{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:21:57Z","timestamp":1786994517893,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.mtbio.2024.101343","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T02:51:18Z","timestamp":1732330278000},"page":"101343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Idarubicin-loaded degradable hydrogel for TACE therapy enhances anti-tumor immunity in hepatocellular carcinoma"],"prefix":"10.1016","volume":"29","author":[{"given":"Xiaokai","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujiao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhou","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haikuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-5675","authenticated-orcid":false,"given":"Zeyu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10360","key":"10.1016\/j.mtbio.2024.101343_bib1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","article-title":"Hepatocellular carcinoma","volume":"400","author":"Vogel","year":"2022","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.mtbio.2024.101343_bib2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1001\/jamaoncol.2017.5847","article-title":"Efficacy and safety of transarterial chemoembolization plus external beam radiotherapy vs sorafenib in hepatocellular carcinoma with macroscopic vascular invasion: a randomized clinical trial","volume":"4","author":"Yoon","year":"2018","journal-title":"JAMA Oncol."},{"issue":"1","key":"10.1016\/j.mtbio.2024.101343_bib3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"10","key":"10.1016\/j.mtbio.2024.101343_bib4","doi-asserted-by":"crossref","first-page":"eaaz4204","DOI":"10.1126\/sciadv.aaz4204","article-title":"Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses","volume":"6","author":"Chao","year":"2020","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.mtbio.2024.101343_bib5","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"EASL clinical practice guidelines: management of hepatocellular carcinoma","volume":"69","year":"2018","journal-title":"J. Hepatol."},{"issue":"9319","key":"10.1016\/j.mtbio.2024.101343_bib6","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/S0140-6736(02)08649-X","article-title":"Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial","volume":"359","author":"Llovet","year":"2002","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.mtbio.2024.101343_bib7","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1159\/000523849","article-title":"Lenvatinib with or without concurrent drug-eluting beads transarterial chemoembolization in patients with unresectable, advanced hepatocellular carcinoma: a real-world, multicenter, retrospective study","volume":"11","author":"Xia","year":"2022","journal-title":"Liver Cancer"},{"issue":"4","key":"10.1016\/j.mtbio.2024.101343_bib8","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3350\/cmh.2015.21.4.344","article-title":"Transarterial chemoembolization using drug eluting beads for the treatment of hepatocellular carcinoma: now and future","volume":"21","author":"Woo","year":"2015","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.mtbio.2024.101343_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121512","article-title":"HIF-2\u03b1-targeted interventional chemoembolization multifunctional microspheres for effective elimination of hepatocellular carcinoma","volume":"284","author":"Chen","year":"2022","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.mtbio.2024.101343_bib10","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1038\/aps.2017.79","article-title":"Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells","volume":"38","author":"Li","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"issue":"6","key":"10.1016\/j.mtbio.2024.101343_bib11","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2011.08.039","article-title":"Basic and therapeutic aspects of angiogenesis","volume":"146","author":"Potente","year":"2011","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.mtbio.2024.101343_bib12","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cell.2020.11.041","article-title":"Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma","volume":"184","author":"Sun","year":"2021","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.mtbio.2024.101343_bib13","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jhep.2023.02.032","article-title":"TREM2(+) macrophages suppress CD8(+) T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma","volume":"79","author":"Tan","year":"2023","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.mtbio.2024.101343_bib14","doi-asserted-by":"crossref","first-page":"288","DOI":"10.14218\/JCTH.2016.00058","article-title":"Impact of different embolic agents for transarterial chemoembolization (TACE) procedures on systemic vascular endothelial growth factor (VEGF) levels","volume":"4","author":"Schicho","year":"2016","journal-title":"J Clin Transl Hepatol"},{"key":"10.1016\/j.mtbio.2024.101343_bib15","article-title":"Safety and efficacy of degradable starch microspheres transcatheter arterial chemoembolization as a bridging therapy in patients with early stage hepatocellular carcinoma and child-pugh stage B eligible for liver transplant","volume":"12","author":"Minici","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mtbio.2024.101343_bib16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.actbio.2022.12.004","article-title":"Idarubicin-loaded biodegradable microspheres enhance sensitivity to anti-PD1 immunotherapy in transcatheter arterial chemoembolization of hepatocellular carcinoma","volume":"157","author":"Zheng","year":"2023","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.mtbio.2024.101343_bib17","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1200\/JCO.21.00608","article-title":"Hepatic arterial infusion of oxaliplatin, fluorouracil, and leucovorin versus transarterial chemoembolization for large hepatocellular carcinoma: a randomized phase III trial","volume":"40","author":"Li","year":"2022","journal-title":"J. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.mtbio.2024.101343_bib18","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrc3380","article-title":"Immunogenic cell death and DAMPs in cancer therapy","volume":"12","author":"Krysko","year":"2012","journal-title":"Nat. Rev. Cancer"},{"issue":"10","key":"10.1016\/j.mtbio.2024.101343_bib19","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1039\/D0DT03470C","article-title":"Immunogenicity and cytotoxicity of a platinum(IV) complex derived from capsaicin","volume":"50","author":"Sun","year":"2021","journal-title":"Dalton Trans."},{"issue":"6","key":"10.1016\/j.mtbio.2024.101343_bib20","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s13402-020-00552-2","article-title":"Oxaliplatin induces immunogenic cell death in hepatocellular carcinoma cells and synergizes with immune checkpoint blockade therapy","volume":"43","author":"Zhu","year":"2020","journal-title":"Cell. Oncol."},{"issue":"2","key":"10.1016\/j.mtbio.2024.101343_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/17425247.2021.1825376","article-title":"Platinum-based chemotherapy in combination with PD-1\/PD-L1 inhibitors: preclinical and clinical studies and mechanism of action","volume":"18","author":"Xue","year":"2021","journal-title":"Expet Opin. Drug Deliv."},{"issue":"9","key":"10.1016\/j.mtbio.2024.101343_bib22","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003311","article-title":"Trans-arterial chemoembolization as a loco-regional inducer of immunogenic cell death in hepatocellular carcinoma: implications for immunotherapy","volume":"9","author":"Pinato","year":"2021","journal-title":"J Immunother Cancer"},{"issue":"2","key":"10.1016\/j.mtbio.2024.101343_bib23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jhep.2019.09.023","article-title":"Role of locoregional therapies in the wake of systemic therapy","volume":"72","author":"Palmer","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mtbio.2024.101343_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2020.100934","article-title":"Radiofrequency-responsive dual-valent gold nanoclusters for enhancing synergistic therapy of tumor ablation and artery embolization","volume":"35","author":"Li","year":"2020","journal-title":"Nano Today"},{"issue":"7","key":"10.1016\/j.mtbio.2024.101343_bib25","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.7150\/thno.80213","article-title":"Bench-to-bedside development of multifunctional flexible embolic agents","volume":"13","author":"Wang","year":"2023","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.mtbio.2024.101343_bib26","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.jvir.2017.07.020","article-title":"Transarterial chemoembolization with small drug-eluting beads in patients with hepatocellular carcinoma: experience from a cohort of 421 patients at an Italian center","volume":"28","author":"Aliberti","year":"2017","journal-title":"J Vasc Interv Radiol"},{"issue":"1","key":"10.1016\/j.mtbio.2024.101343_bib27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/hep.28453","article-title":"Lipiodol transarterial chemoembolization for hepatocellular carcinoma: a systematic review of efficacy and safety data","volume":"64","author":"Lencioni","year":"2016","journal-title":"Hepatology"},{"issue":"17","key":"10.1016\/j.mtbio.2024.101343_bib28","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.7150\/thno.27379","article-title":"Radiopaque and uniform alginate microspheres loaded with tantalum nanoparticles for real-time imaging during transcatheter arterial embolization","volume":"8","author":"Zeng","year":"2018","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.mtbio.2024.101343_bib29","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.jhep.2012.01.008","article-title":"Survival of patients with hepatocellular carcinoma treated by transarterial chemoembolisation (TACE) using Drug Eluting Beads. Implications for clinical practice and trial design","volume":"56","author":"Burrel","year":"2012","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.mtbio.2024.101343_bib30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0169-409X(01)00242-3","article-title":"Thermosensitive sol-gel reversible hydrogels","volume":"54","author":"Jeong","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.mtbio.2024.101343_bib31","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00270-006-0062-3","article-title":"Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies","volume":"30","author":"Marelli","year":"2007","journal-title":"Cardiovasc. Intervent. Radiol."},{"issue":"1","key":"10.1016\/j.mtbio.2024.101343_bib32","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"EASL clinical practice guidelines: management of hepatocellular carcinoma","volume":"69","author":"Galle","year":"2018","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.mtbio.2024.101343_bib33","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1080\/10717544.2018.1480673","article-title":"Hyaluronic acid\/doxorubicin nanoassembly-releasing microspheres for the transarterial chemoembolization of a liver tumor","volume":"25","author":"Lee","year":"2018","journal-title":"Drug Deliv."