{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:39:42Z","timestamp":1790300382894,"version":"4.1.0"},"reference-count":119,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013066","name":"Key Scientific Research Project of Colleges and Universities in Henan Province","doi-asserted-by":"publisher","award":["2021ZDZX2069"],"award-info":[{"award-number":["2021ZDZX2069"]}],"id":[{"id":"10.13039\/501100013066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009075","name":"Guangdong Academy of Sciences","doi-asserted-by":"publisher","award":["2023GDASZH-2023010102"],"award-info":[{"award-number":["2023GDASZH-2023010102"]}],"id":[{"id":"10.13039\/501100009075","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009075","name":"Guangdong Academy of Sciences","doi-asserted-by":"publisher","award":["2022GDASZH-2022010110"],"award-info":[{"award-number":["2022GDASZH-2022010110"]}],"id":[{"id":"10.13039\/501100009075","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023A1515012258"],"award-info":[{"award-number":["2023A1515012258"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.mtbio.2025.101856","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:45:04Z","timestamp":1747190704000},"page":"101856","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["ROS-responsive adaptive injectable hydrogel promoting inflammatory mastoid bone repair through efficient sterilization and regulating oxidative stress and macrophage phenotype"],"prefix":"10.1016","volume":"32","author":[{"given":"Yiwen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maomao","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxiong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6052-3970","authenticated-orcid":false,"given":"Dongling","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxinwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4819-5030","authenticated-orcid":false,"given":"Huilong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2025.101856_bib1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1099\/jmm.0.000155","article-title":"Current concepts in the pathogenesis and treatment of chronic suppurative otitis media","volume":"64","author":"Mittal","year":"2015","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.mtbio.2025.101856_bib2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1017\/S0022215117000299","article-title":"Incidence, 10-year recidivism rate and prognostic factors for cholesteatoma","volume":"131","author":"Britze","year":"2017","journal-title":"J. Laryngol. Otol."},{"key":"10.1016\/j.mtbio.2025.101856_bib3","doi-asserted-by":"crossref","first-page":"12687","DOI":"10.1021\/acsnano.1c04206","article-title":"Functional hydrogels as wound dressing to enhance wound healing","volume":"15","author":"Liang","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.101856_bib4","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1021\/acs.chemmater.1c03944","article-title":"Injectable adhesive self-healing multiple-dynamic-bond crosslinked hydrogel with photothermal antibacterial activity for infected wound healing","volume":"34","author":"Guo","year":"2022","journal-title":"Chem. Mater."},{"key":"10.1016\/j.mtbio.2025.101856_bib5","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1021\/acsnano.1c11040","article-title":"pH\/Glucose dual responsive metformin release hydrogel dressings with adhesion and self-healing via dual-dynamic bonding for athletic diabetic foot wound healing","volume":"16","author":"Liang","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.101856_bib6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jconrel.2023.11.016","article-title":"Mussel-inspired controllable drug release hydrogel for transdermal drug delivery: hydrogen bond and ion-dipole interactions","volume":"365","author":"Cai","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2025.101856_bib7","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/10408363.2022.2158173","article-title":"Mapping of audiometric analysis with microbiological findings in patients with chronic suppurative otitis media (CSOM): a neglected clinical manifestation","volume":"60","author":"Dhingra","year":"2023","journal-title":"Crit. Rev. Clin. Lab Sci."},{"key":"10.1016\/j.mtbio.2025.101856_bib8","doi-asserted-by":"crossref","first-page":"8671","DOI":"10.3390\/ijms21228671","article-title":"Pseudomonas aeruginosa biofilms","volume":"21","author":"Thi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.101856_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.biotechadv.2018.11.013","article-title":"Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies","volume":"37","author":"Pang","year":"2019","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.mtbio.2025.101856_bib10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/antibiotics12010012","article-title":"A review of biofilm formation of Staphylococcus aureus and its regulation mechanism","volume":"12","author":"Peng","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.mtbio.2025.101856_bib11","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fcimb.2014.00178","article-title":"Staphylococcus aureus biofilms: recent developments in biofilm dispersal","volume":"4","author":"Lister","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.mtbio.2025.101856_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41522-021-00200-z","article-title":"Treatment with a neutrophil elastase inhibitor and ofloxacin reduces P. aeruginosa burden in a mouse model of chronic suppurative otitis media","volume":"7","author":"Khomtchouk","year":"2021","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.mtbio.2025.101856_bib13","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/MAO.0b013e318259533f","article-title":"Mastoid biofilm in chronic otitis media","volume":"33","author":"Lampikoski","year":"2012","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.mtbio.2025.101856_bib14","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1039\/D1TB00156F","article-title":"Tannic acid-inspired, self-healing, and dual stimuli responsive