{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:20:51Z","timestamp":1793748051597,"version":"4.6.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2025AFB636 2024AFD100"],"award-info":[{"award-number":["2025AFB636 2024AFD100"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303783"],"award-info":[{"award-number":["82303783"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473299"],"award-info":[{"award-number":["82473299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370638"],"award-info":[{"award-number":["82370638"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272659"],"award-info":[{"award-number":["82272659"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ2092"],"award-info":[{"award-number":["2024JJ2092"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ10095"],"award-info":[{"award-number":["2023JJ10095"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ5560"],"award-info":[{"award-number":["2024JJ5560"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.mtbio.2025.101848","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T02:40:58Z","timestamp":1746758458000},"page":"101848","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Sorafenib-loaded metal-organic framework nanoparticles for anti-hepatocellular carcinoma effects through synergistically potentiating ferroptosis and remodeling tumor immune microenvironment"],"prefix":"10.1016","volume":"32","author":[{"given":"Yuanliang","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6658-6096","authenticated-orcid":false,"given":"Hai-Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-Gen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2047-883X","authenticated-orcid":false,"given":"Zhijie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fada","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruochan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.mtbio.2025.101848_bib1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41575-024-01024-w","article-title":"Precision models in hepatocellular carcinoma","volume":"22","author":"Barcena-Varela","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.mtbio.2025.101848_bib2","first-page":"1192","article-title":"Diagnostic and prognostic value of protein post-translational modifications in hepatocellular carcinoma","volume":"11","author":"Wang","year":"2023","journal-title":"J. Clin. Transl. Hepatol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s40001-023-01411-0","article-title":"FANCD2 as a novel prognostic biomarker correlated with immune and drug therapy in Hepatitis B-related hepatocellular carcinoma","volume":"28","author":"Tang","year":"2023","journal-title":"Eur. J. Med. Res."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40364-021-00350-4","article-title":"Recent advances in systemic therapy for hepatocellular carcinoma","volume":"10","author":"Zhang","year":"2022","journal-title":"Biomark. Res."},{"issue":"5","key":"10.1016\/j.mtbio.2025.101848_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1159\/000529824","article-title":"Survival trends in sorafenib for advanced hepatocellular carcinoma: a reconstructed individual patient data meta-analysis of randomized trials","volume":"12","author":"Tan","year":"2023","journal-title":"Liver Cancer"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000521625","article-title":"Trends of clinical outcomes of patients with advanced hepatocellular carcinoma treated with first-line sorafenib in randomized controlled trials","volume":"9","author":"Brown","year":"2022","journal-title":"Gastrointest. Tumors"},{"issue":"5","key":"10.1016\/j.mtbio.2025.101848_bib7","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.4103\/jcrt.jcrt_308_21","article-title":"Real-world evidence of sorafenib for the treatment of hepatocellular carcinoma: a single-center study","volume":"19","author":"Lopez-Lopez","year":"2023","journal-title":"J. Cancer Res. Therapeut."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib8","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41420-021-00696-6","article-title":"RCN1 induces sorafenib resistance and malignancy in hepatocellular carcinoma by activating c-MYC signaling via the IRE1\u03b1\u2013XBP1s pathway","volume":"7","author":"Wang","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.mtbio.2025.101848_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.101015","article-title":"CRISPR\/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS\/SOD1-dependent mitochondrial oxidative stress","volume":"71","author":"Lu","year":"2023","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.mtbio.2025.101848_bib10","article-title":"Tumor microenvironment responsive nano-platform for overcoming sorafenib resistance of hepatocellular carcinoma","volume":"24","author":"Xu","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2025.101848_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.115589","article-title":"Co-delivery of doxorubicin\/sorafenib by DNA-decorated green ZIF-67-based nanocarriers for chemotherapy and hepatocellular carcinoma treatment","volume":"225","author":"Farasati Far","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.mtbio.2025.101848_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jcis.2023.11.109","article-title":"Dual-drug controllable co-assembly nanosystem for targeted and synergistic treatment of hepatocellular carcinoma","volume":"656","author":"Le","year":"2024","journal-title":"J. Colloid Interface Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib13","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1186\/s40001-024-01948-8","article-title":"Establishment of an ovarian cancer exhausted