},{"issue":"6","key":"10.1016\/j.mtbio.2024.101343_bib34","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00535-012-0537-8","article-title":"Effect of transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma","volume":"47","author":"Yamasaki","year":"2012","journal-title":"J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.mtbio.2024.101343_bib35","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1007\/s00270-011-0218-7","article-title":"A preclinical study of the safety and efficacy of Occlusin\u2122 500 Artificial Embolization Device in sheep","volume":"35","author":"Owen","year":"2012","journal-title":"Cardiovasc. Intervent. Radiol."},{"issue":"9","key":"10.1016\/j.mtbio.2024.101343_bib36","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1021\/acs.accounts.9b00283","article-title":"Smart nanotherapeutic targeting of tumor vasculature","volume":"52","author":"Li","year":"2019","journal-title":"Acc. Chem. Res."},{"issue":"1","key":"10.1016\/j.mtbio.2024.101343_bib37","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10495-015-1185-2","article-title":"Knockdown of HIF-1\u03b1 and IL-8 induced apoptosis of hepatocellular carcinoma triggers apoptosis of vascular endothelial cells","volume":"21","author":"Choi","year":"2016","journal-title":"Apoptosis"},{"issue":"2","key":"10.1016\/j.mtbio.2024.101343_bib38","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s44222-022-00004-6","article-title":"Biomaterials tools to modulate the tumour microenvironment in immunotherapy","volume":"1","author":"Chao","year":"2023","journal-title":"Nature Reviews Bioengineering"},{"issue":"5","key":"10.1016\/j.mtbio.2024.101343_bib39","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.ejcts.2006.02.024","article-title":"Effects of purified poloxamer 407 gel on vascular occlusion and the coronary endothelium","volume":"29","author":"Boodhwani","year":"2006","journal-title":"Eur. J. Cardio. Thorac. Surg."},{"key":"10.1016\/j.mtbio.2024.101343_bib40","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev.immunol.22.012703.104803","article-title":"The three Es of cancer immunoediting","volume":"22","author":"Dunn","year":"2004","journal-title":"Annu. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.mtbio.2024.101343_bib41","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1182\/blood-2002-07-1956","article-title":"VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression","volume":"101","author":"Ohm","year":"2003","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.mtbio.2024.101343_bib42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1084\/jem.20140559","article-title":"VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors","volume":"212","author":"Voron","year":"2015","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.mtbio.2024.101343_bib43","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00270-008-9495-1","article-title":"Experimental liver embolization with four different spherical embolic materials: impact on inflammatory tissue and foreign body reaction","volume":"32","author":"Stampfl","year":"2009","journal-title":"Cardiovasc. Intervent. Radiol."},{"issue":"2","key":"10.1016\/j.mtbio.2024.101343_bib44","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.biomaterials.2010.09.001","article-title":"Influence of degradation on inflammatory profile of polyphosphazene coated PMMA and trisacryl gelatin microspheres in a sheep uterine artery embolization model","volume":"32","author":"Verret","year":"2011","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.mtbio.2024.101343_bib45","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2017.1386829","article-title":"Trial watch: immunogenic cell death induction by anticancer chemotherapeutics","volume":"6","author":"Garg","year":"2017","journal-title":"OncoImmunology"},{"issue":"8","key":"10.1016\/j.mtbio.2024.101343_bib46","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1111\/jcmm.14356","article-title":"Immunogenic cell death in cancer therapy: present and emerging inducers","volume":"23","author":"Zhou","year":"2019","journal-title":"J. Cell Mol. Med."},{"issue":"6062","key":"10.1016\/j.mtbio.2024.101343_bib47","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1126\/science.1208347","article-title":"Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice","volume":"334","author":"Michaud","year":"2011","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.mtbio.2024.101343_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.493","article-title":"Strange attractors: DAMPs and autophagy link tumor cell death and immunity","volume":"4","author":"Hou","year":"2013","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.mtbio.2024.101343_bib49","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-021-01489-2","article-title":"Combination strategies with PD-1\/PD-L1 blockade: current advances and future directions","volume":"21","author":"Yi","year":"2022","journal-title":"Mol. Cancer"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006424004046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006424004046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T18:19:34Z","timestamp":1735064374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006424004046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":49,"alternative-id":["S2590006424004046"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2024.101343","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Idarubicin-loaded degradable hydrogel for TACE therapy enhances anti-tumor immunity in hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2024.101343","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101343"}}