dynamic hydrogel with potent antibacterial and anti-oxidative properties","volume":"9","author":"Shi","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2025.101856_bib15","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.2147\/IJN.S133971","article-title":"Linseed hydrogel-mediated green synthesis of silver nanoparticles for antimicrobial and wound-dressing applications","volume":"12","author":"Haseeb","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2025.101856_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201903022","article-title":"Plant-Inspired pyrogallol-containing functional materials","volume":"29","author":"Shin","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2025.101856_bib17","article-title":"Targeted therapy against metastatic melanoma based on self-assembled metal-phenolic nanocomplexes comprised of green tea catechin","volume":"6","author":"Li","year":"2019","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2025.101856_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119444","article-title":"Polyphenol-driving assembly for constructing chitin-polyphenol-metal hydrogel as wound dressing","volume":"290","author":"Lin","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.101856_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115328","article-title":"Recent progress in tannic acid based approaches as a natural polyphenolic biomaterial for cancer therapy: a review","volume":"166","author":"Ghasemian","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mtbio.2025.101856_bib20","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3390\/gels9110867","article-title":"Natural polymeric hydrogels encapsulating small molecules for diabetic wound healing","volume":"9","author":"Oprita","year":"2023","journal-title":"Gels"},{"key":"10.1016\/j.mtbio.2025.101856_bib21","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3109\/00016489.2015.1011789","article-title":"Expression levels of receptor activator of nuclear factor-\u03baB ligand and osteoprotegerin are associated with middle ear cholesteatoma risk","volume":"135","author":"Chen","year":"2015","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.mtbio.2025.101856_bib22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10162-019-00727-1","article-title":"Osteoclasts modulate bone erosion in cholesteatoma via RANKL signaling","volume":"20","author":"Imai","year":"2019","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1016\/j.mtbio.2025.101856_bib23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000319897","article-title":"Expression of IL-17 and its role in bone destruction in human middle ear cholesteatoma","volume":"72","author":"Haruyama","year":"2010","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"10.1016\/j.mtbio.2025.101856_bib24","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12964-022-00953-w","article-title":"Review of potential medical treatments for middle ear cholesteatoma","volume":"20","author":"Sch\u00fcrmann","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.mtbio.2025.101856_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/srep38761","article-title":"TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation","volume":"6","author":"Jiang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2025.101856_bib26","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.yexmp.2009.12.006","article-title":"Immune cell profile in invasive cholesteatomas: preliminary findings","volume":"88","author":"Hussein","year":"2010","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.mtbio.2025.101856_bib27","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00405-006-0030-1","article-title":"Toll-like receptors 2, 3 and 4 (TLR-2, TLR-3 and TLR-4) are expressed in the microenvironment of human acquired cholesteatoma","volume":"263","author":"Szczepa\u0144ski","year":"2006","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.mtbio.2025.101856_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000323831","article-title":"Expression of tumor necrosis factor-\u03b1, interleukin-1\u03b1, interleukin-6 and interleukin-10 in chronic otitis media with bone osteolysis","volume":"73","author":"Kuczkowski","year":"2011","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"10.1016\/j.mtbio.2025.101856_bib29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.52601\/bpr.2021.200016","article-title":"Endogenous reactive oxygen species and nitric oxide have opposite roles in regulating HIF-1alpha expression in hypoxic astrocytes","volume":"7","author":"Chen","year":"2021","journal-title":"Swwlxb"},{"key":"10.1016\/j.mtbio.2025.101856_bib30","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1021\/acs.jafc.7b02247","article-title":"2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO\u2022) radical scavenging: a new and simple antioxidant assay in vitro","volume":"65","author":"Li","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.mtbio.2025.101856_bib31","first-page":"550","article-title":"A natural polyphenolic nanoparticle--knotted hydrogel scavenger for osteoarthritis therapy","volume":"43","author":"Ding","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101856_bib32","doi-asserted-by":"crossref","first-page":"61638","DOI":"10.1021\/acsami.1c18701","article-title":"Injectable and self-healing hydrogels with double-dynamic bond tunable mechanical, gel-sol transition and drug delivery properties for promoting periodontium regeneration in periodontitis","volume":"13","author":"Guo","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101856_bib33","doi-asserted-by":"crossref","first-page":"20708","DOI":"10.1021\/acsami.1c03566","article-title":"UV-assisted deposition of antibacterial Ag-tannic acid nanocomposite coating","volume":"13","author":"He","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101856_bib34","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1021\/acsmaterialslett.3c00925","article-title":"Dual glucose\/ROS-sensitive injectable adhesive self-healing hydrogel with photothermal antibacterial activity and modulation of macrophage polarization for infected diabetic wound healing","volume":"5","author":"Zhou","year":"2023","journal-title":"ACS Mater. Lett."