CD8+T cells-related genes model by integrated analysis of scRNA-seq and bulk RNA-seq","volume":"29","author":"Hua","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.mtbio.2025.101848_bib14","article-title":"A novel nanomedicine integrating ferroptosis and photothermal therapy, well-suitable for PD-L1-mediated immune checkpoint blockade","volume":"29","author":"Bao","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2025.101848_bib15","article-title":"Photothermal and host immune activated therapy of cutaneous tuberculosis using macrophage targeted mesoporous polydopamine nanoparticles","volume":"28","author":"Fan","year":"2024","journal-title":"Mater. Today Bio"},{"issue":"8","key":"10.1016\/j.mtbio.2025.101848_bib16","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2174\/1573412918666220509032754","article-title":"A review on PCR and POC-PCR - a boon in the diagnosis of COVID-19","volume":"18","author":"Amuthalakshmi","year":"2022","journal-title":"Curr. Pharmaceut. Anal."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101848_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20220002","article-title":"Recent development of pH\u2010responsive theranostic nanoplatforms for magnetic resonance imaging\u2010guided cancer therapy","volume":"3","author":"Li","year":"2023","journal-title":"Exploration"},{"issue":"11","key":"10.1016\/j.mtbio.2025.101848_bib18","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/nmat4718","article-title":"Mechanism of hard-nanomaterial clearance by the liver","volume":"15","author":"Tsoi","year":"2016","journal-title":"Nat. Mater."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib19","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1186\/s40001-024-02050-9","article-title":"TCEB2\/HIF1A signaling axis promotes chemoresistance in ovarian cancer cells by enhancing glycolysis and angiogenesis","volume":"29","author":"Deng","year":"2024","journal-title":"Eur. J. Med. Res."},{"issue":"17","key":"10.1016\/j.mtbio.2025.101848_bib20","doi-asserted-by":"crossref","first-page":"16715","DOI":"10.1021\/acsnano.3c03169","article-title":"Bifunctional cascading nanozymes based on carbon dots promotes photodynamic therapy by regulating hypoxia and glycolysis","volume":"17","author":"Luo","year":"2023","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.mtbio.2025.101848_bib21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.14218\/CSP.2024.00018","article-title":"Ferroptosis in regulating treatment tolerance of digestive system tumors","volume":"3","author":"Quan","year":"2024","journal-title":"Cancer Screening Prevention"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib22","first-page":"207","article-title":"Ferroptosis: from basic research to clinical therapeutics in hepatocellular carcinoma","volume":"11","author":"Huang","year":"2023","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.mtbio.2025.101848_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111163","article-title":"Ropivacaine prompts ferroptosis to enhance the cisplatin-sensitivity of human colorectal cancer through SIRT1\/Nrf2 signaling pathway","volume":"400","author":"Zeng","year":"2024","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s12943-024-02130-8","article-title":"Cuproptosis, ferroptosis and PANoptosis in tumor immune microenvironment remodeling and immunotherapy: culprits or new hope","volume":"23","author":"Zhang","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mtbio.2025.101848_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.160292","article-title":"Ultrasound-enhanced dual-responsive bismuth nanocatalysts for alleviating tumor hypoxia and promoting breast cancer sonodynamic-immunotherapy","volume":"507","author":"Pan","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib26","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1038\/s41467-021-23324-4","article-title":"Interpretation of T cell states from single-cell transcriptomics data using reference atlases","volume":"12","author":"Andreatta","year":"2021","journal-title":"Nat. Commun."},{"issue":"45","key":"10.1016\/j.mtbio.2025.101848_bib27","doi-asserted-by":"crossref","first-page":"18330","DOI":"10.1073\/pnas.1105835108","article-title":"Cd8 enhancer E8I and Runx factors regulate CD8\u03b1 expression in activated CD8+ T cells","volume":"108","author":"Hassan","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101848_bib28","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41556-022-00860-9","article-title":"Temporal and spatial topography of cell proliferation in cancer","volume":"24","author":"Gaglia","year":"2022","journal-title":"Nat. Cell Biol."},{"issue":"9","key":"10.1016\/j.mtbio.2025.101848_bib29","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/annonc\/mdh299","article-title":"Prognostic relevance of cell proliferation in head and neck tumors","volume":"15","author":"Pich","year":"2004","journal-title":"Ann. Oncol."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101848_bib30","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1001\/jamaoncol.2023.2677","article-title":"Critical appraisal of guideline recommendations on systemic therapies for advanced hepatocellular carcinoma","volume":"10","author":"Cappuyns","year":"2024","journal-title":"JAMA Oncol."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101848_bib31","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1158\/0008-5472.CAN-23-1916","article-title":"N6-methyladenosine reader YTHDF1 promotes stemness and therapeutic resistance in hepatocellular carcinoma by enhancing NOTCH1 expression","volume":"84","author":"Zhang","year":"2024","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40364-022-00361-9","article-title":"KSR2-14\u20133-3\u03b6 complex serves as a biomarker and potential therapeutic target in sorafenib-resistant hepatocellular carcinoma","volume":"10","author":"Gao","year":"2022","journal-title":"Biomark. Res."