{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:32:29Z","timestamp":1793424749776,"version":"4.5.0"},"reference-count":216,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["ED431G 2019\/02"],"award-info":[{"award-number":["ED431G 2019\/02"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019179","name":"Fundaci\u00f3n Bancaria Caixa d&apos;Estalvis i Pensions de Barcelona","doi-asserted-by":"publisher","award":["100010434"],"award-info":[{"award-number":["100010434"]}],"id":[{"id":"10.13039\/501100019179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018942","name":"Centro Singular de Investigaci\u00f3n de Galicia","doi-asserted-by":"publisher","award":["2019-2022"],"award-info":[{"award-number":["2019-2022"]}],"id":[{"id":"10.13039\/501100018942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018942","name":"Centro Singular de Investigaci\u00f3n de Galicia","doi-asserted-by":"publisher","award":["2023-2027"],"award-info":[{"award-number":["2023-2027"]}],"id":[{"id":"10.13039\/501100018942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","award":["NCT02464436"],"award-info":[{"award-number":["NCT02464436"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008425","name":"Government of Galicia Department of Education Science Universities and Professional Training","doi-asserted-by":"publisher","award":["ED431C 2021\/17"],"award-info":[{"award-number":["ED431C 2021\/17"]}],"id":[{"id":"10.13039\/501100008425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.mtbio.2025.101767","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T02:47:36Z","timestamp":1744426056000},"page":"101767","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Intraocular injectable hydrogels for the delivery of cells and nanoparticles"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1174-2431","authenticated-orcid":false,"given":"Elena","family":"Ibeas Moreno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-4086","authenticated-orcid":false,"given":"Anna","family":"Abbadessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.mtbio.2025.101767_bib1","doi-asserted-by":"crossref","first-page":"e489","DOI":"10.1016\/S2214-109X(20)30488-5","article-title":"The lancet global Health commission on global eye Health: vision beyond 2020","volume":"9","author":"Burton","year":"2021","journal-title":"Lancet Global Health"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib2","doi-asserted-by":"crossref","DOI":"10.1186\/s13561-024-00546-y","article-title":"Assessing the economic burden of vision loss and irreversible legal blindness in Spain (2021\u20132030): a societal perspective","volume":"14","author":"Pablo","year":"2024","journal-title":"Health Econ. Rev."},{"issue":"14","key":"10.1016\/j.mtbio.2025.101767_bib3","article-title":"World report on vision","volume":"214","year":"2019"},{"key":"10.1016\/j.mtbio.2025.101767_bib4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2147\/CIA.S101835","article-title":"Eye surgery in the elderly","volume":"11","author":"Raczy\u0144ska","year":"2016","journal-title":"Clin. Interv. Aging"},{"issue":"December","key":"10.1016\/j.mtbio.2025.101767_bib5","first-page":"1","article-title":"Biotechnology and biomaterial-based therapeutic strategies for age-related macular degeneration. Part II: cell and tissue engineering therapies","volume":"8","author":"Jemni-Damer","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"7","key":"10.1016\/j.mtbio.2025.101767_bib6","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1167\/iovs.12-11239","article-title":"Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer","volume":"54","author":"Diniz","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101767_bib7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000338749","article-title":"A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer","volume":"48","author":"Hu","year":"2012","journal-title":"Ophthalmic Res."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells10030687","article-title":"Cell\u2013matrix interactions in the eye: from cornea to choroid","volume":"10","author":"Pouw","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib9","doi-asserted-by":"crossref","first-page":"E81","DOI":"10.1073\/pnas.1512590113","article-title":"Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration","volume":"113","author":"Shirai","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib10","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.stemcr.2018.01.032","article-title":"Establishment of immunodeficient retinal degeneration model mice and functional maturation of human ESC-derived retinal sheets after transplantation","volume":"10","author":"Iraha","year":"2018","journal-title":"Stem Cell Rep."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.stemcr.2016.12.008","article-title":"iPSC-derived retina transplants improve vision in rd1 end-stage retinal-degeneration mice","volume":"8","author":"Mandai","year":"2017","journal-title":"Stem Cell Rep."},{"issue":"36","key":"10.1016\/j.mtbio.2025.101767_bib12","first-page":"1","article-title":"Sustained release of nitric oxide and cascade generation of reactive nitrogen\/oxygen species via an injectable hydrogel for tumor synergistic therapy","volume":"32","author":"Wang","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"April","key":"10.1016\/j.mtbio.2025.101767_bib13","article-title":"An injectable and active hydrogel induces mutually enhanced mild magnetic hyperthermia and ferroptosis","volume":"298","author":"Chen","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101767_bib14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.actbio.2021.04.009","article-title":"PEG-based thermosensitive and biodegradable hydrogels","volume":"128","author":"Shi","year":"2021","journal-title":"Acta Biomater."},{"issue":"May","key":"10.1016\/j.mtbio.2025.101767_bib15","first-page":"336","article-title":"Autophagy inhibition mediated via an injectable and NO-releasing hydrogel for amplifying the antitumor efficacy of mild magnetic hyperthermia","volume":"39","author":"Wang","year":"2024","journal-title":"Bioact. Mater."},{"issue":"21","key":"10.1016\/j.mtbio.2025.101767_bib16","first-page":"1","article-title":"Versatile hypoxic extracellular vesicles laden in an injectable and bioactive hydrogel for accelerated bone regeneration","volume":"33","author":"Deng","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"31","key":"10.1016\/j.mtbio.2025.101767_bib17","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.1039\/C7TB01556A","article-title":"Sustained subconjunctival delivery of cyclosporine A using thermogelling polymers for glaucoma filtration surgery","volume":"5","author":"Sun","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2025.101767_bib18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.actbio.2015.05.005","article-title":"Sustained intravitreal delivery of dexamethasone using an injectable and biodegradable thermogel","volume":"23","author":"Zhang","year":"2015","journal-title":"Acta Biomater."},{"issue":"9","key":"10.1016\/j.mtbio.2025.101767_bib19","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1021\/acs.molpharmaceut.5b00828","article-title":"Composite nanoformulation therapeutics for long-term ocular delivery of macromolecules","volume":"13","author":"Agrahari","year":"2016","journal-title":"Mol. Pharm."},{"issue":"7","key":"10.1016\/j.mtbio.2025.101767_bib20","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1080\/02713683.2022.2053166","article-title":"Simultaneous release of aflibercept and dexamethasone from an ocular drug delivery system","volume":"47","author":"Rudeen","year":"2022","journal-title":"Curr. Eye Res."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101767_bib22","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.stemcr.2015.04.008","article-title":"A hyaluronan-based injectable hydrogel improves the survival and integration of stem cell progeny following transplantation","volume":"4","author":"Ballios","year":"2015","journal-title":"Stem Cell Rep."