},{"key":"10.1016\/j.mtbio.2025.101856_bib35","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.1016\/j.bmcl.2012.09.060","article-title":"A new boronic acid based fluorescent reporter for catechol","volume":"22","author":"Wu","year":"2012","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.mtbio.2025.101856_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1817","article-title":"Recent developments in the use of gold and silver nanoparticles in biomedicine","volume":"14","author":"Pasparakis","year":"2022","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2025.101856_bib37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jconrel.2021.11.027","article-title":"A spatiotemporal release platform based on pH\/ROS stimuli-responsive hydrogel in wound repairing","volume":"341","author":"Wu","year":"2022","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2025.101856_bib38","first-page":"306","article-title":"Microenvironment responsive nanocomposite hydrogel with NIR photothermal therapy, vascularization and anti-inflammation for diabetic infected wound healing","volume":"26","author":"Zhu","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101856_bib39","article-title":"Rutin-loaded stimuli-responsive hydrogel for anti-inflammation","author":"Wang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101856_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.120180","article-title":"Injectable and tissue adhesive EGCG-laden hyaluronic acid hydrogel depot for treating oxidative stress and inflammation","volume":"299","author":"He","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.101856_bib41","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1089\/wound.2020.1232","article-title":"Moist wound healing with commonly available dressings","volume":"10","author":"Nuutila","year":"2021","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.mtbio.2025.101856_bib42","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1016\/j.actbio.2013.04.050","article-title":"Stiffness and adhesivity control aortic valve interstitial cell behavior within hyaluronic acid based hydrogels","volume":"9","author":"Duan","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101856_bib43","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.1016\/j.biomaterials.2013.04.004","article-title":"Fibrous hyaluronic acid hydrogels that direct MSC chondrogenesis through mechanical and adhesive cues","volume":"34","author":"Kim","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101856_bib44","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.ijbiomac.2020.08.109","article-title":"Research status of self-healing hydrogel for wound management: a review","volume":"164","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.101856_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2019.03.057","article-title":"Advances in injectable self-healing biomedical hydrogels","volume":"90","author":"Tu","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101856_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202106564","article-title":"Self-healing hydrogel embodied with macrophage-regulation and responsive-gene-silencing properties for synergistic prevention of peritendinous adhesion","volume":"34","author":"Cai","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.101856_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202304896","article-title":"A bioinspired injectable, adhesive, and self-healing hydrogel with dual hybrid network for neural regeneration after spinal cord injury","volume":"35","author":"Xiao","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.101856_bib48","first-page":"129","article-title":"Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing","volume":"30","author":"Qiao","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101856_bib49","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41586-023-06628-x","article-title":"Injectable tissue prosthesis for instantaneous closed-loop rehabilitation","volume":"623","author":"Jin","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2025.101856_bib50","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1038\/s41467-023-38209-x","article-title":"Hydrogel dressing integrating FAK inhibition and ROS scavenging for mechano-chemical treatment of atopic dermatitis","volume":"14","author":"Jia","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.101856_bib51","doi-asserted-by":"crossref","first-page":"34455","DOI":"10.1021\/acsami.2c08870","article-title":"Injectable self-healing adhesive chitosan hydrogel with antioxidative, antibacterial, and hemostatic activities for rapid hemostasis and skin wound healing","volume":"14","author":"Guo","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101856_bib52","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.actbio.2021.02.002","article-title":"Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities","volume":"124","author":"Cheng","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101856_bib53","first-page":"234","article-title":"3D printed biomimetic epithelium\/stroma bilayer hydrogel implant for corneal regeneration","volume":"17","author":"He","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101856_bib54","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwab147","article-title":"Stretchable and self-healable hydrogel artificial skin","volume":"9","author":"Xue","year":"2022","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.mtbio.2025.101856_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.120243","article-title":"An injectable and self-healing cellulose nanofiber-reinforced alginate hydrogel for bone repair","volume":"300","author":"Cui","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.101856_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119824","article-title":"Shear-thinning and self-healing chitosan-graphene oxide hydrogel for hemostasis and wound