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101848_bib33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41419-024-06493-0","article-title":"Targeting AXL induces tumor-intrinsic immunogenic response in tyrosine kinase inhibitor-resistant liver cancer","volume":"15","author":"Xie","year":"2024","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101848_bib34","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1097\/HEP.0000000000000237","article-title":"Mechanisms of drug resistance in HCC","volume":"79","author":"Ladd","year":"2023","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib35","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1186\/s40001-023-01539-z","article-title":"Nanotechnology in leukemia: diagnosis, efficient-targeted drug delivery, and clinical trials","volume":"28","author":"Salama","year":"2023","journal-title":"Eur. J. Med. Res."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101848_bib36","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1166\/jbn.2021.3061","article-title":"Progress in application of nanotechnology in sorafenib","volume":"17","author":"Lai","year":"2021","journal-title":"J. Biomed. Nanotechnol."},{"issue":"12","key":"10.1016\/j.mtbio.2025.101848_bib37","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1039\/D0BM00295J","article-title":"A reduction and pH dual-sensitive nanodrug for targeted theranostics in hepatocellular carcinoma","volume":"8","author":"Cai","year":"2020","journal-title":"Biomater. Sci."},{"issue":"20","key":"10.1016\/j.mtbio.2025.101848_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202200477","article-title":"Reducing postoperative recurrence of early\u2010stage hepatocellular carcinoma by a wound\u2010targeted nanodrug","volume":"9","author":"li","year":"2022","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib39","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1186\/s12951-021-01095-w","article-title":"Sorafenib and triptolide loaded cancer cell-platelet hybrid membrane-camouflaged liquid crystalline lipid nanoparticles for the treatment of hepatocellular carcinoma","volume":"19","author":"Li","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"8","key":"10.1016\/j.mtbio.2025.101848_bib40","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1021\/acs.jcim.3c01872","article-title":"Pore structure compartmentalization for advanced characterization of metal\u2013organic framework materials","volume":"64","author":"Parashar","year":"2024","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s12951-023-02146-0","article-title":"Combination of ferroptosis and pyroptosis dual induction by triptolide nano-MOFs for immunotherapy of Melanoma","volume":"21","author":"Wang","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib42","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12951-022-01759-1","article-title":"Dual-stimuli responsive smart nanoprobe for precise diagnosis and synergistic multi-modalities therapy of superficial squamous cell carcinoma","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101848_bib43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jhep.2021.08.029","article-title":"Intratumoral stem-like CCR4+ regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B","volume":"76","author":"Gao","year":"2022","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101848_bib44","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/liv.12284","article-title":"Improving immunotherapy of hepatocellular carcinoma (HCC) using dendritic cells (DC) engineered to express IL\u201012 in vivo","volume":"34","author":"Vogt","year":"2013","journal-title":"Liver Int."},{"key":"10.1016\/j.mtbio.2025.101848_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215880","article-title":"Sorafenib combined with STAT3 knockdown triggers ER stress-induced HCC apoptosis and cGAS-STING-mediated anti-tumor immunity","volume":"547","author":"Wang","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mtbio.2025.101848_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122962","article-title":"Overcoming tumor hypoxic bismuth-based ternary heterojunctions enable defect modulation-augmented tumor sonocatalytic immunotherapy","volume":"315","author":"He","year":"2025","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.mtbio.2025.101848_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202200811","article-title":"Nanoagonist\u2010mediated GSDME\u2010dependent pyroptosis remodels the inflammatory microenvironment for tumor photoimmunotherapy","volume":"33","author":"Zheng","year":"2023","journal-title":"Adv. Funct. Mater."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425004089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425004089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:42:34Z","timestamp":1762634554000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425004089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":47,"alternative-id":["S2590006425004089"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101848","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sorafenib-loaded metal-organic framework nanoparticles for anti-hepatocellular carcinoma effects through synergistically potentiating ferroptosis and remodeling tumor immune microenvironment","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101848","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101848"}}