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.actbio.2013.09.029","article-title":"Thiolated hyaluronan-based hydrogels crosslinked using oxidized glutathione: an injectable matrix designed for ophthalmic applications","volume":"10","author":"Zarembinski","year":"2014","journal-title":"Acta Biomater."},{"issue":"July 2018","key":"10.1016\/j.mtbio.2025.101767_bib25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biomaterials.2018.12.015","article-title":"Mussel-inspired injectable hydrogel and its counterpart for actuating proliferation and neuronal differentiation of retinal progenitor cells","volume":"194","author":"Tang","year":"2019","journal-title":"Biomaterials"},{"issue":"1\u20132","key":"10.1016\/j.mtbio.2025.101767_bib26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1089\/ten.tea.2012.0209","article-title":"The application of hyaluronic acid hydrogels to retinal progenitor cell transplantation","volume":"19","author":"Liu","year":"2013","journal-title":"Tissue Eng."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12553-019-00380-x","article-title":"Nanocomposites: a brief review","volume":"10","author":"Omanovi\u0107-Mikli\u010danin","year":"2020","journal-title":"Health Technol."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/btm2.10315","article-title":"Nanocomposite hydrogels for biomedical applications","volume":"7","author":"Huang","year":"2022","journal-title":"Bioeng. Transl. Med."},{"issue":"8","key":"10.1016\/j.mtbio.2025.101767_bib29","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/s41433-020-0809-0","article-title":"Advances in ocular drug delivery systems","volume":"34","author":"Kang-Mieler","year":"2020","journal-title":"Eye"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib30","article-title":"Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy","volume":"21","author":"Wei","year":"2023","journal-title":"BioMed Central"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-024-01852-x","article-title":"Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions","volume":"9","author":"Lu","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"September","key":"10.1016\/j.mtbio.2025.101767_bib32","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jconrel.2017.10.031","article-title":"Injectable hydrogels for ophthalmic applications","volume":"268","author":"Wang","year":"2017","journal-title":"J. Contr. Release"},{"issue":"9","key":"10.1016\/j.mtbio.2025.101767_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9091203","article-title":"Recent advances in hydrogels: ophthalmic applications in cell delivery, vitreous substitutes, and ocular adhesives","volume":"9","author":"Lin","year":"2021","journal-title":"Biomedicines"},{"issue":"P1","key":"10.1016\/j.mtbio.2025.101767_bib34","article-title":"Injectable hydrogels based on biopolymers for the treatment of ocular diseases","volume":"269","author":"Yu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.mtbio.2025.101767_bib23","first-page":"990","article-title":"GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision","volume":"1","author":"Wang","year":"2020","journal-title":"Nat. Can."},{"key":"10.1016\/j.mtbio.2025.101767_bib35","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ejpb.2014.10.005","article-title":"Encapsulated cells for long-term secretion of soluble VEGF receptor 1: material optimization and simulation of ocular drug response","volume":"95","author":"Kontturi","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"June 2022","key":"10.1016\/j.mtbio.2025.101767_bib36","article-title":"Both non-coated and polyelectrolytically-coated intraocular collagen-alginate composite gels enhanced photoreceptor survival in retinal degeneration","volume":"293","author":"Wong","year":"2023","journal-title":"Biomaterials"},{"issue":"May","key":"10.1016\/j.mtbio.2025.101767_bib37","article-title":"Hydrogels-based ophthalmic drug delivery systems for treatment of ocular diseases","volume":"127","author":"Fang","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"issue":"July","key":"10.1016\/j.mtbio.2025.101767_bib38","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jconrel.2020.07.031","article-title":"Intravitreal hydrogels for sustained release of therapeutic proteins","volume":"326","author":"Ilochonwu","year":"2020","journal-title":"J. Contr. Release"},{"issue":"May","key":"10.1016\/j.mtbio.2025.101767_bib39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jconrel.2019.05.034","article-title":"Hydrogel-based ocular drug delivery systems: emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations","volume":"306","author":"Cooper","year":"2019","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2025.101767_bib53","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.biocel.2015.02.007","article-title":"Inherited Retinal Dystrophies: the role of gene expression regulators","volume":"61","author":"Karali","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"5","key":"10.1016\/j.mtbio.2025.101767_bib40","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/wnan.1272","article-title":"Controlled ocular drug delivery with nanomicelles","volume":"6","author":"Vaishya","year":"2014","journal-title":"Wiley Interdiscip. Rev. Nanomedicine Nanobiotechnology"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib41","article-title":"Ocular autonomic nervous system: an update from anatomy to physiological functions","volume":"6","author":"Zh","year":"2022","journal-title":"Vis."},{"issue":"8","key":"10.1016\/j.mtbio.2025.101767_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics13081140","article-title":"Is the conjunctiva a potential target for advanced therapy medicinal products?","volume":"13","author":"Diebold","year":"2021","journal-title":"Pharmaceutics"},{"issue":"164","key":"10.1016\/j.mtbio.2025.101767_bib43","first-page":"1","article-title":"Ciliary body and ciliary epithelium nicholas","volume":"4","author":"Manuscript","year":"2011"},{"key":"10.1016\/j.mtbio.2025.101767_bib44","volume":"vol. 134","author":"Hejtmancik","year":"2015"},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib45","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/17469899.2021.1902308","article-title":"Current methods and new approaches to assess aqueous humor dynamics","volume":"16","author":"Toris","year":"2021","journal-title":"Expet Rev. Ophthalmol."},{"issue":"10","key":"10.1016\/j.mtbio.2025.101767_bib46","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/eye.2008.21","article-title":"Adult vitreous structure and postnatal changes","volume":"22","author":"Le Goff","year":"2008","journal-title":"Eye"},{"issue":"June 2019","key":"10.1016\/j.mtbio.2025.101767_bib47","article-title":"Scleral structure and biomechanics","volume":"74","author":"Boote","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib48","first-page":"1","article-title":"Sustained-release corticosteroid expands armamentarium for uveitis","volume":"23","author":"Avula","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.mtbio.2025.101767_bib49","series-title":"2015 IEEE 2nd Int. Conf. Recent Trends Inf. Syst. ReTIS 2015","first-page":"231","article-title":"Detection of macula and fovea for disease analysis in color fundus images","author":"Deka","year":"2015"},{"issue":"8","key":"10.1016\/j.mtbio.2025.101767_bib50","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrn3783","article-title":"Retinal bipolar cells: elementary building blocks of vision","volume":"15","author":"Euler","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"issue":"13","key":"10.1016\/j.mtbio.2025.101767_bib51","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1242\/dev.033175","article-title":"Retinal horizontal cells: challenging paradigms of neural development and cancer biology","volume":"136","author":"Poch\u00e9","year":"2009","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib52","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.clindermatol.2014.10.006","article-title":"Human ocular anatomy","volume":"33","author":"Kels","year":"2015","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.mtbio.2025.101767_bib54","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jconrel.2014.05.031","article-title":"Nanotherapy for posterior eye diseases","volume":"193","author":"Kaur","year":"2014","journal-title":"J. Contr. Release"},{"issue":"4","key":"10.1016\/j.mtbio.2025.101767_bib55","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1517\/17425247.4.4.371","article-title":"Novel approaches to retinal drug delivery","volume":"4","author":"Janoria","year":"2007","journal-title":"Expet Opin. Drug Deliv."