{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:10:05Z","timestamp":1778908205806,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["U22A20156"],"award-info":[{"award-number":["U22A20156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["32171379"],"award-info":[{"award-number":["32171379"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.mtbio.2024.101131","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T12:58:09Z","timestamp":1718715489000},"page":"101131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Enhancing ovarian cancer treatment with maleimide-modified Pt(IV) prodrug nanoparticles"],"prefix":"10.1016","volume":"27","author":[{"given":"Yiting","family":"Bai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongzhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiandi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haorui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2261-4532","authenticated-orcid":false,"given":"Tianmeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9951","key":"10.1016\/j.mtbio.2024.101131_bib1","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0140-6736(13)62146-7","article-title":"Ovarian cancer","volume":"384","author":"Jayson","year":"2014","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.mtbio.2024.101131_bib2","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/cncr.24149","volume":"115","author":"du Bois","year":"2009","journal-title":"Cancer"},{"issue":"10","key":"10.1016\/j.mtbio.2024.101131_bib3","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.2217\/fon.10.100","article-title":"Intraperitoneal therapy for peritoneal cancer","volume":"6","author":"Lu","year":"2010","journal-title":"Future Oncol."},{"issue":"6","key":"10.1016\/j.mtbio.2024.101131_bib4","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00280-016-2976-z","article-title":"Platinum-based drugs: past, present and future","volume":"77","author":"Dilruba","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"11","key":"10.1016\/j.mtbio.2024.101131_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081162","article-title":"Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions","volume":"8","author":"Marullo","year":"2013","journal-title":"PLoS One"},{"issue":"50","key":"10.1016\/j.mtbio.2024.101131_bib6","doi-asserted-by":"crossref","first-page":"47107","DOI":"10.1074\/jbc.M104516200","article-title":"Effect of glutathione depletion on antitumor drug toxicity (apoptosis and necrosis) in U-937 human promonocytic cells. The role of intracellular oxidation","volume":"276","author":"Troyano","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.mtbio.2024.101131_bib7","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.7150\/thno.70194","article-title":"SCD1\/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells","volume":"12","author":"Xuan","year":"2022","journal-title":"Theranostics"},{"issue":"9","key":"10.1016\/j.mtbio.2024.101131_bib8","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1002\/jcb.25937","article-title":"Neferine potentiates the antitumor effect of cisplatin in human lung adenocarcinoma cells via a mitochondria-mediated apoptosis pathway","volume":"118","author":"Sivalingam","year":"2017","journal-title":"J. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.mtbio.2024.101131_bib9","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1517\/14656566.4.6.889","article-title":"Toxicity of platinum compounds","volume":"4","author":"Hartmann","year":"2003","journal-title":"Expet Opin. Pharmacother."},{"issue":"5","key":"10.1016\/j.mtbio.2024.101131_bib10","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1021\/acs.chemrev.5b00597","article-title":"The next generation of platinum drugs: targeted Pt(II) agents, nanoparticle delivery, and Pt(IV) prodrugs","volume":"116","author":"Johnstone","year":"2016","journal-title":"Chem. Rev."},{"issue":"15","key":"10.1016\/j.mtbio.2024.101131_bib11","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/onc.2011.384","article-title":"Molecular mechanisms of cisplatin resistance","volume":"31","author":"Galluzzi","year":"2012","journal-title":"Oncogene"},{"issue":"49","key":"10.1016\/j.mtbio.2024.101131_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202307013","article-title":"Alendronate triggered dual\u2010cascade targeting prodrug nanoparticles for enhanced tumor penetration and STING activation of osteosarcoma","volume":"33","author":"Shen","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"11","key":"10.1016\/j.mtbio.2024.101131_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202310456","article-title":"Platinum prodrug nanoparticles with COX-2 inhibition amplify pyroptosis for enhanced chemotherapy and immune activation of pancreatic cancer","volume":"36","author":"Yu","year":"2024","journal-title":"Adv. Mater."