{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:14:07Z","timestamp":1792721647796,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"publisher","award":["OCENW.SMALL.352"],"award-info":[{"award-number":["OCENW.SMALL.352"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["857253"],"award-info":[{"award-number":["857253"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.mtbio.2025.101728","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T21:25:25Z","timestamp":1743801925000},"page":"101728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Sex-stratified osteochondral organ-on-chip model reveals sex-specific responses to inflammatory stimulation"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-2470","authenticated-orcid":false,"given":"Francisco","family":"Concei\u00e7\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6685-6969","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Meneses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipa","family":"Lebre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5294-9715","authenticated-orcid":false,"given":"Malin","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1459-7592","authenticated-orcid":false,"given":"Nuno","family":"Ara\u00fajo-Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne","family":"Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1349-9595","authenticated-orcid":false,"given":"Ana R.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1132-7992","authenticated-orcid":false,"given":"Ernesto","family":"Alfaro-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8063-207X","authenticated-orcid":false,"given":"Jeroen","family":"Leijten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5039-8369","authenticated-orcid":false,"given":"Liliana","family":"Moreira Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2025.101728_bib1","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/art.42089","article-title":"Prevalence trends of site-specific osteoarthritis from 1990 to 2019: findings from the global burden of disease study 2019","volume":"74","author":"Long","year":"2022","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.mtbio.2025.101728_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41392-023-01330-w","article-title":"Osteoarthritis: pathogenic signaling pathways and therapeutic targets","volume":"8","author":"Yao","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2025.101728_bib3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/annrheumdis-2020-218089","article-title":"Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis","volume":"80","author":"Hu","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.mtbio.2025.101728_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s13075-021-02663-z","article-title":"Expansion of myeloid-derived suppressor cells contributes to metabolic osteoarthritis through subchondral bone remodeling","volume":"23","author":"Zhang","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.mtbio.2025.101728_bib5","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/art.23159","article-title":"Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone","volume":"58","author":"Sanchez","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.mtbio.2025.101728_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194591","article-title":"Comparison of secretome from osteoblasts derived from sclerotic versus non-sclerotic subchondral bone in OA: a pilot study","volume":"13","author":"Sanchez","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.mtbio.2025.101728_bib7","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/9467","article-title":"VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation","volume":"5","author":"Gerber","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.mtbio.2025.101728_bib8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2174\/157339708785133523","article-title":"Animal models of osteoarthritis","volume":"4","author":"Christopher","year":"2008","journal-title":"Curr. Rheumatol. Rev."},{"key":"10.1016\/j.mtbio.2025.101728_bib9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.joca.2018.09.016","article-title":"Models of osteoarthritis: the good, the bad and the promising","volume":"27","author":"Cope","year":"2019","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.mtbio.2025.101728_bib10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s43586-022-00118-6","article-title":"A guide to the organ-on-a-chip","volume":"2","author":"Leung","year":"2022","journal-title":"Nature Reviews Methods Primers"},{"key":"10.1016\/j.mtbio.2025.101728_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/frlct.2024.1376964","article-title":"Guiding organs-on-chips towards applications: a balancing act between integration of advanced technologies and standardization","volume":"3","author":"Meneses","year":"2024","journal-title":"Frontiers in Lab on a Chip Technologies"},{"key":"10.1016\/j.mtbio.2025.101728_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202203172","article-title":"Recent advances in organ-on-chips integrated with bioprinting technologies for drug screening","volume":"12","author":"Tabatabaei Rezaei","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2025.101728_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202300560","article-title":"Integrated electrochemical and optical biosensing in