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib56","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib57","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.57843","article-title":"Outcomes of glaucoma referrals in adults aged 18 to 40 years","volume":"8","author":"Frediani","year":"2025","journal-title":"JAMA Netw. Open"},{"issue":"18","key":"10.1016\/j.mtbio.2025.101767_bib58","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib59","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jcjo.2016.07.013","article-title":"Glaucoma treatment trends: a review","volume":"52","author":"Conlon","year":"2017","journal-title":"Can. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biomedicines11030657","article-title":"Novel therapies for the prevention of fibrosis in glaucoma filtration surgery","volume":"11","author":"Shao","year":"2023","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib61","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.addr.2009.11.026","article-title":"Chitosan-based nanostructures: a delivery platform for ocular therapeutics","volume":"62","author":"de la Fuente","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib62","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/cge.12203","article-title":"Genes and mutations causing retinitis pigmentosa","volume":"84","author":"Daiger","year":"2013","journal-title":"Clin. Genet."},{"issue":"7","key":"10.1016\/j.mtbio.2025.101767_bib63","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.18240\/ijo.2024.07.22","article-title":"Retinitis pigmentosa and stem cell therapy","volume":"17","author":"Qi","year":"2024","journal-title":"Int. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-017-0661-8","article-title":"Long-Term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients","volume":"8","author":"Liu","year":"2017","journal-title":"Stem Cell Res. Ther."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib65","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00441-021-03551-3","article-title":"Stem cell transplantation as a progressing treatment for retinitis pigmentosa","volume":"387","author":"Hosseini Shabanan","year":"2022","journal-title":"Cell Tissue Res."},{"issue":"7","key":"10.1016\/j.mtbio.2025.101767_bib66","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.optm.2008.01.026","article-title":"Review and update: current treatment trends for patients with retinitis pigmentosa","volume":"80","author":"Shintani","year":"2009","journal-title":"Optometry"},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib67","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/7\/2\/024101","article-title":"Injectable hydrogels for central nervous system therapy","volume":"7","author":"Pakulska","year":"2012","journal-title":"Biomed. Mater."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101767_bib68","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.survophthal.2012.01.004","article-title":"Prevalence of diabetic retinopathy in various ethnic groups: a worldwide perspective","volume":"57","author":"Sivaprasad","year":"2012","journal-title":"Surv. Ophthalmol."},{"issue":"5","key":"10.1016\/j.mtbio.2025.101767_bib69","doi-asserted-by":"crossref","first-page":"304","DOI":"10.2174\/157339910793360815","article-title":"Angiogenic growth factors and their inhibitors in diabetic retinopathy","volume":"6","author":"Praidou","year":"2010","journal-title":"Curr. Diabetes Rev."},{"issue":"14","key":"10.1016\/j.mtbio.2025.101767_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.93751","article-title":"Diabetic retinopathy: current understanding, mechanisms, and treatment strategies","volume":"2","author":"Duh","year":"2017","journal-title":"JCI Insight"},{"issue":"9","key":"10.1016\/j.mtbio.2025.101767_bib71","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0161-6420(03)00579-7","article-title":"The long-term effects of laser photocoagulation treatment in patients with diabetic retinopathy: the early treatment diabetic retinopathy follow-up study","volume":"110","author":"Chew","year":"2003","journal-title":"Ophthalmology"},{"issue":"7","key":"10.1016\/j.mtbio.2025.101767_bib72","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/jbm.a.34021","article-title":"Cell-adhesive thermogelling PNIPAAm\/hyaluronic acid cell delivery hydrogels for potential application as minimally invasive retinal therapeutics","volume":"100 A","author":"Mazumder","year":"2012","journal-title":"J. Biomed. Mater. Res., Part A"},{"issue":"7387","key":"10.1016\/j.mtbio.2025.101767_bib73","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/bmj.326.7387.485","article-title":"Age related macular degeneration","volume":"326","author":"Chopdar","year":"2003","journal-title":"Br. Med. J."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib74","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/bjophthalmol-2014-305149","article-title":"Efficacy and adverse events of aflibercept, ranibizumab and bevacizumab in age-related macular degeneration: a trade-off analysis","volume":"99","author":"Schmid","year":"2015","journal-title":"Br. J. Ophthalmol."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101767_bib21","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1039\/C8BM01579A","article-title":"Enhanced proliferation and differentiation of retinal progenitor cells through a self-healing injectable hydrogel","volume":"7","author":"Jiang","year":"2019","journal-title":"Biomater. Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib75","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1039\/D2BM01413K","article-title":"Injectable composite hydrogels encapsulating gelatin methacryloyl\/chitosan microspheres as ARPE-19 cell transplantation carriers","volume":"11","author":"Cheng","year":"2022","journal-title":"Biomater. Sci."},{"issue":"SEP","key":"10.1016\/j.mtbio.2025.101767_bib76","first-page":"1","article-title":"Synthesis and biomedical applications of self-healing hydrogels","volume":"6","author":"Liu","year":"2018","journal-title":"Front. Chem."},{"issue":"25","key":"10.1016\/j.mtbio.2025.101767_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/app.48668","article-title":"Recent advances in shear-thinning and self-healing hydrogels for biomedical applications","volume":"137","author":"Uman","year":"2020","journal-title":"J. Appl. Polym. Sci."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib78","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jconrel.2009.10.030","article-title":"Hydrogel-based drug delivery systems: comparison of drug diffusivity and release kinetics","volume":"142","author":"Brandl","year":"2010","journal-title":"J. Contr. Release"},{"issue":"March","key":"10.1016\/j.mtbio.2025.101767_bib79","first-page":"1","article-title":"Evolution of biomaterials","volume":"9","author":"Vallet-Reg\u00ed","year":"2022","journal-title":"Front. Mater."