healing","volume":"294","author":"Feng","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.101856_bib57","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1021\/acsami.8b20158","article-title":"Rebuilding postinfarcted cardiac functions by injecting TIIA@PDA nanoparticle-cross-linked ROS-sensitive hydrogels","volume":"11","author":"Wang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101856_bib58","doi-asserted-by":"crossref","first-page":"6510","DOI":"10.1021\/acsbiomaterials.0c01190","article-title":"Design strategies and applications of ROS-responsive phenylborate ester-based nanomedicine","volume":"6","author":"Liu","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.mtbio.2025.101856_bib59","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202200990","article-title":"A ROS-responsive liposomal composite hydrogel integrating improved mitochondrial function and pro-angiogenesis for efficient treatment of myocardial infarction","volume":"11","author":"Zheng","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2025.101856_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120286","article-title":"ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds","volume":"258","author":"Zhao","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101856_bib61","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1038\/s41467-020-16439-7","article-title":"Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines","volume":"11","author":"Gao","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.101856_bib62","first-page":"16","article-title":"Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury","volume":"9","author":"Wang","year":"2022","journal-title":"Mil Med Res"},{"key":"10.1016\/j.mtbio.2025.101856_bib63","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.ijbiomac.2020.07.311","article-title":"Alginate hydrogel dressings for advanced wound management","volume":"162","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.101856_bib64","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1021\/acs.accounts.6b00536","article-title":"Designing hydrogels for on-demand therapy","volume":"50","author":"Oliva","year":"2017","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.mtbio.2025.101856_bib65","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/10408398.2018.1536966","article-title":"Multifunctional nanocellulose\/metal and metal oxide nanoparticle hybrid nanomaterials","volume":"60","author":"Oun","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.mtbio.2025.101856_bib66","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/s41467-019-09351-2","article-title":"Plant-inspired adhesive and tough hydrogel based on Ag-Lignin nanoparticles-triggered dynamic redox catechol chemistry","volume":"10","author":"Gan","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.101856_bib67","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40580-018-0167-9","article-title":"Alpinia calcarata: potential source for the fabrication of bioactive silver nanoparticles","volume":"5","author":"Khandel","year":"2018","journal-title":"Nano Converg"},{"key":"10.1016\/j.mtbio.2025.101856_bib68","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.tibtech.2013.01.003","article-title":"The greener synthesis of nanoparticles","volume":"31","author":"Kharissova","year":"2013","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.mtbio.2025.101856_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.120754","article-title":"Antimicrobial activity of silver salt and silver nanoparticles in different forms against microorganisms of different taxonomic groups","volume":"378","author":"Gordienko","year":"2019","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.mtbio.2025.101856_bib70","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1186\/s12951-023-02209-2","article-title":"Ag nanocomposite hydrogels with immune and regenerative microenvironment regulation promote scarless healing of infected wounds","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2025.101856_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.120450","article-title":"Silver doped-silica nanoparticles reinforced poly (ethylene glycol) diacrylate\/hyaluronic acid hydrogel dressings for synergistically accelerating bacterial-infected wound healing","volume":"304","author":"Huang","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.101856_bib72","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3390\/gels9050354","article-title":"Tissue adhesive, biocompatible, antioxidant, and antibacterial hydrogels based on tannic acid and fungal-derived carboxymethyl chitosan for wound-dressing applications","volume":"9","author":"Rao","year":"2023","journal-title":"Gels"},{"key":"10.1016\/j.mtbio.2025.101856_bib73","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/CIRCRESAHA.117.311401","article-title":"Reactive oxygen species in metabolic and inflammatory signaling","volume":"122","author":"Forrester","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.mtbio.2025.101856_bib74","doi-asserted-by":"crossref","first-page":"52643","DOI":"10.1021\/acsami.2c15686","article-title":"Multistage ROS-responsive and natural polyphenol-driven prodrug hydrogels for diabetic wound healing","volume":"14","author":"Ni","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101856_bib75","first-page":"347","article-title":"Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a receptor antagonist modulates antibacterial activity of macrophages for periodontitis treatment","volume":"25","author":"Gan","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101856_bib76","doi-asserted-by":"crossref","first-page":"15752","DOI":"10.1021\/acsami.3c17667","article-title":"Facile reactive oxygen species-scavenging supramolecular hydrogel to promote diabetic wound healing","volume":"16","author":"Jia","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101856_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173090","article-title":"Macrophage M1\/M2 