{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:09:48Z","timestamp":1792184988904,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515220214"],"award-info":[{"award-number":["2023A1515220214"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303806"],"award-info":[{"award-number":["82303806"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024AFB268"],"award-info":[{"award-number":["2024AFB268"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.mtbio.2025.101682","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T12:56:08Z","timestamp":1742302568000},"page":"101682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Novel intravenous formulation for radiosensitization in osteosarcoma treatment"],"prefix":"10.1016","volume":"32","author":[{"given":"Haitao","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixiong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anfei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1356-4369","authenticated-orcid":false,"given":"Yanyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7532-6713","authenticated-orcid":false,"given":"Ming","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 7","key":"10.1016\/j.mtbio.2025.101682_bib1","doi-asserted-by":"crossref","first-page":"vii320","DOI":"10.1093\/annonc\/mdq276","article-title":"Osteosarcoma","volume":"21","author":"Ritter","year":"2010","journal-title":"Ann. Oncol."},{"issue":"Suppl 4","key":"10.1016\/j.mtbio.2025.101682_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/annonc\/mdp154","article-title":"Osteosarcoma: ESMO clinical recommendations for diagnosis, treatment and follow-up","volume":"20","author":"Bielack","year":"2009","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.mtbio.2025.101682_bib3","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1002\/cncr.27651","article-title":"Long-term results (>25 years) of a randomized, prospective clinical trial evaluating chemotherapy in patients with high-grade, operable osteosarcoma","volume":"118","author":"Bernthal","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.mtbio.2025.101682_bib4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejca.2018.11.027","article-title":"Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort","volume":"109","author":"Smeland","year":"2019","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.mtbio.2025.101682_bib5","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMra2103423","article-title":"New horizons in the treatment of osteosarcoma","volume":"385","author":"Meltzer","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2025.101682_bib6","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1200\/JCO.2014.59.4895","article-title":"Osteosarcoma: current treatment and a collaborative pathway to success","volume":"33","author":"Isakoff","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.mtbio.2025.101682_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0140-6736(92)90219-S","article-title":"Clinical practice of radiotherapy","volume":"339","author":"Tobias","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.mtbio.2025.101682_bib8","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/cac2.12576","article-title":"Beyond success: unveiling the hidden potential of radiotherapy and immunotherapy in solid tumors","volume":"44","author":"Wu","year":"2024","journal-title":"Cancer Commun."},{"key":"10.1016\/j.mtbio.2025.101682_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/cells10020366","article-title":"Radiotherapy in the management of pediatric and adult osteosarcomas: a multi-institutional cohort analysis","volume":"10","author":"Spalek","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.mtbio.2025.101682_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tips.2017.11.003","article-title":"Cancer radiosensitizers","volume":"39","author":"Wang","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.mtbio.2025.101682_bib11","article-title":"Enhancing X-ray sensitization with multifunctional nanoparticles","volume":"20","author":"Liu","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2025.101682_bib12","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1039\/D3MH00265A","article-title":"Prospects of nanoparticle-based radioenhancement for radiotherapy","volume":"10","author":"Gerken","year":"2023","journal-title":"Mater. Horiz."},{"key":"10.1016\/j.mtbio.2025.101682_bib13","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.7150\/thno.22172","article-title":"Metal-based NanoEnhancers for future radiotherapy: radiosensitizing and synergistic effects on tumor cells","volume":"8","author":"Liu","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2025.101682_bib14","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/S1470-2045(19)30326-2","article-title":"NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act.In.Sarc): a multicentre, phase 2-3, randomised, controlled trial","volume":"20","author":"Bonvalot","year":"2019","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.mtbio.2025.101682_bib15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejca.2021.01.007","article-title":"Phase I dose-escalation study of NBTXR3 activated by intensity-modulated radiation therapy in elderly patients with locally advanced squamous cell carcinoma of the oral cavity or oropharynx","volume":"146","author":"Hoffmann","year":"2021","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.mtbio.2025.101682_bib16","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1158\/1078-0432.CCR-16-1297","article-title":"First-in-Human study testing a new radioenhancer using nanoparticles (NBTXR3) activated by radiation therapy in patients with locally advanced soft tissue sarcomas","volume":"23","author":"Bonvalot","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mtbio.2025.101682_bib17","doi-asserted-by":"crossref","first-page":"11473","DOI":"10.1039\/D1CC04628D","article-title":"A metal-polyphenolic nanosystem with NIR-II fluorescence-guided combined photothermal therapy and radiotherapy","volume":"57","author":"Li","year":"2021","journal-title":"Chem. Commun."},{"key":"10.1016\/j.mtbio.2025.101682_bib18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1021\/acs.nanolett.3c04031","article-title":"Au nanorods activated the Zn\/Ce composites with cancer cell specific cytotoxicity for enhanced chemodynamic therapy","volume":"24","author":"Feng","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.mtbio.2025.101682_bib19","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nrc3958","article-title":"The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence","volume":"15","author":"Barker","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mtbio.2025.101682_bib20","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.jconrel.2022.10.007","article-title":"Advancements of Prussian blue-based nanoplatforms in biomedical fields: progress and perspectives","volume":"351","author":"Wang","year":"2022","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2025.101682_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800347","article-title":"Progress in applications of prussian blue nanoparticles in biomedicine","volume":"7","author":"Qin","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2025.101682_bib22","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41392-024-01859-4","article-title":"Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer","volume":"9","author":"Yang","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2025.101682_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2021.104298","article-title":"Radiotherapy and cGAS\/STING signaling: impact on MDSCs in the tumor microenvironment","volume":"362","author":"Kho","year":"2021","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.mtbio.2025.101682_bib24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41568-020-0246-1","article-title":"Inflammatory