{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:58:06Z","timestamp":1770742686023,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["23NSFSC1541"],"award-info":[{"award-number":["23NSFSC1541"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["23NSFSC1540"],"award-info":[{"award-number":["23NSFSC1540"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.mtbio.2025.101497","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T19:54:48Z","timestamp":1737230088000},"page":"101497","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A select inhibitor of MORC2 encapsulated by chimeric membranecoated DNA nanocage target alleviation TNBC progression"],"prefix":"10.1016","volume":"31","author":[{"given":"Xiaohan","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunbo","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqi","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shishan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1900-8358","authenticated-orcid":false,"given":"Panke","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingmi","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2025.101497_bib1","first-page":"209","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.mtbio.2025.101497_bib2","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/S0140-6736(20)32381-3","volume":"397","author":"Loibl","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.mtbio.2025.101497_bib3","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1056\/NEJMoa2105215","article-title":"Investigators","volume":"384","author":"Tutt","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2025.101497_bib4","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2147\/CLEP.S206949","volume":"11","author":"Armstrong","year":"2019","journal-title":"Clin. Epidemiol."},{"key":"10.1016\/j.mtbio.2025.101497_bib5","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1056\/NEJMoa1412082","volume":"372","author":"Robert","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2025.101497_bib6","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1056\/NEJMoa1606774","volume":"375","author":"Reck","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2025.101497_bib7","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1056\/NEJMoa1510665","volume":"373","author":"Motzer","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2025.101497_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","volume":"187","author":"Newton","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2025.101497_bib9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0165-6147(03)00026-9","volume":"24","author":"Stewart","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.mtbio.2025.101497_bib10","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1093\/nar\/gkaa130","volume":"48","author":"Liu","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mtbio.2025.101497_bib11","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.1158\/0008-5472.CAN-17-1394","volume":"78","author":"Zhang","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.mtbio.2025.101497_bib12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/cas.13863","volume":"110","author":"Liu","year":"2019","journal-title":"Cancer Sci."},{"key":"10.1016\/j.mtbio.2025.101497_bib13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.humpath.2018.03.011","volume":"76","author":"Ding","year":"2018","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.mtbio.2025.101497_bib14","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1080\/15548627.2019.1659609","volume":"16","author":"Yang","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.mtbio.2025.101497_bib15","volume":"102","author":"Liao","year":"2023","journal-title":"Medicine"},{"key":"10.1016\/j.mtbio.2025.101497_bib16","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1158\/1535-7163.1427.3.11","volume":"3","author":"Fry","year":"2004","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.mtbio.2025.101497_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1470-2045(14)71159-3","volume":"16","author":"Finn","year":"2015","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.mtbio.2025.101497_bib18","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1016\/j.bmcl.2013.05.007","volume":"23","author":"Furet","year":"2013","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.mtbio.2025.101497_bib19","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1056\/NEJMoa1813904","volume":"380","author":"Andre","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2025.101497_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.994","volume":"10","author":"Jimenez-Roses","year":"2022","journal-title":"Pharmacol Res Perspect"},{"key":"10.1016\/j.mtbio.2025.101497_bib21","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1001\/jama.2017.17535","volume":"318","author":"Sachs","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.mtbio.2025.101497_bib22","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1021\/acscentsci.0c00763","volume":"6","author":"Thai","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.mtbio.2025.101497_bib23","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1039\/D0CS00152J","volume":"50","author":"Luo","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.mtbio.2025.101497_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jconrel.2021.08.020","volume":"338","author":"Li","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2025.101497_bib25","volume":"36","author":"Song","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.101497_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2020.05.028","volume":"112","author":"Chen","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101497_bib27","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.1229568","volume":"339","author":"Rodriguez","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2025.101497_bib28","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev-immunol-020711-074942","volume":"30","author":"Amulic","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.mtbio.2025.101497_bib29","volume":"106","author":"He","year":"2020","journal-title":"Mater. Sci. Eng., C"},{"key":"10.1016\/j.mtbio.2025.101497_bib30","doi-asserted-by":"crossref","first-page":"9877","DOI":"10.18632\/oncotarget.3185","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.mtbio.2025.101497_bib31","first-page":"13","author":"Chutani","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.mtbio.2025.101497_bib32","doi-asserted-by":"crossref","first-page":"16461","DOI":"10.18632\/oncotarget.3889","volume":"6","author":"Zhang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.mtbio.2025.101497_bib33","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1093\/nar\/gkaa130","volume":"48","author":"Li","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mtbio.2025.101497_bib34","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-016-0315-4","volume":"16","author":"Murad","year":"2016","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.mtbio.2025.101497_bib35","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1242\/jcs.038166","volume":"122","author":"Dewson","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mtbio.2025.101497_bib36","volume":"19","author":"Yang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.101497_bib37","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1002\/1873-3468.13601","volume":"593","author":"Yoshida","year":"2019","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mtbio.2025.101497_bib38","doi-asserted-by":"crossref","first-page":"44323","DOI":"10.18632\/oncotarget.6249","volume":"6","author":"Yang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.mtbio.2025.101497_bib39","volume":"12","author":"Yuan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mtbio.2025.101497_bib40","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.phymed.2014.04.001","volume":"21","author":"Liu","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.mtbio.2025.101497_bib41","doi-asserted-by":"crossref","first-page":"23746","DOI":"10.1021\/acsnano.3c07555","volume":"17","author":"Cao","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.101497_bib42","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1056\/NEJMra1001389","volume":"363","author":"Foulkes","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2025.101497_bib43","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.1542\/peds.108.1.e12","volume":"108","author":"Nupponen","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.mtbio.2025.101497_bib44","volume":"14","author":"Ludwig","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2025.101497_bib45","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-physiol-021119-034627","volume":"82","author":"Boedtkjer","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mtbio.2025.101497_bib46","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1200\/JCO.2010.31.2835","volume":"29","author":"Cuzick","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.mtbio.2025.101497_bib47","volume":"175","author":"Loison","year":"2021","journal-title":"JoVE."},{"key":"10.1016\/j.mtbio.2025.101497_bib48","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/jca.20077","volume":"21","author":"Schwanke","year":"2006","journal-title":"J. Clin. Apher."},{"key":"10.1016\/j.mtbio.2025.101497_bib49","doi-asserted-by":"crossref","first-page":"6946","DOI":"10.1021\/acs.nanolett.1c02191","volume":"21","author":"Peng","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.mtbio.2025.101497_bib50","volume":"33","author":"Hong","year":"2021","journal-title":"Adv. Mater."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425000559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425000559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:39:57Z","timestamp":1762634397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425000559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":50,"alternative-id":["S2590006425000559"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101497","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A select inhibitor of MORC2 encapsulated by chimeric membranecoated DNA nanocage target alleviation TNBC progression","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101497","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101497"}}