organs-on-chip","volume":"25","author":"Tawade","year":"2024","journal-title":"Chembiochem"},{"key":"10.1016\/j.mtbio.2025.101728_bib14","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.joca.2022.03.012","article-title":"Advances in organ-on-a-chip systems for modelling joint tissue and osteoarthritic diseases","volume":"30","author":"Banh","year":"2022","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.mtbio.2025.101728_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41584-021-00736-6","article-title":"Joint-on-chip platforms: entering a new era of in vitro models for arthritis","volume":"18","author":"Paggi","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.mtbio.2025.101728_bib16","doi-asserted-by":"crossref","unstructured":"Salehi, S., Brambilla, S., Rasponi, M., Lopa, S. & Moretti, M. Development of a Microfluidic Vascularized Osteochondral Model as a Drug Testing Platform for Osteoarthritis. Advanced Healthcare Materials n\/a 2402350 https:\/\/doi.org\/https:\/\/doi.org\/10.1002\/adhm.202402350.","DOI":"10.1002\/adhm.202402350"},{"key":"10.1016\/j.mtbio.2025.101728_bib17","doi-asserted-by":"crossref","DOI":"10.1039\/D4LC00651H","article-title":"A vascularized microfluidic model of the osteochondral unit for modeling inflammatory response and therapeutic screening","author":"Roehm","year":"2025","journal-title":"Lab Chip"},{"key":"10.1016\/j.mtbio.2025.101728_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115510","article-title":"Bioluminescence imaging on-chip platforms for non-invasive high-content bioimaging","volume":"237","author":"Ara\u00fajo-Gomes","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.mtbio.2025.101728_bib19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.22203\/eCM.v019a24","article-title":"Heterotopic bone formation by nano-apatite containing poly(D,L-lactide) composites","volume":"19","author":"Barbieri","year":"2010","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.mtbio.2025.101728_bib20","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/s41563-019-0307-6","article-title":"Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels","volume":"18","author":"Loebel","year":"2019","journal-title":"Nat. Mater."},{"key":"10.1016\/j.mtbio.2025.101728_bib21","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1093\/bioinformatics\/btt276","article-title":"TANGO: a generic tool for high-throughput 3D image analysis for studying nuclear organization","volume":"29","author":"Ollion","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mtbio.2025.101728_bib22","doi-asserted-by":"crossref","first-page":"7876","DOI":"10.3390\/ijms22157876","article-title":"Males and females have distinct molecular events in the articular cartilage during knee osteoarthritis","volume":"22","author":"Li","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.101728_bib23","doi-asserted-by":"crossref","first-page":"194","DOI":"10.21037\/atm-22-4284","article-title":"Identification of CaMK4 as a sex-difference-related gene in knee osteoarthritis","volume":"11","author":"Feng","year":"2023","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.mtbio.2025.101728_bib24","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1365-2842.2012.02332.x","article-title":"Differential expression of IGF1, IGFR1 and IGFBP3 in mandibular condylar cartilage between male and female rats applied with malocclusion","volume":"39","author":"Yu","year":"2012","journal-title":"J. Oral Rehabil."},{"key":"10.1016\/j.mtbio.2025.101728_bib25","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1111\/odi.12905","article-title":"Sexual dimorphism of estrogen-sensitized synoviocytes contributes to gender difference in temporomandibular joint osteoarthritis","volume":"24","author":"Xue","year":"2018","journal-title":"Oral Dis."},{"key":"10.1016\/j.mtbio.2025.101728_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jneuroim.2018.05.009","article-title":"Differences in neuroimmune signalling between male and female patients suffering from knee osteoarthritis","volume":"321","author":"Kosek","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.mtbio.2025.101728_bib27","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1021\/mp500136b","article-title":"Stem cell-based microphysiological osteochondral system to model tissue response to interleukin-1\u03b2","volume":"11","author":"Lin","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.mtbio.2025.101728_bib28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.mtbio.2025.101728_bib29","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.joca.2019.12.005","article-title":"The molecular profile of synovial fluid changes upon joint distraction and is associated with clinical response in knee osteoarthritis","volume":"28","author":"Watt","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.mtbio.2025.101728_bib30","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0014-5793(99)00886-8","article-title":"Flow cytometric analysis of intracellular chemokines in chondrocytes in vivo: constitutive expression and enhancement in osteoarthritis and rheumatoid arthritis","volume":"455","author":"Borz\u0131","year":"1999","journal-title":"FEBS (Fed. Eur. Biochem. Soc.) Lett."