{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:15:40Z","timestamp":1791947740651,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.mtbio.2025.101843","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T13:23:55Z","timestamp":1746797035000},"page":"101843","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Nanoliposome-sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ROS for the treatment of CKD-aP"],"prefix":"10.1016","volume":"32","author":[{"given":"Lichang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longbao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5416-7487","authenticated-orcid":false,"given":"Le","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3314-5399","authenticated-orcid":false,"given":"Xusheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mtbio.2025.101843_bib1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.nefro.2022.04.009","article-title":"Perception of Spanish nephrologists on an old unsolved problem: pruritus associated with chronic kidney disease (CKD-aP)","volume":"43","author":"Goicoechea","year":"2023","journal-title":"Nefrologia"},{"issue":"null","key":"10.1016\/j.mtbio.2025.101843_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2147\/IJNRD.S108045","article-title":"Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges","volume":"10","author":"Shirazian","year":"2017","journal-title":"Int. J. Nephrol. Renovascular Dis."},{"issue":"Supplement_3","key":"10.1016\/j.mtbio.2025.101843_bib3","doi-asserted-by":"crossref","first-page":"i23","DOI":"10.1093\/ckj\/sfab200","article-title":"Unravelling the pathophysiology of chronic kidney disease-associated pruritus","volume":"14","author":"Schricker","year":"2021","journal-title":"Clinical Kidney Journal"},{"issue":"8","key":"10.1016\/j.mtbio.2025.101843_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3390\/toxins13080527","article-title":"Chronic kidney disease-associated pruritus","volume":"13","author":"Agarwal","year":"2021","journal-title":"Toxins"},{"issue":"9","key":"10.1016\/j.mtbio.2025.101843_bib5","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.ekir.2020.04.027","article-title":"CKD-associated pruritus: new insights into diagnosis, pathogenesis, and management","volume":"5","author":"Verduzco","year":"2020","journal-title":"Kidney International Reports"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101843_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.2042-7158.2011.01369.x","article-title":"Microneedles: an emerging transdermal drug delivery system","volume":"64","author":"Bariya","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.mtbio.2025.101843_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.actbio.2020.12.004","article-title":"Microneedle-mediated transdermal drug delivery for treating diverse skin diseases","volume":"121","author":"Yang","year":"2021","journal-title":"Acta Biomater."},{"issue":"31","key":"10.1016\/j.mtbio.2025.101843_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202312088","article-title":"Microneedle-mediated delivery of immunomodulators restores immune privilege in hair follicles and reverses immune-mediated alopecia","volume":"36","author":"Younis","year":"2024","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101843_bib9","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1177\/10600280221115889","article-title":"Difelikefalin: a new \u03ba-opioid receptor agonist for the treatment of hemodialysis-dependent chronic kidney disease\u2013associated pruritus","volume":"57","author":"Fugal","year":"2023","journal-title":"Ann. Pharmacother."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101843_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/13813455.2019.1669056","article-title":"Capsaicin has potent anti-oxidative effects in vivo through a mechanism which is non-receptor mediated","volume":"128","author":"Chaudhary","year":"2022","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.mtbio.2025.101843_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108177","article-title":"Anti-cancer activity of sustained release capsaicin formulations","volume":"238","author":"Merritt","year":"2022","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.mtbio.2025.101843_bib12","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.2147\/IJN.S318266","article-title":"Efficient anti-glioma therapy through the brain-targeted RVG15-modified liposomes loading paclitaxel-cholesterol complex","volume":"16","author":"Xin","year":"2021","journal-title":"Int. J. Nanomed."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101843_bib13","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1007\/s10924-022-02381-w","article-title":"Extraction of silk fibroin with several sericin removal processes and its importance in tissue engineering: a review","volume":"30","author":"Biswal","year":"2022","journal-title":"J. Polym. Environ."},{"key":"10.1016\/j.mtbio.2025.101843_bib14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.biomaterials.2018.02.016","article-title":"Photo-crosslinkable, injectable sericin hydrogel as 3D biomimetic extracellular matrix for minimally invasive repairing cartilage","volume":"163","author":"Qi","year":"2018","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101843_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10328","article-title":"An injectable gelatin\/sericin hydrogel loaded with human umbilical cord mesenchymal stem cells for the treatment of uterine injury","volume":"8","author":"Chen","year":"2023","journal-title":"Bioengineering & Translational Medicine"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101843_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/biomimetics4010017","article-title":"Effects of capsaicin on biomimetic membranes","volume":"4","author":"Sharma","year":"2019","journal-title":"Biomimetics"},{"key":"10.1016\/j.mtbio.2025.101843_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116650","article-title":"Dextran methacrylate hydrogel microneedles loaded with doxorubicin and trametinib for continuous transdermal administration of melanoma","volume":"246","author":"Huang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.101843_bib18","series-title":"ISO 10993: Biological Evaluation of Medical Devices\/\/TIMIRI SHANMUGAM P S, THANGARAJU P, PALANI N, et al. Medical Device Guidelines and Regulations Handbook","first-page":"163","author":"Thangaraju","year":"2022"},{"issue":"9","key":"10.1016\/j.mtbio.2025.101843_bib19","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.jid.2023.02.022","article-title":"Non-neuronal kappa opioid pathway profiling in the skin of different chronic pruritus\u2013associated dermatoses","volume":"143","author":"Wiegmann","year":"2023","journal-title":"J. Invest. Dermatol."