polarization","volume":"877","author":"Yunna","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mtbio.2025.101856_bib78","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mtbio.2025.101856_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.803037","article-title":"Macrophage polarization and its role in liver disease","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2025.101856_bib80","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3390\/ijms19061801","article-title":"Role of human macrophage polarization in inflammation during infectious diseases","volume":"19","author":"Atri","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.101856_bib81","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jconrel.2023.05.047","article-title":"A glucose-responsive nitric oxide release hydrogel for infected diabetic wounds treatment","volume":"359","author":"Zhou","year":"2023","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2025.101856_bib82","article-title":"Natural melanin\/alginate hydrogels achieve cardiac repair through ROS scavenging and macrophage polarization","volume":"8","author":"Zhou","year":"2021","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2025.101856_bib83","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1038\/s41418-023-01194-1","article-title":"TRAF3\/STAT6 axis regulates macrophage polarization and tumor progression","volume":"30","author":"Shi","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mtbio.2025.101856_bib84","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00011-019-01231-1","article-title":"Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors","volume":"68","author":"Korbecki","year":"2019","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.mtbio.2025.101856_bib85","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s41232-023-00285-3","article-title":"Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA","volume":"43","author":"Zhang","year":"2023","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.mtbio.2025.101856_bib86","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41368-021-00132-6","article-title":"Construction of hollow polydopamine nanoparticle based drug sustainable release system and its application in bone regeneration","volume":"13","author":"Wang","year":"2021","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.mtbio.2025.101856_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121903","article-title":"Topography-mediated immunomodulation in osseointegration; ally or enemy","volume":"291","author":"Shirazi","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101856_bib88","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12979-020-00202-z","article-title":"The correlation between the Th17\/Treg cell balance and bone health","volume":"17","author":"Zhu","year":"2020","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.mtbio.2025.101856_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121685","article-title":"Immunology and bioinformatics analysis of injectable organic\/inorganic microfluidic microspheres for promoting bone repair","volume":"288","author":"Xu","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101856_bib90","article-title":"Animal models of middle ear cholesteatoma","volume":"2011","author":"Yamamoto-Fukuda","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.mtbio.2025.101856_bib91","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fcimb.2017.00125","article-title":"In vitro multi-species biofilms of methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa and their host interaction during in vivo colonization of an otitis media rat model","volume":"7","author":"Yadav","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.mtbio.2025.101856_bib92","volume":"2021","author":"Mata","year":"2021"},{"key":"10.1016\/j.mtbio.2025.101856_bib93","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.actbio.2021.12.006","article-title":"The immune microenvironment in cartilage injury and repair","volume":"140","author":"Li","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101856_bib94","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1172\/JCI94606","article-title":"The many ways of osteoclast activation","volume":"127","author":"Lorenzo","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mtbio.2025.101856_bib95","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.mtbio.2025.101856_bib96","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.actbio.2022.07.014","article-title":"Robust coupling of angiogenesis and osteogenesis by VEGF-decorated matrices for bone regeneration","volume":"149","author":"Burger","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101856_bib97","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.cmet.2020.05.004","article-title":"Endothelial lactate controls muscle regeneration from ischemia by inducing M2-like macrophage polarization","volume":"31","author":"Zhang","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.mtbio.2025.101856_bib98","first-page":"24","article-title":"Sequential gastrodin release PU\/n-HA composite scaffolds reprogram macrophages for improved osteogenesis and angiogenesis","volume":"19","author":"Li","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101856_bib99","doi-asserted-by":"crossref","first-page":"5957","DOI":"10.7150\/thno.45422","article-title":"Endothelial cells produce angiocrine factors to regulate bone and cartilage via versatile mechanisms","volume":"10","author":"Zhu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2025.101856_bib100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.actbio.2021.04.052","article-title":"The multifaceted roles of macrophages in bone regeneration: a story of polarization, activation and time","volume":"133","author":"Schlundt","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101856_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121538","article-title":"Biomimetic glycopeptide hydrogel coated PCL\/nHA scaffold for enhanced cranial bone regeneration via macrophage M2 polarization-induced