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib80","doi-asserted-by":"crossref","DOI":"10.3390\/ph15030371","article-title":"Current and future prospective of injectable hydrogels\u2014design challenges and limitations","volume":"15","author":"Almawash","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"December 2020","key":"10.1016\/j.mtbio.2025.101767_bib81","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jconrel.2020.12.008","article-title":"Advances in biodegradable and injectable hydrogels for biomedical applications","volume":"330","author":"Li","year":"2021","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib82","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-020-00431-0","article-title":"Injectable hydrogels of newly designed brush biopolymers as sustained drug-delivery vehicle for melanoma treatment","volume":"6","author":"Shukla","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2025.101767_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep37841","article-title":"Self-healing polysaccharide-based hydrogels as injectable carriers for neural stem cells","volume":"6","author":"Wei","year":"2016","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.mtbio.2025.101767_bib84","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/j.biomaterials.2009.12.004","article-title":"A hydrogel-based stem cell delivery system to treat retinal degenerative diseases","volume":"31","author":"Ballios","year":"2010","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.mtbio.2025.101767_bib85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/advs.202308635","article-title":"Injectable, antioxidative, and tissue-adhesive nanocomposite hydrogel as a potential treatment for inner retina injuries","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mtbio.2025.101767_bib86","first-page":"2024","article-title":"Development of self-healing hydrogels to support choroidal endothelial cell transplantation for the treatment of early age related macular degeneration","volume":"194","author":"Pandala","year":"2024","journal-title":"bioRxiv"},{"issue":"17","key":"10.1016\/j.mtbio.2025.101767_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules27175512","article-title":"Fabrication and evaluation of gellan gum\/hyaluronic acid hydrogel for retinal tissue engineering biomaterial and the influence of substrate stress relaxation on retinal pigment epithelial cells","volume":"27","author":"Youn","year":"2022","journal-title":"Molecules"},{"issue":"32","key":"10.1016\/j.mtbio.2025.101767_bib88","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.1016\/j.biomaterials.2012.07.029","article-title":"Corneal repair by human corneal keratocyte-reprogrammed iPSCs and amphiphatic carboxymethyl-hexanoyl chitosan hydrogel","volume":"33","author":"Chien","year":"2012","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib89","doi-asserted-by":"crossref","DOI":"10.1038\/s41536-021-00195-3","article-title":"A bioinspired gelatin-hyaluronic acid-based hybrid interpenetrating network for the enhancement of retinal ganglion cells replacement therapy","volume":"6","author":"Dromel","year":"2021","journal-title":"NPJ Regen. Med."},{"issue":"April","key":"10.1016\/j.mtbio.2025.101767_bib90","article-title":"Single subcutaneous injection of the minocycline nanocomposite-loaded thermosensitive hydrogel for the effective attenuation of experimental autoimmune uveitis","volume":"622","author":"Zhu","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"9","key":"10.1016\/j.mtbio.2025.101767_bib91","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1002\/jbm.a.34976","article-title":"Hyaluronic acid-based nanocomposite hydrogels for ocular drug delivery applications","volume":"102","author":"Widjaja","year":"2014","journal-title":"J. Biomed. Mater. Res., Part A"},{"issue":"9","key":"10.1016\/j.mtbio.2025.101767_bib92","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1080\/02713683.2017.1302590","article-title":"In vivo efficacy of an injectable microsphere-hydrogel ocular drug delivery system","volume":"42","author":"Osswald","year":"2017","journal-title":"Curr. Eye Res."},{"issue":"September","key":"10.1016\/j.mtbio.2025.101767_bib93","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.ijbiomac.2022.09.101","article-title":"Preparation, physicochemical, and retinal anti-angiogenic evaluation of poloxamer hydrogel containing dexamethasone\/avastin-loaded chitosan-N-acetyl-L-cysteine nanoparticles","volume":"220","author":"Taheri","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib94","first-page":"1","article-title":"Optimization of an injectable hydrogel depot system for the controlled release of retinal-targeted hybrid nanoparticles","volume":"15","author":"Ottonelli","year":"2023","journal-title":"Pharmaceutics"},{"issue":"9","key":"10.1016\/j.mtbio.2025.101767_bib95","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13091335","article-title":"A long-acting curcumin nanoparticle\/in situ hydrogel composite for the treatment of uveal melanoma","volume":"13","author":"Xie","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.mtbio.2025.101767_bib96","article-title":"A novel, liposome-loaded, injectable hydrogel for enhanced treatment of choroidal neovascularization by sub-tenon\u2019s injection","volume":"20","author":"Li","year":"2022","journal-title":"Mater. Today Nano"},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics13020176","article-title":"An injectable nano-enabled thermogel to attain controlled delivery of p11 peptide for the potential treatment of ocular angiogenic disorders of the posterior segment","volume":"13","author":"du Toit","year":"2021","journal-title":"Pharmaceutics"},{"issue":"April 2020","key":"10.1016\/j.mtbio.2025.101767_bib98","article-title":"Rapid bioprinting of conjunctival stem cell micro-constructs for subconjunctival ocular injection","volume":"267","author":"Zhong","year":"2021","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adhm.202001341","article-title":"Recent advances in injectable hydrogels for controlled and local drug delivery","volume":"10","author":"Rizzo","year":"2021","journal-title":"Adv. Healthcare Mater."},{"issue":"5","key":"10.1016\/j.mtbio.2025.101767_bib101","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1097\/ICO.0000000000003475","article-title":"Mesenchymal stem cell-laden in situ-forming hydrogel for preventing corneal stromal opacity","volume":"43","author":"Liu","year":"2024","journal-title":"Cornea"},{"issue":"4","key":"10.1016\/j.mtbio.2025.101767_bib103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/polym13040642","article-title":"Nanoparticle-hydrogel composite drug delivery system for potential ocular applications","volume":"13","author":"Hsu","year":"2021","journal-title":"Polymers"},{"issue":"10","key":"10.1016\/j.mtbio.2025.101767_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/marc.202100025","article-title":"Advances in injectable and self-healing polysaccharide hydrogel based on the Schiff base reaction","volume":"42","author":"Mo","year":"2021","journal-title":"Macromol. Rapid Commun."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101767_bib105","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1039\/c2cs15305j","article-title":"Dynamic imine chemistry","volume":"41","author":"Belowich","year":"2012","journal-title":"Chem. Soc. Rev."},{"issue":"39","key":"10.1016\/j.mtbio.2025.101767_bib106","doi-asserted-by":"crossref","first-page":"19662","DOI":"10.1039\/C5TA05788D","article-title":"Catalyst-free dynamic exchange of aromatic Schiff base bonds and its application to self-healing and remolding of crosslinked polymers","volume":"3","author":"Lei","year":"2015","journal-title":"J. Mater. Chem. A"},{"issue":"January","key":"10.1016\/j.mtbio.2025.101767_bib107","article-title":"An injectable hydrogel based on hyaluronic acid prepared by Schiff base for long-term controlled drug release","volume":"245","author":"Wang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib108","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1021\/cm402180t","article-title":"The Thiol-Michael addition click reaction: a powerful and widely used tool in materials chemistry","volume":"26","author":"Nair","year":"2014","journal-title":"Chem. Mater."