},{"issue":"Suppl 1","key":"10.1016\/j.mtbio.2025.101843_bib20","first-page":"S26","article-title":"Influence of capsaicin on inflammatory cytokines induced by lipopolysaccharide in myoblast cells under in vitro environment","volume":"13","author":"Shang","year":"2017","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.mtbio.2025.101843_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2019.00108","article-title":"Role of keratinocytes in sensitive skin","volume":"6","author":"Talagas","year":"2019","journal-title":"Front. Med."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101843_bib22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s12264-016-0076-z","article-title":"Antioxidants attenuate acute and chronic itch: peripheral and central mechanisms of oxidative stress in pruritus","volume":"33","author":"Zhou","year":"2017","journal-title":"Neurosci. Bull."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101843_bib23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3892\/mmr.2021.11933","article-title":"\u03ba-opioid receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K\/AKT\/Nrf2\/HO-1 pathway","volume":"23","author":"Fan","year":"2021","journal-title":"Mol. Med. Rep."},{"issue":"11","key":"10.1016\/j.mtbio.2025.101843_bib24","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1007\/s11064-023-03983-z","article-title":"The vanilloid receptor TRPV1 agonist in neuroprotection: mechanisms involved and significance","volume":"48","author":"Abdel-Salam","year":"2023","journal-title":"Neurochem. Res."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101843_bib25","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.jaci.2022.03.010","article-title":"Neuroimmune communication regulating pruritus in atopic dermatitis","volume":"149","author":"Steinhoff","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101843_bib26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12950-024-00391-0","article-title":"Lipopolysaccharide pretreatment increases the sensitivity of the TRPV1 channel and promotes an anti-inflammatory phenotype of capsaicin-activated macrophages","volume":"21","author":"Va\u0161ek","year":"2024","journal-title":"J. Inflamm."},{"issue":"11","key":"10.1016\/j.mtbio.2025.101843_bib27","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.3390\/ijms22116135","article-title":"TRPV1: role in skin and skin diseases and potential target for improving wound healing","volume":"22","author":"Bagood","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101843_bib28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/84205","article-title":"Chemokines as regulators of T cell differentiation","volume":"2","author":"Luther","year":"2001","journal-title":"Nat. Immunol."},{"issue":"null","key":"10.1016\/j.mtbio.2025.101843_bib29","first-page":"1","article-title":"Role of CXCL10 in central nervous system inflammation","volume":"6","author":"Michlmayr","year":"2014","journal-title":"Int. J. Interferon Cytokine Mediat. Res."},{"issue":"1654","key":"10.1016\/j.mtbio.2025.101843_bib30","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0595","article-title":"Astroglial cradle in the life of the synapse","volume":"369","author":"Verkhratsky","year":"2014","journal-title":"Phil. Trans. Biol. Sci."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101843_bib31","doi-asserted-by":"crossref","first-page":"414","DOI":"10.7150\/ijbs.89368","article-title":"Elevated SLC40A1 impairs cardiac function and exacerbates mitochondrial dysfunction, oxidative stress, and apoptosis in ischemic myocardia","volume":"20","author":"Feng","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101843_bib32","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"null","key":"10.1016\/j.mtbio.2025.101843_bib33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2147\/CCID.S445008","article-title":"Essential Oil of matricaria chamomilla alleviate psoriatic-like skin inflammation by inhibiting PI3K\/Akt\/mTOR and p38MAPK signaling pathway","volume":"17","author":"Chen","year":"2024","journal-title":"Clin. Cosmet. Invest. Dermatol."},{"issue":"8","key":"10.1016\/j.mtbio.2025.101843_bib34","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.3390\/ijms23084140","article-title":"Opioidergic signaling\u2014a neglected, yet potentially important player in atopic dermatitis","volume":"23","author":"\u00c1d\u00e1m","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.mtbio.2025.101843_bib35","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/bjd.18025","article-title":"Substance P and neurokinin 1 receptor are new targets for the treatment of chronic pruritus","volume":"181","author":"St\u00e4nder","year":"2019","journal-title":"Br. J. Dermatol."},{"issue":"10","key":"10.1016\/j.mtbio.2025.101843_bib36","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1111\/all.14791","article-title":"Interleukin-31: the \u201citchy\u201d cytokine in inflammation and therapy","volume":"76","author":"Datsi","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.mtbio.2025.101843_bib37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuroscience.2023.08.013","article-title":"IL-33\/ST2 signaling in the pathogenesis of chronic pain and itch","volume":"529","author":"Gao","year":"2023","journal-title":"Neuroscience"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259000642500403X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259000642500403X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:30:40Z","timestamp":1762633840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S259000642500403X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":37,"alternative-id":["S259000642500403X"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101843","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanoliposome-sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ROS for the treatment of CKD-aP","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101843","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101843"}}