microenvironment remodelling by tumour cells after radiotherapy","volume":"20","author":"McLaughlin","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mtbio.2025.101682_bib25","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1021\/acsnano.2c10352","article-title":"Biomineralized MnO(2) nanoplatforms mediated delivery of immune checkpoint inhibitors with STING pathway activation to potentiate cancer radio-immunotherapy","volume":"17","author":"Deng","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.101682_bib26","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1039\/D1TB00383F","article-title":"Tannic acid-based metal phenolic networks for bio-applications: a review","volume":"9","author":"Guo","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2025.101682_bib27","article-title":"Mn-phenolic networks as synergistic carrier for STING agonists in tumor immunotherapy","volume":"26","author":"Meng","year":"2024","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.mtbio.2025.101682_bib28","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1021\/acsnano.8b01456","article-title":"Metal ion\/tannic acid assembly as a versatile photothermal platform in engineering multimodal nanotheranostics for advanced applications","volume":"12","author":"Liu","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.101682_bib29","article-title":"Combination of metal-phenolic network-based immunoactive nanoparticles and bipolar irreversible electroporation for effective cancer immunotherapy","volume":"18","author":"Han","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2025.101682_bib30","first-page":"428","article-title":"Photothermal therapy with regulated Nrf2\/NF-kappaB signaling pathway for treating bacteria-induced periodontitis","volume":"9","author":"Tian","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101682_bib31","doi-asserted-by":"crossref","first-page":"9844","DOI":"10.1016\/j.biomaterials.2014.09.004","article-title":"PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy","volume":"35","author":"Cheng","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101682_bib32","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12951-021-00819-2","article-title":"Self-synergistic effect of Prussian blue nanoparticles for cancer therapy: driving photothermal therapy and reducing hyperthermia-induced side effects","volume":"19","author":"Xie","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2025.101682_bib33","article-title":"Copper-enriched prussian blue nanomedicine for in situ disulfiram toxification and photothermal antitumor amplification","volume":"32","author":"Wu","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.101682_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202402039","article-title":"Selenium-doped nanoheterojunctions for highly efficient cancer radiosensitization","volume":"11","author":"Qiao","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mtbio.2025.101682_bib35","doi-asserted-by":"crossref","first-page":"6061","DOI":"10.7150\/thno.42114","article-title":"Gadolinium-doped Au@prussian blue nanoparticles as MR\/SERS bimodal agents for dendritic cell activating and tracking","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2025.101682_bib36","article-title":"Supramolecular protein nanodrugs with coordination- and heating-enhanced photothermal effects for antitumor therapy","volume":"15","author":"Sun","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2025.101682_bib37","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1039\/C8CS00641E","article-title":"Transition metal compounds as cancer radiosensitizers","volume":"48","author":"Gill","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.mtbio.2025.101682_bib38","doi-asserted-by":"crossref","first-page":"33903","DOI":"10.1021\/acsami.3c06838","article-title":"Bi(2-x)Mn(x)O(3) nanospheres engaged radiotherapy with amplifying DNA damage","volume":"15","author":"Chen","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101682_bib39","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.freeradbiomed.2016.07.026","article-title":"Manganese ions enhance mitochondrial H(2)O(2) emission from Krebs cycle oxidoreductases by inducing permeability transition","volume":"99","author":"Bonke","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mtbio.2025.101682_bib40","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41392-022-01224-3","article-title":"GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer","volume":"8","author":"Long","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2025.101682_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202308009","article-title":"RECQL4 inhibits radiation-induced tumor immune awakening via suppressing the cGAS-STING pathway in hepatocellular carcinoma","volume":"11","author":"Hong","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mtbio.2025.101682_bib42","doi-asserted-by":"crossref","DOI":"10.1172\/JCI149310","article-title":"Atrx deletion impairs CGAS\/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus","volume":"133","author":"Floyd","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mtbio.2025.101682_bib43","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s13046-019-1241-9","article-title":"Minichromosome maintenance 3 promotes hepatocellular carcinoma radioresistance by activating the NF-kappaB pathway","volume":"38","author":"Yang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mtbio.2025.101682_bib44","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13046-024-03007-w","article-title":"CDKL1 potentiates the antitumor efficacy of radioimmunotherapy by binding to transcription factor YBX1 and blocking PD-L1 expression in lung cancer","volume":"43","author":"Li","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mtbio.2025.101682_bib45","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nprot.2008.222","article-title":"Protocol for the quantitative assessment of DNA concentration and damage (fragmentation and nicks)","volume":"4","author":"Georgiou","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mtbio.2025.101682_bib46","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.actbio.2022.11.019","article-title":"Integrated manganese (III)-doped nanosystem for optimizing photothermal ablation: amplifying hyperthermia-induced STING pathway and enhancing antitumor immunity","volume":"155","author":"Xia","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101682_bib47","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41422-020-00395-4","article-title":"Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy","volume":"30","author":"Lv","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.mtbio.2025.101682_bib48","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/s41565-021-00962-9","article-title":"Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy","volume":"16","author":"Sun","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.mtbio.2025.101682_bib49","article-title":"Metal-phenolic nanocloaks on cancer cells potentiate STING pathway activation for synergistic cancer immunotherapy","volume":"63","author":"He","year":"2024","journal-title":"Angew Chem. Int. Ed. Engl."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425002418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425002418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:32:26Z","timestamp":1762633946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425002418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":49,"alternative-id":["S2590006425002418"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101682","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel intravenous formulation for radiosensitization in osteosarcoma treatment","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101682","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101682"}}