{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:10:12Z","timestamp":1791601812247,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007935","name":"Hainan Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007935","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015946","name":"Southwest Medical University Institute of Cardiovascular Research","doi-asserted-by":"publisher","award":["KLET-202013"],"award-info":[{"award-number":["KLET-202013"]}],"id":[{"id":"10.13039\/501100015946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.mtbio.2025.101560","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T02:43:15Z","timestamp":1739760195000},"page":"101560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Treating critical bone defects by using core-shell biological scaffold to regulate Fibrosis\u2013Osteogenic homeostasis"],"prefix":"10.1016","volume":"31","author":[{"given":"Yonghang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiping","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingkuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinsong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5467-8269","authenticated-orcid":false,"given":"Lu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2025.101560_bib1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.injury.2014.04.002","article-title":"Delayed union and nonunions: epidemiology, clinical issues, and financial aspects","volume":"45","author":"Hak","year":"2014","journal-title":"Injury"},{"key":"10.1016\/j.mtbio.2025.101560_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00003086-198604000-00036","article-title":"The critical size defect as an experimental model for craniomandibulofacial nonunions","volume":"205","author":"Schmitz J P","year":"1986","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.mtbio.2025.101560_bib3","article-title":"Repair of infected bone defect with Clindamycin-Tetrahedral DNA nanostructure Complex-loaded 3D bioprinted hybrid scaffold","volume":"435","author":"Li","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.mtbio.2025.101560_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.addr.2015.03.013","article-title":"Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair","volume":"94","author":"Agarwal","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2025.101560_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.actbio.2021.09.053","article-title":"Skeletal regeneration for segmental bone loss: vascularised grafts, analogues and surrogates","volume":"136","author":"Dalisson","year":"2021","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101560_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics10020160","article-title":"Bioactive coatings based on hydroxyapatite, kanamycin, and growth factor for biofilm modulation","volume":"10","author":"Gherasim","year":"2021","journal-title":"Antibiotics"},{"issue":"10","key":"10.1016\/j.mtbio.2025.101560_bib7","first-page":"3437","article-title":"Biomimetic Ti\u20136Al\u20134V alloy\/gelatin methacrylate hybrid scaffold with enhanced osteogenic and angiogenic capabilities for large bone defect restoration","volume":"6","author":"Ma","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101560_bib8","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.actbio.2018.09.008","article-title":"Modular ceramic scaffolds for individual implants","volume":"80","author":"Biggemann","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101560_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119555","article-title":"Hierarchical micro\/nanofibrous membranes of sustained releasing VEGF for periosteal regeneration","volume":"227","author":"Wu","year":"2020","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.mtbio.2025.101560_bib10","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41580-020-00279-w","article-title":"Mechanisms of bone development and repair","volume":"21","author":"Salhotra","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101560_bib11","doi-asserted-by":"crossref","DOI":"10.1186\/s42825-023-00144-4","article-title":"Guided bone regeneration in long-bone defect with a bilayer mineralized collagen membrane","volume":"5","author":"Peng","year":"2023","journal-title":"Collagen and Leather"},{"issue":"3","key":"10.1016\/j.mtbio.2025.101560_bib12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/jcmm.17096","article-title":"Biological and molecular profile of fracture non-union tissue: a systematic review and an update on current insights","volume":"26","author":"Panteli","year":"2022","journal-title":"J. Cell Mol. Med."