},{"issue":"52","key":"10.1016\/j.mtbio.2024.101131_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202101460","article-title":"Small-molecule prodrug nanoassemblies: an emerging nanoplatform for anticancer drug delivery","volume":"17","author":"Li","year":"2021","journal-title":"Small"},{"issue":"11","key":"10.1016\/j.mtbio.2024.101131_bib15","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.tips.2014.09.008","article-title":"Prodrug-based nanoparticulate drug delivery strategies for cancer therapy","volume":"35","author":"Luo","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"issue":"22","key":"10.1016\/j.mtbio.2024.101131_bib16","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1039\/c3tb20319k","article-title":"Mesoporous silica nanoparticle-based cisplatin prodrug delivery and anticancer effect under reductive cellular environment","volume":"1","author":"Ahn","year":"2013","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"10.1016\/j.mtbio.2024.101131_bib17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1056\/NEJMoa052985","article-title":"Intraperitoneal cisplatin and paclitaxel in ovarian cancer","volume":"354","author":"Armstrong","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.mtbio.2024.101131_bib18","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1200\/JCO.2001.19.4.1001","volume":"19","author":"Markman","year":"2001","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.mtbio.2024.101131_bib19","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1200\/JCO.2006.07.3494","article-title":"Health-related quality of life during and after intraperitoneal versus intravenous chemotherapy for optimally debulked ovarian cancer: a Gynecologic Oncology Group Study","volume":"25","author":"Wenzel","year":"2007","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.mtbio.2024.101131_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1586\/era.09.167","article-title":"First-line treatment of advanced ovarian cancer: current research and perspectives","volume":"10","author":"Marchetti","year":"2010","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.mtbio.2024.101131_bib21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biomaterials.2016.06.031","article-title":"Nanoparticle tumor localization, disruption of autophagosomal trafficking, and prolonged drug delivery improve survival in peritoneal mesothelioma","volume":"102","author":"Liu","year":"2016","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.mtbio.2024.101131_bib22","doi-asserted-by":"crossref","first-page":"4618","DOI":"10.1021\/acs.nanolett.8b01924","article-title":"Glutathione-scavenging poly(disulfide amide) nanoparticles for the effective delivery of Pt(IV) prodrugs and reversal of cisplatin resistance","volume":"18","author":"Ling","year":"2018","journal-title":"Nano Lett."},{"issue":"1","key":"10.1016\/j.mtbio.2024.101131_bib23","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/acsnano.8b06400","article-title":"Glutathione-responsive prodrug nanoparticles for effective drug delivery and cancer therapy","volume":"13","author":"Ling","year":"2019","journal-title":"ACS Nano"},{"issue":"23","key":"10.1016\/j.mtbio.2024.101131_bib24","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1161\/CIRCULATIONAHA.111.087817","article-title":"A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation","volume":"125","author":"Zhuang","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.mtbio.2024.101131_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101459","article-title":"Boosting ferroptosis via abplatin(iv) for treatment of platinum-resistant recurrent ovarian cancer","volume":"44","author":"Wang","year":"2022","journal-title":"Nano Today"},{"issue":"3","key":"10.1016\/j.mtbio.2024.101131_bib26","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian cancer development and metastasis","volume":"177","author":"Lengyel","year":"2010","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.mtbio.2024.101131_bib27","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.7150\/thno.69424","article-title":"Platinum-based drugs for cancer therapy and anti-tumor strategies","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.mtbio.2024.101131_bib28","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.7150\/thno.29820","article-title":"GSH-sensitive Pt(IV) prodrug-loaded phase-transitional nanoparticles with a hybrid lipid-polymer shell for precise theranostics against ovarian cancer","volume":"9","author":"Huang","year":"2019","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.mtbio.2024.101131_bib29","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2174\/092986706776872970","article-title":"Platinum group antitumor chemistry: design and development of new anticancer drugs complementary to cisplatin","volume":"13","author":"Abu-Surrah","year":"2006","journal-title":"Curr. Med. Chem."},{"issue":"2","key":"10.1016\/j.mtbio.2024.101131_bib30","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrclinonc.2009.217","article-title":"Intraperitoneal therapy for peritoneal tumors: biophysics and clinical evidence","volume":"7","author":"Ceelen","year":"2010","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.mtbio.2024.101131_bib31","doi-asserted-by":"crossref","first-page":"e368","DOI":"10.1016\/S1470-2045(19)30318-3","article-title":"Pressurised intraperitoneal aerosol chemotherapy: rationale, evidence, and potential indications","volume":"20","author":"Alyami","year":"2019","journal-title":"Lancet Oncol."