osteo-immunomodulation","volume":"285","author":"Wang","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101856_bib102","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/jcpe.13258","article-title":"NLRP3 inflammasome mediates M1 macrophage polarization and IL-1\u03b2 production in inflammatory root resorption","volume":"47","author":"Zhang","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.mtbio.2025.101856_bib103","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fimmu.2014.00614","article-title":"Molecular mechanisms that influence the macrophage m1-m2 polarization balance","volume":"5","author":"Wang","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2025.101856_bib104","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1007\/s00018-021-03874-y","article-title":"Idiopathic pulmonary fibrosis and systemic sclerosis: pathogenic mechanisms and therapeutic interventions","volume":"78","author":"Mattoo","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mtbio.2025.101856_bib105","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jconrel.2024.02.035","article-title":"Locally delivered hydrogels with controlled release of nanoscale exosomes promote cardiac repair after myocardial infarction","volume":"368","author":"Tan","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2025.101856_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121683","article-title":"ROS-responsive hydrogel coating modified titanium promotes vascularization and osteointegration of bone defects by orchestrating immunomodulation","volume":"287","author":"Li","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101856_bib107","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.actbio.2017.08.015","article-title":"The synergistic effects of Sr and Si bioactive ions on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration","volume":"61","author":"Mao","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101856_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.110698","article-title":"Recent trends in the application of widely used natural and synthetic polymer nanocomposites in bone tissue regeneration","volume":"110","author":"Bharadwaz","year":"2020","journal-title":"Mater. Sci. Eng., C"},{"key":"10.1016\/j.mtbio.2025.101856_bib109","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3390\/antiox11020318","article-title":"Bone regeneration and oxidative stress: an updated overview","volume":"11","author":"B\u0103dil\u0103","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.mtbio.2025.101856_bib110","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41584-021-00682-3","article-title":"The endothelium-bone axis in development, homeostasis and bone and joint disease","volume":"17","author":"Tuckermann","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.mtbio.2025.101856_bib111","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1186\/s12951-023-02209-2","article-title":"Ag nanocomposite hydrogels with immune and regenerative microenvironment regulation promote scarless healing of infected wounds","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2025.101856_bib112","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.jconrel.2023.12.004","article-title":"Injectable dexamethasone-loaded peptide hydrogel for therapy of radiation-induced ototoxicity by regulating the mTOR signaling pathway","volume":"365","author":"Liu","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2025.101856_bib113","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.2147\/IJN.S195336","article-title":"Dexamethasone-loaded injectable silk-polyethylene glycol hydrogel alleviates cisplatin-induced ototoxicity","volume":"14","author":"Chen","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2025.101856_bib114","doi-asserted-by":"crossref","DOI":"10.59717\/j.xinn-life.2024.100078","article-title":"Advancing bone biology: the mutual promotion of biology and pioneering technologies","volume":"2","author":"Tong","year":"2024","journal-title":"TIL"},{"key":"10.1016\/j.mtbio.2025.101856_bib115","article-title":"Peptide-oligonucleotide nanohybrids designed for precise gene therapy of rheumatoid arthritis","author":"Wang","year":"2025","journal-title":"Advanced Materials n\/a"},{"key":"10.1016\/j.mtbio.2025.101856_bib116","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/BF02630748","article-title":"Enhanced epithelial proliferation due to elevated levels of interleukin-1 receptors in middle ear cholesteatomas","volume":"254","author":"Bujia","year":"1997","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.mtbio.2025.101856_bib117","doi-asserted-by":"crossref","first-page":"100015","DOI":"10.59717\/j.xinn-life.2023.100015","article-title":"Gasotransmitter delivery for bone diseases and regeneration","volume":"1","author":"Xu","year":"2023","journal-title":"TIL"},{"key":"10.1016\/j.mtbio.2025.101856_bib118","article-title":"Immunomodulatory biomaterials against bacterial infections: progress, challenges, and future perspectives","volume":"4","author":"Zhang","year":"2023","journal-title":"Innovation"},{"key":"10.1016\/j.mtbio.2025.101856_bib119","article-title":"Balancing the anti-bacterial and pro-osteogenic properties of ti-based implants by partial conversion of ZnO nanorods into hybrid zinc phosphate nanostructures","volume":"34","author":"Zhao","year":"2024","journal-title":"Adv. Funct. Mater."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425004168?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425004168?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:31:11Z","timestamp":1762633871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425004168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":119,"alternative-id":["S2590006425004168"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101856","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ROS-responsive adaptive injectable hydrogel promoting inflammatory mastoid bone repair through efficient sterilization and regulating oxidative stress and macrophage phenotype","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101856","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101856"}}