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101560_bib13","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/jbmr.3626","article-title":"Periosteal mesenchymal progenitor dysfunction and extraskeletally-derived fibrosis contribute to atrophic fracture nonunion","volume":"34","author":"Wang","year":"2019","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101560_bib14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.5534\/wjmh.17025","article-title":"Feasibility of polycaprolactone scaffolds fabricated by three-dimensional printing for tissue engineering of tunica albuginea","volume":"36","author":"Yu","year":"2018","journal-title":"World J Mens Health"},{"key":"10.1016\/j.mtbio.2025.101560_bib15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jconrel.2019.01.026","article-title":"Injectable thermosensitive hydrogel systems based on functional PEG\/PCL block polymer for local drug delivery","volume":"297","author":"Deng","year":"2019","journal-title":"J. Contr. Release"},{"issue":"11","key":"10.1016\/j.mtbio.2025.101560_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/nano12111829","article-title":"Advances in electrospun hybrid nanofibers for biomedical applications","volume":"12","author":"Nirwan","year":"2022","journal-title":"Nanomaterials"},{"issue":"12","key":"10.1016\/j.mtbio.2025.101560_bib17","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.addr.2009.07.005","article-title":"Electrospun silk biomaterial scaffolds for regenerative medicine","volume":"61","author":"Zhang","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101560_bib18","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2967\/jnumed.118.215913","article-title":"(68)Ga-FAPI PET\/CT: biodistribution and preliminary dosimetry estimate of 2 DOTA-containing FAP-targeting agents in patients with various cancers","volume":"60","author":"Giesel","year":"2019","journal-title":"J. Nucl. Med."},{"issue":"27","key":"10.1016\/j.mtbio.2025.101560_bib19","article-title":"A multifunctional composite hydrogel that rescues the ROS microenvironment and guides the immune response for repair of osteoporotic bone defects","volume":"32","author":"Chen","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"15","key":"10.1016\/j.mtbio.2025.101560_bib20","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1080\/09205063.2018.1506399","article-title":"Release characteristics and processing-structure-performance relationship of electro-spinning curcumin-loaded polyethersulfone based porous ultrafine fibers","volume":"29","author":"Wei","year":"2018","journal-title":"J. Biomater. Sci. Polym. Ed."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101560_bib21","doi-asserted-by":"crossref","first-page":"426","DOI":"10.7150\/thno.34126","article-title":"Type H blood vessels in bone modeling and remodeling","volume":"10","author":"Peng","year":"2020","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.mtbio.2025.101560_bib22","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/s41591-018-0020-z","article-title":"Targeting skeletal endothelium to ameliorate bone loss","volume":"24","author":"Xu","year":"2018","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.mtbio.2025.101560_bib23","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12784","article-title":"Ophiopogonin D promotes bone regeneration by stimulating CD31(hi) EMCN(hi) vessel formation","volume":"53","author":"Yang","year":"2020","journal-title":"Cell Prolif."},{"issue":"14","key":"10.1016\/j.mtbio.2025.101560_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202006598","article-title":"Biomimetic, stiff, and adhesive periosteum with osteogenic-angiogenic coupling effect for bone regeneration","volume":"17","author":"Yang","year":"2021","journal-title":"Small"},{"issue":"32","key":"10.1016\/j.mtbio.2025.101560_bib25","doi-asserted-by":"crossref","first-page":"36395","DOI":"10.1021\/acsami.2c08400","article-title":"Self-adhesive hydrogel biomimetic periosteum to promote critical-size bone defect repair via synergistic osteogenesis and angiogenesis","volume":"14","author":"Yang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5777","key":"10.1016\/j.mtbio.2025.101560_bib26","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1126\/science.1126313","article-title":"Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3","volume":"312","author":"Jones","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2025.101560_bib27","article-title":"Vascular endothelial growth FactorVascularPermeability factor produces NitricOxide-dependent hypotension","author":"Horowitz","year":"1997","journal-title":"Comparative Study"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101560_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-43618-z","article-title":"Local H2 release remodels senescence microenvironment for improved repair of injured bone","volume":"14","author":"Chen","year":"2023","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.mtbio.2025.101560_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202201096","article-title":"Spatiotemporal delivery of pBMP2 and pVEGF by a core-sheath structured fiber-hydrogel gene-activated matrix loaded with peptide-modified nanoparticles for critical-sized bone defect repair","volume":"11","author":"He","year":"2022","journal-title":"Adv. Healthcare Mater."