},{"issue":"10","key":"10.1016\/j.mtbio.2024.101131_bib32","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/S0959-8049(98)00230-5","article-title":"Pharmacogenetics and cancer chemotherapy","volume":"34","author":"Iyer","year":"1998","journal-title":"Eur. J. Cancer"},{"issue":"11","key":"10.1016\/j.mtbio.2024.101131_bib33","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1021\/nn9010973","article-title":"Label-free Raman spectral imaging of intracellular delivery and degradation of polymeric nanoparticle systems","volume":"3","author":"Chernenko","year":"2009","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2024.101131_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122187","article-title":"Maleimide as the PEG end-group promotes macrophage-targeted drug delivery of PEGylated nanoparticles in vivo by enhancing interaction with circulating erythrocytes","volume":"300","author":"Wang","year":"2023","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.mtbio.2024.101131_bib35","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1039\/C8BM00692J","article-title":"In situ low-immunogenic albumin-conjugating-corona guiding nanoparticles for tumor-targeting chemotherapy","volume":"6","author":"Li","year":"2018","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.mtbio.2024.101131_bib36","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9156285","article-title":"Critical role of zinc as either an antioxidant or a prooxidant in cellular systems","volume":"2018","author":"Lee","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"23","key":"10.1016\/j.mtbio.2024.101131_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202300548","article-title":"Impairing tumor metabolic plasticity via a stable metal-phenolic-based polymeric nanomedicine to suppress colorectal cancer","volume":"35","author":"Li","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2024.101131_bib38","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.2147\/IJN.S247114","article-title":"Nanotechnology-based cisplatin intracellular delivery to enhance chemo-sensitivity of ovarian cancer","volume":"15","author":"Bortot","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"7","key":"10.1016\/j.mtbio.2024.101131_bib39","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrc1123","article-title":"Ovarian cancer: strategies for overcoming resistance to chemotherapy","volume":"3","author":"Agarwal","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mtbio.2024.101131_bib40","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejpb.2015.03.018","article-title":"Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy","volume":"93","author":"Perez-Herrero","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.mtbio.2024.101131_bib41","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jconrel.2020.06.005","article-title":"Reduction-sensitive platinum (IV)-prodrug nano-sensitizer with an ultra-high drug loading for efficient chemo-radiotherapy of Pt-resistant cervical cancer in vivo","volume":"326","author":"Luo","year":"2020","journal-title":"J. Contr. Release"},{"issue":"9","key":"10.1016\/j.mtbio.2024.101131_bib42","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nrc1958","article-title":"Polymer conjugates as anticancer nanomedicines","volume":"6","author":"Duncan","year":"2006","journal-title":"Nat. Rev. Cancer"},{"issue":"17","key":"10.1016\/j.mtbio.2024.101131_bib43","article-title":"Enhancing Pt(IV) complexes' anticancer activity upon encapsulation in stimuli-responsive nanocages","volume":"12","author":"Sancho-Albero","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2024.101131_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.07.043","article-title":"Exploiting shape, cellular-hitchhiking and antibodies to target nanoparticles to lung endothelium: synergy between physical, chemical and biological approaches","volume":"68","author":"Anselmo","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2024.101131_bib45","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jconrel.2016.01.020","article-title":"Nanoparticle-liver interactions: cellular uptake and hepatobiliary elimination","volume":"240","author":"Zhang","year":"2016","journal-title":"J. Contr. Release"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259000642400190X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259000642400190X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:27:41Z","timestamp":1778905661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S259000642400190X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":45,"alternative-id":["S259000642400190X"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2024.101131","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhancing ovarian cancer treatment with maleimide-modified Pt(IV) prodrug nanoparticles","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2024.101131","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101131"}}