},{"issue":"9","key":"10.1016\/j.mtbio.2025.101767_bib109","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/anie.200903924","article-title":"Thiol-ene click chemistry","volume":"49","author":"Hoyle","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1021\/acsbiomaterials.5b00420","article-title":"Thiol-ene click hydrogels for therapeutic delivery","volume":"2","author":"Kharkar","year":"2016","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"5","key":"10.1016\/j.mtbio.2025.101767_bib111","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.cclet.2020.11.073","article-title":"Photo-crosslinkable hydrogel and its biological applications","volume":"32","author":"Wang","year":"2021","journal-title":"Chin. Chem. Lett."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib112","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejpb.2007.02.025","article-title":"Thermoresponsive hydrogels in biomedical applications","volume":"68","author":"Klouda","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"26","key":"10.1016\/j.mtbio.2025.101767_bib113","doi-asserted-by":"crossref","first-page":"5823","DOI":"10.1021\/acs.jpcb.5b11448","article-title":"Properties of poloxamer molecules and poloxamer micelles dissolved in water and next to lipid bilayers: results from computer simulations","volume":"120","author":"Adhikari","year":"2016","journal-title":"J. Phys. Chem. B"},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib114","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10020042","article-title":"Alginate in wound dressings","volume":"10","author":"Aderibigbe","year":"2018","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib115","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.progpolymsci.2011.06.003","article-title":"Alginate: properties and biomedical applications","volume":"37","author":"Lee","year":"2012","journal-title":"Prog. Polym. Sci."},{"issue":"8","key":"10.1016\/j.mtbio.2025.101767_bib116","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.drudis.2019.04.009","article-title":"Retinal cell regeneration using tissue engineered polymeric scaffolds","volume":"24","author":"Abedin Zadeh","year":"2019","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.mtbio.2025.101767_bib117","first-page":"1314","article-title":"PNIPAAm-grafted-collagen as an injectable, in situ gelling cell delivery scaffold","volume":"3","author":"Fitzpatrick","year":"2008","journal-title":"8th World Biomater. Congr."},{"key":"10.1016\/j.mtbio.2025.101767_bib118","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/BF00920064","article-title":"Graefe's Archive for Clinical and Experimental Ophthalmology Regenerative and proliferative capacity of adult human retinal cells in vitro","volume":"228","author":"Thanos","year":"1990","journal-title":"Arch Clin Exp Ophthalmol"},{"issue":"6126","key":"10.1016\/j.mtbio.2025.101767_bib119","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/328131a0","article-title":"A common progenitor for neurons and glia persists in rat retina late in development","volume":"328","author":"Turner","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2025.101767_bib120","article-title":"Safety and tolerability of hRPC in retinitis pigmentosa (hRPCRP)","year":"2023","journal-title":"ClinicalTrials.gov ID NCT02464436"},{"issue":"5","key":"10.1016\/j.mtbio.2025.101767_bib121","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.exer.2008.07.016","article-title":"Rod photoreceptor differentiation in fetal and infant human retina","volume":"87","author":"Hendrickson","year":"2008","journal-title":"Exp. Eye Res."},{"issue":"8","key":"10.1016\/j.mtbio.2025.101767_bib122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm10081785","article-title":"Trends of stem cell therapies in age-related macular degeneration","volume":"10","author":"Maeda","year":"2021","journal-title":"J. Clin. Med."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101767_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajo.2006.12.007","article-title":"Adult retinal pigment epithelial transplantation in exudative age-related macular degeneration","volume":"143","author":"Tezel","year":"2007","journal-title":"Am. J. Ophthalmol."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101767_bib124","doi-asserted-by":"crossref","first-page":"455","DOI":"10.5966\/sctm.2012-0184","article-title":"Adipose tissue-derived multipotent stromal cells have a higher immunomodulatory capacity than their bone marrow-derived counterparts","volume":"2","author":"Melief","year":"2013","journal-title":"Stem Cells Transl. Med."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1167\/iovs.14-15415","article-title":"Intravitreal autologous bone marrow cd34+ cell therapy for ischemic and degenerative retinal disorders: preliminary phase 1 clinical trial findings","volume":"56","author":"Park","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"9477","key":"10.1016\/j.mtbio.2025.101767_bib126","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/S0140-6736(05)66555-5","article-title":"Semantics and ethics of human embryonic stem-cell research","volume":"365","author":"Shenfield","year":"2005","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib127","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.expneurol.2008.09.007","article-title":"Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation","volume":"214","author":"Vugler","year":"2008","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101767_bib128","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib129","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10792-007-9164-4","article-title":"Fungal keratitis following amniotic membrane transplantation","volume":"29","author":"Das","year":"2009","journal-title":"Int. Ophthalmol."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101767_bib130","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/archopht.120.6.783","article-title":"Human limbal progenitor cells expanded on intact amniotic membrane ex vivo","volume":"120","author":"Grueterich M","year":"2002","journal-title":"Arch. Ophthalmol."},{"issue":"9","key":"10.1016\/j.mtbio.2025.101767_bib131","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1080\/14712598.2017.1346079","article-title":"Induced pluripotent stem cell-based therapy for age-related macular degeneration","volume":"17","author":"Bracha","year":"2017","journal-title":"Expet Opin. Biol. Ther."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib132","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-020-02128-1","article-title":"CAR T cells in solid tumors: challenges and opportunities","volume":"12","author":"Marofi","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib133","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jconrel.2010.08.028","article-title":"Barrier analysis of periocular drug delivery to the posterior segment","volume":"148","author":"Ranta","year":"2010","journal-title":"J. Contr. Release"},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib134","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/ICU.0b013e328338679a","article-title":"Complications of intravitreal injections","volume":"21","author":"Sampat","year":"2010","journal-title":"Curr. Opin. Ophthalmol."