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101560_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202008364","article-title":"MMP\u20102 responsive unidirectional hydrogel\u2010electrospun patch loading TGF\u2010\u03b21 siRNA polyplexes for peritendinous anti\u2010adhesion","volume":"31","author":"Cai","year":"2020","journal-title":"Adv. Funct. Mater."},{"issue":"8","key":"10.1016\/j.mtbio.2025.101560_bib31","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1021\/acs.biomac.7b00567","article-title":"A combination of guanidyl and Phenyl groups on a dendrimer enables efficient siRNA and DNA delivery","volume":"18","author":"Chang","year":"2017","journal-title":"Biomacromolecules"},{"issue":"17","key":"10.1016\/j.mtbio.2025.101560_bib32","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1016\/j.cell.2023.06.013","article-title":"Engineering RNA export for measurement and manipulation of living cells","volume":"186","author":"Horns","year":"2023","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.mtbio.2025.101560_bib33","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1021\/acs.chemrev.7b00663","article-title":"DNA nanotechnology-enabled drug delivery systems","volume":"119","author":"Hu","year":"2019","journal-title":"Chem Rev"},{"issue":"3","key":"10.1016\/j.mtbio.2025.101560_bib34","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/15583724.2017.1292402","article-title":"Polymeric scaffold based gene delivery strategies to improve angiogenesis in tissue engineering: a review","volume":"57","author":"Hadjizadeh","year":"2017","journal-title":"Polym. Rev."},{"key":"10.1016\/j.mtbio.2025.101560_bib35","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biomaterials.2015.08.045","article-title":"Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels","volume":"73","author":"Yue","year":"2015","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.mtbio.2025.101560_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202106564","article-title":"Self-healing hydrogel embodied with macrophage-regulation and responsive-gene-silencing properties for synergistic prevention of peritendinous adhesion","volume":"34","author":"Cai","year":"2022","journal-title":"Adv Mater"},{"issue":"10","key":"10.1016\/j.mtbio.2025.101560_bib37","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1002\/adfm.201101662","article-title":"Functional human vascular network generated in photocrosslinkable gelatin methacrylate hydrogels","volume":"22","author":"Chen","year":"2012","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2025.101560_bib38","article-title":"Human urine-derived stem cell exosomes delivered via injectable GelMA templated hydrogel accelerate bone regeneration","volume":"19","author":"Lu","year":"2023","journal-title":"Mater Today Bio"},{"issue":"24","key":"10.1016\/j.mtbio.2025.101560_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001410","article-title":"Hybrid printing using cellulose nanocrystals reinforced GelMA\/HAMA hydrogels for improved structural integration","volume":"9","author":"Fan","year":"2020","journal-title":"Adv. Healthcare Mater."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101560_bib40","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1021\/bc100479t","article-title":"Synthesis of PAMAM dendrimer derivatives with enhanced buffering capacity and remarkable gene transfection efficiency","volume":"22","author":"Yu","year":"2011","journal-title":"Bioconjug. Chem."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101560_bib41","doi-asserted-by":"crossref","first-page":"V","DOI":"10.3415\/VCOT-14-10-0162","article-title":"Healing large bone defects","volume":"27","author":"Johnson","year":"2014","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"10.1016\/j.mtbio.2025.101560_bib42","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.biomaterials.2018.07.017","article-title":"Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives","volume":"180","author":"Ho-Shui-Ling","year":"2018","journal-title":"Biomaterials"},{"issue":"1\u20132","key":"10.1016\/j.mtbio.2025.101560_bib43","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ijpharm.2018.05.045","article-title":"Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA\/siRNA for cancer therapy","volume":"546","author":"Li","year":"2018","journal-title":"Int J Pharm"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425001188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425001188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:25:17Z","timestamp":1762633517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425001188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":43,"alternative-id":["S2590006425001188"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101560","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treating critical bone defects by using core-shell biological scaffold to regulate Fibrosis\u2013Osteogenic homeostasis","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101560","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101560"}}