},{"key":"10.1016\/j.mtbio.2025.101728_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201909802","article-title":"Metabolic labeling to probe the spatiotemporal accumulation of matrix at the chondrocyte-hydrogel interface","volume":"30","author":"Loebel","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2025.101728_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/284873","article-title":"The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis","author":"Maldonado","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.mtbio.2025.101728_bib33","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3390\/ijms22020569","article-title":"Cartilage targets of knee osteoarthritis shared by both genders","volume":"22","author":"Li","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.101728_bib34","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.mtbio.2025.101728_bib35","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/rheumatology\/keab378","article-title":"Towards sex-specific osteoarthritis risk models: evaluation of risk factors for knee osteoarthritis in males and females","volume":"61","author":"Szilagyi","year":"2021","journal-title":"Rheumatology"},{"key":"10.1016\/j.mtbio.2025.101728_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/S2665-9913(23)00163-7","article-title":"Global, regional, and national burden of osteoarthritis, 1990\u20132020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021","volume":"5","author":"Steinmetz","year":"2023","journal-title":"The Lancet Rheumatology"},{"key":"10.1016\/j.mtbio.2025.101728_bib37","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1016\/j.cell.2021.07.038","article-title":"Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations","volume":"184","author":"Boer","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2025.101728_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.881500","article-title":"Innate immunity at the core of sex differences in osteoarthritic pain?","volume":"13","author":"Valdrighi","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mtbio.2025.101728_bib39","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/adhm.201200333","article-title":"Gradient-regulated hydrogel for interface tissue engineering: steering simultaneous osteo\/chondrogenesis of stem cells on a chip","volume":"2","author":"Shi","year":"2013","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2025.101728_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2019.00411","article-title":"Osteochondral tissue chip derived from iPSCs: modeling OA pathologies and testing drugs","volume":"7","author":"Lin","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2025.101728_bib41","doi-asserted-by":"crossref","first-page":"13027","DOI":"10.1074\/jbc.RA118.006865","article-title":"Translational regulation contributes to the secretory response of chondrocytic cells following exposure to interleukin-1\u03b2","volume":"294","author":"McDermott","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mtbio.2025.101728_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-01063-2","article-title":"Basal and IL-1\u03b2 enhanced chondrocyte chemotactic activity on monocytes are co-dependent on both IKK\u03b1 and IKK\u03b2 NF-\u03baB activating kinases","volume":"11","author":"Olivotto","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2025.101728_bib43","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s13018-024-04628-9","article-title":"MiR-98-5p plays suppressive effects on IL-1\u03b2-induced chondrocyte injury associated with osteoarthritis by targeting CASP3","volume":"19","author":"Lv","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.mtbio.2025.101728_bib44","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/art.27311","article-title":"Sex differences of chondrogenic progenitor cells in late stages of osteoarthritis","volume":"62","author":"Koelling","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.mtbio.2025.101728_bib45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13293-016-0080-z","article-title":"Characterization of osteoarthritic human knees indicates potential sex differences","volume":"7","author":"Pan","year":"2016","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.mtbio.2025.101728_bib46","doi-asserted-by":"crossref","first-page":"499","DOI":"10.4049\/jimmunol.144.2.499","article-title":"IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro","volume":"144","author":"Guerne","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.mtbio.2025.101728_bib47","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/jcb.1104","article-title":"Increased mRNA expression and protein secretion of interleukin-6 in primary human osteoblasts differentiated in vitro from rheumatoid and osteoarthritic bone","volume":"81","author":"Chenoufi","year":"2001","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mtbio.2025.101728_bib48","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0014-5793(90)81404-C","article-title":"Interleukin-1\u03b2 induces synthesis and secretion of interleukin-6 in human chondrocytes","volume":"263","author":"Bender","year":"1990","journal-title":"FEBS (Fed. Eur. Biochem. Soc.) Lett."