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib135","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.stem.2008.02.005","article-title":"Cell delivery mechanisms for tissue repair","volume":"2","author":"Mooney","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mtbio.2025.101767_bib136","first-page":"75","article-title":"Anoikis","author":"Malagobadan","year":"2018","journal-title":"Encycl. Cancer"},{"issue":"11","key":"10.1016\/j.mtbio.2025.101767_bib137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers11111775","article-title":"Molecular mechanisms underlying autophagy-mediated treatment resistance in cancer","volume":"11","author":"Ho","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"11","key":"10.1016\/j.mtbio.2025.101767_bib138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/polym12112567","article-title":"Polysaccharide extracted from bletilla striata promotes proliferation and migration of human tenocytes","volume":"12","author":"Chen","year":"2020","journal-title":"Polymers"},{"issue":"18","key":"10.1016\/j.mtbio.2025.101767_bib139","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1016\/j.biomaterials.2011.02.029","article-title":"Advantages of RGD peptides for directing cell association with biomaterials","volume":"32","author":"Bellis","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101767_bib140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijbiomac.2017.11.113","article-title":"Injectable hydrogels for delivering biotherapeutic molecules","volume":"110","author":"Mathew","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.101767_bib141","article-title":"Biomedical applications of stimuli-responsive \u2018smart\u2019 interpenetrating polymer network hydrogels","volume":"25","author":"Wu","year":"2024","journal-title":"Mater. Today Bio"},{"issue":"June","key":"10.1016\/j.mtbio.2025.101767_bib142","first-page":"1","article-title":"Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101767_bib143","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/(SICI)1099-1581(199604)7:4<197::AID-PAT514>3.0.CO;2-4","article-title":"The current status of interpenetrating polymer networks","volume":"7","author":"Sperling","year":"1996","journal-title":"Polym. Adv. Technol."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib144","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4155\/tde.10.40","article-title":"Recent advances in ophthalmic drug delivery","volume":"1","author":"Kompella UB","year":"2010","journal-title":"Ther. Deliv."},{"issue":"July","key":"10.1016\/j.mtbio.2025.101767_bib145","article-title":"3D bioprinting of hydrogels for retina cell culturing","volume":"12","author":"Wang","year":"2018","journal-title":"Bioprinting"},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib146","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/jbm.a.32571","article-title":"Elastic properties of porcine ocular posterior soft tissues","volume":"93","author":"Chen","year":"2010","journal-title":"J. Biomed. Mater. Res., Part A"},{"issue":"7","key":"10.1016\/j.mtbio.2025.101767_bib147","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1021\/bm500502n","article-title":"Thermoreversible poly(ethylene glycol)-g-Chitosan hydrogel as a therapeutic T lymphocyte depot for localized glioblastoma immunotherapy","volume":"15","author":"Ching-Ting Tsao","year":"2014","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.mtbio.2025.101767_bib148","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.actbio.2016.03.016","article-title":"The functional response of alginate-gelatin-nanocrystalline cellulose injectable hydrogels toward delivery of cells and bioactive molecules","volume":"36","author":"Wang","year":"2016","journal-title":"Acta Biomater."},{"issue":"15","key":"10.1016\/j.mtbio.2025.101767_bib149","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.3390\/ma12152416","article-title":"The influence of astaxanthin on the proliferation of adipose-derived mesenchymal stem cells in gelatin-methacryloyl (GelMA) hydrogels","volume":"12","author":"Choi BY","year":"2019","journal-title":"Materials"},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ophtha.2005.11.019","article-title":"Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration","volume":"113","author":"Avery","year":"2006","journal-title":"Ophthalmology"},{"issue":"10","key":"10.1016\/j.mtbio.2025.101767_bib151","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1517\/17425247.2014.927864","article-title":"Intravitreal drug delivery in retinal disease: are we out of our depth?","volume":"11","author":"Thakur","year":"2014","journal-title":"Expet Opin. Drug Deliv."},{"issue":"5","key":"10.1016\/j.mtbio.2025.101767_bib152","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.ophtha.2007.01.017","article-title":"Pharmacokinetics of intravitreal bevacizumab (avastin)","volume":"114","author":"Bakri","year":"2007","journal-title":"Ophthalmology"},{"issue":"November 2020","key":"10.1016\/j.mtbio.2025.101767_bib153","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jconrel.2020.12.008","article-title":"Advances in biodegradable and injectable hydrogels for biomedical applications","volume":"330","author":"Li","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2025.101767_bib154","article-title":"Title Personalized cancer nanomedicine: overcoming biological barriers for intracellular delivery of biopharmaceuticals","author":"L\u00f3pez\u2010Est\u00e9vez","year":"2023","journal-title":"Adv. Mater."},{"issue":"20","key":"10.1016\/j.mtbio.2025.101767_bib155","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.3390\/molecules25204593","article-title":"Enzyme stability in nanoparticle preparations Part 1: bovine serum albumin improves enzyme function","volume":"25","author":"Duskey JT","year":"2020","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.mtbio.2025.101767_bib156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nano11112946","article-title":"Tween\u00ae preserves enzyme activity and stability in PLGA nanoparticles","volume":"11","author":"Duskey","year":"2021","journal-title":"Nanomaterials"},{"issue":"1\u20132","key":"10.1016\/j.mtbio.2025.101767_bib157","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ijpharm.2018.07.070","article-title":"Diffusion through the ex vivo vitreal body \u2013 bovine, porcine, and ovine models are poor surrogates for the human vitreous","volume":"550","author":"Shafaie","year":"2018","journal-title":"Int. J. Pharm."},{"issue":"May","key":"10.1016\/j.mtbio.2025.101767_bib158","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejpb.2019.05.023","article-title":"The obstacle course to the inner retina: hyaluronic acid-coated lipoplexes cross the vitreous but fail to overcome the inner limiting membrane","volume":"141","author":"Devoldere","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"September","key":"10.1016\/j.mtbio.2025.101767_bib159","article-title":"Melatonin loaded hybrid nanomedicine: DoE approach, optimization and in vitro study on diabetic retinopathy model","volume":"627","author":"Romeo","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101767_bib160","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/anie.201610618","article-title":"Photo-modulated therapeutic protein release from a hydrogel depot using visible light","volume":"56","author":"Basuki","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib161","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s40123-022-00453-7","article-title":"Evaluation of the structural, physicochemical, and biological characteristics of SB11, as Lucentis\u00ae (ranibizumab) biosimilar","volume":"11","author":"Kim","year":"2022","journal-title":"Ophthalmol. Ther."},{"key":"10.1016\/j.mtbio.2025.101767_bib162","first-page":"1","article-title":"The clinical effects and mechanism of action of ranibizumab in treating myopic choroidal neovascularization","author":"Gu","year":"2025","journal-title":"Int. Ophthalmol."},{"issue":"8","key":"10.1016\/j.mtbio.2025.101767_bib163","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M110.005264","article-title":"Pharmacoproteomic analysis of a novel cell-permeable peptide inhibitor of tumor-induced angiogenesis","volume":"10","author":"Bang","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.mtbio.2025.101767_bib164","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7836828","article-title":"Role of oxidative stress in retinal disease and the early intervention strategies: a review","volume":"2022","author":"Wang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-021-01199-3","article-title":"Polydopamine nanoparticles attenuate retina ganglion cell degeneration and restore visual function after optic nerve injury","volume":"19","author":"Lou","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"March","key":"10.1016\/j.mtbio.2025.101767_bib166","article-title":"Polydopamine nanoparticles as dual-task platform for osteoarthritis therapy: a scavenger for reactive oxygen species and regulator for cellular powerhouses","volume":"417","author":"Wang","year":"2021","journal-title":"Chem. Eng. J."