.mtbio.2023.100804_bib11","article-title":"viaPhillygenin attenuates carbon tetrachloride-induced liver fibrosis","volume":"12","author":"Wang","year":"2021","journal-title":"Modulating Inflammation and Gut Microbiota"},{"key":"10.1016\/j.mtbio.2023.100804_bib12","article-title":"Hepatoprotective effect of phillygenin on carbon tetrachloride-induced liver fibrosis and its effects on short chain","volume":"296","author":"Wang","year":"2022","journal-title":"fatty acid and bile acid metabolism"},{"key":"10.1016\/j.mtbio.2023.100804_bib13","series-title":"Evaluation of the Pharmacokinetics and Hepatoprotective Effects of Phillygenin in Mouse","author":"Song","year":"2018"},{"key":"10.1016\/j.mtbio.2023.100804_bib14","article-title":"Self-microemulsifying drug delivery system of phillygenin: formulation development","volume":"12","author":"Wang","year":"2020","journal-title":"Characterization and Pharmacokinetic Evaluation"},{"key":"10.1016\/j.mtbio.2023.100804_bib15","first-page":"396","article-title":"Using exosomes, naturally-equipped nanocarriers","volume":"219","author":"Batrakova","year":"2015","journal-title":"Drug Deliv."},{"key":"10.1016\/j.mtbio.2023.100804_bib16","first-page":"585","article-title":"Prospects and challenges of extracellular vesicle-based drug delivery system","volume":"27","author":"Meng","year":"2020","journal-title":"considering cell source"},{"key":"10.1016\/j.mtbio.2023.100804_bib17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2015.10.020","article-title":"Bovine milk-derived exosomes for drug delivery","volume":"371","author":"Munagala","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mtbio.2023.100804_bib18","first-page":"688","volume":"18","author":"Li","year":"2021","journal-title":"The Potential of Milk-Derived Exosomes for Drug Delivery"},{"key":"10.1016\/j.mtbio.2023.100804_bib19","first-page":"2029","volume":"12","author":"Wu","year":"2022","journal-title":"Milk-derived exosomes exhibit versatile effects for improved oral drug delivery"},{"key":"10.1016\/j.mtbio.2023.100804_bib20","volume":"vol. 9","author":"Roehlen","year":"2020"},{"key":"10.1016\/j.mtbio.2023.100804_bib21","article-title":"Hyaluronic acid-based activatable nanomaterials for stimuli-responsive imaging and therapeutics: beyond CD44-mediated","volume":"31","author":"Choi","year":"2019","journal-title":"Drug Deliv."},{"key":"10.1016\/j.mtbio.2023.100804_bib22","first-page":"693","volume":"10","author":"Li","year":"2020","journal-title":"Targeted delivery of hyaluronic acid nanomicelles to hepatic stellate cells in hepatic fibrosis rats"},{"key":"10.1016\/j.mtbio.2023.100804_bib23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ymeth.2015.05.028","article-title":"Integrated isolation and quantitative analysis of exosome shuttled proteins and nucleic acids using immunocapture approaches","volume":"87","author":"Zarovni","year":"2015","journal-title":"Methods"},{"key":"10.1016\/j.mtbio.2023.100804_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jim.2014.06.007","article-title":"Isolation of biologically-active exosomes from human plasma","volume":"411","author":"Muller","year":"2014","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.mtbio.2023.100804_bib25","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1681\/ASN.2013101066","article-title":"Human urinary exosomes as innate immune effectors","volume":"25","author":"Hiemstra","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mtbio.2023.100804_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070727","article-title":"Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis","volume":"8","author":"Doyle","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.mtbio.2023.100804_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3892\/ijmm.2015.2194","article-title":"Isolation of extracellular vesicles: determining the correct approach (Review)","volume":"36","author":"Szatanek","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mtbio.2023.100804_bib28","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.3168\/jds.2014-9076","article-title":"Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages","volume":"98","author":"Izumi","year":"2015","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.mtbio.2023.100804_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2020.108032","article-title":"Hyaluronan decoration of milk exosomes directs tumor-specific delivery of doxorubicin","volume":"493","author":"Li","year":"2020","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.mtbio.2023.100804_bib30","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.3389\/fmicb.2019.01384","article-title":"A new isolate of pediococcus pentosaceus (SL001) with antibacterial activity against fish pathogens and potency in facilitating the immunity and growth performance of grass carps","volume":"10","author":"Gong","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.mtbio.2023.100804_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127038","article-title":"Protective effects and molecular mechanisms of baicalein on thioacetamide-induced toxicity in zebrafish larvae","volume":"256","author":"Zhang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.mtbio.2023.100804_bib32","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.3168\/jds.2012-5489","article-title":"Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions","volume":"95","author":"Izumi","year":"2012","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.mtbio.2023.100804_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3168\/jds.2019-16959","article-title":"Invited