},{"key":"10.1016\/j.mtbio.2025.101728_bib49","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrrheum.2010.198","article-title":"The role of the cartilage matrix in osteoarthritis","volume":"7","author":"Heineg\u00e5rd","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.mtbio.2025.101728_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/srep38852","article-title":"High fidelity visualization of cell-to-cell variation and temporal dynamics in nascent extracellular matrix formation","volume":"6","author":"McLeod","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2025.101728_bib51","doi-asserted-by":"crossref","DOI":"10.1177\/19476035221121792","article-title":"Sexual dimorphism in the extracellular and pericellular matrix of articular cartilage","volume":"13","author":"Hernandez","year":"2022","journal-title":"CARTILAGE"},{"key":"10.1016\/j.mtbio.2025.101728_bib52","doi-asserted-by":"crossref","unstructured":"Veenendaal, L. et al. Donor ethnicity, sex, and age impact chondrogenic re-differentiation capacity: a multi-demographic study of human articular chondrocytes in vitro. J. Roy. Soc. N. Z. 1-21 https:\/\/doi.org\/10.1080\/03036758.2024.2340481.","DOI":"10.1080\/03036758.2024.2340481"},{"key":"10.1016\/j.mtbio.2025.101728_bib53","article-title":"Engineered human meniscus in modeling sex differences of knee osteoarthritis in vitro","volume":"10","author":"Ma","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2025.101728_bib54","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s10544-023-00660-4","article-title":"Development of a novel microfluidic perfusion 3D cell culture system for improved neuronal cell differentiation","volume":"25","author":"Park","year":"2023","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.mtbio.2025.101728_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.mtbio.2023.100818","article-title":"Heart and kidney organoids maintain organ-specific function in a microfluidic system","volume":"23","author":"Gabbin","year":"2023","journal-title":"Materials Today Bio"},{"key":"10.1016\/j.mtbio.2025.101728_bib56","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jbiosc.2022.07.001","article-title":"Perfusion culture of multi-layered HepG2 hepatocellular carcinoma cells in a pressure-driven microphysiological system","volume":"134","author":"Sugiura","year":"2022","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.mtbio.2025.101728_bib57","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/1874312901206010024","article-title":"Histological examination of collagen and proteoglycan changes in osteoarthritic menisci","volume":"6","author":"Sun","year":"2012","journal-title":"Open Rheumatol. J."},{"key":"10.1016\/j.mtbio.2025.101728_bib58","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3390\/polym8080269","article-title":"3D culture of chondrocytes in gelatin hydrogels with different stiffness","volume":"8","author":"Li","year":"2016","journal-title":"Polymers"},{"key":"10.1016\/j.mtbio.2025.101728_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.00373","article-title":"Stiffness matters: fine-tuned hydrogel elasticity alters chondrogenic redifferentiation","volume":"8","author":"Bachmann","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2025.101728_bib60","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.actbio.2022.08.058","article-title":"Biomaterial composition and stiffness as decisive properties of 3D bioprinted constructs for type II collagen stimulation","volume":"152","author":"Martyniak","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101728_bib61","doi-asserted-by":"crossref","first-page":"6286","DOI":"10.1074\/jbc.M307765200","article-title":"Cleavage of fibromodulin in cartilage explants involves removal of the N-terminal tyrosine sulfate-rich region by proteolysis at a site that is sensitive to matrix metalloproteinase-13","volume":"279","author":"Heathfield","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mtbio.2025.101728_bib62","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0014-4827(03)00180-0","article-title":"Induction of matrix metalloproteinase-13 gene expression by TNF-\u03b1 is mediated by MAP kinases, AP-1, and NF-\u03baB transcription factors in articular chondrocytes","volume":"288","author":"Liacini","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mtbio.2025.101728_bib63","doi-asserted-by":"crossref","first-page":"e225","DOI":"10.1016\/S2665-9913(23)00060-7","article-title":"The influence of sex hormones on musculoskeletal pain and osteoarthritis","volume":"5","author":"Gulati","year":"2023","journal-title":"The Lancet Rheumatology"},{"key":"10.1016\/j.mtbio.2025.101728_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.615250","article-title":"17\u03b2-Estradiol induces mitophagy upregulation to protect chondrocytes via the SIRT1-mediated AMPK\/mTOR signaling pathway","volume":"11","author":"Mei","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mtbio.2025.101728_bib65","doi-asserted-by":"crossref","first-page":"339","DOI":"10.21037\/atm-23-1546","article-title":"Closing the gap: sex-related differences in osteoarthritis and the ongoing need for translational studies","volume":"11","author":"Colbath","year":"2023","journal-title":"Ann. Transl. Med."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259000642500287X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259000642500287X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:34:33Z","timestamp":1762634073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S259000642500287X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":65,"alternative-id":["S259000642500287X"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101728","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-stratified osteochondral organ-on-chip model reveals sex-specific responses to inflammatory stimulation","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101728","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101728"}}