},{"issue":"November","key":"10.1016\/j.mtbio.2025.101767_bib167","article-title":"Biotechnology and biomaterial-based therapeutic strategies for age-related macular degeneration. Part I: biomaterials-based drug delivery devices","volume":"8","author":"Jemni-Damer","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101767_bib168","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.arr.2009.06.002","article-title":"Regulatory role of HIF-1\u03b1 in the pathogenesis of age-related macular degeneration (AMD)","volume":"8","author":"Arjamaa","year":"2009","journal-title":"Ageing Res. Rev."},{"issue":"8","key":"10.1016\/j.mtbio.2025.101767_bib169","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.biomaterials.2006.11.028","article-title":"Ocular drug delivery by liposome-chitosan nanoparticle complexes (LCS-NP)","volume":"28","author":"Diebold","year":"2007","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.mtbio.2025.101767_bib170","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1167\/iovs.05-0495","article-title":"Chitosan nanoparticles as a potential drug delivery system for the ocular surface: toxicity, uptake mechanism and in vivo tolerance","volume":"47","author":"De Salamanca","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mtbio.2025.101767_bib171","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.trac.2015.06.014","article-title":"PLGA-based nanoparticles: a new paradigm in biomedical applications","volume":"80","author":"Sharma","year":"2016","journal-title":"TrAC, Trends Anal. Chem."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib172","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0939-6411(97)00056-8","article-title":"Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres","volume":"43","author":"Blanco","year":"1997","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1\u20133","key":"10.1016\/j.mtbio.2025.101767_bib173","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0168-3659(97)00106-5","article-title":"Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method","volume":"50","author":"Zambaux","year":"1998","journal-title":"J. Contr. Release"},{"issue":"June","key":"10.1016\/j.mtbio.2025.101767_bib198","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jconrel.2024.11.001","article-title":"Injectable nanocomposite hydrogel with cascade drug release for treatment of uveal melanoma","volume":"376","author":"Guo","year":"2024","journal-title":"J. Contr. Release"},{"issue":"May","key":"10.1016\/j.mtbio.2025.101767_bib197","article-title":"Nanoparticle-hydrogel composite as dual-drug delivery system for the potential application of corneal graft rejection","volume":"201","author":"Xu","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"P1","key":"10.1016\/j.mtbio.2025.101767_bib100","article-title":"Development of an injectable oxidized dextran\/gelatin hydrogel capable of promoting the healing of alkali burn-associated corneal wounds","volume":"273","author":"Ge","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"P2","key":"10.1016\/j.mtbio.2025.101767_bib102","article-title":"Injectable hydrogels embedded with chitosan nanoparticles coated with hyaluronic acid for sequential release of dual drugs","volume":"256","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib174","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0168-3659(00)00361-8","article-title":"Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency","volume":"70","author":"Mao","year":"2001","journal-title":"J. Contr. Release"},{"issue":"4","key":"10.1016\/j.mtbio.2025.101767_bib175","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/wnan.65","article-title":"Toxicity of nanomaterials to the eye","volume":"2","author":"Prow","year":"2010","journal-title":"Wiley Interdiscip. Rev. Nanomedicine Nanobiotechnology"},{"key":"10.1016\/j.mtbio.2025.101767_bib176","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.addr.2017.04.001","article-title":"Nanoparticles for drug delivery to the anterior segment of the eye","volume":"122","author":"Janagam","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101767_bib177","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/tvst.9.6.20","article-title":"Intraocular distribution and kinetics of intravitreally injected antibodies and nanoparticles in rabbit eyes","volume":"9","author":"Kim","year":"2020","journal-title":"Transl. Vis. Sci. Technol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib178","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics13010108","article-title":"Ocular drug delivery to the retina: current innovations and future perspectives","volume":"13","author":"Kim","year":"2021","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib179","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1080\/10717544.2017.1375578","article-title":"Toward smart design of retinal drug carriers: a novel bovine retinal explant model to study the barrier role of the vitreoretinal interface","volume":"24","author":"Peynshaert","year":"2017","journal-title":"Drug Deliv."},{"issue":"12","key":"10.1016\/j.mtbio.2025.101767_bib180","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.2217\/nnm.12.202","article-title":"Measuring the intravitreal mobility of nanomedicines with single-particle tracking microscopy","volume":"8","author":"Martens","year":"2013","journal-title":"Nanomedicine"},{"issue":"3","key":"10.1016\/j.mtbio.2025.101767_bib181","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.yexmp.2008.12.004","article-title":"Nanoparticle-based targeted drug delivery","volume":"86","author":"Singh","year":"2009","journal-title":"Exp. Mol. Pathol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib182","doi-asserted-by":"crossref","DOI":"10.1186\/s43094-023-00569-y","article-title":"Pharmacokinetics of nanoparticles: current knowledge, future directions and its implications in drug delivery","volume":"9","author":"Haripriyaa","year":"2023","journal-title":"Futur. J. Pharm. Sci."},{"issue":"14","key":"10.1016\/j.mtbio.2025.101767_bib183","first-page":"2029","article-title":"Structural specializations of human retinal glial cells","volume":"36","author":"Ram\u00edrez","year":"1996","journal-title":"Vis. Resour."},{"issue":"12","key":"10.1016\/j.mtbio.2025.101767_bib184","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1016\/j.biomaterials.2012.01.030","article-title":"The movement of self-assembled amphiphilic polymeric nanoparticles in the vitreous and retina after intravitreal injection","volume":"33","author":"Koo","year":"2012","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.mtbio.2025.101767_bib185","doi-asserted-by":"crossref","first-page":"e888","DOI":"10.1016\/S2214-109X(17)30293-0","article-title":"Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis","volume":"5","author":"Bourne","year":"2017","journal-title":"Lancet Global Health"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib186","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-020-00745-9","article-title":"Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy","volume":"19","author":"Swetledge","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"8006","key":"10.1016\/j.mtbio.2025.101767_bib187","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41586-024-07130-8","article-title":"Compartmentalized ocular lymphatic system mediates eye\u2013brain immunity","volume":"628","author":"Yin","year":"2024","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.mtbio.2025.101767_bib188","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics11080365","article-title":"Pharmacokinetics of intravitreal anti-VEGF drugs in age-related macular degeneration","volume":"11","author":"Garc\u00eda-Quintanilla","year":"2019","journal-title":"Pharmaceutics"},{"issue":"October 2019","key":"10.1016\/j.mtbio.2025.101767_bib189","article-title":"Intravitreal anti-VEGF drug delivery systems for age-related macular degeneration","volume":"573","author":"Luaces-Rodr\u00edguez","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.mtbio.2025.101767_bib190","first-page":"2843","article-title":"Preclinical PET study of intravitreal injections","volume":"58","author":"Fern\u00e1ndez-Ferreiro","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mtbio.2025.101767_bib191","first-page":"1959","article-title":"T. principles of humane experimental technique","volume":"vol. 238","author":"C","year":"1959"},{"issue":"9","key":"10.1016\/j.mtbio.2025.101767_bib192","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1021\/acs.bioconjchem.7b00325","article-title":"89Zr-Immuno-Positron emission Tomography in oncology: state-of-the-art 89Zr radiochemistry","volume":"28","author":"Heskamp","year":"2017","journal-title":"Bioconjug. Chem."