review: MicroRNAs in bovine colostrum-Focus on their origin and potential health benefits for the calf","volume":"103","author":"Van Hese","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.mtbio.2023.100804_bib34","doi-asserted-by":"crossref","first-page":"9506","DOI":"10.1021\/acs.jafc.7b03123","article-title":"Small interfering RNA in milk exosomes is resistant to digestion and crosses the intestinal barrier in vitro","volume":"65","author":"Shandilya","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.mtbio.2023.100804_bib35","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s12010-017-2478-4","article-title":"Curcumin encapsulated in milk exosomes resists human digestion and possesses enhanced intestinal permeability in vitro","volume":"183","author":"Vashisht","year":"2017","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.mtbio.2023.100804_bib36","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/jbm.a.35704","article-title":"Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts","volume":"104","author":"Lord","year":"2016","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.mtbio.2023.100804_bib37","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI1018","article-title":"Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors","volume":"102","author":"Iredale","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mtbio.2023.100804_bib38","first-page":"1265","article-title":"CD95\/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair","volume":"151","author":"Saile","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mtbio.2023.100804_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-34351-5","article-title":"Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model","volume":"8","author":"van der Helm","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2023.100804_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/869390","article-title":"Autophagy: a multifaceted partner in liver fibrosis","volume":"2014","author":"Mallat","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.mtbio.2023.100804_bib41","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.2147\/DDDT.S317701","article-title":"Doxazosin attenuates liver fibrosis by inhibiting autophagy in hepatic stellate cells via activation of the PI3K\/Akt\/mTOR signaling pathway","volume":"15","author":"Xiu","year":"2021","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.mtbio.2023.100804_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2018.11.025","article-title":"Allicin attenuates pathological cardiac hypertrophy by inhibiting autophagy via activation of PI3K\/Akt\/mTOR and MAPK\/ERK\/mTOR signaling pathways","volume":"58","author":"Ba","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.mtbio.2023.100804_bib43","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.bbadis.2018.02.003","article-title":"PI3K\/AKT\/mTOR activation and autophagy inhibition plays a key role in increased cholesterol during IL-17A mediated inflammatory response in psoriasis","volume":"1864","author":"Varshney","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.mtbio.2023.100804_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12020130","article-title":"Self-microemulsifying drug delivery system of phillygenin: formulation development, characterization and pharmacokinetic evaluation","volume":"12","author":"Wang","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.mtbio.2023.100804_bib45","doi-asserted-by":"crossref","first-page":"16701","DOI":"10.1021\/acsomega.0c01582","article-title":"Zeta potential of extracellular vesicles: toward understanding the attributes that determine colloidal stability","volume":"5","author":"Midekessa","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.mtbio.2023.100804_bib46","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0959-437X(00)00074-5","article-title":"Zebrafish: a model system for the study of human disease","volume":"10","author":"Dooley","year":"2000","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.mtbio.2023.100804_bib47","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1053\/j.gastro.2015.08.034","article-title":"An important tool for liver disease research","volume":"149","author":"Goessling","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2023.100804_bib48","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrg2091","article-title":"Animal models of human disease: zebrafish swim into view","volume":"8","author":"Lieschke","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.mtbio.2023.100804_bib49","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1002\/hep.25757","article-title":"The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: analysis of stellate cell entry into the developing liver","volume":"56","author":"Yin","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.mtbio.2023.100804_bib50","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006423002648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006423002648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:35:39Z","timestamp":1762907739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006423002648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":50,"alternative-id":["S2590006423002648"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2023.100804","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preparation of Phillygenin-Hyaluronic acid composite milk-derived exosomes and its anti-hepatic fibrosis effect","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2023.100804","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100804"}}