},{"issue":"12","key":"10.1016\/j.mtbio.2025.101767_bib193","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1634\/theoncologist.12-12-1379","article-title":"Immuno-PET: a navigator in monoclonal antibody development and applications","volume":"12","author":"van Dongen","year":"2007","journal-title":"Oncologist"},{"issue":"July","key":"10.1016\/j.mtbio.2025.101767_bib194","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ejpb.2020.06.024","article-title":"PET study of ocular and blood pharmacokinetics of intravitreal bevacizumab and aflibercept in rats","volume":"154","author":"Luaces-Rodr\u00edguez","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"October","key":"10.1016\/j.mtbio.2025.101767_bib195","article-title":"PET study of intravitreal adalimumab pharmacokinetics in a uveitis rat model","volume":"627","author":"Garc\u00eda-Otero","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.mtbio.2025.101767_bib196","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22052719","article-title":"The role of tumor necrosis factor alpha (Tnf-\u03b1) in autoimmune disease and current tnf-\u03b1 inhibitors in therapeutics","volume":"22","author":"Jang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"23","key":"10.1016\/j.mtbio.2025.101767_bib200","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1002\/marc.201600371","article-title":"Stimuli-sensitive injectable hydrogels based on polysaccharides and their biomedical applications","volume":"37","author":"Thambi","year":"2016","journal-title":"Macromol. Rapid Commun."},{"issue":"12","key":"10.1016\/j.mtbio.2025.101767_bib202","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/natrevmats.2016.71","article-title":"Designing hydrogels for controlled drug delivery","volume":"1","author":"Li","year":"2016","journal-title":"Nat. Rev. Mater."},{"issue":"July","key":"10.1016\/j.mtbio.2025.101767_bib203","article-title":"Injectable hydrogels for cartilage and bone tissue regeneration: a review","volume":"246","author":"Ghandforoushan","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101767_bib204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-023-02063-2","article-title":"Application of biomedical materials in the diagnosis and treatment of myocardial infarction","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"8","key":"10.1016\/j.mtbio.2025.101767_bib205","first-page":"1521","article-title":"Therapeutics and for 3D-printing","volume":"12","author":"Loebel","year":"2020"},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib206","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/btm2.10158","article-title":"Hydrogels in the clinic","volume":"5","author":"Mandal","year":"2020","journal-title":"Bioeng. Transl. Med."},{"issue":"5","key":"10.1016\/j.mtbio.2025.101767_bib207","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.exer.2004.07.002","article-title":"Tear film and ocular surface tests in animal models of dry eye: uses and limitations","volume":"79","author":"Barabino","year":"2004","journal-title":"Exp. Eye Res."},{"issue":"52","key":"10.1016\/j.mtbio.2025.101767_bib208","doi-asserted-by":"crossref","first-page":"26280","DOI":"10.1073\/pnas.1902292116","article-title":"The primate model for understanding and restoring vision","volume":"116","author":"Picaud","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101767_bib209","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.survophthal.2024.07.002","article-title":"Advances in ophthalmic therapeutic delivery: a comprehensive overview of present and future directions","volume":"69","author":"Torkashvand","year":"2024","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.mtbio.2025.101767_bib210","article-title":"Study evaluating the treatment of OTX-TKI for subjects with neovascular age-related macular degeneration","author":"Ocular Therapeutix","year":"2024","journal-title":"ClinicalTrials.gov ID NCT04989699"},{"issue":"January","key":"10.1016\/j.mtbio.2025.101767_bib211","doi-asserted-by":"crossref","first-page":"787644","DOI":"10.3389\/fmed.2021.787644","article-title":"Considerations for polymers used in ocular drug delivery","volume":"8","author":"Allyn","year":"2022","journal-title":"Front. Med."},{"issue":"March","key":"10.1016\/j.mtbio.2025.101767_bib212","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2147\/OPTH.S354531","article-title":"Hydrogel sealant for closure of clear corneal incisions in combined glaucoma procedures","volume":"16","author":"Machiele","year":"2022","journal-title":"Clin. Ophthalmol."},{"issue":"12","key":"10.1016\/j.mtbio.2025.101767_bib213","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/j.jcrs.2014.03.034","article-title":"Hydrogel sealant versus sutures to prevent fluid egress after cataract surgery","volume":"40","author":"Masket","year":"2014","journal-title":"J. Cataract Refract. Surg."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101767_bib214","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jcrs.2018.09.023","article-title":"Multicenter randomized phase 3 study of a sustained-release intracanalicular dexamethasone insert for treatment of ocular inflammation and pain after cataract surgery","volume":"45","author":"Tyson","year":"2019","journal-title":"J. Cataract Refract. Surg."},{"key":"10.1016\/j.mtbio.2025.101767_bib215","unstructured":"Astellas Pharma Inc (Astellas Institute for Regenerative Medicine), \u201cSafety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt's Macular Dystrophy (SMD),\u201d ClinicalTrials.gov, ID NCT01469832. https:\/\/clinicaltrials.gov\/study\/NCT01469832 (accessed Jan. 21, 2025)."},{"key":"10.1016\/j.mtbio.2025.101767_bib216","article-title":"Long term follow up of sub-retinal transplantation of hESC derived RPE cells in patients with AMD","year":"2024","journal-title":"ClinicalTrials.gov ID NCT02463344"},{"key":"10.1016\/j.mtbio.2025.101767_bib217","article-title":"Treatment of dry age related macular degeneration disease with retinal pigment epithelium derived from human embryonic stem cells","author":"Qi Zhou","year":"2018","journal-title":"ClinicalTrials.gov ID NCT03046407"},{"key":"10.1016\/j.mtbio.2025.101767_bib218","article-title":"Autologous transplantation of induced pluripotent stem cell-derived retinal pigment epithelium for geographic atrophy associated with age-related macular degeneration","year":"2024","journal-title":"ClinicalTrials.gov ID NCT04339764"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425003278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425003278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:33:58Z","timestamp":1778906038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425003278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":216,"alternative-id":["S2590006425003278"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101767","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intraocular injectable hydrogels for the delivery of cells and nanoparticles","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101767","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101767"}}